SI1377574T1 - - Google Patents

Info

Publication number
SI1377574T1
SI1377574T1 SI200230083T SI200230083T SI1377574T1 SI 1377574 T1 SI1377574 T1 SI 1377574T1 SI 200230083 T SI200230083 T SI 200230083T SI 200230083 T SI200230083 T SI 200230083T SI 1377574 T1 SI1377574 T1 SI 1377574T1
Authority
SI
Slovenia
Prior art keywords
pde3
inhibitors
compounds
formula
description
Prior art date
Application number
SI200230083T
Other languages
English (en)
Inventor
Dieter Flockerzi
Beate Schmidt
Gerhard Grundler
Armin Hatzelmann
Rolf Beume
Daniela Bundschuh
Hans-Peter Kley
Ruediger Nave
Karl Zech
Felix Reutter
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of SI1377574T1 publication Critical patent/SI1377574T1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/16Central respiratory analeptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
SI200230083T 2001-02-21 2002-02-21 SI1377574T1 (sh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01104086 2001-02-21
EP02722110A EP1377574B1 (en) 2001-02-21 2002-02-21 6-phenylbenzonaphthyridines
PCT/EP2002/001819 WO2002066476A1 (en) 2001-02-21 2002-02-21 6-phenylbenzonaphthyridines

Publications (1)

Publication Number Publication Date
SI1377574T1 true SI1377574T1 (sh) 2005-08-31

Family

ID=8176545

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200230083T SI1377574T1 (sh) 2001-02-21 2002-02-21

Country Status (12)

Country Link
US (1) US6936622B2 (sh)
EP (1) EP1377574B1 (sh)
JP (1) JP4248245B2 (sh)
AT (1) ATE287403T1 (sh)
AU (1) AU2002253045B2 (sh)
CA (1) CA2438717C (sh)
DE (1) DE60202669T2 (sh)
DK (1) DK1377574T3 (sh)
ES (1) ES2236504T3 (sh)
PT (1) PT1377574E (sh)
SI (1) SI1377574T1 (sh)
WO (1) WO2002066476A1 (sh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004018465A2 (en) * 2002-08-17 2004-03-04 Altana Pharma Ag Benzonaphthyridines with pde 3/4 inhibiting activity
CA2495597A1 (en) * 2002-08-17 2004-03-04 Altana Pharma Ag Novel phenanthridines
WO2004019945A1 (en) 2002-08-29 2004-03-11 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors
ES2286494T3 (es) * 2002-09-04 2007-12-01 Nycomed Gmbh Nuevas benzonaftiridinas.
US7470704B2 (en) * 2002-09-04 2008-12-30 Nycomed Gmbh Benzonaphthyridines
WO2005077906A1 (en) 2004-02-18 2005-08-25 Altana Pharma Ag Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
PL2589599T4 (pl) 2004-03-03 2015-06-30 Takeda Gmbh Nowe hydroksy-6-heteroarylofenantrydyny i ich zastosowanie jako inhibitorów PDE4
US20070185149A1 (en) * 2004-03-10 2007-08-09 Altana Pharma Ag Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibtors
WO2005090345A1 (en) 2004-03-17 2005-09-29 Altana Pharma Ag Novel n- (alkoxyalkyl) carbamoyl - substituted 6-phenyl-benzonaphthyridine derivatives and their use as pde3/4 inhibitors
US7718668B2 (en) 2005-03-02 2010-05-18 Nycomed Gmbh Salts of 6-heterocycle substituted hexahydrophenanthridine derivatives
WO2018069210A1 (en) 2016-10-10 2018-04-19 Takeda Gmbh Tetrahydrofuro[3,4-c]isoquinolines as inhibitors of pde4

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA001551B1 (ru) * 1996-11-11 2001-04-23 Бык Гюльден Ломберг Хемише Фабрик Гмбх Бензонафтиридины в качестве бронхиальных терапевтических средств
AU6825898A (en) 1997-03-07 1998-09-29 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel tetrazoles
ES2193539T3 (es) * 1997-06-03 2003-11-01 Altana Pharma Ag Benzonaftiridinas.
DE59904535D1 (de) 1998-05-05 2003-04-17 Altana Pharma Ag Neue Benzonaphtyridin-N-oxide
AU5970199A (en) * 1998-08-31 2000-03-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity

Also Published As

Publication number Publication date
ES2236504T3 (es) 2005-07-16
EP1377574A1 (en) 2004-01-07
DK1377574T3 (da) 2005-04-25
AU2002253045B2 (en) 2007-07-12
US20040097537A1 (en) 2004-05-20
EP1377574B1 (en) 2005-01-19
CA2438717C (en) 2011-08-30
ATE287403T1 (de) 2005-02-15
WO2002066476A1 (en) 2002-08-29
CA2438717A1 (en) 2002-08-29
JP2004526712A (ja) 2004-09-02
DE60202669D1 (de) 2005-02-24
US6936622B2 (en) 2005-08-30
PT1377574E (pt) 2005-05-31
WO2002066476A9 (en) 2003-10-30
DE60202669T2 (de) 2005-09-15
JP4248245B2 (ja) 2009-04-02

Similar Documents

Publication Publication Date Title
RS20050117A (en) Novel benzonaphthyridines
SI1070056T1 (en) Phthalazinone pde iii/iv inhibitors
RS20050116A (en) Novel phenanthridines
DE60310576D1 (en) 2-hydroxy-6-phenylphenanthridine als pde-4-hemmer
PL372926A1 (en) Piperidine-pyridazones and phthalazones as pde4 inhibitors
MXPA02009567A (es) Benzoilpirzoles y su uso como herbicidas.
MX9700557A (es) Dihidrobenzofuranos.
DE60311662D1 (en) 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren
MXPA03008754A (es) Derivados de piridina fundidos para utilizarse como agonistas receptores vaniloide para tratar dolor.
WO2002085906A3 (en) Phthalazinones derivatives useful as pde4/7 inhibitors
HK1096549A1 (en) Imidazopyridine-derivatives as inducible no-synthase inhibitors
AU2001274220A1 (en) Serine protease inhibitors
MXPA04003886A (es) Tiofen- y tiazolsulfonamidas como agentes antineoplasticos.
GB0114185D0 (en) Compounds
GB0030303D0 (en) Compounds
GB0030306D0 (en) Compounds
SI1086096T1 (en) Benzamides with tetrahydrofuranyloxy substitutents as phosphodiesterase 4 inhibitors
SI1377574T1 (sh)
HK1096548A1 (en) Imidazopyridine-derivatives as inductible no-synthase inhibitors
TR200201128T2 (tr) PDE4 inhibitörleri olarak tetrahidrotiyopiranfitalazinon türevleri.
MXPA04003755A (es) Endoprotesis vasculares.
MXPA06003345A (es) Derivados de aminopiridina como inhibidores de la no-sintasa inducible.
MXPA06000372A (es) Compuestos de silicio y su uso.
GB9923710D0 (en) Chemical compounds
RS20050181A (en) Novel benzonaphthyridines