ATE172201T1 - Morphinan-derivate und medizinische verwendung - Google Patents

Morphinan-derivate und medizinische verwendung

Info

Publication number
ATE172201T1
ATE172201T1 AT93902520T AT93902520T ATE172201T1 AT E172201 T1 ATE172201 T1 AT E172201T1 AT 93902520 T AT93902520 T AT 93902520T AT 93902520 T AT93902520 T AT 93902520T AT E172201 T1 ATE172201 T1 AT E172201T1
Authority
AT
Austria
Prior art keywords
medical uses
nch3
morphinane derivatives
morphinane
derivatives
Prior art date
Application number
AT93902520T
Other languages
English (en)
Inventor
Hiroshi Nagase
Koji Kawai
Kuniaki Kawamura
Jun Hayakawa
Takashi Endo
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Application granted granted Critical
Publication of ATE172201T1 publication Critical patent/ATE172201T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Fertilizers (AREA)
AT93902520T 1992-01-23 1993-01-22 Morphinan-derivate und medizinische verwendung ATE172201T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1011592 1992-01-23
JP29430892 1992-11-02

Publications (1)

Publication Number Publication Date
ATE172201T1 true ATE172201T1 (de) 1998-10-15

Family

ID=26345314

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93902520T ATE172201T1 (de) 1992-01-23 1993-01-22 Morphinan-derivate und medizinische verwendung

Country Status (15)

