PL2589599T4 - Nowe hydroksy-6-heteroarylofenantrydyny i ich zastosowanie jako inhibitorów PDE4 - Google Patents
Nowe hydroksy-6-heteroarylofenantrydyny i ich zastosowanie jako inhibitorów PDE4Info
- Publication number
- PL2589599T4 PL2589599T4 PL12196702T PL12196702T PL2589599T4 PL 2589599 T4 PL2589599 T4 PL 2589599T4 PL 12196702 T PL12196702 T PL 12196702T PL 12196702 T PL12196702 T PL 12196702T PL 2589599 T4 PL2589599 T4 PL 2589599T4
- Authority
- PL
- Poland
- Prior art keywords
- heteroarylphenanthridines
- pde4 inhibitors
- novel hydroxy
- hydroxy
- novel
- Prior art date
Links
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 title 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 title 1
Classifications
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04004973 | 2004-03-03 | ||
| EP04106359 | 2004-12-07 | ||
| EP20120196702 EP2589599B1 (en) | 2004-03-03 | 2005-03-02 | Novel hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors |
| EP05716889.0A EP1723135B1 (en) | 2004-03-03 | 2005-03-02 | Novel hydroxy-6-heroarylphenanthridines and their use as pde4 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL2589599T3 PL2589599T3 (pl) | 2015-04-30 |
| PL2589599T4 true PL2589599T4 (pl) | 2015-06-30 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12196702T PL2589599T4 (pl) | 2004-03-03 | 2005-03-02 | Nowe hydroksy-6-heteroarylofenantrydyny i ich zastosowanie jako inhibitorów PDE4 |
| PL05716889T PL1723135T3 (pl) | 2004-03-03 | 2005-03-02 | Nowe hydroksy-6-heteroarylofenantrydyny i ich zastosowanie jako inhibitorów PDE4 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL05716889T PL1723135T3 (pl) | 2004-03-03 | 2005-03-02 | Nowe hydroksy-6-heteroarylofenantrydyny i ich zastosowanie jako inhibitorów PDE4 |
Country Status (29)
| Country | Link |
|---|---|
| US (8) | US8003798B2 (pl) |
| EP (2) | EP2589599B1 (pl) |
| JP (2) | JP4801039B2 (pl) |
| KR (2) | KR101152488B1 (pl) |
| CN (6) | CN1922170A (pl) |
| AR (1) | AR049319A1 (pl) |
| AU (1) | AU2005219576B2 (pl) |
| BR (1) | BRPI0508321B1 (pl) |
| CA (1) | CA2557752C (pl) |
| CO (1) | CO5700749A2 (pl) |
| CY (2) | CY1114319T1 (pl) |
| DK (2) | DK2589599T3 (pl) |
| EA (2) | EA017282B1 (pl) |
| ES (2) | ES2505473T3 (pl) |
| HK (4) | HK1207635A1 (pl) |
| HR (2) | HRP20130828T1 (pl) |
| IL (2) | IL177073A (pl) |
| ME (1) | ME01955B (pl) |
| MX (2) | MX341474B (pl) |
| NO (2) | NO336538B1 (pl) |
| NZ (1) | NZ549108A (pl) |
| PL (2) | PL2589599T4 (pl) |
| PT (2) | PT2589599E (pl) |
| RS (2) | RS53543B1 (pl) |
| SG (1) | SG182194A1 (pl) |
| SI (2) | SI2589599T1 (pl) |
| TW (2) | TWI372750B (pl) |
| WO (1) | WO2005085225A1 (pl) |
| ZA (1) | ZA200606176B (pl) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2496459C (en) | 2002-08-29 | 2013-06-25 | Altana Pharma Ag | 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
| EP1720835B1 (en) | 2004-02-18 | 2012-12-12 | Nycomed GmbH | Novel guanidinyl-substituted hydroxy-6-phenylphenanthridines as effective phosphodiesterase (pde) 4 inhibitors |
| PL2589599T4 (pl) | 2004-03-03 | 2015-06-30 | Takeda Gmbh | Nowe hydroksy-6-heteroarylofenantrydyny i ich zastosowanie jako inhibitorów PDE4 |
| WO2006082185A1 (en) | 2005-02-01 | 2006-08-10 | Nycomed Gmbh | Novel 6-pyridylphenanthridines |
| ES2337083T3 (es) | 2005-03-02 | 2010-04-20 | Nycomed Gmbh | (2r,4ar,10br)-6-(2,6-dimetoxipiridin-3-il)-9-exoti-8-metoxi-1,2,3,4,4a,10b-hexahidrofenantridin-2-ol, sal de hc1. |
| EP1856092A1 (en) * | 2005-03-02 | 2007-11-21 | Nycomed GmbH | 6-heteroaryl-1,2,3,4,4a,10b-hexahydro-phenanthridines as pde-4 inhibitors for the treatment of inflammatory disorders |
| MEP8509A (en) * | 2006-09-07 | 2011-12-20 | Combination treatment for diabetes mellitus | |
| JP5694765B2 (ja) * | 2007-05-17 | 2015-04-01 | コーテックス ファーマシューティカルズ, インコーポレイテッド | グルタミン酸作動性シナプス反応を増強するための二置換アミド |
| WO2009025823A1 (en) * | 2007-08-21 | 2009-02-26 | Amgen Inc. | Phosphodiesterase 10 inhibitors |
| WO2009109525A1 (en) * | 2008-03-03 | 2009-09-11 | Nycomed Gmbh | Use of a specific pde4 inhibitor for the treatment and/or prophylaxis of non-alcoholic fatty liver disease |
| AR074318A1 (es) * | 2008-11-14 | 2011-01-05 | Nycomed Gmbh | Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias. |
| WO2015110394A1 (en) * | 2014-01-22 | 2015-07-30 | Takeda Gmbh | Treatment of partly controlled or uncontrolled severe asthma with a pde4 inhibitor (and in combination with a leukotriene modifier) |
| CN103936661B (zh) * | 2014-04-04 | 2016-08-24 | 常州大学 | 一种6-烷基菲啶衍生物的合成方法 |
| WO2017017165A1 (en) * | 2015-07-29 | 2017-02-02 | Takeda Gmbh | Pde4 inhibitor for the treatment of diabetic nephropathy |
| EP3503892A1 (en) * | 2016-08-26 | 2019-07-03 | Takeda GmbH | Treatment of nonalcoholic fatty liver disease |
| CN110573148A (zh) * | 2017-03-16 | 2019-12-13 | 武田有限公司 | 特发性肺纤维化的治疗 |
| AU2019387367A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Diarylhydantoin compounds and methods of use thereof |
| AU2019387370A1 (en) * | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| TWI753296B (zh) * | 2019-08-30 | 2022-01-21 | 國立陽明交通大學 | 11-芳香基噌啉[2,3-f]菲啶鹽化合物及其製造方法 |
| TWI785816B (zh) * | 2019-08-30 | 2022-12-01 | 國立陽明交通大學 | 11-芳香基噌啉[2,3-f]菲啶鹽化合物及其製造方法 |
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- 2005-03-02 CN CNA2005800057687A patent/CN1922170A/zh active Pending
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