ES2079576T3 - Derivados piranicos biciclicos y su uso como inhibidores de 5-lipoxigenasa. - Google Patents

Derivados piranicos biciclicos y su uso como inhibidores de 5-lipoxigenasa.

Info

Publication number
ES2079576T3
ES2079576T3 ES91305532T ES91305532T ES2079576T3 ES 2079576 T3 ES2079576 T3 ES 2079576T3 ES 91305532 T ES91305532 T ES 91305532T ES 91305532 T ES91305532 T ES 91305532T ES 2079576 T3 ES2079576 T3 ES 2079576T3
Authority
ES
Spain
Prior art keywords
elevated
square
bicycle
pyranic
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91305532T
Other languages
English (en)
Inventor
Pierre Andre Raymond Bruneau
Graham Charles Chapel Crawley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca SAS
Syngenta Ltd
Original Assignee
ICI Pharma SA
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ICI Pharma SA, Zeneca Ltd filed Critical ICI Pharma SA
Application granted granted Critical
Publication of ES2079576T3 publication Critical patent/ES2079576T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • C07D273/04—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

LA INVENCION SE REFIERE A UN COMPUESTO HETEROCICLICO BICICLICO DE LA FORMULA I EN LA QUE Q ES UNA MITAD HETEROCICLICA BICICLICA DE 10 MIEMBROS OPCIONALMENTE SUSTITUIDA QUE CONTIENE 1 O 2 N Y UN HETEROATOMO DE O O S ADICIONAL; A ELEVADO 1 ES UN ENLACE DIRECTO A X ELEVADO 1 O (1-3C)ALQUILENO; X ELEVADO 1 ES OXI, TIO, SULFINILO, SULFONILO O IMINO; AR ES FENILENO O PIRIDILENO OPCIONALMENTE SUSTITUIDO; R ELEVADO 1 ES (1-4C)ALQUILO, (3-4C)ALQUENILO O (3-4C)ALQUINILO; Y R (AL CUADRADO) Y R ELEVADO 3 JUNTOS FORMAN UN GRUPO DE LA FORMULA -A (AL CUADRADO) -X (AL CUADRADO) -A ELEVADO 3AL QUE A (AL CUADRADO) Y A ELEVADO 3 ESTAN UNIDOS, DEFINE UN ANILLO QUE TIENE ENTRE 5 Y 7 ATOMOS DE ANILLO, DONDE CADA UNO DE A (AL CUADRADO) Y A ELEVADO 3 ES (1-3C)ALQUILENO Y X (AL CUADRADO) ES OXI, TIO, SULFINILO O SULFONILO; O UNA SAL SUYA FARMACEUTICAMENTE ACEPTABLE. LOS COMPUESTOS DE LA INVENCION SON INHIBIDORES DE LA ENZIMA 5-LIPOXIGENASA .
ES91305532T 1990-06-21 1991-06-19 Derivados piranicos biciclicos y su uso como inhibidores de 5-lipoxigenasa. Expired - Lifetime ES2079576T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP90401757 1990-06-21
EP91400076 1991-01-15

Publications (1)

Publication Number Publication Date
ES2079576T3 true ES2079576T3 (es) 1996-01-16

Family

ID=26127306

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91305532T Expired - Lifetime ES2079576T3 (es) 1990-06-21 1991-06-19 Derivados piranicos biciclicos y su uso como inhibidores de 5-lipoxigenasa.

Country Status (26)

Country Link
US (3) US5217969A (es)
EP (1) EP0462813B1 (es)
JP (1) JP3112981B2 (es)
KR (1) KR920000738A (es)
AR (1) AR247886A1 (es)
AT (1) ATE129497T1 (es)
AU (1) AU637500B2 (es)
CA (1) CA2044219A1 (es)
CS (1) CS187491A3 (es)
DE (1) DE69114052T2 (es)
DK (1) DK0462813T3 (es)
ES (1) ES2079576T3 (es)
FI (1) FI913048A (es)
GB (1) GB9113132D0 (es)
GR (1) GR3017888T3 (es)
HU (2) HU210919B (es)
IE (1) IE911919A1 (es)
IL (1) IL98396A (es)
MY (1) MY106366A (es)
NO (1) NO912411L (es)
NZ (1) NZ238470A (es)
PL (1) PL168310B1 (es)
PT (1) PT98041A (es)
RU (1) RU2059627C1 (es)
TW (1) TW217412B (es)
ZW (1) ZW7091A1 (es)

Families Citing this family (29)

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US5254581A (en) * 1990-06-21 1993-10-19 Imperial Chemical Industries Plc Pyran derivatives and their use as inhibitors of 5-lipoxygenase
IE911853A1 (en) * 1990-06-21 1992-01-01 Ici Plc Heterocyclene derivatives
IE913655A1 (en) * 1990-11-06 1992-05-22 Zeneca Ltd Synergistic agents
IE914005A1 (en) * 1990-12-14 1992-06-17 Zeneca Ltd Novel intermediates
DE69206725T2 (de) * 1991-09-10 1996-05-02 Zeneca Ltd Benzolsulfonamidderivate als 5-Lipoxygenasehemmer
CA2094465A1 (en) * 1992-04-23 1993-10-24 Pierre Andre Raymond Bruneau Cycloalkane derivatives
CA2095005A1 (en) * 1992-05-12 1993-11-13 Philip Neil Edwards Hydroxylamine derivatives
CA2095006A1 (en) * 1992-05-12 1993-11-13 Philip Neil Edwards Oxime derivatives
AU4444393A (en) * 1992-09-01 1994-03-10 Zeneca Limited Pyrrolidine derivatives
US5354865A (en) * 1992-09-10 1994-10-11 Abbott Laboratories Phenylmethyl derivatives having lipoxygenase inhibitory activity
AP9400632A0 (en) * 1993-04-29 1995-10-07 Zeneca Ltd Ether derivatives.
US5424320A (en) * 1993-06-23 1995-06-13 Merck Frosst Canada, Inc. Heteroaryl coumarins as inhibitors of leukotriene biosynthesis
US5360815A (en) * 1993-06-23 1994-11-01 Merck Frosst Canada, Inc. Heteroaryl cinnamic acids as inhibitors of leukotriene biosynthesis
US5459271A (en) * 1993-07-20 1995-10-17 Merck Frosst Canada, Inc. Arylbicyclooctanes as inhibitors of leukotriene biosynthesis
IL110280A0 (en) * 1993-07-27 1994-10-21 Zeneca Ltd Thiazole derivatives
ZA945250B (en) * 1993-07-27 1995-01-27 Zeneca Ltd Thiazole derivatives
EP0636624A1 (en) * 1993-07-27 1995-02-01 Zeneca Limited Thiazole derivatives as lipoxygenase inhibitors
US5350760A (en) * 1993-08-04 1994-09-27 Merck Frosst Canada, Inc. Aza-5,5-fused hetrocyclic acids as leukotriene antagonists
ES2119377T3 (es) * 1994-03-28 1998-10-01 Pfizer Derivados bencisotiazoles inhibidores de la biosintesis de la 5-lipoxigenasa.
WO1995030668A1 (en) * 1994-05-06 1995-11-16 Zeneca Limited Cyclic ether derivatives and pharmaceutical composition containing them
US5643933A (en) * 1995-06-02 1997-07-01 G. D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
US5891460A (en) * 1995-06-07 1999-04-06 University Of Southern California University Park Campus Method for reducing or preventing post-surgical adhesion formation using ketotifen and analogs thereof
US6677364B2 (en) * 1998-04-20 2004-01-13 G.D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
WO2002085868A1 (en) 2001-04-23 2002-10-31 Astrazeneca Ab Benzoxazinone derivatives for use in the treatment of angiogenesis
US7378415B2 (en) 2004-09-30 2008-05-27 Roche Palo Alto Llc Benzoxazine and quinoxaline derivatives and uses thereof
JP2009523820A (ja) * 2006-01-23 2009-06-25 アミラ ファーマシューティカルス，インコーポレーテッド ５−リポキシゲナーゼの三環系抑制剤
WO2007130014A1 (en) * 2006-04-28 2007-11-15 E. I. Du Pont De Nemours And Company Organosilicon polymers
AU2007354632B2 (en) * 2007-06-04 2014-06-26 Techfields Inc Pro-drugs of NSAIAs with very high skin and membranes penetration rates and their new medicinal uses
NZ624963A (en) 2009-04-29 2016-07-29 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same

Family Cites Families (25)

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Publication number Priority date Publication date Assignee Title
US3661917A (en) * 1970-05-21 1972-05-09 Smith Kline French Lab 3-sulfonamido-4-hydroxyphenyl-2-piperidylcarbinols
US3743737A (en) * 1970-05-21 1973-07-03 Smith Kline French Lab 3-sulfonamido-4-hydroxyphenyl-2-piperindinylcarbinol compositions
US4567184A (en) * 1982-12-01 1986-01-28 Usv Pharmaceutical Corporation Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies
US4794188A (en) * 1982-12-01 1988-12-27 Usv Pharmaceutical Corporation Certain unsymmetrical quinolinyl ethers having anti-inflammatory and anti-allergic activity
IE56702B1 (en) * 1982-12-01 1991-11-06 Usv Pharma Corp Antiinflammatory antiallergic compounds
NO174506B (no) * 1984-10-30 1994-02-07 Usv Pharma Corp Analogifremgangsmaate ved fremstilling av terapeutisk aktive forbindelser
US4625034A (en) * 1985-02-04 1986-11-25 Usv Pharmaceutical Corp. 1,2-Dihydro; 1,2,3,4-tetrahydro; 5,8 dihydro; and 5,6,7,8-tetrahydroquinoline derivatives
US4839369A (en) * 1985-04-16 1989-06-13 Rorer Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4631287A (en) * 1985-04-16 1986-12-23 Usv Pharmaceutical Corp. Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4725619A (en) * 1985-04-16 1988-02-16 Usv Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4728668A (en) * 1985-04-16 1988-03-01 Usv Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4876346A (en) * 1985-05-02 1989-10-24 American Home Products Corporation Quinoline compounds
EP0271287A3 (en) * 1986-12-11 1990-06-13 Merck Frosst Canada Inc. Quinoline dioic acids and amides
US4920133A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920130A (en) * 1987-11-02 1990-04-24 Rorer Pharamceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920132A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920131A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4918081A (en) * 1988-06-20 1990-04-17 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene d4
EP0349062A1 (en) * 1988-06-27 1990-01-03 Merck Frosst Canada Inc. Quinoline ether alkanoic acid
GB8926981D0 (en) * 1988-12-23 1990-01-17 Ici Plc Heterocyclic derivatives
US5003087A (en) * 1989-02-03 1991-03-26 Tanabe Seiyaku Co., Ltd. Process for preparing a naphthalene derivative and a synthetic intermediate thereof
IL93343A0 (en) * 1989-02-28 1990-11-29 Ici Plc Heterocyclic cycloalkanes
IL93344A0 (en) * 1989-02-28 1990-11-29 Ici Plc Heterocyclic cyclic ethers
IE70521B1 (en) * 1989-02-28 1996-12-11 Zeneca Pharma Sa Heterocycles with inhibitory activity of 5-lipoxygenase
JP2996475B2 (ja) * 1989-12-22 1999-12-27 サントリー株式会社 ベンズオキサジノン誘導体及びそれを有効成分として含有する除草剤

Also Published As

Publication number Publication date
GB9113132D0 (en) 1991-08-07
HU210919B (en) 1995-09-28
US5373007A (en) 1994-12-13
CS187491A3 (en) 1992-02-19
NZ238470A (en) 1993-07-27
EP0462813A2 (en) 1991-12-27
FI913048A (fi) 1991-12-22
DE69114052D1 (de) 1995-11-30
CA2044219A1 (en) 1991-12-22
EP0462813A3 (en) 1992-01-22
ZW7091A1 (en) 1992-03-25
AU7816191A (en) 1992-01-02
HUT61298A (en) 1992-12-28
DK0462813T3 (da) 1996-02-05
PL290757A1 (en) 1992-08-24
NO912411D0 (no) 1991-06-20
GR3017888T3 (en) 1996-01-31
PT98041A (pt) 1992-04-30
FI913048A0 (fi) 1991-06-20
NO912411L (no) 1991-12-23
AU637500B2 (en) 1993-05-27
IE911919A1 (en) 1992-01-01
US5217969A (en) 1993-06-08
JP3112981B2 (ja) 2000-11-27
HU211133A9 (en) 1995-10-30
DE69114052T2 (de) 1996-10-17
IL98396A0 (en) 1992-07-15
AR247886A1 (es) 1995-04-28
RU2059627C1 (ru) 1996-05-10
HU912003D0 (en) 1991-12-30
IL98396A (en) 1995-11-27
KR920000738A (ko) 1992-01-29
EP0462813B1 (en) 1995-10-25
JPH04230283A (ja) 1992-08-19
PL168310B1 (pl) 1996-02-29
MY106366A (en) 1995-05-30
TW217412B (es) 1993-12-11
US5321025A (en) 1994-06-14
ATE129497T1 (de) 1995-11-15

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