ATE375346T1 - Cyclohexylphenyl vasopressin agonisten - Google Patents
Cyclohexylphenyl vasopressin agonistenInfo
- Publication number
- ATE375346T1 ATE375346T1 AT02721730T AT02721730T ATE375346T1 AT E375346 T1 ATE375346 T1 AT E375346T1 AT 02721730 T AT02721730 T AT 02721730T AT 02721730 T AT02721730 T AT 02721730T AT E375346 T1 ATE375346 T1 AT E375346T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- optionally substituted
- aromatic ring
- membered aromatic
- nitrogen atom
- Prior art date
Links
- 229940083335 Vasopressin agonist Drugs 0.000 title abstract 2
- -1 CYCLOHEXYLPHENYL Chemical class 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 206010053567 Coagulopathies Diseases 0.000 abstract 1
- 208000008967 Enuresis Diseases 0.000 abstract 1
- 206010046543 Urinary incontinence Diseases 0.000 abstract 1
- 102100026383 Vasopressin-neurophysin 2-copeptin Human genes 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000740 bleeding effect Effects 0.000 abstract 1
- 208000015294 blood coagulation disease Diseases 0.000 abstract 1
- 230000009852 coagulant defect Effects 0.000 abstract 1
- 201000010064 diabetes insipidus Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000031169 hemorrhagic disease Diseases 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000027939 micturition Effects 0.000 abstract 1
- 206010029446 nocturia Diseases 0.000 abstract 1
- 208000005346 nocturnal enuresis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28338701P | 2001-04-12 | 2001-04-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE375346T1 true ATE375346T1 (de) | 2007-10-15 |
Family
ID=23085813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02721730T ATE375346T1 (de) | 2001-04-12 | 2002-04-11 | Cyclohexylphenyl vasopressin agonisten |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7053083B2 (de) |
| EP (1) | EP1381608B1 (de) |
| JP (1) | JP2004526771A (de) |
| CN (1) | CN1294134C (de) |
| AT (1) | ATE375346T1 (de) |
| BR (1) | BR0208824A (de) |
| CA (1) | CA2443870A1 (de) |
| DE (1) | DE60222879T2 (de) |
| DK (1) | DK1381608T3 (de) |
| ES (1) | ES2294130T3 (de) |
| MX (1) | MXPA03009159A (de) |
| WO (1) | WO2002083685A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0210397D0 (en) | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
| KR20140143461A (ko) | 2007-08-06 | 2014-12-16 | 알레간 인코포레이티드 | 데스모프레신 약물 전달을 위한 방법 및 장치 |
| US20100286045A1 (en) | 2008-05-21 | 2010-11-11 | Bjarke Mirner Klein | Methods comprising desmopressin |
| ES2756706T3 (es) * | 2008-05-21 | 2020-04-27 | Ferring Bv | Desmopresina bucodispersable para aumentar el periodo inicial de sueño ininterrumpido por nocturia |
| US11963995B2 (en) | 2008-05-21 | 2024-04-23 | Ferring B.V. | Methods comprising desmopressin |
| EP3116509B1 (de) * | 2014-03-12 | 2022-06-22 | The Trustees of Columbia University in the City of New York | Neue klasse von mu-opioidrezeptoragonisten |
| AU2016323977B9 (en) | 2015-09-16 | 2021-03-04 | The Trustees Of Columbia University In The City Of New York | Carboxylic diarylthiazepineamines as mu-opioid receptor agonists |
| WO2017074914A1 (en) * | 2015-10-29 | 2017-05-04 | Merck Sharp & Dohme Corp. | Novel tricyclic compounds as inhibitors of mutant idh enzymes |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5516774A (en) | 1993-07-29 | 1996-05-14 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
| US5736540A (en) | 1993-07-29 | 1998-04-07 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
| US5686445A (en) | 1993-07-29 | 1997-11-11 | American Cyanamid Company | Pyridobenzoxazepine and pyridobenzothiazepine vasopressin antagonists |
| US5736538A (en) | 1993-07-29 | 1998-04-07 | American Cyanamid Company | Tricyclic Benzazepine vasopressin antagonists |
| US5760031A (en) | 1993-07-29 | 1998-06-02 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| US5739128A (en) | 1993-07-29 | 1998-04-14 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| US5693635A (en) | 1993-07-29 | 1997-12-02 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| US5733905A (en) | 1993-07-29 | 1998-03-31 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
| US5747487A (en) | 1993-07-29 | 1998-05-05 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| DK0765314T3 (da) * | 1994-06-15 | 2003-08-25 | Otsuka Pharma Co Ltd | Benzoheterocykliske derivater, der kan anvendes som vasopressin- eller oxytocinmodulatorer |
| US5700796A (en) | 1995-01-17 | 1997-12-23 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| US5849735A (en) | 1995-01-17 | 1998-12-15 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| US5753648A (en) | 1995-01-17 | 1998-05-19 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| US5532235A (en) | 1995-01-17 | 1996-07-02 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| AR002459A1 (es) | 1995-01-17 | 1998-03-25 | American Cyanamid Co | Antagonistas de vasopresina de benzacepina triciclicos, una composicion farmaceutica que los contiene, un metodo para tratar enfermedades y unprocedimiento para su preparacion. |
| US5536718A (en) | 1995-01-17 | 1996-07-16 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| US5696112A (en) | 1995-01-17 | 1997-12-09 | American Cyanamid Company | Fused heterocyclic azepines as vasopressin antagonists |
| US5521173A (en) | 1995-01-17 | 1996-05-28 | American Home Products Corporation | Tricyclic benzazepine vasopressin antagonists |
| TW359669B (en) | 1995-12-15 | 1999-06-01 | Otsuka Pharma Co Ltd | Benzazepine derivatives |
| AU4168999A (en) | 1998-06-19 | 2000-01-05 | Wakamoto Pharmaceutical Co., Ltd. | Ocular tension lowering agents and phosphoric ester derivatives |
| EP1147115B3 (de) | 1999-01-19 | 2008-12-24 | Ortho-McNeil Pharmaceutical, Inc. | Tricyclische benzodiazepine als vasopressin antagonisten |
-
2002
- 2002-04-11 US US10/120,917 patent/US7053083B2/en not_active Expired - Fee Related
- 2002-04-11 CN CNB028116402A patent/CN1294134C/zh not_active Expired - Fee Related
- 2002-04-11 AT AT02721730T patent/ATE375346T1/de not_active IP Right Cessation
- 2002-04-11 JP JP2002581440A patent/JP2004526771A/ja not_active Ceased
- 2002-04-11 WO PCT/US2002/011538 patent/WO2002083685A1/en not_active Ceased
- 2002-04-11 BR BR0208824-0A patent/BR0208824A/pt not_active IP Right Cessation
- 2002-04-11 DK DK02721730T patent/DK1381608T3/da active
- 2002-04-11 MX MXPA03009159A patent/MXPA03009159A/es active IP Right Grant
- 2002-04-11 ES ES02721730T patent/ES2294130T3/es not_active Expired - Lifetime
- 2002-04-11 CA CA002443870A patent/CA2443870A1/en not_active Abandoned
- 2002-04-11 EP EP02721730A patent/EP1381608B1/de not_active Expired - Lifetime
- 2002-04-11 DE DE60222879T patent/DE60222879T2/de not_active Expired - Fee Related
-
2006
- 2006-04-11 US US11/403,072 patent/US7329653B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1294134C (zh) | 2007-01-10 |
| BR0208824A (pt) | 2004-03-09 |
| MXPA03009159A (es) | 2004-02-12 |
| JP2004526771A (ja) | 2004-09-02 |
| US20020198191A1 (en) | 2002-12-26 |
| US7053083B2 (en) | 2006-05-30 |
| EP1381608A1 (de) | 2004-01-21 |
| DE60222879D1 (de) | 2007-11-22 |
| US7329653B2 (en) | 2008-02-12 |
| US20060183734A1 (en) | 2006-08-17 |
| CN1514834A (zh) | 2004-07-21 |
| DK1381608T3 (da) | 2008-02-04 |
| EP1381608B1 (de) | 2007-10-10 |
| WO2002083685A1 (en) | 2002-10-24 |
| CA2443870A1 (en) | 2002-10-24 |
| DE60222879T2 (de) | 2008-07-24 |
| ES2294130T3 (es) | 2008-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |