BR112018008506B8 - Compostos inibidores do fator xia, composição farmacêutica e usos dos mesmos - Google Patents
Compostos inibidores do fator xia, composição farmacêutica e usos dos mesmosInfo
- Publication number
- BR112018008506B8 BR112018008506B8 BR112018008506A BR112018008506A BR112018008506B8 BR 112018008506 B8 BR112018008506 B8 BR 112018008506B8 BR 112018008506 A BR112018008506 A BR 112018008506A BR 112018008506 A BR112018008506 A BR 112018008506A BR 112018008506 B8 BR112018008506 B8 BR 112018008506B8
- Authority
- BR
- Brazil
- Prior art keywords
- factor xia
- pharmaceutical composition
- compounds
- inhibitor compounds
- xia inhibitor
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 229940122036 Factor XIa inhibitor Drugs 0.000 title abstract 2
- 108010080805 Factor XIa Proteins 0.000 abstract 2
- 208000005189 Embolism Diseases 0.000 abstract 1
- 102000003827 Plasma Kallikrein Human genes 0.000 abstract 1
- 108090000113 Plasma Kallikrein Proteins 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
- 230000003176 fibrotic effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 201000005665 thrombophilia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/08—Bridged systems
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562248075P | 2015-10-29 | 2015-10-29 | |
US62/248,075 | 2015-10-29 | ||
PCT/US2016/058362 WO2017074832A1 (en) | 2015-10-29 | 2016-10-24 | FACTOR XIa INHIBITORS |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112018008506A2 BR112018008506A2 (pt) | 2018-10-23 |
BR112018008506B1 BR112018008506B1 (pt) | 2023-11-14 |
BR112018008506B8 true BR112018008506B8 (pt) | 2023-12-05 |
Family
ID=58631804
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018008506A BR112018008506B8 (pt) | 2015-10-29 | 2016-10-24 | Compostos inibidores do fator xia, composição farmacêutica e usos dos mesmos |
Country Status (12)
Country | Link |
---|---|
US (1) | US10214512B2 (pt) |
EP (1) | EP3368036B1 (pt) |
JP (1) | JP6892858B2 (pt) |
KR (1) | KR20180073602A (pt) |
CN (1) | CN108430471B (pt) |
AU (1) | AU2016344476B2 (pt) |
BR (1) | BR112018008506B8 (pt) |
CA (1) | CA2998902C (pt) |
MA (1) | MA43128A (pt) |
MX (1) | MX2018005045A (pt) |
RU (1) | RU2728783C2 (pt) |
WO (1) | WO2017074832A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020086416A1 (en) * | 2018-10-25 | 2020-04-30 | Merck Sharp & Dohme Corp. | FACTOR Xla INHIBITORS |
JP7270770B2 (ja) | 2019-04-16 | 2023-05-10 | チャイナ・リソースズ・バイオファーマシューティカル・カンパニー・リミテッド | XIa因子阻害剤としての大環状誘導体 |
CN114008047B (zh) * | 2019-07-23 | 2023-03-21 | 南京明德新药研发有限公司 | 作为XIa因子抑制剂的大环衍生物 |
CA3206548A1 (en) * | 2021-01-28 | 2022-08-04 | John S. Debenham | Factor xia inhibitors |
US11845748B2 (en) | 2021-03-18 | 2023-12-19 | Janssen Pharmaceutica Nv | Bicyclic pyridine N-oxide derivatives useful as a factor XIa inhibitors |
US11919881B2 (en) | 2021-03-18 | 2024-03-05 | Janssen Pharmaceutica Nv | Substituted pyridine N-oxide derivatives useful as a factor XIa inhibitors |
US11814364B2 (en) | 2021-03-18 | 2023-11-14 | Janssen Pharmaceutica Nv | Pyridine N-oxide derivatives useful as factor XIa inhibitors |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002227269A1 (en) | 2000-11-07 | 2002-06-03 | Bristol-Myers Squibb Company | Acid derivatives useful as serine protease inhibitors |
WO2002037937A2 (en) | 2000-11-07 | 2002-05-16 | Bristol-Myers Squibb Company | Acid derivatives useful as serine protease inhibitors |
JP2004518688A (ja) | 2001-01-30 | 2004-06-24 | ブリストル−マイヤーズ スクイブ カンパニー | ファクターXa阻害剤のスルホンアミドラクタムおよびその方法 |
AU2002331707A1 (en) | 2001-08-20 | 2003-03-03 | Bristol-Myers Squibb Company | Tetrahydroquinoline derivatives as antithrombotic agents |
EP1523483A4 (en) | 2002-06-26 | 2006-03-08 | Bristol Myers Squibb Co | AMINO-BICYCLIC PYRAZINONE AND PYRIDINONE FOR INHIBITING THE COOKING OF SERIN PROTEASE |
US20040180855A1 (en) | 2003-02-19 | 2004-09-16 | Schumacher William A. | Methods of treating thrombosis with reduced risk of increased bleeding times |
US7138412B2 (en) | 2003-03-11 | 2006-11-21 | Bristol-Myers Squibb Company | Tetrahydroquinoline derivatives useful as serine protease inhibitors |
US7129264B2 (en) | 2003-04-16 | 2006-10-31 | Bristol-Myers Squibb Company | Biarylmethyl indolines and indoles as antithromboembolic agents |
US7417063B2 (en) | 2004-04-13 | 2008-08-26 | Bristol-Myers Squibb Company | Bicyclic heterocycles useful as serine protease inhibitors |
US7453002B2 (en) | 2004-06-15 | 2008-11-18 | Bristol-Myers Squibb Company | Five-membered heterocycles useful as serine protease inhibitors |
US7429604B2 (en) | 2004-06-15 | 2008-09-30 | Bristol Myers Squibb Company | Six-membered heterocycles useful as serine protease inhibitors |
US20060074103A1 (en) | 2004-10-06 | 2006-04-06 | Corte James R | Cyclic beta-amino acid derivatives as factor Xa inhibitors |
ATE405553T1 (de) | 2004-12-08 | 2008-09-15 | Bristol Myers Squibb Co | Heterocyclische verbindungen als inhibitoren von faktor viia |
ES2349428T3 (es) | 2005-01-10 | 2011-01-03 | Bristol-Myers Squibb Company | Derivados de fenilglicinamida útiles como anticoagulantes. |
US7459564B2 (en) | 2005-01-13 | 2008-12-02 | Bristol-Myers Squibb Company | Substituted biaryl compounds as factor XIa inhibitors |
US20060183771A1 (en) | 2005-02-17 | 2006-08-17 | Seiffert Dietmar A | Novel combination of selective factor VIIa and/or factor XIa inhibitors and selective plasma kallikrein inhibitors |
AU2006240423A1 (en) * | 2005-04-20 | 2006-11-02 | Janssen Pharmaceutica, N.V. | Fluorinated pyridine N-oxide thrombin modulators and process for N-oxidation of nitrogen containing heteroaryls |
US8466295B2 (en) | 2005-12-14 | 2013-06-18 | Bristol-Myers Squibb Company | Thiophene derivatives as factor XIa inhibitors |
US7626039B2 (en) | 2005-12-14 | 2009-12-01 | Bristol-Myers Squibb Company | Arylpropionamide, arylacrylamide, ayrlpropynamide, or arylmethylurea analogs as factor XIa inhibitors |
AU2006325746A1 (en) | 2005-12-14 | 2007-06-21 | Bristol-Myers Squibb Company | Six-membered heterocycles useful as serine protease inhibitors |
US7829584B2 (en) * | 2006-03-21 | 2010-11-09 | Janssen Pharmaceutica Nv | Pyridines and pyridine N-oxides as modulators of thrombin |
JP5342450B2 (ja) | 2006-12-15 | 2013-11-13 | ブリストル−マイヤーズ スクイブ カンパニー | 第XIa因子インヒビターとしてのアリールプロピオンアミド、アリールアクリルアミド、アリールプロピンアミド、またはアリールメチルウレアアナログ |
US8367709B2 (en) * | 2007-06-13 | 2013-02-05 | Bristol-Myers Squibb Company | Dipeptide analogs as coagulation factor inhibitors |
US8324199B2 (en) | 2008-03-13 | 2012-12-04 | Bristol-Myers Squibb Company | Pyridazine derivatives as factor xia inhibitors |
ES2674745T3 (es) | 2010-02-11 | 2018-07-03 | Bristol-Myers Squibb Company | Macrociclos como inhibidores del factor XIa |
TW201319068A (zh) | 2011-08-05 | 2013-05-16 | 必治妥美雅史谷比公司 | 作為xia因子抑制劑之環狀p1接合劑 |
TW201311689A (zh) * | 2011-08-05 | 2013-03-16 | 必治妥美雅史谷比公司 | 作為因子xia抑制劑之新穎巨環化合物 |
IN2014CN02805A (pt) | 2011-10-14 | 2015-07-03 | Bristol Myers Squibb Co | |
CN103987697B (zh) | 2011-10-14 | 2017-04-26 | 百时美施贵宝公司 | 作为因子xia抑制剂的取代的四氢异喹啉化合物 |
PT2766346T (pt) | 2011-10-14 | 2017-05-26 | Bristol Myers Squibb Co | Compostos de tetrahidroisoquinolina substituídos como inibidores do fator xia |
EP3290413B9 (en) | 2011-12-21 | 2020-04-29 | ONO Pharmaceutical Co., Ltd. | Pyridinone and pyrimidinone derivatives as factor xia inhibitors |
JP2015083542A (ja) | 2012-02-08 | 2015-04-30 | 大日本住友製薬株式会社 | 3位置換プロリン誘導体 |
CA2880898A1 (en) * | 2012-08-03 | 2014-02-06 | Bristol-Myers Squibb Company | Dihydropyridone p1 as factor xia inhibitors |
CA2880866A1 (en) * | 2012-08-03 | 2014-02-06 | Bristol-Myers Squibb Company | Dihydropyridone p1 as factor xia inhibitors |
WO2014160592A2 (en) | 2013-03-27 | 2014-10-02 | Merck Sharp & Dohme Corp. | FACTOR XIa INHIBITORS |
KR20240017118A (ko) * | 2014-01-31 | 2024-02-06 | 브리스톨-마이어스 스큅 컴퍼니 | 인자 XIa 억제제로서의 헤테로시클릭 P2' 기를 갖는 마크로사이클 |
NO2760821T3 (pt) * | 2014-01-31 | 2018-03-10 | ||
US9663527B2 (en) * | 2014-02-11 | 2017-05-30 | Merck Sharp & Dohme Corp. | Factor XIa inhibitors |
WO2015157115A1 (en) * | 2014-04-11 | 2015-10-15 | The University Of North Carolina At Chapel Hill | Mertk-specific pyrimidine compounds |
US9453018B2 (en) * | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
US20180162821A1 (en) * | 2016-12-14 | 2018-06-14 | Bristol-Myers Squibb Company | Factor xia macrocycles with novel p1 groups |
-
2016
- 2016-10-24 BR BR112018008506A patent/BR112018008506B8/pt active IP Right Grant
- 2016-10-24 US US15/771,538 patent/US10214512B2/en active Active
- 2016-10-24 CN CN201680059577.7A patent/CN108430471B/zh active Active
- 2016-10-24 KR KR1020187013433A patent/KR20180073602A/ko not_active Application Discontinuation
- 2016-10-24 MA MA043128A patent/MA43128A/fr unknown
- 2016-10-24 EP EP16860556.6A patent/EP3368036B1/en active Active
- 2016-10-24 JP JP2018521211A patent/JP6892858B2/ja active Active
- 2016-10-24 MX MX2018005045A patent/MX2018005045A/es unknown
- 2016-10-24 WO PCT/US2016/058362 patent/WO2017074832A1/en active Application Filing
- 2016-10-24 CA CA2998902A patent/CA2998902C/en active Active
- 2016-10-24 RU RU2018119015A patent/RU2728783C2/ru active
- 2016-10-24 AU AU2016344476A patent/AU2016344476B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20180339977A1 (en) | 2018-11-29 |
WO2017074832A1 (en) | 2017-05-04 |
CA2998902A1 (en) | 2017-05-04 |
MX2018005045A (es) | 2018-08-01 |
JP6892858B2 (ja) | 2021-06-23 |
RU2728783C2 (ru) | 2020-07-31 |
RU2018119015A3 (pt) | 2020-02-18 |
JP2018531954A (ja) | 2018-11-01 |
BR112018008506A2 (pt) | 2018-10-23 |
RU2018119015A (ru) | 2019-11-29 |
MA43128A (fr) | 2018-09-05 |
CN108430471A (zh) | 2018-08-21 |
CA2998902C (en) | 2024-03-26 |
AU2016344476A1 (en) | 2018-03-08 |
AU2016344476B2 (en) | 2020-08-13 |
EP3368036A1 (en) | 2018-09-05 |
US10214512B2 (en) | 2019-02-26 |
EP3368036A4 (en) | 2019-04-17 |
KR20180073602A (ko) | 2018-07-02 |
CN108430471B (zh) | 2021-07-09 |
BR112018008506B1 (pt) | 2023-11-14 |
EP3368036B1 (en) | 2022-07-20 |
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Legal Events
Date | Code | Title | Description |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B25A | Requested transfer of rights approved |
Owner name: MERCK SHARP AND DOHME LLC (US) |
|
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/10/2016, OBSERVADAS AS CONDICOES LEGAIS |
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B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: REFERENTE A RPI 2758 DE 14/11/2023, QUANTO AO ITEM (73) ENDERECO DO TITULAR. |