SE9401727D0 - New compounds I - Google Patents

New compounds I

Info

Publication number
SE9401727D0
SE9401727D0 SE9401727A SE9401727A SE9401727D0 SE 9401727 D0 SE9401727 D0 SE 9401727D0 SE 9401727 A SE9401727 A SE 9401727A SE 9401727 A SE9401727 A SE 9401727A SE 9401727 D0 SE9401727 D0 SE 9401727D0
Authority
SE
Sweden
Prior art keywords
alkyl
hydrogen
group
pct
alkoxy
Prior art date
Application number
SE9401727A
Other languages
English (en)
Inventor
Helmut Schmidhammer
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9401727A priority Critical patent/SE9401727D0/sv
Publication of SE9401727D0 publication Critical patent/SE9401727D0/sv
Priority to IL11362795A priority patent/IL113627A0/xx
Priority to ZA953699A priority patent/ZA953699B/xx
Priority to BR9507656A priority patent/BR9507656A/pt
Priority to SK1396-96A priority patent/SK139696A3/sk
Priority to JP7529554A priority patent/JPH10500132A/ja
Priority to CN95194032A priority patent/CN1152314A/zh
Priority to AU25818/95A priority patent/AU690281B2/en
Priority to US08/507,365 priority patent/US5886001A/en
Priority to PL95317250A priority patent/PL317250A1/xx
Priority to NZ287177A priority patent/NZ287177A/en
Priority to CA002189139A priority patent/CA2189139A1/en
Priority to EP95920329A priority patent/EP0759923A1/en
Priority to PCT/SE1995/000504 priority patent/WO1995031464A1/en
Priority to HU9603171A priority patent/HU9603171D0/hu
Priority to IS4381A priority patent/IS4381A/is
Priority to NO964871A priority patent/NO964871L/no
Priority to FI964576A priority patent/FI964576A/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
SE9401727A 1994-05-18 1994-05-18 New compounds I SE9401727D0 (sv)

Priority Applications (18)

Application Number Priority Date Filing Date Title
SE9401727A SE9401727D0 (sv) 1994-05-18 1994-05-18 New compounds I
IL11362795A IL113627A0 (en) 1994-05-18 1995-05-07 New agonist compounds
ZA953699A ZA953699B (en) 1994-05-18 1995-05-08 New agonist compounds
HU9603171A HU9603171D0 (en) 1994-05-18 1995-05-09 New agonist compounds
US08/507,365 US5886001A (en) 1994-05-18 1995-05-09 Agonist compounds
NZ287177A NZ287177A (en) 1994-05-18 1995-05-09 Morphinane derivatives; medicaments
JP7529554A JPH10500132A (ja) 1994-05-18 1995-05-09 新規なアゴニスト化合物
CN95194032A CN1152314A (zh) 1994-05-18 1995-05-09 新的兴奋剂化合物
AU25818/95A AU690281B2 (en) 1994-05-18 1995-05-09 New agonist compounds
BR9507656A BR9507656A (pt) 1994-05-18 1995-05-09 Composto utilização de um composto composição farmacéutica e processos para o tratamento de um paciente que sofre de dor e para a preparação de um composto
PL95317250A PL317250A1 (en) 1994-05-18 1995-05-09 Novel agonistic compounds
SK1396-96A SK139696A3 (en) 1994-05-18 1995-05-09 New agonist compounds
CA002189139A CA2189139A1 (en) 1994-05-18 1995-05-09 New agonist compounds
EP95920329A EP0759923A1 (en) 1994-05-18 1995-05-09 New agonist compounds
PCT/SE1995/000504 WO1995031464A1 (en) 1994-05-18 1995-05-09 New agonist compounds
IS4381A IS4381A (is) 1994-05-18 1996-11-08 Ný gerandefni
NO964871A NO964871L (no) 1994-05-18 1996-11-15 Nye agonistforbindelser
FI964576A FI964576A (sv) 1994-05-18 1996-11-15 Nya agonistföreningar

