MX9300988A - Agentes antineoplasticos de quinobenzoxazina, quinobenzotiazina y pirido-acridina y composicion farmaceutica que los contiene. - Google Patents
Agentes antineoplasticos de quinobenzoxazina, quinobenzotiazina y pirido-acridina y composicion farmaceutica que los contiene.Info
- Publication number
- MX9300988A MX9300988A MX9300988A MX9300988A MX9300988A MX 9300988 A MX9300988 A MX 9300988A MX 9300988 A MX9300988 A MX 9300988A MX 9300988 A MX9300988 A MX 9300988A MX 9300988 A MX9300988 A MX 9300988A
- Authority
- MX
- Mexico
- Prior art keywords
- quinobenzotiazine
- acridina
- quinobenzoxazine
- pirido
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/06—Peri-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se describen las quirobenzoxazinas, quinobenzotiazinas, y derivados pirido-acridina de la fórmula así como las sales, ésteres, amidas y profármacos farmacéuticamente aceptables de los mismos, en donde R1 es hidrógeno o un grupo protector carboxi, R2 y R3 son sustituyentes, A es oxígeno, azufre, o carbono, Z es un halógeno, o un grupo que contiene nitrógeno, X es hidrógeno, halógeno, o alquilo, y W es hidrógeno, alquilo, amino o halógeno. Los compuestos tienen potente actividad antineoplástica.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/842,910 US5318965A (en) | 1990-08-24 | 1992-02-27 | Quinobenzoxazine, antineoplastic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9300988A true MX9300988A (es) | 1993-11-01 |
Family
ID=25288547
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9300988A MX9300988A (es) | 1992-02-27 | 1993-02-24 | Agentes antineoplasticos de quinobenzoxazina, quinobenzotiazina y pirido-acridina y composicion farmaceutica que los contiene. |
Country Status (7)
Country | Link |
---|---|
US (2) | US5318965A (es) |
JP (1) | JP2578576B2 (es) |
AU (1) | AU3780393A (es) |
IL (1) | IL104749A0 (es) |
MX (1) | MX9300988A (es) |
PH (1) | PH29997A (es) |
WO (1) | WO1993016702A1 (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5618813A (en) * | 1995-05-26 | 1997-04-08 | Abbott Laboratories | Benzo[5.6]pyrano[2.3.4-ij]quinolizine and benzo[5.6]thiopyrano[2.3.4-ij]quinolizine derivatives as antibacterial and antineoplastic agents |
DE19651893B4 (de) * | 1996-12-13 | 2006-10-05 | TRüTZSCHLER GMBH & CO. KG | Verfahren und Vorrichtung an einer Karde zur Verarbeitung von Textilfasern z. B. Baumwolle, Chemiefasern u. dgl. |
US6528517B1 (en) | 1998-02-04 | 2003-03-04 | Board Of Regents, The University Of Texas System | Synthesis of quinobenzoxazine analogues with topoisomerase II and quadruplex interactions for use as antineoplastic agents |
FR2796943A1 (fr) * | 1999-07-30 | 2001-02-02 | Aventis Pharma Sa | Derives de benzoxazinnes, leur procede de preparation et leur utilisation en therapeutique |
DE19954707A1 (de) * | 1999-11-13 | 2001-05-17 | Merck Patent Gmbh | Imidazolverbindungen als Phosphodiesterase VII-Hemmer |
DE60234057D1 (de) | 2001-07-25 | 2009-11-26 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
US7354916B2 (en) * | 2003-04-07 | 2008-04-08 | Cylene Pharmaceuticals | Substituted quinobenzoxazine analogs |
US7163948B2 (en) * | 2003-04-07 | 2007-01-16 | Cylene Pharmaceuticals, Inc. | Heterocyclic substituted 1,4-dihydri-4ox9-1,8-naphthyridine analogs |
WO2004091504A2 (en) * | 2003-04-07 | 2004-10-28 | Cylene Pharmaceuticals, Inc. | Substituted quinobenzoxazine analogs |
CN1809572B (zh) * | 2003-04-07 | 2010-05-12 | 赛林药物股份有限公司 | 取代醌苯并恶嗪类似物 |
US7507727B2 (en) * | 2003-04-07 | 2009-03-24 | Cylene Pharmaceuticals, Inc. | Substituted quinobenzoxazine analogs and methods of using thereof |
ES2383525T3 (es) | 2003-11-05 | 2012-06-21 | Sarcode Bioscience Inc. | Moduladores de la adhesión celular |
ZA200609924B (en) * | 2004-05-06 | 2008-12-31 | Univ California | Substituted enaminones, their derivatives and uses thereof |
EP1874731A4 (en) * | 2005-04-15 | 2009-08-05 | Cylene Pharmaceuticals Inc | CHINOBENZOXAZINANALOGA AND METHOD FOR THE APPLICATION |
EP1889198B1 (en) | 2005-04-28 | 2014-11-26 | Proteus Digital Health, Inc. | Pharma-informatics system |
CA2609053C (en) | 2005-05-17 | 2017-04-25 | Sarcode Corporation | Compositions and methods for treatment of eye disorders |
WO2008036682A2 (en) | 2006-09-18 | 2008-03-27 | Raptor Pharmaceutical Inc. | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
EP3797775A1 (en) | 2007-10-19 | 2021-03-31 | Novartis AG | Compositions and methods for treatment of diabetic retinopathy |
WO2009139817A2 (en) | 2008-04-15 | 2009-11-19 | Sarcode Corporation | Crystalline pharmaceutical and methods of preparation and use thereof |
DK3395372T3 (da) | 2009-02-20 | 2022-04-19 | Enhanx Biopharm Inc | System til afgivelse af glutathion-baseret medikament |
EP2427178B1 (en) | 2009-05-06 | 2023-01-04 | Laboratory Skin Care, Inc. | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
US8378105B2 (en) | 2009-10-21 | 2013-02-19 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
WO2011056566A2 (en) * | 2009-10-26 | 2011-05-12 | Sunesis Pharmaceuticals, Inc. | Compounds and methods for treatment of cancer |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
MX2015001098A (es) | 2012-07-25 | 2015-09-25 | Sarcode Bioscience Inc | Inhibidor del antigeno-1 asociado a la funcion del linfocito (lfa-1) y polimorfo del mismo. |
US9096698B2 (en) | 2012-08-09 | 2015-08-04 | Americas Styrenics, LLC | Styrenic resin incorporating recycled polystyrene |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4507032A (en) * | 1983-06-13 | 1985-03-26 | Peck & Hale, Inc. | Retractable twistlock for securement of a container to a support |
US4533663A (en) * | 1984-04-26 | 1985-08-06 | Abbott Laboratories | Quino-benzothiazine antibacterial compounds |
US4542133A (en) * | 1984-04-26 | 1985-09-17 | Abbott Laboratories | Methylenedioxy quino-benoxazine derivatives and antibacterial use |
US4528285A (en) * | 1984-04-26 | 1985-07-09 | Abbott Laboratories | Methylenedioxy quino-benzothiazine derivatives |
US4607032A (en) * | 1984-04-26 | 1986-08-19 | Abbott Laboratories | Quino-benoxazine antibacterial compounds |
US4529725A (en) * | 1984-04-26 | 1985-07-16 | Abbott Laboratories | 1-Pyridine substituted quino-benzothiazine |
US4540694A (en) * | 1984-04-26 | 1985-09-10 | Abbott Laboratories | 1-Pyridine substituted quino-benoxazines and antibacterial use |
US4689325A (en) * | 1985-12-23 | 1987-08-25 | Abbott Laboratories | Isoxazolo-pyrido-phenoxazine and isothiazolo-pyrido-phenoxazine derivatives |
DE3600891A1 (de) * | 1986-01-15 | 1987-07-16 | Bayer Ag | 1,8-verbrueckte 4-chinolon-3-carbonsaeuren und diese enthaltende arzneimittel |
-
1992
- 1992-02-27 US US07/842,910 patent/US5318965A/en not_active Expired - Fee Related
-
1993
- 1993-02-16 IL IL104749A patent/IL104749A0/xx unknown
- 1993-02-17 PH PH45740A patent/PH29997A/en unknown
- 1993-02-24 MX MX9300988A patent/MX9300988A/es unknown
- 1993-02-26 JP JP5515097A patent/JP2578576B2/ja not_active Expired - Lifetime
- 1993-02-26 WO PCT/US1993/001766 patent/WO1993016702A1/en active Application Filing
- 1993-02-26 AU AU37803/93A patent/AU3780393A/en not_active Abandoned
-
1994
- 1994-06-06 US US08/254,801 patent/US5624924A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
IL104749A0 (en) | 1993-06-10 |
JPH07500611A (ja) | 1995-01-19 |
US5624924A (en) | 1997-04-29 |
JP2578576B2 (ja) | 1997-02-05 |
US5318965A (en) | 1994-06-07 |
AU3780393A (en) | 1993-09-13 |
PH29997A (en) | 1996-10-29 |
WO1993016702A1 (en) | 1993-09-02 |
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