ES2129483T3 - Derivados de indol-7-carboxamida como analgesicos. - Google Patents

Derivados de indol-7-carboxamida como analgesicos.

Info

Publication number
ES2129483T3
ES2129483T3 ES93118753T ES93118753T ES2129483T3 ES 2129483 T3 ES2129483 T3 ES 2129483T3 ES 93118753 T ES93118753 T ES 93118753T ES 93118753 T ES93118753 T ES 93118753T ES 2129483 T3 ES2129483 T3 ES 2129483T3
Authority
ES
Spain
Prior art keywords
loweralkyl
arylloweralkyl
chem
formula
carboxamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93118753T
Other languages
English (en)
Inventor
Gregory Shutske
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of ES2129483T3 publication Critical patent/ES2129483T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBEN UNOS DERIVADOS DE INDOL-7-CARBOXAMIDA DE FORMULA (I) DONDE R1 A TRAVES DE R6 SON INDEPENDIENTEMENTE H, ALQUILO INFERIOR; Y EN ADICION R3 Y R4 SE PUEDEN UNIR PARA FORMAR UN ANILLO DE PIPERAZINA DE FORMULA (II) DONDE R7 ES H, ALQUILO INFERIOR, ARILO, ARILO INFERIOR, PIRIMIDILO; R4 Y R5 SE PUEDEN UNIR PARA FORMAR UN ANILLO DE PIRROLIDINA DE FORMULA (III), DONDE R8 ES H, ALQUILO INFERIOR, ARILOALQUILO INFERIOR; X ES H, ALQUILO INFERIOR, HALOGENO, NO2, CF3, NH2, OR9; DONDE R9 ES ALQUILO INFERIOR ARILOALQUILO INFERIOR Y N ES UN ENTERO DE 1 A 3; Y SUS SALES ACEPTABLES FARMACEUTICAMENTE E ISOMEROS OPTICOS DONDE EXISTEN LOS ISOMEROS
ES93118753T 1992-11-24 1993-11-22 Derivados de indol-7-carboxamida como analgesicos. Expired - Lifetime ES2129483T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/980,869 US5330986A (en) 1992-11-24 1992-11-24 Indole-7-carboxamide derivatives

Publications (1)

Publication Number Publication Date
ES2129483T3 true ES2129483T3 (es) 1999-06-16

Family

ID=25527913

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93118753T Expired - Lifetime ES2129483T3 (es) 1992-11-24 1993-11-22 Derivados de indol-7-carboxamida como analgesicos.

Country Status (8)

Country Link
US (1) US5330986A (es)
EP (1) EP0599240B1 (es)
JP (1) JP3161892B2 (es)
AT (1) ATE178319T1 (es)
DE (1) DE69324212T2 (es)
DK (1) DK0599240T3 (es)
ES (1) ES2129483T3 (es)
GR (1) GR3030364T3 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998006715A1 (en) * 1996-08-09 1998-02-19 Smithkline Beecham Corporation Novel piperazine containing compounds
DE19934432A1 (de) * 1999-07-22 2001-02-01 Merck Patent Gmbh Indolderivate
DE19934433A1 (de) * 1999-07-22 2001-01-25 Merck Patent Gmbh N-(Indolcarbonyl-)piperazinderivate
GB0400895D0 (en) * 2004-01-15 2004-02-18 Smithkline Beecham Corp Chemical compounds
AR050253A1 (es) * 2004-06-24 2006-10-11 Smithkline Beecham Corp Compuesto derivado de indazol carboxamida, composicion que lo comprende y su uso para la preparacion de un medicamento
PE20060748A1 (es) * 2004-09-21 2006-10-01 Smithkline Beecham Corp Derivados de indolcarboxamida como inhibidores de quinasa ikk2
US8063071B2 (en) * 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
JP2009513677A (ja) * 2005-10-25 2009-04-02 スミスクライン・ビーチャム・コーポレイション 化合物
PE20081889A1 (es) 2007-03-23 2009-03-05 Smithkline Beecham Corp Indol carboxamidas como inhibidores de ikk2
WO2010102968A1 (en) 2009-03-10 2010-09-16 Glaxo Group Limited Indole derivatives as ikk2 inhibitors
US8765792B2 (en) 2010-12-01 2014-07-01 Glaxosmithkline Llc Indoles
CN107176927B (zh) * 2016-03-12 2020-02-18 福建金乐医药科技有限公司 组蛋白去甲基化酶lsd1抑制剂
US10988481B2 (en) 2016-05-19 2021-04-27 Virginia Commonwealth University Potent and selective mu opioid receptor modulators

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3582371D1 (de) * 1984-07-06 1991-05-08 Otsuka Pharma Co Ltd Oxindolverbindungen, diese enthaltende zusammensetzungen sowie verfahren zur herstellung derselben.
US4908367A (en) * 1985-07-11 1990-03-13 Roussel Uclaf N-(1H-indole-4-yl)-benzamides
HU895334D0 (en) * 1986-07-30 1990-01-28 Sandoz Ag Process for the preparation of nasal pharmaceutical compositions
US5124332A (en) * 1991-01-28 1992-06-23 Warner-Lambert Company Substituted indoles as central nervous system agents

Also Published As

Publication number Publication date
US5330986A (en) 1994-07-19
EP0599240B1 (en) 1999-03-31
JP3161892B2 (ja) 2001-04-25
EP0599240A1 (en) 1994-06-01
DE69324212D1 (de) 1999-05-06
DE69324212T2 (de) 1999-09-16
DK0599240T3 (da) 1999-10-11
GR3030364T3 (en) 1999-09-30
JPH06211788A (ja) 1994-08-02
ATE178319T1 (de) 1999-04-15

Similar Documents

Publication Publication Date Title
ES2112830T3 (es) 4-pirimidinaminas y -pirimidindiaminas sustituidas en n, un procedimiento para su preparacion y su uso como medicamentos.
ATE247654T1 (de) Neue heterozyklische verbindungen
ATE172201T1 (de) Morphinan-derivate und medizinische verwendung
DZ1467A1 (fr) Dérivés d'acides amines.
ES2129483T3 (es) Derivados de indol-7-carboxamida como analgesicos.
ES2132284T3 (es) Derivados de carbamato de 2-(piperidin-4-il, piridin-4-il y tetrahidropiridin-4-il)-benzofurano-7, su preparacion y su uso como inhibidores de acetilcolinesterasa.
ATE155465T1 (de) Phenoxy- oder phenoxyalkyl-piperidine als antivirale mittel
DE69830045D1 (de) Arylpiperidinopropanol und arylpiperazinopropanol derivate und die selbe enthaltende pharmazeutika
MX21088A (es) N-heteroanil-purin-6-aminas, y un proceso para su preparacion y su uso como medicamentos.
ES2059929T3 (es) 1-(piridinilamino)-2-pirrolidinonas, un procedimiento para su preparacion y su uso como medicamentos.
DK0591058T3 (da) Ellipticinderivater med antitumoraktivitet
NO910904L (no) Fremgangsmaate for fremstilling av en substituert aminforbindelse.
DE69810373D1 (de) Pyrrolidin Derivate, Anti-ulcus und Antibakterielle Arzneimittel
DE69230498D1 (de) 2-Pyrazinylethylamin-Derivate und ihre Verwendung als Arzneimittel.
ATE169015T1 (de) Aminobenzoesäure derivate
ATE205209T1 (de) Chinolincarbonsäurederivate und ihre salze
UY26448A1 (es) 1,2,3,4,5,6-hexahidro-2,6-metano -3 - benzazocinas sustituidas y su empleo como medicamentos.
EP0911336A4 (es)

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 599240

Country of ref document: ES