YU46998B - Postupak za dobijanje derivata cefema i medjuproizvoda za iste - Google Patents

Postupak za dobijanje derivata cefema i medjuproizvoda za iste

Info

Publication number
YU46998B
YU46998B YU54189A YU54189A YU46998B YU 46998 B YU46998 B YU 46998B YU 54189 A YU54189 A YU 54189A YU 54189 A YU54189 A YU 54189A YU 46998 B YU46998 B YU 46998B
Authority
YU
Yugoslavia
Prior art keywords
cefem
procedure
same
sub
intermediate products
Prior art date
Application number
YU54189A
Other languages
English (en)
Other versions
YU54189A (en
Inventor
T. Kamiya
T. Naito
Y. Komatu
Y. Kai
T. Nakamura
M. Sasho
S. Negi
J. Sugiyama
K. Katsu
H. Yamauchi
Original Assignee
Eisai Co. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co. Ltd. filed Critical Eisai Co. Ltd.
Publication of YU54189A publication Critical patent/YU54189A/xx
Publication of YU46998B publication Critical patent/YU46998B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)

Abstract

POSTUPAK ZA DOBIJANJE DERIVATA CEFEMA I MEDJUPROIZVODA ZA ISTE, predstavljenih formulom: gde R označava fluor-supstituisani niži alkil, a A1 označava cikličnu ili acikličnu amonio-grupu, ili njenu netoksičnu so, naznačen time, što obuhvata reakciju jedinjenja predstavljenog formulom: gde A1 ima značenje kao napred, jedinjenja dobijenog blokiranjem -COO- pomenutog drugog jedinjenja sa zaštitnom grupom, ili njegove soli, - sa drugim jedinjenjem predstavljenim formulom: gde R1 ima isto značenje kao napred, u inertnom rastvaraču u prisustvu ili odsustvu baze, pri rasponu temperature od -50В°C do 50В°C, te se jedinjenje dobija blokiranjem amino grupe prvoimenovanog jedinjenja sa zaštitnom grupom, reaktivnim derivatom prvoimenovanog jedinjenja na njegovoj karboksilnoj grupi ili njegovom soli, i uklanjanjem zaštitnih grupa, ukoliko je potrebno. Prijava sadrži 1 nezavisan zahtev i 10 zavisnih zahteva.
YU54189A 1988-03-16 1989-03-16 Postupak za dobijanje derivata cefema i medjuproizvoda za iste YU46998B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6051188 1988-03-16

Publications (2)

Publication Number Publication Date
YU54189A YU54189A (en) 1990-12-31
YU46998B true YU46998B (sh) 1994-11-15

Family

ID=13144412

Family Applications (1)

Application Number Title Priority Date Filing Date
YU54189A YU46998B (sh) 1988-03-16 1989-03-16 Postupak za dobijanje derivata cefema i medjuproizvoda za iste

Country Status (12)

