PE20030702A1 - Inhibidores de pde9 para tratamiento de transtornos cardiovasculares - Google Patents

Inhibidores de pde9 para tratamiento de transtornos cardiovasculares

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Publication number
PE20030702A1
PE20030702A1 PE2002001070A PE2002001070A PE20030702A1 PE 20030702 A1 PE20030702 A1 PE 20030702A1 PE 2002001070 A PE2002001070 A PE 2002001070A PE 2002001070 A PE2002001070 A PE 2002001070A PE 20030702 A1 PE20030702 A1 PE 20030702A1
Authority
PE
Peru
Prior art keywords
alkyl
ona
pyrimidin
dihydro
treatment
Prior art date
Application number
PE2002001070A
Other languages
English (en)
Inventor
Michael Paul Deninno
Bernadette Hughes
Anthony Wood
Michael John Palmer
Mark Ian Kemp
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0126395A external-priority patent/GB0126395D0/en
Priority claimed from GB0130695A external-priority patent/GB0130695D0/en
Priority claimed from GB0216761A external-priority patent/GB0216761D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of PE20030702A1 publication Critical patent/PE20030702A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Abstract

SE REFIERE A COMPUESTOS DE FORMULA I DONDE R1 ES H, ALQUILO C1-C6 DONDE R1 SE UNE A N1 O N2; R2 ES ALQUILO C1-C6, CICLOALQUILO C3-C7, HETEROCICLO DE 5-6 MIEMBROS CON ALQUILO, OH, ALCOXI; R3 ES ALQUILO C1-C6 CON Ar2, CICLOALQUILO C3-C7, ENTRE OTROS; Ar2 ES EL GRUPO a CONDE R4, R5, R6 SON H, HALO, FENOXI, FENILO, CF3, CF3, ENTRE OTROS. CUANDO R1 ESTA UNIDO A N1, R1 ES ALQUILO C1-C6 Y R2 ES PROPILO ENTONCE R3 NO ES METILO SUSTITUIDO CON Ar1; R1 ESTA UNIDO A N1, R1 ES ALQUILO C1-C6, R2 ES METILO ENTONCES R3 NO ES ALQUILO C1-C4 SUSTITUIDO CON Ar1. SON COMPUESTOS PREFERIDOS 5-(-3-CLOROBENZIL)-3-ISOPROPIL-1,6-DIHIDRO-PIRAZOL[4,3-d]PIRIMIDIN-7-ONA, 3-ISOPROPIL-5-(2-FENOXIBENZIL)-1,6-DIHIDRO-PIRAZOL[4,3-d]PIRIMIDIN-7-ONA. 3-(3-PIRIDINIL)-5-(-2-BENCILOXIBENZIL)-1,6-DIHIDRO-PIRAZOL[4,3-d]PIRIMIDIN-7-ONA. 3-ISOPROPIL-5-(2-TRIFLUOROMETOXIBENCIL)-1,6-DIHIDRO-PIRAZOL[4,3-d]PIRIMIDIN-7-ONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE LA FOSFODIESTERASA 9 (PDE9) Y SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES
PE2002001070A 2001-11-02 2002-10-30 Inhibidores de pde9 para tratamiento de transtornos cardiovasculares PE20030702A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0126395A GB0126395D0 (en) 2001-11-02 2001-11-02 Pyrazolo[4,3]pyrimidine derivatives and their use in treating disease
GB0130695A GB0130695D0 (en) 2001-12-21 2001-12-21 Pyrazola[4,3]pyrimidine
GB0216761A GB0216761D0 (en) 2002-07-18 2002-07-18 PDE9 Inhibitors for treating cardiovascular disorders

Publications (1)

Publication Number Publication Date
PE20030702A1 true PE20030702A1 (es) 2003-08-21

Family

ID=27256310

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002001070A PE20030702A1 (es) 2001-11-02 2002-10-30 Inhibidores de pde9 para tratamiento de transtornos cardiovasculares

Country Status (14)

Country Link
EP (1) EP1440073A1 (es)
JP (1) JP2005511575A (es)
AR (1) AR037329A1 (es)
BR (1) BR0214096A (es)
CA (1) CA2466824A1 (es)
DO (1) DOP2002000482A (es)
HN (1) HN2002000317A (es)
MX (1) MXPA04004171A (es)
PA (1) PA8557401A1 (es)
PE (1) PE20030702A1 (es)
SV (1) SV2004001373A (es)
TW (1) TW200300081A (es)
UY (1) UY27522A1 (es)
WO (1) WO2003037899A1 (es)

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