DE60135854D1 - 2-(4-Pyridyl)amino-6-dialkoxyphenyl-pyrido(2,3-d)pyrimidin-7-one - Google Patents
2-(4-Pyridyl)amino-6-dialkoxyphenyl-pyrido(2,3-d)pyrimidin-7-oneInfo
- Publication number
- DE60135854D1 DE60135854D1 DE60135854T DE60135854T DE60135854D1 DE 60135854 D1 DE60135854 D1 DE 60135854D1 DE 60135854 T DE60135854 T DE 60135854T DE 60135854 T DE60135854 T DE 60135854T DE 60135854 D1 DE60135854 D1 DE 60135854D1
- Authority
- DE
- Germany
- Prior art keywords
- dialkoxyphenyl
- pyrido
- pyrimidin
- pyridyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22308300P | 2000-08-04 | 2000-08-04 | |
PCT/US2001/022881 WO2002012238A2 (en) | 2000-08-04 | 2001-07-20 | 2-(4-PYRIDYL)AMINO-6-DIALKOXYPHENYL-PYRIDO[2,3-d]PYRIMIDIN-7-ONES |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60135854D1 true DE60135854D1 (de) | 2008-10-30 |
Family
ID=22834955
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60135854T Expired - Lifetime DE60135854D1 (de) | 2000-08-04 | 2001-07-20 | 2-(4-Pyridyl)amino-6-dialkoxyphenyl-pyrido(2,3-d)pyrimidin-7-one |
Country Status (21)
Country | Link |
---|---|
US (1) | US7022711B2 (de) |
EP (1) | EP1307450B1 (de) |
JP (1) | JP2004519422A (de) |
AP (1) | AP1333A (de) |
AR (1) | AR030310A1 (de) |
AT (1) | ATE408613T1 (de) |
AU (1) | AU2001277032A1 (de) |
BR (1) | BR0112857A (de) |
CA (1) | CA2417942C (de) |
DE (1) | DE60135854D1 (de) |
DO (1) | DOP2001000227A (de) |
ES (1) | ES2311532T3 (de) |
GT (1) | GT200100158A (de) |
HN (1) | HN2001000171A (de) |
MX (1) | MXPA02011263A (de) |
PA (1) | PA8524101A1 (de) |
PE (1) | PE20020305A1 (de) |
SV (1) | SV2002000572A (de) |
TN (1) | TNSN01118A1 (de) |
UY (1) | UY26867A1 (de) |
WO (1) | WO2002012238A2 (de) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005507392A (ja) * | 2000-08-04 | 2005-03-17 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 2−(4−ピリジル)アミノ−6−ジアルキルオキシフェニルピリド〔2,3−d〕ピリミジン−7−オン類の製造方法 |
WO2002012237A2 (en) * | 2000-08-04 | 2002-02-14 | Warner-Lambert Company | Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido[2,3-d]pyrimidin-7-ones |
OA12755A (en) | 2002-01-22 | 2006-07-03 | Warner Lambert Co | 2-(pyridin-2-ylamino)-pyridoÄ2,3dÜpyrimidin-7-ones. |
US7196090B2 (en) * | 2002-07-25 | 2007-03-27 | Warner-Lambert Company | Kinase inhibitors |
US20060105445A1 (en) * | 2002-07-29 | 2006-05-18 | Klaus Godl | Medium and method for enriching, purifying or depleting atp binding proteins from a pool of proteins |
US7098332B2 (en) * | 2002-12-20 | 2006-08-29 | Hoffmann-La Roche Inc. | 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones |
CN100420687C (zh) * | 2002-12-20 | 2008-09-24 | 霍夫曼-拉罗奇有限公司 | 作为选择性kdr和fgfr抑制剂的吡啶并[2,3-d]嘧啶衍生物 |
EP1608317B1 (de) | 2003-03-25 | 2012-09-26 | Takeda Pharmaceutical Company Limited | Dipeptidylpeptidase-hemmer |
CN1867560A (zh) | 2003-08-13 | 2006-11-22 | 武田药品工株式会社 | 4-嘧啶酮衍生物及其作为肽基肽酶抑制剂的用途 |
US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
EP1699777B1 (de) | 2003-09-08 | 2012-12-12 | Takeda Pharmaceutical Company Limited | Dipeptidylpeptidase-hemmer |
CA2545258A1 (en) * | 2003-11-10 | 2005-05-26 | Synta Pharmaceuticals, Corp. | Pyridine compounds |
WO2005072826A2 (en) | 2004-01-21 | 2005-08-11 | Emory University | Compositions and use of tyrosine kinase inhibitors to treat pathogenic infection |
US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
WO2005095381A1 (en) | 2004-03-15 | 2005-10-13 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
EP1753730A1 (de) | 2004-06-04 | 2007-02-21 | Takeda Pharmaceutical Company Limited | Dipeptidylpeptidasehemmer |
FR2873118B1 (fr) | 2004-07-15 | 2007-11-23 | Sanofi Synthelabo | Derives de pyrido-pyrimidine, leur application en therapeutique |
WO2006019965A2 (en) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
WO2006038112A1 (en) * | 2004-10-01 | 2006-04-13 | Warner-Lambert Company Llc | Use of kinase inhibitors to promote neochondrogenesis |
WO2006068978A2 (en) | 2004-12-21 | 2006-06-29 | Takeda Pharmaceutial Company Limited | Dipeptidyl peptidase inhibitors |
FR2887882B1 (fr) | 2005-07-01 | 2007-09-07 | Sanofi Aventis Sa | Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique |
EP1942898B2 (de) | 2005-09-14 | 2014-05-14 | Takeda Pharmaceutical Company Limited | Dipeptidyl-peptidase-hemmer zur behandlung von diabetes |
CN102675221A (zh) | 2005-09-16 | 2012-09-19 | 武田药品工业株式会社 | 用于制备嘧啶二酮衍生物的方法中的中间体 |
FR2896246B1 (fr) | 2006-01-13 | 2008-08-15 | Sanofi Aventis Sa | Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique. |
WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
SI2073810T1 (sl) * | 2006-09-13 | 2011-12-30 | Takeda Pharmaceutical | Uporaba 2-6(3-amino-piperidin-1-il)-3-metil-2,4-diokso-3,4-dihidro-2H-pirimidin -1-ilmetil-4-fluoro-benzonitrila za zdravljenje diabetesa, raka, avtoimunskih motenj in infekcije s HIV |
WO2008055842A1 (en) * | 2006-11-09 | 2008-05-15 | F. Hoffmann-La Roche Ag | Substituted 6-phenyl-pyrido [2,3-d] pyrimidin-7-one derivatives as kinase inhibitors and methods for using the same |
TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
US8131527B1 (en) | 2006-12-22 | 2012-03-06 | Astex Therapeutics Ltd. | FGFR pharmacophore compounds |
WO2008078091A1 (en) | 2006-12-22 | 2008-07-03 | Astex Therapeutics Limited | Bicyclic heterocyclic compounds as fgfr inhibitors |
WO2008078100A2 (en) | 2006-12-22 | 2008-07-03 | Astex Therapeutics Limited | Tricyclic amine derivatives as protein tyrosine kinase inhibitors |
FR2910813B1 (fr) | 2006-12-28 | 2009-02-06 | Sanofi Aventis Sa | Nouvelle utilisation therapeutique pour le traitement des leucemies |
WO2008104473A2 (en) * | 2007-02-28 | 2008-09-04 | F. Hoffmann-La Roche Ag | Pyrazolopyriidine derivatives and their use as kinase inhibitors |
US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
JP2012518657A (ja) | 2009-02-25 | 2012-08-16 | オーエスアイ・ファーマシューティカルズ,エルエルシー | 併用抗癌治療 |
WO2010099363A1 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
JP2012519282A (ja) | 2009-02-27 | 2012-08-23 | オーエスアイ・ファーマシューティカルズ,エルエルシー | 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法 |
WO2010099138A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
CN101671336B (zh) | 2009-09-23 | 2013-11-13 | 辽宁利锋科技开发有限公司 | 芳杂环并嘧啶衍生物和类似物及其制备方法和用途 |
MX2012015023A (es) | 2010-06-30 | 2013-04-03 | Fujifilm Corp | Derivado novedoso de nicotinamida o sal del mismo. |
JP2014519813A (ja) | 2011-04-25 | 2014-08-21 | オーエスアイ・ファーマシューティカルズ,エルエルシー | 癌薬剤発見、診断、および治療におけるemt遺伝子シグネチャーの使用 |
WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
EP2872491B1 (de) * | 2012-07-11 | 2021-05-05 | Blueprint Medicines Corporation | Fibroblasten-wachstumsfaktor-hemmer |
EP3943087A1 (de) | 2013-03-15 | 2022-01-26 | Celgene CAR LLC | Heteroarylverbindungen und verwendungen davon |
AR095464A1 (es) | 2013-03-15 | 2015-10-21 | Celgene Avilomics Res Inc | Compuestos de heteroarilo y usos de los mismos |
CN105307657B (zh) * | 2013-03-15 | 2020-07-10 | 西建卡尔有限责任公司 | 杂芳基化合物和其用途 |
HRP20220840T1 (hr) | 2013-10-25 | 2022-10-14 | Blueprint Medicines Corporation | Inhibitori receptora faktora rasta fibroblasta |
WO2015108992A1 (en) | 2014-01-15 | 2015-07-23 | Blueprint Medicines Corporation | Heterobicyclic compounds and their use as fgfr4 receptor inhibitors |
US9828373B2 (en) | 2014-07-26 | 2017-11-28 | Sunshine Lake Pharma Co., Ltd. | 2-amino-pyrido[2,3-D]pyrimidin-7(8H)-one derivatives as CDK inhibitors and uses thereof |
US10449195B2 (en) | 2016-03-29 | 2019-10-22 | Shenzhen Pharmacin Co., Ltd. | Pharmaceutical formulation of palbociclib and a preparation method thereof |
WO2018005865A1 (en) | 2016-07-01 | 2018-01-04 | G1 Therapeutics, Inc. | Synthesis of n-(heteroaryl)-pyrrolo[3,2-d]pyrimidin-2-amines |
AU2018226315B2 (en) * | 2017-02-27 | 2021-01-28 | Betta Pharmaceuticals Co., Ltd. | FGFR inhibitor and application thereof |
SG11202101807SA (en) | 2018-08-24 | 2021-03-30 | G1 Therapeutics Inc | Improved synthesis of 1,4-diazaspiro[5.5]undecan-3-one |
US20210261544A1 (en) * | 2018-09-14 | 2021-08-26 | Abbisko Therapeutics Co., Ltd. | Fgfr inhibitor, preparation method therefor and application thereof |
WO2020140055A1 (en) * | 2018-12-28 | 2020-07-02 | Spv Therapeutics Inc. | Cyclin-dependent kinase inhibitors |
CN114306245A (zh) | 2020-09-29 | 2022-04-12 | 深圳市药欣生物科技有限公司 | 无定形固体分散体的药物组合物及其制备方法 |
EP4274546A1 (de) * | 2021-01-06 | 2023-11-15 | The Penn State Research Foundation | Verfahren und materialien zur behandlung von haarausfall |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5620981A (en) * | 1995-05-03 | 1997-04-15 | Warner-Lambert Company | Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation |
US5945422A (en) * | 1997-02-05 | 1999-08-31 | Warner-Lambert Company | N-oxides of amino containing pyrido 2,3-D! pyrimidines |
JP2005507392A (ja) * | 2000-08-04 | 2005-03-17 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 2−(4−ピリジル)アミノ−6−ジアルキルオキシフェニルピリド〔2,3−d〕ピリミジン−7−オン類の製造方法 |
WO2002012237A2 (en) * | 2000-08-04 | 2002-02-14 | Warner-Lambert Company | Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido[2,3-d]pyrimidin-7-ones |
-
2001
- 2001-07-20 AP APAP/P/2001/002230A patent/AP1333A/en active
- 2001-07-20 EP EP01954811A patent/EP1307450B1/de not_active Expired - Lifetime
- 2001-07-20 JP JP2002518213A patent/JP2004519422A/ja active Pending
- 2001-07-20 US US10/343,847 patent/US7022711B2/en not_active Expired - Fee Related
- 2001-07-20 AU AU2001277032A patent/AU2001277032A1/en not_active Abandoned
- 2001-07-20 MX MXPA02011263A patent/MXPA02011263A/es active IP Right Grant
- 2001-07-20 CA CA2417942A patent/CA2417942C/en not_active Expired - Fee Related
- 2001-07-20 ES ES01954811T patent/ES2311532T3/es not_active Expired - Lifetime
- 2001-07-20 AT AT01954811T patent/ATE408613T1/de not_active IP Right Cessation
- 2001-07-20 WO PCT/US2001/022881 patent/WO2002012238A2/en active Application Filing
- 2001-07-20 BR BR0112857-4A patent/BR0112857A/pt not_active IP Right Cessation
- 2001-07-20 DE DE60135854T patent/DE60135854D1/de not_active Expired - Lifetime
- 2001-07-27 SV SV2001000572A patent/SV2002000572A/es not_active Application Discontinuation
- 2001-08-01 TN TNTNSN01118A patent/TNSN01118A1/en unknown
- 2001-08-03 GT GT200100158A patent/GT200100158A/es unknown
- 2001-08-03 AR ARP010103716A patent/AR030310A1/es not_active Application Discontinuation
- 2001-08-03 UY UY26867A patent/UY26867A1/es not_active Application Discontinuation
- 2001-08-03 HN HN2001000171A patent/HN2001000171A/es unknown
- 2001-08-03 DO DO2001000227A patent/DOP2001000227A/es unknown
- 2001-08-03 PE PE2001000776A patent/PE20020305A1/es not_active Application Discontinuation
- 2001-08-03 PA PA20018524101A patent/PA8524101A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
DOP2001000227A (es) | 2002-12-15 |
BR0112857A (pt) | 2005-02-09 |
MXPA02011263A (es) | 2003-03-10 |
AR030310A1 (es) | 2003-08-20 |
SV2002000572A (es) | 2002-07-18 |
CA2417942A1 (en) | 2002-02-14 |
CA2417942C (en) | 2010-06-29 |
ES2311532T3 (es) | 2009-02-16 |
AP2001002230A0 (en) | 2001-09-30 |
EP1307450B1 (de) | 2008-09-17 |
GT200100158A (es) | 2002-07-18 |
PE20020305A1 (es) | 2002-05-09 |
EP1307450A2 (de) | 2003-05-07 |
AU2001277032A1 (en) | 2002-02-18 |
US7022711B2 (en) | 2006-04-04 |
PA8524101A1 (es) | 2002-10-24 |
WO2002012238A3 (en) | 2002-05-10 |
JP2004519422A (ja) | 2004-07-02 |
US20030220345A1 (en) | 2003-11-27 |
ATE408613T1 (de) | 2008-10-15 |
TNSN01118A1 (en) | 2005-11-10 |
UY26867A1 (es) | 2001-10-25 |
WO2002012238A2 (en) | 2002-02-14 |
AP1333A (en) | 2004-11-28 |
HN2001000171A (es) | 2001-09-21 |
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