ES2129483T3 - Derivados de indol-7-carboxamida como analgesicos. - Google Patents

Derivados de indol-7-carboxamida como analgesicos.

Info

Publication number
ES2129483T3
ES2129483T3 ES93118753T ES93118753T ES2129483T3 ES 2129483 T3 ES2129483 T3 ES 2129483T3 ES 93118753 T ES93118753 T ES 93118753T ES 93118753 T ES93118753 T ES 93118753T ES 2129483 T3 ES2129483 T3 ES 2129483T3
Authority
ES
Spain
Prior art keywords
loweralkyl
arylloweralkyl
chem
formula
carboxamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93118753T
Other languages
English (en)
Inventor
Gregory Shutske
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of ES2129483T3 publication Critical patent/ES2129483T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBEN UNOS DERIVADOS DE INDOL-7-CARBOXAMIDA DE FORMULA (I) DONDE R1 A TRAVES DE R6 SON INDEPENDIENTEMENTE H, ALQUILO INFERIOR; Y EN ADICION R3 Y R4 SE PUEDEN UNIR PARA FORMAR UN ANILLO DE PIPERAZINA DE FORMULA (II) DONDE R7 ES H, ALQUILO INFERIOR, ARILO, ARILO INFERIOR, PIRIMIDILO; R4 Y R5 SE PUEDEN UNIR PARA FORMAR UN ANILLO DE PIRROLIDINA DE FORMULA (III), DONDE R8 ES H, ALQUILO INFERIOR, ARILOALQUILO INFERIOR; X ES H, ALQUILO INFERIOR, HALOGENO, NO2, CF3, NH2, OR9; DONDE R9 ES ALQUILO INFERIOR ARILOALQUILO INFERIOR Y N ES UN ENTERO DE 1 A 3; Y SUS SALES ACEPTABLES FARMACEUTICAMENTE E ISOMEROS OPTICOS DONDE EXISTEN LOS ISOMEROS
ES93118753T 1992-11-24 1993-11-22 Derivados de indol-7-carboxamida como analgesicos. Expired - Lifetime ES2129483T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/980,869 US5330986A (en) 1992-11-24 1992-11-24 Indole-7-carboxamide derivatives

Publications (1)

Publication Number Publication Date
ES2129483T3 true ES2129483T3 (es) 1999-06-16

Family

ID=25527913

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93118753T Expired - Lifetime ES2129483T3 (es) 1992-11-24 1993-11-22 Derivados de indol-7-carboxamida como analgesicos.

Country Status (8)

Country Link
US (1) US5330986A (es)
EP (1) EP0599240B1 (es)
JP (1) JP3161892B2 (es)
AT (1) ATE178319T1 (es)
DE (1) DE69324212T2 (es)
DK (1) DK0599240T3 (es)
ES (1) ES2129483T3 (es)
GR (1) GR3030364T3 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001506230A (ja) * 1996-08-09 2001-05-15 スミスクライン・ビーチャム・コーポレイション 新規ピペラジン含有化合物
DE19934432A1 (de) * 1999-07-22 2001-02-01 Merck Patent Gmbh Indolderivate
DE19934433A1 (de) * 1999-07-22 2001-01-25 Merck Patent Gmbh N-(Indolcarbonyl-)piperazinderivate
GB0400895D0 (en) * 2004-01-15 2004-02-18 Smithkline Beecham Corp Chemical compounds
TW200616967A (en) * 2004-06-24 2006-06-01 Smithkline Beecham Corp Novel indazole carboxamides and their use
TW200626142A (en) * 2004-09-21 2006-08-01 Glaxo Group Ltd Chemical compounds
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
WO2007102883A2 (en) * 2005-10-25 2007-09-13 Smithkline Beecham Corporation Chemical compounds
PE20081889A1 (es) 2007-03-23 2009-03-05 Smithkline Beecham Corp Indol carboxamidas como inhibidores de ikk2
JP2012520257A (ja) 2009-03-10 2012-09-06 グラクソ グループ リミテッド Ｉｋｋ２阻害剤としてのインドール誘導体
JP5908493B2 (ja) * 2010-12-01 2016-04-26 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ インドール
CN107176927B (zh) * 2016-03-12 2020-02-18 福建金乐医药科技有限公司 组蛋白去甲基化酶lsd1抑制剂
EP3458061B1 (en) * 2016-05-19 2023-01-18 Virginia Commonwealth University Potent and selective mu opioid receptor modulators

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3582371D1 (de) * 1984-07-06 1991-05-08 Otsuka Pharma Co Ltd Oxindolverbindungen, diese enthaltende zusammensetzungen sowie verfahren zur herstellung derselben.
US4908367A (en) * 1985-07-11 1990-03-13 Roussel Uclaf N-(1H-indole-4-yl)-benzamides
NL8701682A (nl) * 1986-07-30 1988-02-16 Sandoz Ag Werkwijze voor het therapeutisch toepassen van serotonine antagonisten, aktieve verbindingen en farmaceutische preparaten die deze verbindingen bevatten.
US5124332A (en) * 1991-01-28 1992-06-23 Warner-Lambert Company Substituted indoles as central nervous system agents

Also Published As

Publication number Publication date
JPH06211788A (ja) 1994-08-02
EP0599240B1 (en) 1999-03-31
EP0599240A1 (en) 1994-06-01
DE69324212T2 (de) 1999-09-16
GR3030364T3 (en) 1999-09-30
ATE178319T1 (de) 1999-04-15
DK0599240T3 (da) 1999-10-11
JP3161892B2 (ja) 2001-04-25
DE69324212D1 (de) 1999-05-06
US5330986A (en) 1994-07-19

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