Country Link
US (2) US6323212B1 (de)
EP (2) EP0846694A1 (de)
JP (1) JP2525552B2 (de)
KR (1) KR970011390B1 (de)
AT (1) ATE172201T1 (de)
AU (2) AU666702B2 (de)
CA (1) CA2105072C (de)
DE (1) DE69321525T2 (de)
DK (1) DK0577847T3 (de)
ES (1) ES2121988T3 (de)
FI (1) FI106126B (de)
NO (1) NO302755B1 (de)
NZ (1) NZ246687A (de)
TW (1) TW332814B (de)
WO (1) WO1993015081A1 (de)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2525552B2 (ja) * 1992-01-23 1996-08-21 東レ株式会社 モルヒナン誘導体および医薬用途
CN1111900A (zh) * 1993-06-30 1995-11-15 东丽株式会社 止咳药
KR100341950B1 (ko) * 1993-07-19 2002-11-29 도레이 가부시끼가이샤 뇌세포보호제
NZ268969A (en) * 1993-07-23 1997-06-24 Toray Industries Morphinan derivatives and pharmaceutical compositions
SE9401727D0 (sv) * 1994-05-18 1994-05-18 Astra Ab New compounds I
DE19602968A1 (de) * 1995-12-20 1997-07-31 Nycomed Arzneimittel Gmbh Neue Morphinderivate, Verfahren zu deren Herstellung und deren Verwendung
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
EP0829481A1 (de) * 1996-09-16 1998-03-18 Pfizer Inc. Morphinan-Hydroxamsäure-Derivate
CN1535687A (zh) * 1996-11-25 2004-10-13 ������������ʽ���� 止痒药物
EP0915094B1 (de) * 1997-03-27 2007-11-07 Toray Industries, Inc. Morphinanderivate und ihre medizinische Anwendung
CA2265767C (en) 1997-07-11 2007-12-04 Nobuyuki Hanamura Stable pharmaceutical composition including 4,5-epoxy-morphinan derivative
US5760023A (en) * 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
JP2003526594A (ja) * 1997-07-14 2003-09-09 アドラー コーポレーション カッパ・アゴニスト抗掻痒薬学的製剤およびそれにより掻痒を治療する方法
WO1999005146A1 (en) * 1997-07-25 1999-02-04 Toray Industries, Inc. Hyponatremia remedies
CA2270955C (en) * 1997-09-02 2007-08-07 Toray Industries Inc. Pharmaceutical composition containing morphinan derivative for treating drug dependence
US6083944A (en) * 1997-10-07 2000-07-04 Cephalon, Inc. Quinoline-containing α-ketoamide cysteine and serine protease inhibitors
TW570920B (en) * 1998-12-22 2004-01-11 Janssen Pharmaceutica Nv 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
ES2308990T3 (es) * 1999-08-24 2008-12-16 Toray Industries, Inc. Remedios para el dolor neuropatico y modelos animales de dolor neuropatico.
NZ519897A (en) * 1999-12-03 2004-02-27 Iouri Malov Electroretinogram (ERG) using image segments which stimulate output signals with very little cross-correlation
WO2001074819A1 (en) * 2000-04-03 2001-10-11 Toray Industries, Inc. Analgesics containing morphinan n-oxide derivatives as the active ingredient
JP4453254B2 (ja) * 2001-03-30 2010-04-21 東レ株式会社 レストレス・レッグズ症候群治療薬
WO2002080918A1 (en) * 2001-04-02 2002-10-17 Toray Industries, Inc. Remedial or prophylactic agent for frequent urination or urinary incontinence
DE10161963A1 (de) * 2001-12-17 2003-07-03 Johannes Schuetz 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung
US7501433B2 (en) 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US7923454B2 (en) 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
WO2003097608A2 (en) 2002-05-17 2003-11-27 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
CN100537573C (zh) 2002-10-09 2009-09-09 东丽株式会社 尿频或尿失禁的治疗或预防剂以及具有含氮环状取代基的吗啡烷衍生物
US8017622B2 (en) * 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
JP2007526217A (ja) * 2003-06-04 2007-09-13 アルカーメス，インコーポレイテッド ナルトレキソンの多型形態
DK1758452T3 (en) * 2004-05-28 2017-05-01 Human Biomolecular Res Inst METABOLIC STABLE ANALGETICS AND Painkillers
TW200621785A (en) * 2004-11-04 2006-07-01 Toray Industries Analgesic
RU2397173C2 (ru) * 2005-04-06 2010-08-20 Торей Индастриз, Инк. Кристаллические производные морфинана и способ их получения
ES2307352B1 (es) * 2005-04-12 2009-09-18 Bti, I+D, S.L. Implante dental y piezas destinadas a ser conectadas a un implante dental, y la conexion interna entre el implante dental y cada pieza.
ES2629766T3 (es) 2006-04-21 2017-08-14 Nektar Therapeutics Reducción estereoselectiva de una morfinona
MX2009011449A (es) 2007-04-24 2010-01-25 Toray Industries Agente terapeutico o profilactico para disquinesia.
CA2685131C (en) 2007-04-26 2015-05-19 Toray Industries, Inc. Stable solid preparation containing 4,5-epoxymorphinan derivative
MX2009014181A (es) * 2007-06-22 2010-03-04 Toray Industries Remedio o preventivo para sindrome de disfuncion de integracion.