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9401727A SE9401727D0 (sv) 1994-05-18 1994-05-18 New compounds I

Publications (1)

Publication Number Publication Date
SE9401727D0 true SE9401727D0 (sv) 1994-05-18

Family

ID=20394058

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9401727A SE9401727D0 (sv) 1994-05-18 1994-05-18 New compounds I

Country Status (18)

Country Link
US (1) US5886001A (sv)
EP (1) EP0759923A1 (sv)
JP (1) JPH10500132A (sv)
CN (1) CN1152314A (sv)
AU (1) AU690281B2 (sv)
BR (1) BR9507656A (sv)
CA (1) CA2189139A1 (sv)
FI (1) FI964576A (sv)
HU (1) HU9603171D0 (sv)
IL (1) IL113627A0 (sv)
IS (1) IS4381A (sv)
NO (1) NO964871L (sv)
NZ (1) NZ287177A (sv)
PL (1) PL317250A1 (sv)
SE (1) SE9401727D0 (sv)
SK (1) SK139696A3 (sv)
WO (1) WO1995031464A1 (sv)
ZA (1) ZA953699B (sv)

Families Citing this family (66)

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AU712012B2 (en) * 1995-09-26 1999-10-28 Toray Industries, Inc. Indole derivatives and medical application thereof
DE69822937T2 (de) * 1997-01-16 2004-08-12 Toray Industries, Inc. Indolmorphinan-derivate und medikamente zur behandlung/mittel zur vorbeugung von cerebralen störungen
GB9717629D0 (en) * 1997-08-21 1997-10-22 Johnson Matthey Plc Removal of residual organic solvents
WO2000008027A1 (en) * 1998-08-06 2000-02-17 Regents Of The University Of Minnesota Kappa (op2) opioid receptor antagonists
US7232829B2 (en) 2001-04-06 2007-06-19 Regents Of The University Of Minnesota Therapeutic compounds and methods
WO2002080919A1 (en) * 2001-04-06 2002-10-17 Regents Of The University Of Minnesota Therapeutic compounds and methods
DE10229842A1 (de) * 2002-07-03 2004-02-05 Helmut Prof. Dr. Schmidhammer Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung
KR20140015122A (ko) 2003-10-01 2014-02-06 아돌로 코포레이션 스피로시클릭 헤테로시클릭 유도체 및 이의 사용 방법
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US7576207B2 (en) 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US20080119452A1 (en) 2006-09-12 2008-05-22 Dolle Roland E Methods for enhancing cognitive function
US9321116B2 (en) * 2009-03-05 2016-04-26 United Technologies Corporation Cold metal transfer gas metal arc welding apparatus and method of operation
EP2340832A1 (en) 2009-12-23 2011-07-06 Universität Innsbruck Morphinan-6-one compounds for the treatment or prevention of neurodegenerative diseases
JP6091426B2 (ja) 2010-12-23 2017-03-08 フェニックス ファーマラブス インク 鎮痛剤として有用な新規モルフィナン類
US9303038B2 (en) 2011-09-06 2016-04-05 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy and neurological diseases
CA2873093A1 (en) 2012-05-07 2013-11-14 Cellixbio Private Limited Compositions and methods for treatment of neuromuscular disorders and neurodegenerative disorders
CA2872975A1 (en) 2012-05-07 2013-11-14 Cellixbio Private Limited Compositions and methods for the treatment of neurological disorders
US9399634B2 (en) 2012-05-07 2016-07-26 Cellix Bio Private Limited Compositions and methods for the treatment of depression
WO2013167991A1 (en) 2012-05-08 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of metabolic disorders
WO2013167992A1 (en) 2012-05-08 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of inflammatory disorders
US9434704B2 (en) 2012-05-08 2016-09-06 Cellix Bio Private Limited Compositions and methods for the treatment of neurological degenerative disorders
WO2013168023A1 (en) 2012-05-08 2013-11-14 Mahesh Kandula Compositions and methods for treatment of parkinson's disease
US9309233B2 (en) 2012-05-08 2016-04-12 Cellix Bio Private Limited Compositions and methods for the treatment of blood clotting disorders
WO2013168033A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for treatment of neurologic diseases
US9339484B2 (en) 2012-05-10 2016-05-17 Cellix Bio Private Limited Compositions and methods for the treatment of restless leg syndrome and fibromyalgia
WO2013168002A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of neurological conditions
SG11201407318UA (en) 2012-05-10 2014-12-30 Cellix Bio Private Ltd Compositions and methods for the treatment of metabolic syndrome
US9499527B2 (en) 2012-05-10 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of familial amyloid polyneuropathy
US9573927B2 (en) 2012-05-10 2017-02-21 Cellix Bio Private Limited Compositions and methods for the treatment of severe pain
WO2013167999A2 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of neurologic diseases
US9321775B2 (en) 2012-05-10 2016-04-26 Cellix Bio Private Limited Compositions and methods for the treatment of moderate to severe pain
US9394288B2 (en) 2012-05-10 2016-07-19 Cellix Bio Private Limited Compositions and methods for the treatment of asthma and allergy
US9315478B2 (en) 2012-05-10 2016-04-19 Cellix Bio Private Limited Compositions and methods for the treatment of metabolic syndrome
US9242939B2 (en) 2012-05-10 2016-01-26 Cellix Bio Private Limited Compositions and methods for the treatment of respiratory disorders
US9273061B2 (en) 2012-05-10 2016-03-01 Cellix Bio Private Limited Compositions and methods for the treatment of chronic pain
WO2013168004A2 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of fibromyalgia pain
WO2013175359A2 (en) 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of multiple sclerosis
US9434729B2 (en) 2012-05-23 2016-09-06 Cellix Bio Private Limited Compositions and methods for the treatment of periodontitis and rheumatoid arthritis
CN104583182A (zh) 2012-05-23 2015-04-29 塞利克斯比奥私人有限公司 用于治疗粘膜炎的组合物和方法
WO2013175376A2 (en) 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of local pain
SG11201407319YA (en) 2012-05-23 2014-12-30 Cellix Bio Private Ltd Compositions and methods for treatment of inflammatory bowel disease
WO2013175347A2 (en) 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of respiratory disorders
US9108942B1 (en) 2014-11-05 2015-08-18 Mahesh Kandula Compositions and methods for the treatment of moderate to severe pain
WO2014020480A2 (en) 2012-08-03 2014-02-06 Mahesh Kandula Compositions and methods for the treatment migraine and neurologic diseases
US9624168B2 (en) 2012-09-06 2017-04-18 Cellix Bio Private Limited Compositions and methods for the treatment inflammation and lipid disorders
CA2873029A1 (en) 2012-09-08 2014-03-13 Cellixbio Private Limited Compositions and methods for the treatment of inflammation and lipid disorders
HU231191B1 (hu) 2013-04-15 2021-08-30 Szegedi Tudományegyetem Izotóp tartalmú morfin molekulák
US9333187B1 (en) 2013-05-15 2016-05-10 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
WO2014195961A1 (en) 2013-06-04 2014-12-11 Mahesh Kandula Compositions and methods for the treatment of diabetes and pre-diabetes
EP3077398B1 (en) 2013-12-05 2020-03-11 The University of Bath Novel opioid compounds and their uses
US9096537B1 (en) 2014-12-31 2015-08-04 Mahesh Kandula Compositions and methods for the treatment of mucositis
CA2976314C (en) 2014-09-26 2021-02-23 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy and neurological disorders
EP3201168B1 (en) 2014-09-29 2020-03-18 Cellix Bio Private Limited Compounds and compositions for the treatment of multiple sclerosis
WO2016098119A1 (en) 2014-10-27 2016-06-23 Cellix Bio Private Limited Three component salts of fumaric acid monomethyl ester with piperazine or ethylene diamine for the treatment of multiple sclerosis
US9175008B1 (en) 2014-11-05 2015-11-03 Cellix Bio Private Limited Prodrugs of anti-platelet agents
US9173877B1 (en) 2014-11-05 2015-11-03 Cellix Bio Private Limited Compositions and methods for the treatment of local pain
US9290486B1 (en) 2014-11-05 2016-03-22 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy
US9150557B1 (en) 2014-11-05 2015-10-06 Cellix Bio Private Limited Compositions and methods for the treatment of hyperglycemia
US9284287B1 (en) 2014-11-05 2016-03-15 Cellix Bio Private Limited Compositions and methods for the suppression of carbonic anhydrase activity
US9321716B1 (en) 2014-11-05 2016-04-26 Cellix Bio Private Limited Compositions and methods for the treatment of metabolic syndrome
US10208014B2 (en) 2014-11-05 2019-02-19 Cellix Bio Private Limited Compositions and methods for the treatment of neurological disorders
WO2016073615A1 (en) 2014-11-07 2016-05-12 Regents Of The University Of Minnesota Salts and compositions useful for treating disease
US9932294B2 (en) 2014-12-01 2018-04-03 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis
US9206111B1 (en) 2014-12-17 2015-12-08 Cellix Bio Private Limited Compositions and methods for the treatment of neurological diseases
DK3242869T3 (da) 2015-01-06 2022-01-31 Cellix Bio Private Ltd Sammensætninger og fremgangsmåder til behanding af inflammation og smerte
CA3018750A1 (en) 2016-03-22 2017-09-28 Regents Of The University Of Minnesota Combination for treating pain

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
US4816586A (en) * 1987-07-29 1989-03-28 Regents Of The University Of Minnesota Delta opioid receptor antagonists
JP2906654B2 (ja) * 1989-11-28 1999-06-21 東レ株式会社 免疫抑制剤及びその製造方法
US5223507A (en) * 1992-01-21 1993-06-29 G. D. Searle & Co. Method of using opioid compounds as delta opioid selective agonist analgesics
US5225417A (en) * 1992-01-21 1993-07-06 G. D. Searle & Co. Opioid agonist compounds
ES2121988T3 (es) * 1992-01-23 1998-12-16 Toray Industries Derivado de morfinano y uso medicinal.
AU672033B2 (en) * 1992-09-29 1996-09-19 Toray Industries, Inc. Indole derivative, process for producing the same, and medicinal use thereof
US5464841A (en) * 1993-11-08 1995-11-07 Univ Minnesota Use of delta opioid receptor antagonists to treat immunoregulatory disorders
US5780479A (en) * 1997-04-04 1998-07-14 Regents Of The University Of Minnesota Use of opioid antagonists to treat impulse-control disorders

Also Published As

Publication number Publication date
SK139696A3 (en) 1997-05-07
NZ287177A (en) 1997-11-24
IS4381A (is) 1996-11-08
IL113627A0 (en) 1995-08-31
JPH10500132A (ja) 1998-01-06
NO964871D0 (no) 1996-11-15
US5886001A (en) 1999-03-23
WO1995031464A1 (en) 1995-11-23
AU690281B2 (en) 1998-04-23
EP0759923A1 (en) 1997-03-05
BR9507656A (pt) 1997-09-23
FI964576A0 (sv) 1996-11-15
HU9603171D0 (en) 1997-01-28
PL317250A1 (en) 1997-04-01
NO964871L (no) 1996-11-15
FI964576A (sv) 1996-11-15
ZA953699B (en) 1995-11-20
AU2581895A (en) 1995-12-05
CN1152314A (zh) 1997-06-18
CA2189139A1 (en) 1995-11-23

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