ES2058809T3 - Derivados heterociclicos. - Google Patents
Derivados heterociclicos.Info
- Publication number
- ES2058809T3 ES2058809T3 ES90310332T ES90310332T ES2058809T3 ES 2058809 T3 ES2058809 T3 ES 2058809T3 ES 90310332 T ES90310332 T ES 90310332T ES 90310332 T ES90310332 T ES 90310332T ES 2058809 T3 ES2058809 T3 ES 2058809T3
- Authority
- ES
- Spain
- Prior art keywords
- members
- atoms
- nitrogen
- formula
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- -1 AMINO Chemical class 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 101000740162 Homo sapiens Sodium- and chloride-dependent transporter XTRP3 Proteins 0.000 abstract 1
- 102100037189 Sodium- and chloride-dependent transporter XTRP3 Human genes 0.000 abstract 1
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical class O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001721 carbon Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical group CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- XTQHKBHJIVJGKJ-UHFFFAOYSA-N sulfur monoxide Chemical class S=O XTQHKBHJIVJGKJ-UHFFFAOYSA-N 0.000 abstract 1
- RRBYUSWBLVXTQN-UHFFFAOYSA-N tricyclene Chemical compound C12CC3CC2C1(C)C3(C)C RRBYUSWBLVXTQN-UHFFFAOYSA-N 0.000 abstract 1
- RRBYUSWBLVXTQN-VZCHMASFSA-N tricyclene Natural products C([C@@H]12)C3C[C@H]1C2(C)C3(C)C RRBYUSWBLVXTQN-VZCHMASFSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Quinoline Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
DICHOS DERIVADOS TIENEN LA FORMULA (I): EN LA QUE ! ES UN MONOCICLICO DE 6 MIEMBROS (SUSTITUIDOS OPCIONALMENTE), O UN BICICLICO DE 10 MIEMBROS, AMBOS CONTENIENDO UNO O DOS ATOMOS DE NITROGENO; X1 ES OXI, TIO, SULFINIL, SULFONIL O AMINO; AR ES UN FENILENO QUE PUEDE LLEVAR OPCIONALMENTE UNO O DOS SUSTITUYENTES, O TAMBIEN PUEDE SER UN HETEROCICLENO DE 6 MIEMBROS QUE CONTINEN MAS DE TRES ATOMOS DE NITROGENO; R1 ES UN ALQUILO (1 C), ALQUENILO (3 JUNTOS UN GRUPO DE FORMULA -A2 -X2 -A3-, LA CUAL, JUNTO CON EL ATOMO DE CARBONO AL QUE ESTAN FIJOS A2 Y A3, DEFINE UN ANILLO QUE TIENE DE 4 A 7 ATOMOS EN ANILLO, EN EL QUE A2 Y A3 (QUE PUEDEN SER IGUALES O NO), SON ALQUILENO (1 O, SULFINIL, SULFONIL O IMINO; O SUS SALES ACEPTABLES FARMACEUTICAMENTE. LOS COMPONENTES DE ESTA INVENCION SON INHIBIDORES DE LA ENCIMA S-LIPOXIGENASA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP89402699 | 1989-09-29 | ||
EP90401183 | 1990-05-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2058809T3 true ES2058809T3 (es) | 1994-11-01 |
Family
ID=26123295
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90310332T Expired - Lifetime ES2058809T3 (es) | 1989-09-29 | 1990-09-21 | Derivados heterociclicos. |
Country Status (19)
Country | Link |
---|---|
US (2) | US5221677A (es) |
EP (1) | EP0420511B1 (es) |
JP (1) | JP2996708B2 (es) |
AT (1) | ATE110073T1 (es) |
AU (1) | AU632356B2 (es) |
CA (1) | CA2024258A1 (es) |
DD (1) | DD300434A5 (es) |
DE (1) | DE69011609T2 (es) |
DK (1) | DK0420511T3 (es) |
ES (1) | ES2058809T3 (es) |
FI (1) | FI904591A0 (es) |
GB (1) | GB9018134D0 (es) |
HU (1) | HUT59134A (es) |
IE (1) | IE64251B1 (es) |
IL (1) | IL95481A (es) |
MY (1) | MY107266A (es) |
NO (1) | NO904249L (es) |
NZ (1) | NZ235016A (es) |
PT (1) | PT95455A (es) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5236919A (en) * | 1989-02-28 | 1993-08-17 | Imperial Chemical Industries Plc | Quinoxalinyl derivatives suitable for use in leukotriene mediated disease |
US5254581A (en) * | 1990-06-21 | 1993-10-19 | Imperial Chemical Industries Plc | Pyran derivatives and their use as inhibitors of 5-lipoxygenase |
GB9113137D0 (en) * | 1990-07-13 | 1991-08-07 | Ici Plc | Thioxo heterocycles |
IE913655A1 (en) * | 1990-11-06 | 1992-05-22 | Zeneca Ltd | Synergistic agents |
IE913866A1 (en) * | 1990-11-28 | 1992-06-03 | Ici Plc | Aryl derivatives |
IE914005A1 (en) * | 1990-12-14 | 1992-06-17 | Zeneca Ltd | Novel intermediates |
IL100483A0 (en) * | 1991-01-17 | 1992-09-06 | Ici Plc | Sulphonamide derivatives |
EP0532239B1 (en) * | 1991-09-10 | 1995-12-13 | Zeneca Limited | Benzenesulphonamide derivatives as 5-lipoxygenase inhibitors |
CA2094465A1 (en) * | 1992-04-23 | 1993-10-24 | Pierre Andre Raymond Bruneau | Cycloalkane derivatives |
CA2095005A1 (en) * | 1992-05-12 | 1993-11-13 | Philip Neil Edwards | Hydroxylamine derivatives |
CA2095006A1 (en) * | 1992-05-12 | 1993-11-13 | Philip Neil Edwards | Oxime derivatives |
AU4444393A (en) * | 1992-09-01 | 1994-03-10 | Zeneca Limited | Pyrrolidine derivatives |
EP0586229A1 (en) * | 1992-09-01 | 1994-03-09 | Zeneca Limited | 3-Hydroxy-3-(subst-akyl)-pyrrolidines as 5-lipoxygenase inhibitors |
ES2055657B1 (es) * | 1992-10-08 | 1995-02-16 | Ici Plc | Derivados de bencenosulfonamida. |
IL109254A (en) * | 1993-04-29 | 1999-03-12 | Zeneca Ltd | History of the tetrahydropyran and tetrahydropuran site preparation and pharmaceutical preparations containing them |
AU7070594A (en) * | 1993-06-07 | 1995-01-03 | Zeneca Limited | 2-oxo-1,2,3,4-tetrahydroquinoline derivatives |
US5459271A (en) * | 1993-07-20 | 1995-10-17 | Merck Frosst Canada, Inc. | Arylbicyclooctanes as inhibitors of leukotriene biosynthesis |
US5410054A (en) * | 1993-07-20 | 1995-04-25 | Merck Frosst Canada, Inc. | Heteroaryl quinolines as inhibitors of leukotriene biosynthesis |
IL110280A0 (en) * | 1993-07-27 | 1994-10-21 | Zeneca Ltd | Thiazole derivatives |
ZA945250B (en) * | 1993-07-27 | 1995-01-27 | Zeneca Ltd | Thiazole derivatives |
EP0636624A1 (en) * | 1993-07-27 | 1995-02-01 | Zeneca Limited | Thiazole derivatives as lipoxygenase inhibitors |
US5740861A (en) * | 1996-05-21 | 1998-04-21 | Fmc Corporation | Replaceable consumable erosion detector |
DE60129445T2 (de) * | 2000-08-09 | 2008-04-24 | F. Hoffmann-La Roche Ag | Quinolin-derivate als antientzündungsmittel |
EP2332527A3 (en) | 2004-10-20 | 2011-11-16 | Resverlogix Corp. | Flavanoids and Isoflavanoids for the prevention and treatment of cardiovascular diseases |
AU2006275514B2 (en) | 2005-07-29 | 2012-04-05 | Resverlogix Corp. | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
PT2118074E (pt) | 2007-02-01 | 2014-03-20 | Resverlogix Corp | Compostos para a prevenção e tratamento de doenças cardiovasculares |
CA2711103C (en) | 2008-06-26 | 2016-08-09 | Resverlogix Corp. | Methods of preparing quinazolinone derivatives |
CA2747417C (en) | 2009-01-08 | 2017-01-03 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular disease |
CA3146333A1 (en) | 2009-03-18 | 2010-09-23 | Resverlogix Corp. | Phenyl-quinazolin-4(3h)-one and phenyl-pyrido[2,3-d]pyrimidin-4(3h)-one derivatives and compositions thereof useful as anti-inflammatory agents |
LT2421533T (lt) | 2009-04-22 | 2018-12-27 | Resverlogix Corp. | Nauji priešuždegiminiai agentai |
NZ789295A (en) | 2009-04-29 | 2024-02-23 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
JP5992049B2 (ja) | 2011-11-01 | 2016-09-14 | レスバーロジックス コーポレイション | 置換されたキナゾリノンのための経口速放性製剤 |
US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
AU2013365926B9 (en) | 2012-12-21 | 2019-01-17 | Zenith Epigenetics Ltd. | Novel heterocyclic compounds as bromodomain inhibitors |
WO2016147053A1 (en) | 2015-03-13 | 2016-09-22 | Resverlogix Corp. | Compositions and therapeutic methods for the treatment of complement-associated diseases |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1216878B (de) * | 1963-04-02 | 1966-05-18 | Cassella Farbwerke Mainkur Ag | Verfahren zur Herstellung von coronargefaesserweiternden Derivaten des 7-Hydroxy-2-oxo-1, 2-dihydrochinolins |
US3743737A (en) * | 1970-05-21 | 1973-07-03 | Smith Kline French Lab | 3-sulfonamido-4-hydroxyphenyl-2-piperindinylcarbinol compositions |
US3661917A (en) * | 1970-05-21 | 1972-05-09 | Smith Kline French Lab | 3-sulfonamido-4-hydroxyphenyl-2-piperidylcarbinols |
DE2901336A1 (de) * | 1979-01-15 | 1980-07-24 | Boehringer Mannheim Gmbh | Neue arylether, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
IE56702B1 (en) * | 1982-12-01 | 1991-11-06 | Usv Pharma Corp | Antiinflammatory antiallergic compounds |
US4567184A (en) * | 1982-12-01 | 1986-01-28 | Usv Pharmaceutical Corporation | Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies |
US4794188A (en) * | 1982-12-01 | 1988-12-27 | Usv Pharmaceutical Corporation | Certain unsymmetrical quinolinyl ethers having anti-inflammatory and anti-allergic activity |
NZ213986A (en) * | 1984-10-30 | 1989-07-27 | Usv Pharma Corp | Heterocyclic or aromatic compounds, and pharmaceutical compositions containing such |
US4625034A (en) * | 1985-02-04 | 1986-11-25 | Usv Pharmaceutical Corp. | 1,2-Dihydro; 1,2,3,4-tetrahydro; 5,8 dihydro; and 5,6,7,8-tetrahydroquinoline derivatives |
US4725619A (en) * | 1985-04-16 | 1988-02-16 | Usv Pharmaceutical Corporation | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
US4839369A (en) * | 1985-04-16 | 1989-06-13 | Rorer Pharmaceutical Corporation | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
US4631287A (en) * | 1985-04-16 | 1986-12-23 | Usv Pharmaceutical Corp. | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
US4728668A (en) * | 1985-04-16 | 1988-03-01 | Usv Pharmaceutical Corporation | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
US4876346A (en) * | 1985-05-02 | 1989-10-24 | American Home Products Corporation | Quinoline compounds |
EP0271287A3 (en) * | 1986-12-11 | 1990-06-13 | Merck Frosst Canada Inc. | Quinoline dioic acids and amides |
US4920132A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
