PE20060380A1 - Derivados de pirido-pirimidina en la prevencion y tratamiento de la proliferacion celular - Google Patents

Derivados de pirido-pirimidina en la prevencion y tratamiento de la proliferacion celular

Info

Publication number
PE20060380A1
PE20060380A1 PE2005000811A PE2005000811A PE20060380A1 PE 20060380 A1 PE20060380 A1 PE 20060380A1 PE 2005000811 A PE2005000811 A PE 2005000811A PE 2005000811 A PE2005000811 A PE 2005000811A PE 20060380 A1 PE20060380 A1 PE 20060380A1
Authority
PE
Peru
Prior art keywords
treatment
cellular proliferation
pyrid
prevention
benzodioxol
Prior art date
Application number
PE2005000811A
Other languages
English (en)
Inventor
Bernard Bourrie
Pierre Casellas
Pierre Perreaut
Samir Jegham
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PE20060380A1 publication Critical patent/PE20060380A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 ES ALQUILO C1-C6, CICLOALQUILO C3-C7, FENILO, ENTRE OTROS; Ar1 ES 1,3-BENZODIOXOL-2-CARBOXILATO DE METILO, 1,3-BENZODIOXOL-2-AMINOCARBONIL, 1,3-BENZODIOXOL-2,2-DIAMINOCARBONIL, ENTRE OTROS; Ar2 ES FENILO, 2,6-DICLOROFENILO, 3,5-DIMETOXIFENILO, 2,6-DIBROMOFENILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: A, B, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE TRASTORNOS DE LA PROLIFERACION CELULAR TALES COMO LEUCEMIAS, TUMORES SOLIDOS PRIMARIOS Y METASTASICOS, CARCINOMAS Y CANCER
PE2005000811A 2004-07-15 2005-07-14 Derivados de pirido-pirimidina en la prevencion y tratamiento de la proliferacion celular PE20060380A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0407898A FR2873118B1 (fr) 2004-07-15 2004-07-15 Derives de pyrido-pyrimidine, leur application en therapeutique

Publications (1)

Publication Number Publication Date
PE20060380A1 true PE20060380A1 (es) 2006-06-06

Family

ID=34947008

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000811A PE20060380A1 (es) 2004-07-15 2005-07-14 Derivados de pirido-pirimidina en la prevencion y tratamiento de la proliferacion celular

Country Status (28)

Country Link
US (2) US7544682B2 (es)
EP (1) EP1773835B1 (es)
JP (1) JP5161568B2 (es)
KR (1) KR101236676B1 (es)
CN (1) CN101124223A (es)
AR (1) AR049845A1 (es)
AU (1) AU2005271071B2 (es)
BR (1) BRPI0513287A (es)
CA (1) CA2572614A1 (es)
CR (1) CR8842A (es)
EA (1) EA011406B1 (es)
EC (1) ECSP067111A (es)
FR (1) FR2873118B1 (es)
GT (1) GT200500191A (es)
HN (1) HN2005000370A (es)
IL (1) IL180256A (es)
MA (1) MA28742B1 (es)
MX (1) MX2007000508A (es)
NO (1) NO20070837L (es)
PA (1) PA8639301A1 (es)
PE (1) PE20060380A1 (es)
SV (1) SV2006002170A (es)
TN (1) TNSN06440A1 (es)
TW (1) TWI391390B (es)
UA (1) UA95223C2 (es)
UY (1) UY29015A1 (es)
WO (1) WO2006016067A2 (es)
ZA (1) ZA200700992B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2873118B1 (fr) * 2004-07-15 2007-11-23 Sanofi Synthelabo Derives de pyrido-pyrimidine, leur application en therapeutique
US7750015B2 (en) * 2005-05-17 2010-07-06 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
US7737155B2 (en) * 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
AU2006247695B2 (en) * 2005-05-17 2012-08-09 Merck Sharp & Dohme Corp. Heterocycles as nicotinic acid receptor agonists for the treatment of dyslipidemia
FR2887882B1 (fr) 2005-07-01 2007-09-07 Sanofi Aventis Sa Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
FR2896246B1 (fr) 2006-01-13 2008-08-15 Sanofi Aventis Sa Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
CA2637717A1 (en) * 2006-01-20 2007-08-02 Schering Corporation Heterocycles as nicotinic acid receptor agonists for the treatment of dyyslipidemia
FR2910813B1 (fr) * 2006-12-28 2009-02-06 Sanofi Aventis Sa Nouvelle utilisation therapeutique pour le traitement des leucemies
SA08280783B1 (ar) * 2007-01-11 2011-04-24 استرازينيكا ايه بي مشتقات بيريدوبيريميدين كمثبطات pde4
TW200835497A (en) * 2007-01-11 2008-09-01 Astrazeneca Ab Chemical compounds 636
PT2168966T (pt) 2007-06-15 2017-01-02 Msd Kk Derivado de bicicloanilina
FR2933701A1 (fr) * 2008-07-08 2010-01-15 Sanofi Aventis Derives anticancereux, leur preparation et leur application en therapeutique
FR2955109B1 (fr) * 2010-01-08 2012-09-07 Sanofi Aventis Derives de 5-oxo-5,8-dihydro-pyrido[2, 3-d]pyrimidine, leur preparation et leur application en therapeutique