BRPI0817804A8 (pt) 2007-10-05 2017-04-18 Toray Industries Agente terapêutico para melhorar as propriedades da pele compreendendo um derivado de morfinano ou qualquer um de seus sais de adição de ácido farmacologicamente permissíveis como um ingrediente ativo
JP2011512360A (ja) * 2008-02-14 2011-04-21 アルカーメス，インコーポレイテッド 選択的オピオイド化合物
WO2010006299A1 (en) * 2008-07-11 2010-01-14 Regents Of The University Of Minnesota Analgesic agents
DK2356989T3 (en) 2008-10-24 2018-05-07 Toray Industries Stable tablet containing 4,5-epoxymorphinane derivative
JP5784507B2 (ja) * 2009-02-23 2015-09-24 マリンクロッド エルエルシー （＋）−モルフィナニウム第四級塩およびその生成方法
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8563724B2 (en) * 2009-02-23 2013-10-22 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
CN102325777B (zh) * 2009-02-23 2015-08-12 马林克罗特公司 (+)-吗啡喃*n-氧化物及其制备方法
US8471023B2 (en) * 2009-06-11 2013-06-25 Mallinckrodt Llc Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer
CA2764915C (en) * 2009-06-11 2017-07-11 Mallinckrodt Llc Preparation of 6-alpha-amino n-substituted morphinans by catalytic hydrogen transfer
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
US10363251B2 (en) 2009-07-16 2019-07-30 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
PH12012501552A1 (en) 2010-01-29 2017-04-26 Toray Industries Therapeutic or prophylactic agent for biliary diseases
CA2936749C (en) 2010-06-11 2019-07-09 Rhodes Technologies Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
TWI471289B (zh) 2010-06-11 2015-02-01 Rhodes Technologies 使三級胺進行ｎ－脫烷反應之方法
WO2012008984A1 (en) * 2010-07-16 2012-01-19 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
BR112013009505B1 (pt) * 2010-10-19 2022-06-21 Memorial Sloan-Kettering Cancer Center Composto, composição farmacêutica, métodos para ensaio quanto a um receptor, e, usos de um composto
CN103327977B (zh) 2011-01-31 2016-05-04 东丽株式会社 恶液质的治疗或预防剂
ES2698408T3 (es) 2011-06-09 2019-02-04 SpecGx LLC Aminación reductora de 6-ceto morfinanos por transferencia de hidrógeno catalítico
KR20140063763A (ko) 2011-09-08 2014-05-27 말린크로트 엘엘씨 중간체를 단리하지 않는 알칼로이드의 제조 방법
ES2750640T3 (es) * 2012-08-16 2020-03-26 Scripps Research Inst Ligandos opioides kappa novedosos
TWI449704B (zh) * 2013-04-26 2014-08-21 臺灣永光化學工業股份有限公司 嗎啡喃衍生物之結晶、其製造方法、及使用其之醫藥組成物
WO2015082932A1 (en) 2013-12-05 2015-06-11 The University Of Bath Novel opioid compounds and their uses
JP2015166331A (ja) * 2014-05-14 2015-09-24 遼東化学工業株式会社 ナルフラフィンの結晶およびその製造方法
JPWO2016152953A1 (ja) * 2015-03-24 2018-01-11 東レ株式会社 モルヒナン誘導体及びその医薬用途
EP4212532A3 (de) 2015-04-30 2023-09-27 Memorial Sloan Kettering Cancer Center Mitragynin-analoga und verwendungen davon
WO2017073710A1 (ja) 2015-10-29 2017-05-04 東レ株式会社 モルヒナン誘導体及びその医薬用途
WO2017165558A1 (en) 2016-03-22 2017-09-28 Regents Of The University Of Minnesota Combination for treating pain
US10988481B2 (en) * 2016-05-19 2021-04-27 Virginia Commonwealth University Potent and selective mu opioid receptor modulators
JP6814470B2 (ja) 2017-02-10 2021-01-20 国立大学法人 筑波大学 モルヒナン誘導体
WO2019168985A1 (en) * 2018-02-27 2019-09-06 Delpor, Inc. Compositions for small molecule therapeutic agent compounds
CA3091752A1 (en) 2018-03-08 2019-09-12 Victoria Link Ltd Treatment of demyelinating diseases
WO2020205735A1 (en) * 2019-03-29 2020-10-08 Humanwell Pharmaceutical US Novel morphinans useful for treating medical disorders
CA3146163A1 (en) * 2019-07-08 2021-01-14 University Of Health Sciences & Pharmacy In St. Louis G-protein biased opioid receptor agonist/analgesics with reduced arrestin recruitment
WO2021065898A1 (ja) 2019-09-30 2021-04-08 日本ケミファ株式会社 アゼパン誘導体
AU2020372131B2 (en) * 2019-10-24 2025-10-30 Toray Industries, Inc. Therapeutic or prophylactic agent for cachexia
KR20230031207A (ko) 2020-06-30 2023-03-07 도레이 카부시키가이샤 대사이상을 수반하는 질환 또는 증후군에 있어서의 근력 저하 증상의 개선제 또는 예방제
CN115181109B (zh) * 2021-04-02 2024-06-04 南京正大天晴制药有限公司 吗啡喃衍生物的晶体及其制备方法
JPWO2022225045A1 (de) 2021-04-23 2022-10-27
MX2023014819A (es) 2021-06-14 2024-03-21 Scorpion Therapeutics Inc Derivados de la urea que pueden ser utilizados para tratar el cancer.
CN115960108B (zh) * 2021-10-09 2026-02-03 山东新时代药业有限公司 一种无定型盐酸纳呋拉啡及其制备方法
EP4482840A4 (de) * 2022-02-22 2026-02-25 Univ Virginia Commonwealth Naltrexaminderivate mit 5-gliedrigen heterocyclischen ringsystemen als opioidrezeptormodulatoren
WO2023190665A1 (ja) * 2022-03-29 2023-10-05 東レ株式会社 モルヒナン誘導体及びその医薬用途

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL290054A (de) *
US3236851A (en) * 1966-02-22 Unsaturated morphinan derivatives
DE622231C (de) * 1934-03-09 1935-11-23 Hermann Fischer Dr Verfahren zur Herstellung von Diacetylmorphin
GB864107A (en) * 1958-09-10 1961-03-29 Albert Boehringer Morphine derivatives
GB919311A (en) * 1958-10-29 1963-02-20 T & H Smith Ltd Derivatives of 14-hydroxycodeine and their preparation
DE2254298A1 (de) 1972-11-06 1974-05-16 Boehringer Sohn Ingelheim Neue (heteroarylmethyl)-normorphine, deren saeureadditionssalze, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
GB1587831A (en) * 1977-03-23 1981-04-08 Reckitt & Colmann Prod Ltd Morphine derivatives
GB1593191A (en) 1977-03-23 1981-07-15 Reckitt & Colmann Prod Ltd Derivatives of morphine
US4362870A (en) * 1980-01-16 1982-12-07 Regents Of The University Of Minnesota Selective opioid receptor alkylating agents
JPS574991A (en) * 1980-06-10 1982-01-11 Sankyo Co Ltd Cyclopropylmethylnormorphine-6-sulfuric ester
US4401672A (en) 1981-10-13 1983-08-30 Regents Of The University Of Minnesota Non-addictive narcotic antitussive preparation
US4668685A (en) * 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
US4767718A (en) * 1984-06-18 1988-08-30 Southern Illinois University Foundation Fluorescent opioid reagents and methods of use thereof in the detection of opioid receptors
IN163125B (de) 1985-01-08 1988-08-13 Alkaloida Vegyeszeti Gyar
DE3617182A1 (de) 1985-05-23 1986-11-27 Sandoz-Patent-GmbH, 79539 Lörrach Morphinan-derivate
HU196376B (en) 1985-05-23 1988-11-28 Sandoz Ag Process for preparing morphinane derivatives and pharmaceutical compositions containing such compounds
US4806556A (en) 1985-12-12 1989-02-21 Regents Of The University Of Minnesota Gut-selective opiates
US4730048A (en) 1985-12-12 1988-03-08 Regents Of The University Of Minnesota Gut-selective opiates
US4673679A (en) * 1986-05-14 1987-06-16 E. I. Du Pont De Nemours And Company Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration
US4816586A (en) * 1987-07-29 1989-03-28 Regents Of The University Of Minnesota Delta opioid receptor antagonists
JPH01149788A (ja) * 1987-12-08 1989-06-12 Chugai Pharmaceut Co Ltd 新規なモルヒネ誘導体
FR2636330B1 (fr) * 1988-09-13 1990-11-30 Sanofi Sa Procede de preparation de derives de morphinane
US5219861A (en) * 1988-12-21 1993-06-15 Chugai Seiyaku Kabushiki Kaisha 6 β-Thiomorphine derivatives
CA2006311A1 (en) * 1988-12-21 1990-06-21 Ken Kanematsu Morphine derivative
US5258386A (en) * 1991-06-05 1993-11-02 The United States Of America As Represented By The Secretary Of The Army (+)-3-substituted-N alkylmorphinans, synthesis and use as anticonvulsant and neuroprotective agents
JP2525552B2 (ja) * 1992-01-23 1996-08-21 東レ株式会社 モルヒナン誘導体および医薬用途
CN1111900A (zh) * 1993-06-30 1995-11-15 东丽株式会社 止咳药

