ATE172201T1 - Morphinan-derivate und medizinische verwendung - Google Patents

Morphinan-derivate und medizinische verwendung

Info

Publication number
ATE172201T1
ATE172201T1 AT93902520T AT93902520T ATE172201T1 AT E172201 T1 ATE172201 T1 AT E172201T1 AT 93902520 T AT93902520 T AT 93902520T AT 93902520 T AT93902520 T AT 93902520T AT E172201 T1 ATE172201 T1 AT E172201T1
Authority
AT
Austria
Prior art keywords
medical uses
nch3
morphinane derivatives
morphinane
derivatives
Prior art date
Application number
AT93902520T
Other languages
English (en)
Inventor
Hiroshi Nagase
Koji Kawai
Kuniaki Kawamura
Jun Hayakawa
Takashi Endo
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Application granted granted Critical
Publication of ATE172201T1 publication Critical patent/ATE172201T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Fertilizers (AREA)
AT93902520T 1992-01-23 1993-01-22 Morphinan-derivate und medizinische verwendung ATE172201T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1011592 1992-01-23
JP29430892 1992-11-02

Publications (1)

Publication Number Publication Date
ATE172201T1 true ATE172201T1 (de) 1998-10-15

Family

ID=26345314

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93902520T ATE172201T1 (de) 1992-01-23 1993-01-22 Morphinan-derivate und medizinische verwendung

Country Status (15)

Country Link
US (2) US6323212B1 (de)
EP (2) EP0846694A1 (de)
JP (1) JP2525552B2 (de)
KR (1) KR970011390B1 (de)
AT (1) ATE172201T1 (de)
AU (2) AU666702B2 (de)
CA (1) CA2105072C (de)
DE (1) DE69321525T2 (de)
DK (1) DK0577847T3 (de)
ES (1) ES2121988T3 (de)
FI (1) FI106126B (de)
NO (1) NO302755B1 (de)
NZ (1) NZ246687A (de)
TW (1) TW332814B (de)
WO (1) WO1993015081A1 (de)

Families Citing this family (80)

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EP0661283B1 (de) * 1993-07-19 1998-10-21 Toray Industries, Inc. Wirkstoff zum schutze von gehirnzellen
EP0663401B1 (de) * 1993-07-23 2000-06-07 Toray Industries, Inc. Morphinan-derivate und ihre medizinische verwendung
SE9401727D0 (sv) * 1994-05-18 1994-05-18 Astra Ab New compounds I
DE19602963A1 (de) * 1995-12-20 1997-07-31 Nycomed Arzneimittel Gmbh Neue Morphinderivate, Verfahren zu deren Herstellung und deren Verwendung
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
EP0829481A1 (de) * 1996-09-16 1998-03-18 Pfizer Inc. Morphinan-Hydroxamsäure-Derivate
ATE359076T1 (de) * 1996-11-25 2007-05-15 Toray Industries Mittel gegen juckreiz
KR20000016052A (ko) 1997-03-27 2000-03-25 히라이 가쯔히꼬 몰피난 유도체 및 의약용도_
US6372755B2 (en) 1997-07-11 2002-04-16 Toray Industries, Inc. Stable medicinal compositions containing 4,5-epoxymorphinan derivatives
CA2288828A1 (en) * 1997-07-14 1999-01-28 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
US5760023A (en) * 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
WO1999005146A1 (en) * 1997-07-25 1999-02-04 Toray Industries, Inc. Hyponatremia remedies
JP4359711B2 (ja) 1997-09-02 2009-11-04 東レ株式会社 薬物依存症治療薬
US6083944A (en) * 1997-10-07 2000-07-04 Cephalon, Inc. Quinoline-containing α-ketoamide cysteine and serine protease inhibitors
TW570920B (en) * 1998-12-22 2004-01-11 Janssen Pharmaceutica Nv 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
DE60039444D1 (de) * 1999-08-24 2008-08-21 Toray Industries Heilmittel für neuropathischen schmerz und versuchstier-modelle des neuropathischen schmerzes
US6688746B2 (en) * 1999-12-03 2004-02-10 Iouri Malov Field testing using spread spectrum technique
WO2001074819A1 (en) * 2000-04-03 2001-10-11 Toray Industries, Inc. Analgesics containing morphinan n-oxide derivatives as the active ingredient
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WO2002080918A1 (en) * 2001-04-02 2002-10-17 Toray Industries, Inc. Remedial or prophylactic agent for frequent urination or urinary incontinence
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US8017622B2 (en) * 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
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BRPI0608671B1 (pt) * 2005-04-06 2022-07-19 Toray Industries, Inc Processos para produzir um cristal de forma a de cloridrato de 17-ciclopropilmetil-3,14 b-diidróxi-4,5a-epóxi-6b-[n-metil-trans-3-(3-furil)-acril amido]-morfinano
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TWI893157B (zh) 2020-06-30 2025-08-11 日商東麗股份有限公司 具有嗎啡喃骨架之化合物或其藥理學上可容許之酸加成鹽的用途
CN115181109B (zh) * 2021-04-02 2024-06-04 南京正大天晴制药有限公司 吗啡喃衍生物的晶体及其制备方法
TW202308627A (zh) 2021-04-23 2023-03-01 日商東麗股份有限公司 伴隨著飢餓素抗性之惡病體質的治療劑或預防劑
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Also Published As

Publication number Publication date
TW332814B (en) 1998-06-01
EP0577847B1 (de) 1998-10-14
JP2525552B2 (ja) 1996-08-21
WO1993015081A1 (en) 1993-08-05
NO302755B1 (no) 1998-04-20
AU3367193A (en) 1993-09-01
EP0577847A4 (de) 1994-12-07
AU686483B2 (en) 1998-02-05
EP0577847A1 (de) 1994-01-12
FI934144L (fi) 1993-09-22
US6277859B1 (en) 2001-08-21
KR970011390B1 (ko) 1997-07-10
ES2121988T3 (es) 1998-12-16
AU666702B2 (en) 1996-02-22
DE69321525T2 (de) 1999-03-04
DE69321525D1 (de) 1998-11-19
NO933376D0 (no) 1993-09-22
FI934144A0 (fi) 1993-09-22
JPH08502275A (ja) 1996-03-12
CA2105072A1 (en) 1993-07-24
NZ246687A (en) 1996-12-20
EP0846694A1 (de) 1998-06-10
DK0577847T3 (da) 1999-06-23
US6323212B1 (en) 2001-11-27
AU4067195A (en) 1996-03-07
NO933376L (no) 1993-09-23
CA2105072C (en) 1998-07-28
FI106126B (fi) 2000-11-30

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