Family Cites Families (23)

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GB1171218A (en) * 1967-11-09 1969-11-19 Parke Davis & Co New Heterocyclic Amine Compounds and Methods for their Production
IL115256A0 (en) * 1994-11-14 1995-12-31 Warner Lambert Co 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
ATE190978T1 (de) * 1994-11-14 2000-04-15 Warner Lambert Co 6-aryl-pyrido(2,3-d)pyrimidine und -naphthyridine zur hemmung der durch protein-tyrosin-kinase hervorgerufenen zellvermehrung
IL117923A (en) 1995-05-03 2000-06-01 Warner Lambert Co Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
US5620981A (en) 1995-05-03 1997-04-15 Warner-Lambert Company Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
EP1218336A2 (en) 1999-09-20 2002-07-03 Takeda Chemical Industries, Ltd. Melanin concentrating hormone antagonist
GT200100016A (es) 2000-01-25 2001-10-19 Pirido[2,3,-d]pirimidin-2,7-diaminas inhibidoras de cinasas.
US7053070B2 (en) * 2000-01-25 2006-05-30 Warner-Lambert Company Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors
AP2002002643A0 (en) 2000-03-06 2002-12-31 Warner Lambert Co 5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors
JP2004519422A (ja) 2000-08-04 2004-07-02 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー ２−（４−ピリジル）アミノ−６−ジアルコキシフェニルピリド〔２，３−ｄ〕ピリミジン−７−オン
AU2002324450A1 (en) 2001-06-21 2003-01-08 Ariad Pharmaceuticals, Inc. Novel pyridopyrimidines and uses thereof
WO2003026666A1 (en) * 2001-09-26 2003-04-03 Bayer Pharmaceuticals Corporation 2-phenylamino-4- (5-pyrazolylamino)-pyrimidine derivatives as kinase inhibitors, in particular, as src kinase inhibitors
WO2003055866A1 (en) * 2001-12-21 2003-07-10 Bayer Pharmaceuticals Corporation Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
PL374544A1 (en) * 2002-04-03 2005-10-31 F.Hoffmann-La Roche Ag Imidazo fused compounds
AU2002952453A0 (en) * 2002-11-01 2002-11-21 Novogen Research Pty Ltd Aminated isoflavonoid derivatives and uses thereof
TW200413381A (en) * 2002-11-04 2004-08-01 Hoffmann La Roche Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents
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MXPA06003996A (es) * 2003-10-08 2006-07-05 Irm Llc Compuestos y composiciones como inhibidores de la proteina cinasa.
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FR2873118B1 (fr) * 2004-07-15 2007-11-23 Sanofi Synthelabo Derives de pyrido-pyrimidine, leur application en therapeutique
FR2887882B1 (fr) * 2005-07-01 2007-09-07 Sanofi Aventis Sa Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
FR2896246B1 (fr) 2006-01-13 2008-08-15 Sanofi Aventis Sa Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.

Also Published As

Publication number Publication date
JP5161568B2 (ja) 2013-03-13
TNSN06440A1 (fr) 2008-02-22
NO20070837L (no) 2007-04-16
AR049845A1 (es) 2006-09-06
KR20070037489A (ko) 2007-04-04
UY29015A1 (es) 2006-02-24
US7544682B2 (en) 2009-06-09
JP2008506673A (ja) 2008-03-06
MX2007000508A (es) 2007-03-29
BRPI0513287A (pt) 2008-05-06
CA2572614A1 (fr) 2006-02-16
TWI391390B (zh) 2013-04-01
FR2873118A1 (fr) 2006-01-20
IL180256A0 (en) 2007-07-04
HN2005000370A (es) 2009-06-01
KR101236676B1 (ko) 2013-02-22
ZA200700992B (en) 2008-05-28
TW200607808A (en) 2006-03-01
FR2873118B1 (fr) 2007-11-23
UA95223C2 (ru) 2011-07-25
AU2005271071A1 (en) 2006-02-16
CN101124223A (zh) 2008-02-13
PA8639301A1 (es) 2006-11-09
EA200700144A1 (ru) 2007-08-31
AU2005271071B2 (en) 2011-09-15
US20070167469A1 (en) 2007-07-19
WO2006016067A3 (fr) 2006-06-01
CR8842A (es) 2007-08-28
EP1773835A2 (fr) 2007-04-18
IL180256A (en) 2014-04-30
GT200500191A (es) 2006-03-07
EP1773835B1 (fr) 2014-09-24
WO2006016067A2 (fr) 2006-02-16
US20090233923A1 (en) 2009-09-17
US7893259B2 (en) 2011-02-22
ECSP067111A (es) 2007-01-26
MA28742B1 (fr) 2007-07-02
EA011406B1 (ru) 2009-02-27
SV2006002170A (es) 2006-01-13

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FG Grant, registration
FD Application declared void or lapsed