DE68928174T2 - Verfahren zur Herstellung von Cephemderivaten - Google Patents

Verfahren zur Herstellung von Cephemderivaten

Info

Publication number
DE68928174T2
DE68928174T2 DE68928174T DE68928174T DE68928174T2 DE 68928174 T2 DE68928174 T2 DE 68928174T2 DE 68928174 T DE68928174 T DE 68928174T DE 68928174 T DE68928174 T DE 68928174T DE 68928174 T2 DE68928174 T2 DE 68928174T2
Authority
DE
Germany
Prior art keywords
sub
compound
preparation
cephem derivatives
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68928174T
Other languages
English (en)
Other versions
DE68928174D1 (de
Inventor
Takashi Kamiya
Toshihiko Naito
Yuuki Komatu
Yasunobu Kai
Takaharu Nakamura
Masanobu Sasho
Shigeto Negi
Isao Sugiyama
Kanemasa Katsu
Hiroshi Yamauchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of DE68928174D1 publication Critical patent/DE68928174D1/de
Publication of DE68928174T2 publication Critical patent/DE68928174T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE68928174T 1988-03-16 1989-03-15 Verfahren zur Herstellung von Cephemderivaten Expired - Fee Related DE68928174T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6051188 1988-03-16

Publications (2)

Publication Number Publication Date
DE68928174D1 DE68928174D1 (de) 1997-08-21
DE68928174T2 true DE68928174T2 (de) 1997-12-18

Family

ID=13144412

Family Applications (2)

Application Number Title Priority Date Filing Date
DE68929368T Expired - Fee Related DE68929368T2 (de) 1988-03-16 1989-03-15 Cephemderivate und Verfahren zu ihrer Herstellung
DE68928174T Expired - Fee Related DE68928174T2 (de) 1988-03-16 1989-03-15 Verfahren zur Herstellung von Cephemderivaten

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE68929368T Expired - Fee Related DE68929368T2 (de) 1988-03-16 1989-03-15 Cephemderivate und Verfahren zu ihrer Herstellung

Country Status (12)

Country Link
US (1) US5128465A (de)
EP (3) EP0612751A3 (de)
JP (1) JPH07179472A (de)
CN (1) CN1022837C (de)
AT (2) ATE212027T1 (de)
CA (1) CA1339738C (de)
DE (2) DE68929368T2 (de)
ES (1) ES2013403A6 (de)
GR (1) GR1000462B (de)
HU (1) HU215925B (de)
PT (1) PT90022B (de)
YU (1) YU46998B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5254545A (en) * 1989-09-30 1993-10-19 Eisai Co., Ltd. Injectable preparations containing cephalosporin medicament
FR2663332B1 (fr) * 1990-06-15 1997-11-07 Roussel Uclaf Nouvelles cephalosporines comportant en position 3 un radical propenyle substitue par un ammonium quaternaire, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus.
US5126336A (en) * 1990-08-23 1992-06-30 Bristol-Myers Squibb Company Antibiotic c-3 catechol-substituted cephalosporin compounds, compositions and method of use thereof
AT396108B (de) * 1991-08-21 1993-06-25 Biochemie Gmbh Neues verfahren und neue zwischenprodukte zur herstellung von 7-aminocephalosporansaeurederivaten
KR950014571B1 (ko) * 1991-11-18 1995-12-08 제일제당주식회사 세펨 유도체의 제조방법
GB9216759D0 (en) * 1992-08-07 1992-09-23 Finpael Spa Process for the production of 7-amino thiazolyl cephalosporins
JPH07173168A (ja) * 1993-07-14 1995-07-11 Sumitomo Chem Co Ltd セフェム系化合物、その製法、およびそれのセフェム系抗生物質製造への利用
FR2722790B1 (fr) 1994-07-19 1996-10-04 Roussel Uclaf Nouvelles cephalosporines comportant en position 7 un radical benzyloxymino subtitue, leur procede de preparation leur application comme medicaments
JPH08151354A (ja) 1994-11-29 1996-06-11 Eisai Kagaku Kk アミノアセトアミド誘導体の製造法
KR0174117B1 (ko) * 1995-12-28 1999-02-01 윤원영 새로운 세팔로스포린 유도체 및 그 제조방법
IT1283489B1 (it) * 1996-07-23 1998-04-21 Chiesi Farma Spa Ammidi di alfa-amminoacidi,loro preparazione e loro impiego terapeutico
CA2216259A1 (en) * 1996-09-25 1998-03-25 Eisai Chemical Co., Ltd. Production process of cephem compound
EP1090013A1 (de) * 1998-06-22 2001-04-11 F. Hoffmann-La Roche Ag Propenyl-cephalosporin-derivate
KR100441901B1 (ko) * 2001-07-02 2004-07-27 일동제약주식회사 세팔로스포린 유도체의 개선된 제조방법
US7214825B2 (en) 2003-10-17 2007-05-08 Honeywell International Inc. O-(3-chloropropenyl) hydroxylamine free base
PT2308874E (pt) 2005-12-07 2013-04-26 Basilea Pharmaceutica Ag Monobactamas ligadas por pontes, úteis como inibidores de beta-lactamase
CN105418641B (zh) * 2015-12-30 2018-08-10 广东金城金素制药有限公司 一种原研制品质头孢曲松钠及其药物制剂
WO2018185211A1 (en) 2017-04-06 2018-10-11 Syngenta Participations Ag Microbiocidal oxadiazole derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB762850A (en) * 1953-11-09 1956-12-05 Dow Chemical Co Alpha-amino-beta-alkoxy-propionamides
FR1467942A (fr) * 1965-12-23 1967-02-03 Procédé de préparation de dérivés nu-disubstitués de l'aminoacétamide et nouveaux dérivés de ce type
US4486586A (en) * 1983-02-10 1984-12-04 Bristol-Myers Company Cephalosporin derivatives
CA1276929C (en) * 1984-04-09 1990-11-27 Masahisa Oka Cephalosporin antibacterial agents
US4751295A (en) * 1984-04-09 1988-06-14 Bristol-Myers Company Cephalosporin derivatives
DE3419012A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Ss-lactamantibiotika, verfahren zu deren herstellung sowie ihre verwendung als arzneimittel oder wachstumsfoerderer in der tieraufzucht oder als antioxidantien
WO1987003875A1 (en) * 1985-12-26 1987-07-02 Eisai Co., Ltd. Cephalosporin derivatives
JPH0796502B2 (ja) * 1986-06-16 1995-10-18 東レ株式会社 アミド基の加水分解方法
IL84128A (en) * 1986-10-13 1992-12-01 Eisai Co Ltd 3-propenylcephem derivatives, their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ATE155469T1 (de) 1997-08-15
US5128465A (en) 1992-07-07
ES2013403A6 (es) 1990-05-01
ATE212027T1 (de) 2002-02-15
PT90022B (pt) 1994-05-31
HUT50345A (en) 1990-01-29
JPH07179472A (ja) 1995-07-18
EP0764648B1 (de) 2002-01-16
EP0612751A2 (de) 1994-08-31
DE68929368D1 (de) 2002-02-21
CA1339738C (en) 1998-03-17
PT90022A (pt) 1989-11-10
CN1022837C (zh) 1993-11-24
CN1036769A (zh) 1989-11-01
EP0333154A3 (de) 1991-10-09
EP0764648A1 (de) 1997-03-26
DE68929368T2 (de) 2002-08-14
YU54189A (en) 1990-12-31
EP0333154B1 (de) 1997-07-16
EP0333154A2 (de) 1989-09-20
GR890100162A (en) 1990-01-19
HU215925B (hu) 1999-03-29
YU46998B (sh) 1994-11-15
EP0612751A3 (en) 1994-09-21
GR1000462B (el) 1992-07-30
DE68928174D1 (de) 1997-08-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee