PA8639301A1 - Derivados de piridio-pirimidina, su preparacion, su enterapeutica - Google Patents

Derivados de piridio-pirimidina, su preparacion, su enterapeutica

Info

Publication number
PA8639301A1
PA8639301A1 PA20058639301A PA8639301A PA8639301A1 PA 8639301 A1 PA8639301 A1 PA 8639301A1 PA 20058639301 A PA20058639301 A PA 20058639301A PA 8639301 A PA8639301 A PA 8639301A PA 8639301 A1 PA8639301 A1 PA 8639301A1
Authority
PA
Panama
Prior art keywords
piridio
enterapeutics
preparation
group
pyrimidine derivatives
Prior art date
Application number
PA20058639301A
Other languages
English (en)
Inventor
Bernard Bourrie
Pierre Casellas
Samir Jegham
Pierre Perreaut
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PA8639301A1 publication Critical patent/PA8639301A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION TIENE POR OBJETO COMPUESTOS QUE RESPONDEN A LA FORMULA (I): EN LA CUAL: - R1 REPRESENTA UN GRUPO ALQUILO (C1-C6), UN GRUPO NR2R3 O CH2COR4; - R2 Y R3 REPRESENTAN, CADA UNO INDEPENDIENTEMENTE ENTRE SI, UN ATOMO DE HIDROGENO O ALQUILO (C1-C6); - R4 REPRESENTA UN GRUPO HIDROXILO, ALCOXI (C1-C4), AMINO, ALQUILAMINO (C1-C4), DIALQUILAMINO (C1-C4); - AR1 REPRESENTA UN RADICAL ELEGIDO ENTRE: - AR2 REPRESENTA UN GRUPO FENILO NO SUBSTITUIDO O SUBSTITUIDO
PA20058639301A 2004-07-15 2005-07-14 Derivados de piridio-pirimidina, su preparacion, su enterapeutica PA8639301A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0407898A FR2873118B1 (fr) 2004-07-15 2004-07-15 Derives de pyrido-pyrimidine, leur application en therapeutique

Publications (1)

Publication Number Publication Date
PA8639301A1 true PA8639301A1 (es) 2006-11-09

Family

ID=34947008

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20058639301A PA8639301A1 (es) 2004-07-15 2005-07-14 Derivados de piridio-pirimidina, su preparacion, su enterapeutica

Country Status (28)

Country Link
US (2) US7544682B2 (es)
EP (1) EP1773835B1 (es)
JP (1) JP5161568B2 (es)
KR (1) KR101236676B1 (es)
CN (1) CN101124223A (es)
AR (1) AR049845A1 (es)
AU (1) AU2005271071B2 (es)
BR (1) BRPI0513287A (es)
CA (1) CA2572614A1 (es)
CR (1) CR8842A (es)
EA (1) EA011406B1 (es)
EC (1) ECSP067111A (es)
FR (1) FR2873118B1 (es)
GT (1) GT200500191A (es)
HN (1) HN2005000370A (es)
IL (1) IL180256A (es)
MA (1) MA28742B1 (es)
MX (1) MX2007000508A (es)
NO (1) NO20070837L (es)
PA (1) PA8639301A1 (es)
PE (1) PE20060380A1 (es)
SV (1) SV2006002170A (es)
TN (1) TNSN06440A1 (es)
TW (1) TWI391390B (es)
UA (1) UA95223C2 (es)
UY (1) UY29015A1 (es)
WO (1) WO2006016067A2 (es)
ZA (1) ZA200700992B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2873118B1 (fr) * 2004-07-15 2007-11-23 Sanofi Synthelabo Derives de pyrido-pyrimidine, leur application en therapeutique
BRPI0610133A2 (pt) * 2005-05-17 2010-06-01 Schering Corp heterociclos como agonistas de receptor de ácido nicotìnico para o tratamento de dislipidemia
US7750015B2 (en) * 2005-05-17 2010-07-06 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
US7737155B2 (en) * 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
FR2887882B1 (fr) 2005-07-01 2007-09-07 Sanofi Aventis Sa Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
FR2896246B1 (fr) 2006-01-13 2008-08-15 Sanofi Aventis Sa Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
JP2009525961A (ja) * 2006-01-20 2009-07-16 シェーリング コーポレイション 異常脂質血症の処置のためのニコチン酸受容体アゴニストとしての複素環
FR2910813B1 (fr) * 2006-12-28 2009-02-06 Sanofi Aventis Sa Nouvelle utilisation therapeutique pour le traitement des leucemies
TW200835497A (en) * 2007-01-11 2008-09-01 Astrazeneca Ab Chemical compounds 636
SA08280783B1 (ar) * 2007-01-11 2011-04-24 استرازينيكا ايه بي مشتقات بيريدوبيريميدين كمثبطات pde4
CA2689429C (en) * 2007-06-15 2012-08-21 Banyu Pharmaceutical Co., Ltd. Bicycloaniline derivatives
FR2933701A1 (fr) * 2008-07-08 2010-01-15 Sanofi Aventis Derives anticancereux, leur preparation et leur application en therapeutique
FR2955109B1 (fr) * 2010-01-08 2012-09-07 Sanofi Aventis Derives de 5-oxo-5,8-dihydro-pyrido[2, 3-d]pyrimidine, leur preparation et leur application en therapeutique

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1171218A (en) 1967-11-09 1969-11-19 Parke Davis & Co New Heterocyclic Amine Compounds and Methods for their Production
ES2146782T3 (es) * 1994-11-14 2000-08-16 Warner Lambert Co 6-aril-pirido(2,3-d)pirimidinas y naftiridinas para la inhibicion de la proliferacion celular inducida por la proteina tirosina quinasa.
IL115256A0 (en) 1994-11-14 1995-12-31 Warner Lambert Co 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
IL117923A (en) 1995-05-03 2000-06-01 Warner Lambert Co Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
US5620981A (en) * 1995-05-03 1997-04-15 Warner-Lambert Company Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
WO2001021577A2 (en) 1999-09-20 2001-03-29 Takeda Chemical Industries, Ltd. Melanin concentrating hormone antagonist
US7053070B2 (en) * 2000-01-25 2006-05-30 Warner-Lambert Company Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors
KR20020065939A (ko) 2000-01-25 2002-08-14 워너-램버트 캄파니 피리도[2,3-ｄ]피리미딘-2,7-디아민 카이나제 억제제
AP2002002643A0 (en) 2000-03-06 2002-12-31 Warner Lambert Co 5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors
DE60135854D1 (de) 2000-08-04 2008-10-30 Warner Lambert Co 2-(4-Pyridyl)amino-6-dialkoxyphenyl-pyrido(2,3-d)pyrimidin-7-one
WO2003000011A2 (en) 2001-06-21 2003-01-03 Ariad Pharmaceuticals, Inc. Novel pyridopyrimidines and uses thereof
WO2003026664A1 (en) * 2001-09-26 2003-04-03 Bayer Corporation 2-phenylamino-4- (5-pyrazolylamino) -pyramidine derivatives as kinase inhibitors, in particular, src kinase inhibitors
AU2002361846A1 (en) * 2001-12-21 2003-07-15 Bayer Pharmaceuticals Corporation Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
MXPA04009585A (es) * 2002-04-03 2005-01-11 Hoffmann La Roche Compuestos imidazo fusionados.
AU2002952453A0 (en) * 2002-11-01 2002-11-21 Novogen Research Pty Ltd Aminated isoflavonoid derivatives and uses thereof
TW200413381A (en) * 2002-11-04 2004-08-01 Hoffmann La Roche Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents
US20050009849A1 (en) 2003-01-03 2005-01-13 Veach Darren R. Pyridopyrimidine kinase inhibitors
TW200502236A (en) * 2003-03-28 2005-01-16 Hoffmann La Roche Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
CA2542105C (en) * 2003-10-08 2011-08-02 Irm Llc Compounds and compositions as protein kinase inhibitors
WO2005105097A2 (en) 2004-04-28 2005-11-10 Gpc Biotech Ag Pyridopyrimidines for treating inflammatory and other diseases
FR2873118B1 (fr) * 2004-07-15 2007-11-23 Sanofi Synthelabo Derives de pyrido-pyrimidine, leur application en therapeutique
FR2887882B1 (fr) 2005-07-01 2007-09-07 Sanofi Aventis Sa Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
FR2896246B1 (fr) 2006-01-13 2008-08-15 Sanofi Aventis Sa Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.

Also Published As

Publication number Publication date
ZA200700992B (en) 2008-05-28
EP1773835A2 (fr) 2007-04-18
US20070167469A1 (en) 2007-07-19
HN2005000370A (es) 2009-06-01
US7893259B2 (en) 2011-02-22
EA200700144A1 (ru) 2007-08-31
GT200500191A (es) 2006-03-07
NO20070837L (no) 2007-04-16
JP2008506673A (ja) 2008-03-06
FR2873118A1 (fr) 2006-01-20
EP1773835B1 (fr) 2014-09-24
CR8842A (es) 2007-08-28
BRPI0513287A (pt) 2008-05-06
KR20070037489A (ko) 2007-04-04
WO2006016067A2 (fr) 2006-02-16
CN101124223A (zh) 2008-02-13
MA28742B1 (fr) 2007-07-02
SV2006002170A (es) 2006-01-13
US7544682B2 (en) 2009-06-09
IL180256A (en) 2014-04-30
TWI391390B (zh) 2013-04-01
KR101236676B1 (ko) 2013-02-22
TW200607808A (en) 2006-03-01
JP5161568B2 (ja) 2013-03-13
AU2005271071A1 (en) 2006-02-16
CA2572614A1 (fr) 2006-02-16
AR049845A1 (es) 2006-09-06
AU2005271071B2 (en) 2011-09-15
WO2006016067A3 (fr) 2006-06-01
TNSN06440A1 (fr) 2008-02-22
ECSP067111A (es) 2007-01-26
UA95223C2 (ru) 2011-07-25
MX2007000508A (es) 2007-03-29
FR2873118B1 (fr) 2007-11-23
UY29015A1 (es) 2006-02-24
IL180256A0 (en) 2007-07-04
US20090233923A1 (en) 2009-09-17
EA011406B1 (ru) 2009-02-27
PE20060380A1 (es) 2006-06-06

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