Country Link
US (1) US5128465A (sh)
EP (3) EP0764648B1 (sh)
JP (1) JPH07179472A (sh)
CN (1) CN1022837C (sh)
AT (2) ATE212027T1 (sh)
CA (1) CA1339738C (sh)
DE (2) DE68929368T2 (sh)
ES (1) ES2013403A6 (sh)
GR (1) GR1000462B (sh)
HU (1) HU215925B (sh)
PT (1) PT90022B (sh)
YU (1) YU46998B (sh)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2059947T3 (es) * 1989-09-30 1994-11-16 Eisai Co Ltd Preparados inyectables que contienen cefalosporina y utilizacion de los mismos.
FR2663332B1 (fr) * 1990-06-15 1997-11-07 Roussel Uclaf Nouvelles cephalosporines comportant en position 3 un radical propenyle substitue par un ammonium quaternaire, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus.
US5126336A (en) * 1990-08-23 1992-06-30 Bristol-Myers Squibb Company Antibiotic c-3 catechol-substituted cephalosporin compounds, compositions and method of use thereof
AT396108B (de) * 1991-08-21 1993-06-25 Biochemie Gmbh Neues verfahren und neue zwischenprodukte zur herstellung von 7-aminocephalosporansaeurederivaten
KR950014571B1 (ko) * 1991-11-18 1995-12-08 제일제당주식회사 세펨 유도체의 제조방법
GB9216759D0 (en) * 1992-08-07 1992-09-23 Finpael Spa Process for the production of 7-amino thiazolyl cephalosporins
JPH07173168A (ja) * 1993-07-14 1995-07-11 Sumitomo Chem Co Ltd セフェム系化合物、その製法、およびそれのセフェム系抗生物質製造への利用
FR2722790B1 (fr) 1994-07-19 1996-10-04 Roussel Uclaf Nouvelles cephalosporines comportant en position 7 un radical benzyloxymino subtitue, leur procede de preparation leur application comme medicaments
JPH08151354A (ja) 1994-11-29 1996-06-11 Eisai Kagaku Kk アミノアセトアミド誘導体の製造法
KR0174117B1 (ko) * 1995-12-28 1999-02-01 윤원영 새로운 세팔로스포린 유도체 및 그 제조방법
IT1283489B1 (it) * 1996-07-23 1998-04-21 Chiesi Farma Spa Ammidi di alfa-amminoacidi,loro preparazione e loro impiego terapeutico
CA2216259A1 (en) * 1996-09-25 1998-03-25 Eisai Chemical Co., Ltd. Production process of cephem compound
EP1090013A1 (en) * 1998-06-22 2001-04-11 F. Hoffmann-La Roche Ag Propenyl cephalosporin derivatives
KR100441901B1 (ko) * 2001-07-02 2004-07-27 일동제약주식회사 세팔로스포린 유도체의 개선된 제조방법
US7214825B2 (en) 2003-10-17 2007-05-08 Honeywell International Inc. O-(3-chloropropenyl) hydroxylamine free base
CA2783572C (en) 2005-12-07 2016-08-09 Basilea Pharmaceutica Ag Useful combinations of monobactam antibiotics with beta-lactamase inhibitors
CN105418641B (zh) * 2015-12-30 2018-08-10 广东金城金素制药有限公司 一种原研制品质头孢曲松钠及其药物制剂
WO2018185211A1 (en) 2017-04-06 2018-10-11 Syngenta Participations Ag Microbiocidal oxadiazole derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB762850A (en) * 1953-11-09 1956-12-05 Dow Chemical Co Alpha-amino-beta-alkoxy-propionamides
FR1467942A (fr) * 1965-12-23 1967-02-03 Procédé de préparation de dérivés nu-disubstitués de l'aminoacétamide et nouveaux dérivés de ce type
US4486586A (en) * 1983-02-10 1984-12-04 Bristol-Myers Company Cephalosporin derivatives
US4751295A (en) * 1984-04-09 1988-06-14 Bristol-Myers Company Cephalosporin derivatives
CA1276929C (en) * 1984-04-09 1990-11-27 Masahisa Oka Cephalosporin antibacterial agents
DE3419012A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Ss-lactamantibiotika, verfahren zu deren herstellung sowie ihre verwendung als arzneimittel oder wachstumsfoerderer in der tieraufzucht oder als antioxidantien
DE3650157T2 (de) * 1985-12-26 1995-05-04 Eisai Co Ltd Cephalosporin-verbindungen.
JPH0796502B2 (ja) * 1986-06-16 1995-10-18 東レ株式会社 アミド基の加水分解方法
IL84128A (en) * 1986-10-13 1992-12-01 Eisai Co Ltd 3-propenylcephem derivatives, their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DE68928174D1 (de) 1997-08-21
GR890100162A (en) 1990-01-19
GR1000462B (el) 1992-07-30
EP0333154A2 (en) 1989-09-20
ATE155469T1 (de) 1997-08-15
EP0612751A2 (en) 1994-08-31
EP0333154B1 (en) 1997-07-16
PT90022B (pt) 1994-05-31
EP0764648B1 (en) 2002-01-16
CN1022837C (zh) 1993-11-24
ATE212027T1 (de) 2002-02-15
EP0333154A3 (en) 1991-10-09
DE68929368D1 (de) 2002-02-21
PT90022A (pt) 1989-11-10
JPH07179472A (ja) 1995-07-18
CA1339738C (en) 1998-03-17
HU215925B (hu) 1999-03-29
EP0764648A1 (en) 1997-03-26
CN1036769A (zh) 1989-11-01
HUT50345A (en) 1990-01-29
DE68928174T2 (de) 1997-12-18
US5128465A (en) 1992-07-07
ES2013403A6 (es) 1990-05-01
DE68929368T2 (de) 2002-08-14
EP0612751A3 (en) 1994-09-21
YU54189A (en) 1990-12-31

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