DE69630209D1 - Bicyclische benzazepin-derivate als vasopressin-antagonisten - Google Patents

Bicyclische benzazepin-derivate als vasopressin-antagonisten

Info

Publication number
DE69630209D1
DE69630209D1 DE69630209T DE69630209T DE69630209D1 DE 69630209 D1 DE69630209 D1 DE 69630209D1 DE 69630209 T DE69630209 T DE 69630209T DE 69630209 T DE69630209 T DE 69630209T DE 69630209 D1 DE69630209 D1 DE 69630209D1
Authority
DE
Germany
Prior art keywords
vasopressin antagonists
benzazepine derivatives
bicyclic
bicyclic benzazepine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69630209T
Other languages
English (en)
Other versions
DE69630209T2 (de
Inventor
Donald Albright
Santos Guillermo Delos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Wyeth LLC
Original Assignee
Wyeth Holdings LLC
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Holdings LLC, Wyeth LLC filed Critical Wyeth Holdings LLC
Publication of DE69630209D1 publication Critical patent/DE69630209D1/de
Application granted granted Critical
Publication of DE69630209T2 publication Critical patent/DE69630209T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69630209T 1995-01-17 1996-01-16 Bicyclische benzazepin-derivate als vasopressin-antagonisten Expired - Fee Related DE69630209T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/373,839 US5696112A (en) 1995-01-17 1995-01-17 Fused heterocyclic azepines as vasopressin antagonists
US373839 1995-01-17
PCT/US1996/001096 WO1996022294A1 (en) 1995-01-17 1996-01-16 Bicyclic benzazepine derivatives as vasopressin antagonists

Publications (2)

Publication Number Publication Date
DE69630209D1 true DE69630209D1 (de) 2003-11-06
DE69630209T2 DE69630209T2 (de) 2004-08-19

Family

ID=23474102

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69630209T Expired - Fee Related DE69630209T2 (de) 1995-01-17 1996-01-16 Bicyclische benzazepin-derivate als vasopressin-antagonisten

Country Status (23)

Country Link
US (2) US5696112A (de)
EP (1) EP0811008B1 (de)
JP (1) JPH10512572A (de)
KR (1) KR19980703098A (de)
CN (1) CN1177356A (de)
AR (1) AR010195A1 (de)
AT (1) ATE251166T1 (de)
AU (1) AU716008B2 (de)
BR (1) BR9607153A (de)
CA (1) CA2210571A1 (de)
CZ (1) CZ224697A3 (de)
DE (1) DE69630209T2 (de)
DK (1) DK0811008T3 (de)
EA (1) EA001427B1 (de)
ES (1) ES2207672T3 (de)
HU (1) HUP9800466A3 (de)
IL (1) IL116776A (de)
MX (1) MX9705312A (de)
NZ (1) NZ302119A (de)
PT (1) PT811008E (de)
TW (1) TW342385B (de)
WO (1) WO1996022294A1 (de)
ZA (1) ZA96298B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7338796A (en) * 1995-11-09 1997-05-29 Japan Tobacco Inc. Five-membered fused heterocyclic azepine derivatives and pharmaceutical use thereof
US6235900B1 (en) 1999-02-04 2001-05-22 American Home Products Corporation Tricyclic pyridine N-oxides vasopressin agonists
US6297234B1 (en) 1999-02-04 2001-10-02 American Home Products Corporation Arylthiophene vasopressin agonists
US6437006B1 (en) 1999-09-27 2002-08-20 American Cyanamid Company Pharmaceutical carrier formulation
US7064120B2 (en) * 2001-04-12 2006-06-20 Wyeth Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
WO2002083145A1 (en) 2001-04-12 2002-10-24 Wyeth N-biphenylcarbonyl- and n-phenylpyridylcarbonyl substituted bi- and tricyclic azepines and diazepines as vasopressing agonists
US7326700B2 (en) * 2001-04-12 2008-02-05 Wyeth Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US7202239B2 (en) * 2001-04-12 2007-04-10 Wyeth Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
US7109193B2 (en) 2001-04-12 2006-09-19 Wyeth Tricyclic diazepines tocolytic oxytocin receptor antagonists
DE60222879T2 (de) 2001-04-12 2008-07-24 Wyeth Cyclohexylphenyl vasopressin agonisten
US7022699B2 (en) 2001-04-12 2006-04-04 Wyeth Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
US6977254B2 (en) * 2001-04-12 2005-12-20 Wyeth Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US6900200B2 (en) 2001-04-12 2005-05-31 Wyeth Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
SE0102299D0 (sv) 2001-06-26 2001-06-26 Astrazeneca Ab Compounds
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
EP1632494A1 (de) * 2004-08-24 2006-03-08 Ferring B.V. Vasopressin v1a antagonisten
KR101081293B1 (ko) 2006-01-18 2011-11-08 에프. 호프만-라 로슈 아게 11 베타-에이치에스디1 억제제로서 티아졸
WO2010101967A2 (en) * 2009-03-04 2010-09-10 Idenix Pharmaceuticals, Inc. Phosphothiophene and phosphothiazole hcv polymerase inhibitors
WO2010116176A1 (en) 2009-04-09 2010-10-14 Astrazeneca Ab Pyrazolo [4, 5-e] pyrimidine derivative and its use to treat diabetes and obesity
US10626126B2 (en) 2016-04-08 2020-04-21 Pulmocide Limited Compounds

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA821020B (en) * 1981-02-18 1983-10-26 Thomae Gmbh Dr K Azepine derivatives, process for their preparation and pharmaceutical compositions thereof
US4766108A (en) * 1986-12-04 1988-08-23 Smith Kline Beckman Corporation Tyr-Arg-vasopressin antagonists
US5055448A (en) * 1987-06-25 1991-10-08 Medical College Of Ohio Linear derivatives of arginine vasopressin antagonists
EP0382185B1 (de) * 1989-02-10 1994-06-15 Otsuka Pharmaceutical Co., Ltd. Carbostyrilderivate
US5258510A (en) * 1989-10-20 1993-11-02 Otsuka Pharma Co Ltd Benzoheterocyclic compounds
EP0450097B1 (de) * 1989-10-20 1996-04-24 Otsuka Pharmaceutical Co., Ltd. Benzoheterozyklische verbindungen
US5070187A (en) * 1989-11-03 1991-12-03 Trustees Of Boston University Pharmacologically effective antagonists of arginine-vasopressin
TW199153B (de) * 1990-08-07 1993-02-01 Dtsuka Seiyaku Kk
CA2066104C (en) * 1991-04-19 2003-05-27 Hidenori Ogawa Benzazepine derivatives as vasopressin antagonists
DE69223573D1 (de) * 1991-09-16 1998-01-29 Merck & Co Inc Hydantoin und Succinimid-substituierte Spiroindanylcamphorsulfonyl als Oxytocin-Antagonisten
EP0533242A3 (en) * 1991-09-16 1993-09-15 Merck & Co. Inc. Substituted derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
EP0533240A3 (en) * 1991-09-16 1993-09-29 Merck & Co. Inc. Substituted amine derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
US5204349A (en) * 1991-09-16 1993-04-20 Merck & Co., Inc. Amide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists
WO1994004525A1 (en) * 1992-08-20 1994-03-03 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds as oxytocin and vasopressin antagonists
TW270927B (de) * 1992-10-16 1996-02-21 Otsuka Pharma Co Ltd
WO1994012476A1 (en) * 1992-11-25 1994-06-09 Yamanouchi Pharmaceutical Co., Ltd. Benzanilide derivative
AU5692094A (en) * 1992-12-21 1994-07-19 Yamanouchi Pharmaceutical Co., Ltd. Novel n-(pyridylcarbonyl)benzazepine derivative and intermediate therefor
WO1994020473A1 (en) * 1993-03-11 1994-09-15 Yamanouchi Pharmaceutical Co., Ltd. Compound with vasopressin antagonism
GB9307527D0 (en) * 1993-04-13 1993-06-02 Fujisawa Pharmaceutical Co New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same

Also Published As

Publication number Publication date
AU716008B2 (en) 2000-02-17
AR010195A1 (es) 2000-06-07
WO1996022294A1 (en) 1996-07-25
CN1177356A (zh) 1998-03-25
US5696112A (en) 1997-12-09
CZ224697A3 (cs) 1998-01-14
NZ302119A (en) 2000-02-28
ES2207672T3 (es) 2004-06-01
IL116776A (en) 2000-10-31
ZA96298B (en) 1997-07-15
US5654297A (en) 1997-08-05
CA2210571A1 (en) 1996-07-25
KR19980703098A (ko) 1998-10-15
AU4770696A (en) 1996-08-07
BR9607153A (pt) 1997-11-11
EP0811008A1 (de) 1997-12-10
HUP9800466A3 (en) 1998-12-28
EA199700115A1 (ru) 1997-12-30
MX9705312A (es) 1997-10-31
TW342385B (en) 1998-10-11
JPH10512572A (ja) 1998-12-02
DK0811008T3 (da) 2004-01-26
IL116776A0 (en) 1996-05-14
EA001427B1 (ru) 2001-02-26
EP0811008B1 (de) 2003-10-01
DE69630209T2 (de) 2004-08-19
HUP9800466A2 (hu) 1998-07-28
PT811008E (pt) 2004-02-27
ATE251166T1 (de) 2003-10-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee