PE20061117A1 - DERIVADOS DE FENILGLICINAMIDA COMO INHIBIDORES DEL FACTOR VIIa - Google Patents

DERIVADOS DE FENILGLICINAMIDA COMO INHIBIDORES DEL FACTOR VIIa

Info

Publication number
PE20061117A1
PE20061117A1 PE2006000049A PE2006000049A PE20061117A1 PE 20061117 A1 PE20061117 A1 PE 20061117A1 PE 2006000049 A PE2006000049 A PE 2006000049A PE 2006000049 A PE2006000049 A PE 2006000049A PE 20061117 A1 PE20061117 A1 PE 20061117A1
Authority
PE
Peru
Prior art keywords
alkyl
inhibitors
factor viia
preferred
phenylglycinamide
Prior art date
Application number
PE2006000049A
Other languages
English (en)
Inventor
Xiaojun Zhang
Eldon Scott Priestley
Alexandra A Nirschl
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20061117A1 publication Critical patent/PE20061117A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE Y ES A, B, ENTRE OTROS; R1 ES H, F, Cl, ALQUILO C1-C5, ENTRE OTROS; R2 Y R3 SON CADA UNO H, F, Cl, OCF3, CN, ENTRE OTROS; R4 ES H, F, CN, NO2, ALQUILO C1-C6, ENTRE OTROS; W ES NH, O; Z ES DE PREFERENCIA 1-ISOQUINOLIN; A ES UN HETEROCICLO DE 4-8 MIEMBROS, DE PREFERENCIA N-PIRROLIDIN; R8 ES H, CN, TETRAZOLILO, ALQUILO C1-C4 SUSTITUIDO; R9 ES FENILACETAMIDA, 2-ISOPROPILTIOFENIL, 3-NITROFENIL, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: SAL ACIDO TRIFLUOROACETICO DE 2-(1-AMINOSIOQUINOLIN-6-ILAMINO)-2-(3-ETOXI-4-ISOPROPOXIFENIL)-1-(2-FENILPIRROLIDIN-1-IL)ETANONA; SAL ACIDO TRIFLUOROACETICO DE N-(3-((S)-1-((R)-2-(1-AMINOISOQUINOLIN-6-ILAMINO)-2-(3-ETOXI-4-ISOPROPOXIFENIL)ACETIL)PIRROLIDIN-2-IL)FENIL)ACETAMIDA; ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE LA SERINA PROTEASA DE LA CASCADA DE COAGULACION, EN PARTICULAR DEL FACTOR VIIa UTILES EN EL TRATAMIENTO DE TRASTORNOS TROMBOEMBOLICOS
PE2006000049A 2005-01-10 2006-01-09 DERIVADOS DE FENILGLICINAMIDA COMO INHIBIDORES DEL FACTOR VIIa PE20061117A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64275105P 2005-01-10 2005-01-10

Publications (1)

Publication Number Publication Date
PE20061117A1 true PE20061117A1 (es) 2006-10-13

Family

ID=36587246

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000049A PE20061117A1 (es) 2005-01-10 2006-01-09 DERIVADOS DE FENILGLICINAMIDA COMO INHIBIDORES DEL FACTOR VIIa

Country Status (9)

Country Link
US (1) US7622585B2 (es)
EP (1) EP1856096B1 (es)
AR (1) AR054321A1 (es)
AT (1) ATE479676T1 (es)
DE (1) DE602006016566D1 (es)
ES (1) ES2349428T3 (es)
PE (1) PE20061117A1 (es)
TW (1) TW200637843A (es)
WO (1) WO2006076246A2 (es)

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ATE405553T1 (de) * 2004-12-08 2008-09-15 Bristol Myers Squibb Co Heterocyclische verbindungen als inhibitoren von faktor viia
ATE455103T1 (de) * 2005-06-24 2010-01-15 Bristol Myers Squibb Co Als antikoagulationsmittel geeignete phenylglycinamid- und pyridylglycinamidderivate
AR058380A1 (es) * 2005-12-23 2008-01-30 Bristol Myers Squibb Co Inhibidores del factor viia macrociclicos utiles como anticoagulantes
US20070161670A1 (en) * 2006-01-09 2007-07-12 Bristol-Myers Squibb Company Process for the preparation of substituted heterocycles
CN101500993A (zh) 2006-06-08 2009-08-05 百时美施贵宝公司 作为凝血因子Ⅶa抑制剂用作抗凝血药的2-氨基羰基苯基氨基-2-苯基乙酰胺
PE20081775A1 (es) * 2006-12-20 2008-12-18 Bristol Myers Squibb Co Compuestos macrociclicos como inhibidores del factor viia
US8039506B2 (en) * 2006-12-20 2011-10-18 Bristol-Myers Squibb Company Bicyclic lactam factor VIIa inhibitors useful as anticoagulants
GB2467670B (en) * 2007-10-04 2012-08-01 Intellikine Inc Chemical entities and therapeutic uses thereof
WO2009114870A2 (en) 2008-03-14 2009-09-17 Intellikine, Inc. Kinase inhibitors and methods of use
US8993580B2 (en) * 2008-03-14 2015-03-31 Intellikine Llc Benzothiazole kinase inhibitors and methods of use
CA2730106A1 (en) 2008-07-08 2010-01-14 Intellikine, Inc. Kinase inhibitors and methods of use
EP2149565A1 (de) 2008-07-24 2010-02-03 Bayer Schering Pharma AG Sulfonsubstituierte Chinazolinderivate als Immunmodulatoren zur Behandlung von enzündlichen und allergischen Erkrankungen
JP5417860B2 (ja) * 2008-08-26 2014-02-19 住友化学株式会社 α−ヒドロキシエステル類の製造方法
US8476431B2 (en) * 2008-11-03 2013-07-02 Itellikine LLC Benzoxazole kinase inhibitors and methods of use
MX337662B (es) 2010-10-06 2016-03-14 Glaxosmithkline Llc Derivados de bencimidazol como inhibidores de cinasa pi3.
TWI592411B (zh) 2011-02-23 2017-07-21 英特爾立秦有限責任公司 激酶抑制劑之組合及其用途
WO2015123091A1 (en) 2014-02-11 2015-08-20 Merck Sharp & Dohme Corp. Factor xia inhibitors
EP3104703B1 (en) 2014-02-11 2020-11-18 Merck Sharp & Dohme Corp. Factor xia inhibitors
EP3134408B1 (en) 2014-04-22 2020-08-12 Merck Sharp & Dohme Corp. FACTOR XIa INHIBITORS
US9868727B2 (en) 2014-07-28 2018-01-16 Merck Sharp & Dohme Corp. Factor XIa inhibitors
WO2017074833A1 (en) 2015-10-29 2017-05-04 Merck Sharp & Dohme Corp. Macrocyclic spirocarbamate derivatives as factor xia inhibitors, pharmaceutically acceptable compositions and their use
BR112018008506B8 (pt) 2015-10-29 2023-12-05 Merck Sharp & Dohme Compostos inibidores do fator xia, composição farmacêutica e usos dos mesmos
WO2017158147A1 (en) 2016-03-18 2017-09-21 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
EP3500556B1 (en) 2016-08-22 2023-08-02 Merck Sharp & Dohme LLC Pyridine-1-oxide derivatives and their use as factor xia inhibitors
CN112225647A (zh) * 2020-10-14 2021-01-15 河南中医药大学 一种合成5-溴-2-甲氧基苯酚的方法

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ATE455103T1 (de) 2005-06-24 2010-01-15 Bristol Myers Squibb Co Als antikoagulationsmittel geeignete phenylglycinamid- und pyridylglycinamidderivate

Also Published As

Publication number Publication date
US20060166997A1 (en) 2006-07-27
AR054321A1 (es) 2007-06-20
TW200637843A (en) 2006-11-01
ATE479676T1 (de) 2010-09-15
WO2006076246A2 (en) 2006-07-20
ES2349428T3 (es) 2011-01-03
DE602006016566D1 (de) 2010-10-14
US7622585B2 (en) 2009-11-24
EP1856096B1 (en) 2010-09-01
WO2006076246A3 (en) 2006-09-28
EP1856096A2 (en) 2007-11-21

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