AR010195A1 - Antagonistas de vasopresina de benzacepina triciclicos y procedimiento para su preparacion. - Google Patents

Antagonistas de vasopresina de benzacepina triciclicos y procedimiento para su preparacion.

Info

Publication number
AR010195A1
AR010195A1 ARP960101028A AR10102896A AR010195A1 AR 010195 A1 AR010195 A1 AR 010195A1 AR P960101028 A ARP960101028 A AR P960101028A AR 10102896 A AR10102896 A AR 10102896A AR 010195 A1 AR010195 A1 AR 010195A1
Authority
AR
Argentina
Prior art keywords
lower alkyl
chnh
alkyl
unsaturated
membered
Prior art date
Application number
ARP960101028A
Other languages
English (en)
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of AR010195A1 publication Critical patent/AR010195A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Antagonistas de bvasopresina de benzacepina tricíclos que se seleccionan entre los de la formula I, donde E-Y se selecciono de las porciones -CH=CH-,-CH2-NR6-, -CH2-CH2- y cunado Y es -CH2-CH2- y cuando Y es -CH2-, Eestá seleccionado dela s porciones: >C=O alquilo inferior (C1-C6)-CHO, -CHOH,alquiloinferior (C1-C6)-CH-S, CHNH2, alquilo inferior (C1-C6)-CHN, C(N-alquilo inferior (C1-C6))2 o de formula II, -CHOCO- alquilo inferior C1-6, -CHNH (CH2)mNH2;-CHNH(CH2)m-NH-alquiloinf erior C1-6,-CHNH(CH2)m-N(alquilo inferior C1-6)2; -CHNH(CH2)m-S-alquilo inferior C1-6, -CHNH(CH2)m-O-alquilo inferior C1-6, -COHalquilo inferior C1-5,S,O,-NH,-N-alquilo inferior C1-6,-NCO-alquilo inferior C1-6;m es un entero de 1 a 6 y laporcion cíclica Z representa (1) un anilloaromático heterocílico insaturado, fusionado de 6 miembros que contiene dos átomos de nitrogeno,que está opcionalmente substituido con 1 o 2 substituyentesseleccionados de alquilo inferior C1-3,halogeno, amino, alcoxi inferior C1-3 o alquilamino inferior (C1-C3); (2) un anillo heterocíclico aromático(insaturado) fusionado de 5 miembros que tiene un heteroátomo que está seleccionado de O, N o S; (3) un anillo heterocíclicoaromático (insaturado) d e5 miembros que tiene dos átomos de nitrogeno; (4) un anillo heterocíclico aromático (insaturado) de 5 miembros que tiene un átomo de nitrogenoconjuntamente con un oxígeno o con un átomo de azufre, en el que losanillos heterocíclicos de 5 o 6 miembros están opcionalmente substituidos con alquiloinferior (C1-C3), halogeno o alcoxi inferior (C1-C3); R3 es -COAr, donde Ar es una porcion que está seleccionada del grupo que consiste en formula III, dondeXestá seleccionad de O, S, -NH, -NC H3 y -NCOCH3; R4 está seleccionado de Hidrogeno, alquilo inferior (C1-C3)-CO-alquilo inferior (C1-C3), o de Formula
ARP960101028A 1995-01-17 1996-01-15 Antagonistas de vasopresina de benzacepina triciclicos y procedimiento para su preparacion. AR010195A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/373,839 US5696112A (en) 1995-01-17 1995-01-17 Fused heterocyclic azepines as vasopressin antagonists

Publications (1)

Publication Number Publication Date
AR010195A1 true AR010195A1 (es) 2000-06-07

Family

ID=23474102

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960101028A AR010195A1 (es) 1995-01-17 1996-01-15 Antagonistas de vasopresina de benzacepina triciclicos y procedimiento para su preparacion.

Country Status (23)

Country Link
US (2) US5696112A (es)
EP (1) EP0811008B1 (es)
JP (1) JPH10512572A (es)
KR (1) KR19980703098A (es)
CN (1) CN1177356A (es)
AR (1) AR010195A1 (es)
AT (1) ATE251166T1 (es)
AU (1) AU716008B2 (es)
BR (1) BR9607153A (es)
CA (1) CA2210571A1 (es)
CZ (1) CZ224697A3 (es)
DE (1) DE69630209T2 (es)
DK (1) DK0811008T3 (es)
EA (1) EA001427B1 (es)
ES (1) ES2207672T3 (es)
HU (1) HUP9800466A3 (es)
IL (1) IL116776A (es)
MX (1) MX9705312A (es)
NZ (1) NZ302119A (es)
PT (1) PT811008E (es)
TW (1) TW342385B (es)
WO (1) WO1996022294A1 (es)
ZA (1) ZA96298B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7338796A (en) * 1995-11-09 1997-05-29 Japan Tobacco Inc. Five-membered fused heterocyclic azepine derivatives and pharmaceutical use thereof
US6235900B1 (en) 1999-02-04 2001-05-22 American Home Products Corporation Tricyclic pyridine N-oxides vasopressin agonists
US6297234B1 (en) 1999-02-04 2001-10-02 American Home Products Corporation Arylthiophene vasopressin agonists
US6437006B1 (en) 1999-09-27 2002-08-20 American Cyanamid Company Pharmaceutical carrier formulation
JP2004530668A (ja) * 2001-04-12 2004-10-07 ワイス バソプレッシンアゴニストとしてのｎ−ビフェニルカルボニル−およびｎ−フェニルピリジルカルボニル置換二および三環アゼピンおよびジアゼピン
US7326700B2 (en) * 2001-04-12 2008-02-05 Wyeth Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
CN1294134C (zh) 2001-04-12 2007-01-10 惠氏公司 环己基苯基血管升压素激动剂
US6977254B2 (en) * 2001-04-12 2005-12-20 Wyeth Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US7202239B2 (en) * 2001-04-12 2007-04-10 Wyeth Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
US7109193B2 (en) 2001-04-12 2006-09-19 Wyeth Tricyclic diazepines tocolytic oxytocin receptor antagonists
US7064120B2 (en) * 2001-04-12 2006-06-20 Wyeth Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US6900200B2 (en) 2001-04-12 2005-05-31 Wyeth Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US7022699B2 (en) 2001-04-12 2006-04-04 Wyeth Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
SE0102299D0 (sv) 2001-06-26 2001-06-26 Astrazeneca Ab Compounds
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
EP1632494A1 (en) * 2004-08-24 2006-03-08 Ferring B.V. Vasopressin v1a antagonists
WO2007082808A2 (en) * 2006-01-18 2007-07-26 F. Hoffmann-La Roche Ag Thiazoles as 11 beta-hsd1 inhibitors
EP2403860B1 (en) * 2009-03-04 2015-11-04 IDENIX Pharmaceuticals, Inc. Phosphothiophene and phosphothiazole as hcv polymerase inhibitors
AR076221A1 (es) 2009-04-09 2011-05-26 Astrazeneca Ab Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad
WO2017175000A1 (en) 2016-04-08 2017-10-12 Pulmocide Limited Compounds

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA821020B (en) * 1981-02-18 1983-10-26 Thomae Gmbh Dr K Azepine derivatives, process for their preparation and pharmaceutical compositions thereof
US4766108A (en) * 1986-12-04 1988-08-23 Smith Kline Beckman Corporation Tyr-Arg-vasopressin antagonists
US5055448A (en) * 1987-06-25 1991-10-08 Medical College Of Ohio Linear derivatives of arginine vasopressin antagonists
EP0382185B1 (en) * 1989-02-10 1994-06-15 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
US5258510A (en) * 1989-10-20 1993-11-02 Otsuka Pharma Co Ltd Benzoheterocyclic compounds
DK0450097T3 (da) * 1989-10-20 1996-05-20 Otsuka Pharma Co Ltd Benzoheterocykliske forbindelser
US5070187A (en) * 1989-11-03 1991-12-03 Trustees Of Boston University Pharmacologically effective antagonists of arginine-vasopressin
TW199153B (es) * 1990-08-07 1993-02-01 Dtsuka Seiyaku Kk
CA2066104C (en) * 1991-04-19 2003-05-27 Hidenori Ogawa Benzazepine derivatives as vasopressin antagonists
US5204349A (en) * 1991-09-16 1993-04-20 Merck & Co., Inc. Amide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists
EP0533240A3 (en) * 1991-09-16 1993-09-29 Merck & Co. Inc. Substituted amine derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
EP0533243B1 (en) * 1991-09-16 1997-12-17 Merck & Co. Inc. Hydantoin and succinimide-substituted spiroindanylcamphorsulfonyl derivatives
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AU657431B2 (en) * 1992-08-20 1995-03-09 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclic compounds as oxytocin and vasopressin antagonists
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Also Published As

Publication number Publication date
DE69630209T2 (de) 2004-08-19
NZ302119A (en) 2000-02-28
IL116776A (en) 2000-10-31
PT811008E (pt) 2004-02-27
JPH10512572A (ja) 1998-12-02
TW342385B (en) 1998-10-11
US5654297A (en) 1997-08-05
WO1996022294A1 (en) 1996-07-25
KR19980703098A (ko) 1998-10-15
DE69630209D1 (de) 2003-11-06
EP0811008B1 (en) 2003-10-01
DK0811008T3 (da) 2004-01-26
AU4770696A (en) 1996-08-07
EP0811008A1 (en) 1997-12-10
ES2207672T3 (es) 2004-06-01
CN1177356A (zh) 1998-03-25
HUP9800466A3 (en) 1998-12-28
EA199700115A1 (ru) 1997-12-30
BR9607153A (pt) 1997-11-11
ZA96298B (en) 1997-07-15
MX9705312A (es) 1997-10-31
CZ224697A3 (cs) 1998-01-14
US5696112A (en) 1997-12-09
EA001427B1 (ru) 2001-02-26
CA2210571A1 (en) 1996-07-25
IL116776A0 (en) 1996-05-14
HUP9800466A2 (hu) 1998-07-28
ATE251166T1 (de) 2003-10-15
AU716008B2 (en) 2000-02-17

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