US4920133A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
US4920130A (en) * | 1987-11-02 | 1990-04-24 | Rorer Pharamceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
US4920131A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
US4918081A (en) * | 1988-06-20 | 1990-04-17 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene d4 |
EP0349062A1 (en) * | 1988-06-27 | 1990-01-03 | Merck Frosst Canada Inc. | Quinoline ether alkanoic acid |
IE70521B1 (en) * | 1989-02-28 | 1996-12-11 | Zeneca Pharma Sa | Heterocycles with inhibitory activity of 5-lipoxygenase |
IE64358B1 (en) * | 1989-07-18 | 1995-07-26 | Ici Plc | Diaryl ether heterocycles |
GB9113137D0 (en) * | 1990-07-13 | 1991-08-07 | Ici Plc | Thioxo heterocycles |
-
1990
- 1990-08-17 GB GB909018134A patent/GB9018134D0/en active Pending
- 1990-08-21 IE IE302690A patent/IE64251B1/en not_active IP Right Cessation
- 1990-08-21 AU AU61182/90A patent/AU632356B2/en not_active Ceased
- 1990-08-22 NZ NZ235016A patent/NZ235016A/xx unknown
- 1990-08-23 IL IL9548190A patent/IL95481A/xx not_active IP Right Cessation
- 1990-08-29 CA CA002024258A patent/CA2024258A1/en not_active Abandoned
- 1990-09-18 FI FI904591A patent/FI904591A0/fi not_active Application Discontinuation
- 1990-09-21 EP EP90310332A patent/EP0420511B1/en not_active Expired - Lifetime
- 1990-09-21 DK DK90310332.3T patent/DK0420511T3/da active
- 1990-09-21 US US07/585,944 patent/US5221677A/en not_active Expired - Lifetime
- 1990-09-21 ES ES90310332T patent/ES2058809T3/es not_active Expired - Lifetime
- 1990-09-21 DE DE69011609T patent/DE69011609T2/de not_active Expired - Fee Related
- 1990-09-21 AT AT90310332T patent/ATE110073T1/de not_active IP Right Cessation
- 1990-09-27 MY MYPI90001669A patent/MY107266A/en unknown
- 1990-09-28 PT PT95455A patent/PT95455A/pt not_active Application Discontinuation
- 1990-09-28 NO NO90904249A patent/NO904249L/no unknown
- 1990-09-28 HU HU906252A patent/HUT59134A/hu unknown
- 1990-09-28 JP JP2260280A patent/JP2996708B2/ja not_active Expired - Fee Related
- 1990-09-28 DD DD344286A patent/DD300434A5/de unknown
-
1993
- 1993-02-08 US US08/014,673 patent/US5302594A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69011609D1 (de) | 1994-09-22 |
EP0420511A2 (en) | 1991-04-03 |
DK0420511T3 (da) | 1994-09-12 |
US5221677A (en) | 1993-06-22 |
JP2996708B2 (ja) | 2000-01-11 |
HU906252D0 (en) | 1991-03-28 |
DD300434A5 (de) | 1992-06-11 |
EP0420511B1 (en) | 1994-08-17 |
IL95481A0 (en) | 1991-06-30 |
PT95455A (pt) | 1991-05-22 |
AU632356B2 (en) | 1992-12-24 |
IE903026A1 (en) | 1991-04-10 |
MY107266A (en) | 1995-10-31 |
DE69011609T2 (de) | 1994-11-24 |
JPH03130281A (ja) | 1991-06-04 |
EP0420511A3 (en) | 1991-08-28 |
IE64251B1 (en) | 1995-07-26 |
ATE110073T1 (de) | 1994-09-15 |
HUT59134A (en) | 1992-04-28 |
NO904249D0 (no) | 1990-09-28 |
GB9018134D0 (en) | 1990-10-03 |
CA2024258A1 (en) | 1991-03-30 |
NZ235016A (en) | 1993-04-28 |
AU6118290A (en) | 1991-04-11 |
US5302594A (en) | 1994-04-12 |
IL95481A (en) | 1994-11-28 |
NO904249L (no) | 1991-04-02 |
FI904591A0 (fi) | 1990-09-18 |
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