Also Published As

Publication number Publication date
ES2121988T3 (es) 1998-12-16
NO302755B1 (no) 1998-04-20
EP0577847B1 (de) 1998-10-14
AU666702B2 (en) 1996-02-22
KR970011390B1 (ko) 1997-07-10
NO933376D0 (no) 1993-09-22
FI934144L (fi) 1993-09-22
CA2105072A1 (en) 1993-07-24
TW332814B (en) 1998-06-01
JP2525552B2 (ja) 1996-08-21
JPH08502275A (ja) 1996-03-12
NO933376L (no) 1993-09-23
DK0577847T3 (da) 1999-06-23
US6323212B1 (en) 2001-11-27
FI106126B (fi) 2000-11-30
AU3367193A (en) 1993-09-01
EP0577847A1 (de) 1994-01-12
US6277859B1 (en) 2001-08-21
DE69321525D1 (de) 1998-11-19
NZ246687A (en) 1996-12-20
EP0846694A1 (de) 1998-06-10
AU686483B2 (en) 1998-02-05
WO1993015081A1 (en) 1993-08-05
DE69321525T2 (de) 1999-03-04
EP0577847A4 (de) 1994-12-07
FI934144A0 (fi) 1993-09-22
CA2105072C (en) 1998-07-28
AU4067195A (en) 1996-03-07

Similar Documents

Publication Publication Date Title
AU666702B2 (en) Morphinan derivative and medicinal use
NO941101D0 (no) Quinazolin-derivater
KR960702464A (ko) Dc-89 유도체[dc-89 derivative]
ATE116306T1 (de) Hypoglykämische oxazolidindion-derivate.
ATE129498T1 (de) Kondensierte heterozyklische verbindungen, ihre herstellung und verwendung.
ATE247654T1 (de) Neue heterozyklische verbindungen
DE69428977D1 (de) Arzneimittel gegen Parkinsonsche Krankheit
FI943142A0 (fi) Amidi- ja ureajohdannaiset, joilla on veren korkeita kolesteroliarvoja vastustava vaikutus, niiden valmistus ja terapeuttiset käytöt
PL292101A1 (en) Method of obtaining novel derivatives of cyclopentylpurine and cyclopentylpyrimidine
DE69505470D1 (de) Pyrrolocarbazol
YU46998B (sh) Postupak za dobijanje derivata cefema i medjuproizvoda za iste
NO944371L (no) Kjemisk forbindelse med blodplateaggregeringsinhibiotoraktivitet
ATE92489T1 (de) Imid-derivate, ihre herstellung und verwendung.
DE68919378D1 (de) Thienotriazolodiazepine und ihre pharmazeutische Verwendung.
DK147588D0 (da) Benzoxazinderivat samt fremgangsmaade til fremstilling deraf
FI906021A0 (fi) Oxetanderivat, framstaellning av dessa samt anvaendning som svampmotverkande eller foerstoerande aemnen.
ATE55057T1 (de) Zentralwirkende muskelrelaxante.
ES2035915T3 (es) Agentes antiarritmicos n-fenetil-aminoalquil-benzamida.
DK0601191T3 (da) Hidtil ukendt tetracyklisk forbindelse
ATE58532T1 (de) (2-amino-4-aryl-thiazol-5-yl)aethanol, und deren derivate mit diuretischer aktivitaet und verfahren zu deren herstellung.
ATE205209T1 (de) Chinolincarbonsäurederivate und ihre salze
PT99250A (pt) Processo para a preparacao de derivados de piperazina
JPS56131571A (en) Novel hetero ring substituted carboxyamide and methyl amine compound
ES2149180T3 (es) Derivado de pirazolotiazolopirimidina.
IT1204960B (it) Composti dotati di attivita' antiallergica

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification