MX2007004738A - Inhibidores de mif. - Google Patents

Inhibidores de mif.

Info

Publication number
MX2007004738A
MX2007004738A MX2007004738A MX2007004738A MX2007004738A MX 2007004738 A MX2007004738 A MX 2007004738A MX 2007004738 A MX2007004738 A MX 2007004738A MX 2007004738 A MX2007004738 A MX 2007004738A MX 2007004738 A MX2007004738 A MX 2007004738A
Authority
MX
Mexico
Prior art keywords
mif
inhibitors
cycloalkyl
aryl
substituted
Prior art date
Application number
MX2007004738A
Other languages
English (en)
Inventor
Andreas Billich
Philipp Lehr
Hubert Gstach
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2007004738A publication Critical patent/MX2007004738A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)

Abstract

3,4-dihidro-benzo-[e]-[1,3]-oxazin-2-onas, las cuales estan sustituidas en el atomo de nitrogeno por cicloalquilo (de 3 a 6 atomos de carbono), alquilo (de 1 a 4 atomos de carbono)-cicloalquilo (de 3 a 8 atomos de carbono), arilo (de 6 a 18 atomos de carbono)-alquilo (de 1 a 4 atomos de carbono) insustituidos o sustituidos, y su uso como productos farmaceuticos.
MX2007004738A 2004-10-21 2005-10-19 Inhibidores de mif. MX2007004738A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0423405.0A GB0423405D0 (en) 2004-10-21 2004-10-21 Organic compounds
PCT/EP2005/011233 WO2006045505A1 (en) 2004-10-21 2005-10-19 Mif-inhibitors

Publications (1)

Publication Number Publication Date
MX2007004738A true MX2007004738A (es) 2007-06-18

Family

ID=33484961

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007004738A MX2007004738A (es) 2004-10-21 2005-10-19 Inhibidores de mif.

Country Status (17)

Country Link
US (1) US7378416B2 (es)
EP (1) EP1805170B1 (es)
JP (1) JP2008517020A (es)
KR (1) KR100875767B1 (es)
CN (1) CN101035782A (es)
AT (1) ATE464307T1 (es)
AU (1) AU2005298923B2 (es)
BR (1) BRPI0516981A (es)
CA (1) CA2581981A1 (es)
DE (1) DE602005020666D1 (es)
ES (1) ES2344655T3 (es)
GB (1) GB0423405D0 (es)
MX (1) MX2007004738A (es)
PL (1) PL1805170T3 (es)
PT (1) PT1805170E (es)
RU (1) RU2383541C2 (es)
WO (1) WO2006045505A1 (es)

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* Cited by examiner, † Cited by third party
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GB0507695D0 (en) * 2005-04-15 2005-05-25 Novartis Ag Organic compounds
PL1928438T3 (pl) 2005-09-26 2013-08-30 Avigen Inc Zastosowanie ibudilastu do leczenia uzależnień od środków odurzających
WO2007142923A1 (en) * 2006-05-31 2007-12-13 Avigen, Inc. Mif inhibitors for treating neuropathic pain and associated syndromes
CA2653345A1 (en) * 2006-05-31 2007-12-13 Avigen, Inc. Ibudilast for inhibiting macrophage migration inhibitory factor (mif) activity
JP2012500260A (ja) * 2008-08-18 2012-01-05 イェール・ユニヴァーシティー Ｍｉｆモジュレーター
US9643922B2 (en) * 2008-08-18 2017-05-09 Yale University MIF modulators
US9540322B2 (en) 2008-08-18 2017-01-10 Yale University MIF modulators
EP2198879A1 (en) 2008-12-11 2010-06-23 Institut Curie CD74 modulator agent for regulating dendritic cell migration and device for studying the motility capacity of a cell
US9549988B2 (en) 2013-06-09 2017-01-24 RJS Biologics Pharmaceutical compounds targeted by MIF affinity-tethered moieties
US9617212B2 (en) 2013-12-17 2017-04-11 Controlled Chemicals, Inc. Isoindolin-1-ones as macrophage migration inhibitory factor (MIF) inhibitors
EP2944310B1 (en) 2014-05-16 2018-03-21 Mifcare MIF inhibitors for the acute or chronic treatment of pulmonary hypertension
US10899739B2 (en) 2017-11-15 2021-01-26 Yale University Macrophage migration inhibitory factor inhibitors, and methods of making and using same
WO2019178480A1 (en) 2018-03-15 2019-09-19 Yale University Pyrazole-containing macrophage migration inhibitory factor inhibitors
US11767301B2 (en) 2018-04-09 2023-09-26 Yale University Bi-functional molecules to degrade circulating proteins
US20220023434A1 (en) 2018-12-19 2022-01-27 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional Molecules for Lysosomal Targeting and Related Compositions and Methods
WO2022093817A1 (en) * 2020-10-26 2022-05-05 Yale University Macrophage migration inhibitory factor inhibitors, and methods of making and using same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6081182A (ja) * 1983-10-12 1985-05-09 Kissei Pharmaceut Co Ltd チオフエン誘導体及びその製造方法
JP4403305B2 (ja) * 2001-09-03 2010-01-27 武田薬品工業株式会社 １，３−ベンゾチアジノン誘導体および用途
GB0507695D0 (en) * 2005-04-15 2005-05-25 Novartis Ag Organic compounds

Also Published As

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ES2344655T3 (es) 2010-09-02
CA2581981A1 (en) 2006-05-04
US7378416B2 (en) 2008-05-27
ATE464307T1 (de) 2010-04-15
RU2007118727A (ru) 2008-11-27
US20070219189A1 (en) 2007-09-20
CN101035782A (zh) 2007-09-12
KR20070054253A (ko) 2007-05-28
GB0423405D0 (en) 2004-11-24
KR100875767B1 (ko) 2008-12-26
BRPI0516981A (pt) 2008-09-30
EP1805170A1 (en) 2007-07-11
AU2005298923A1 (en) 2006-05-04
AU2005298923B2 (en) 2009-12-17
JP2008517020A (ja) 2008-05-22
PT1805170E (pt) 2010-07-12
DE602005020666D1 (en) 2010-05-27
EP1805170B1 (en) 2010-04-14
PL1805170T3 (pl) 2010-09-30
RU2383541C2 (ru) 2010-03-10
WO2006045505A1 (en) 2006-05-04

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