NO933376L - Morfinan-derivater og medisinsk anvendelse derav - Google Patents

Morfinan-derivater og medisinsk anvendelse derav

Info

Publication number
NO933376L
NO933376L NO93933376A NO933376A NO933376L NO 933376 L NO933376 L NO 933376L NO 93933376 A NO93933376 A NO 93933376A NO 933376 A NO933376 A NO 933376A NO 933376 L NO933376 L NO 933376L
Authority
NO
Norway
Prior art keywords
medical applications
morphinan derivatives
nch3
morphinan
xso2
Prior art date
Application number
NO93933376A
Other languages
English (en)
Other versions
NO933376D0 (no
NO302755B1 (no
Inventor
Hiroshi Nagase
Koji Kawai
Kuniaki Kawamura
Jun Hayakawa
Takashi Endoh
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Publication of NO933376D0 publication Critical patent/NO933376D0/no
Publication of NO933376L publication Critical patent/NO933376L/no
Publication of NO302755B1 publication Critical patent/NO302755B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fertilizers (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Saccharide Compounds (AREA)
NO933376A 1992-01-23 1993-09-22 Morfinan-derivater NO302755B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP1011592 1992-01-23
JP29430892 1992-11-02
PCT/JP1993/000080 WO1993015081A1 (fr) 1992-01-23 1993-01-22 Derive de morphinane et utilisation en medicine

Publications (3)

Publication Number Publication Date
NO933376D0 NO933376D0 (no) 1993-09-22
NO933376L true NO933376L (no) 1993-09-23
NO302755B1 NO302755B1 (no) 1998-04-20

Family

ID=26345314

Family Applications (1)

Application Number Title Priority Date Filing Date
NO933376A NO302755B1 (no) 1992-01-23 1993-09-22 Morfinan-derivater

Country Status (15)

Country Link
US (2) US6323212B1 (no)
EP (2) EP0577847B1 (no)
JP (1) JP2525552B2 (no)
KR (1) KR970011390B1 (no)
AT (1) ATE172201T1 (no)
AU (2) AU666702B2 (no)
CA (1) CA2105072C (no)
DE (1) DE69321525T2 (no)
DK (1) DK0577847T3 (no)
ES (1) ES2121988T3 (no)
FI (1) FI106126B (no)
NO (1) NO302755B1 (no)
NZ (1) NZ246687A (no)
TW (1) TW332814B (no)
WO (1) WO1993015081A1 (no)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
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DE69413933T2 (de) * 1993-06-30 1999-04-08 Toray Industries Antitussiva
CA2144770C (en) * 1993-07-19 2006-02-28 Hiroshi Nagase Brain cell protective agent
WO1995003308A1 (en) * 1993-07-23 1995-02-02 Toray Industries, Inc. Morphinan derivative and medicinal use
SE9401727D0 (sv) * 1994-05-18 1994-05-18 Astra Ab New compounds I
DE19602970A1 (de) * 1995-12-20 1997-07-31 Nycomed Arzneimittel Gmbh Neue 7,8- Dihydromorphinderivate, Verfahren zu deren Herstellung und deren Verwendung
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
EP0829481A1 (en) * 1996-09-16 1998-03-18 Pfizer Inc. Morphinan hydroxamic acid compounds
ATE291429T1 (de) * 1996-11-25 2005-04-15 Toray Industries Mittel gegen juckreiz
DE69838662T2 (de) * 1997-03-27 2008-08-28 Toray Industries, Inc. Morphinanderivate und ihre medizinische Anwendung
EP0948965B1 (en) * 1997-07-11 2004-06-02 Toray Industries, Inc. Stable medicinal compositions containing 4,5-epoxymorphinane derivatives
US5760023A (en) * 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
BR9810706A (pt) * 1997-07-14 2000-08-08 Adolor Corp Processo para a prevenção ou tratamento do prurido em um mamìfero em necessidade de tal prevenção ou tratamento
WO1999005146A1 (fr) * 1997-07-25 1999-02-04 Toray Industries, Inc. Remedes contre l'hyponatremie
WO1999011289A1 (fr) * 1997-09-02 1999-03-11 Toray Industries, Inc. Remedes contre la toxicomanie
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DE10161963A1 (de) * 2001-12-17 2003-07-03 Johannes Schuetz 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung
US7923454B2 (en) 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
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AU2010357625B2 (en) * 2010-07-16 2015-04-23 Mallinckrodt Llc (+)-morphinans as antagonists of Toll-like receptor 9 and therapeutic uses thereof
KR101960107B1 (ko) * 2010-10-19 2019-03-19 메모리얼 슬로안 케터링 캔서 센터 통증의 치료를 위한 ４,５에이-에폭시모르피난의 ６-아미도 유도체
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WO2021065898A1 (ja) 2019-09-30 2021-04-08 日本ケミファ株式会社 アゼパン誘導体
TW202128165A (zh) 2019-10-24 2021-08-01 日商東麗股份有限公司 惡病質之治療劑或預防劑
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CN115181109A (zh) * 2021-04-02 2022-10-14 南京正大天晴制药有限公司 吗啡喃衍生物的晶体及其制备方法
CN117177772A (zh) 2021-04-23 2023-12-05 东丽株式会社 伴有饥饿素抵抗性的恶病质的治疗剂或预防剂
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Also Published As

Publication number Publication date
FI934144A0 (fi) 1993-09-22
ATE172201T1 (de) 1998-10-15
DK0577847T3 (da) 1999-06-23
EP0577847A4 (en) 1994-12-07
CA2105072A1 (en) 1993-07-24
CA2105072C (en) 1998-07-28
FI106126B (fi) 2000-11-30
AU4067195A (en) 1996-03-07
WO1993015081A1 (fr) 1993-08-05
ES2121988T3 (es) 1998-12-16
FI934144A (fi) 1993-09-22
US6277859B1 (en) 2001-08-21
EP0577847B1 (en) 1998-10-14
AU686483B2 (en) 1998-02-05
AU666702B2 (en) 1996-02-22
AU3367193A (en) 1993-09-01
EP0577847A1 (en) 1994-01-12
KR970011390B1 (ko) 1997-07-10
EP0846694A1 (en) 1998-06-10
JPH08502275A (ja) 1996-03-12
DE69321525D1 (de) 1998-11-19
TW332814B (en) 1998-06-01
NZ246687A (en) 1996-12-20
NO933376D0 (no) 1993-09-22
DE69321525T2 (de) 1999-03-04
JP2525552B2 (ja) 1996-08-21
NO302755B1 (no) 1998-04-20
US6323212B1 (en) 2001-11-27

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