BR112018077155A2 - processo para preparar um composto, e, composto - Google Patents

processo para preparar um composto, e, composto

Info

Publication number
BR112018077155A2
BR112018077155A2 BR112018077155-4A BR112018077155A BR112018077155A2 BR 112018077155 A2 BR112018077155 A2 BR 112018077155A2 BR 112018077155 A BR112018077155 A BR 112018077155A BR 112018077155 A2 BR112018077155 A2 BR 112018077155A2
Authority
BR
Brazil
Prior art keywords
compound
preparing
cancers
tumors
limited
Prior art date
Application number
BR112018077155-4A
Other languages
English (en)
Inventor
Smith Alexander
S. White Hannah
Xavier Tavares Francis
Krasutsky Sergiy
Chen Jian-Xie
L. Dorrow Roberta
Zhong Hua
Original Assignee
G1 Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by G1 Therapeutics, Inc. filed Critical G1 Therapeutics, Inc.
Publication of BR112018077155A2 publication Critical patent/BR112018077155A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

essa invenção está na área de sintetizar compostos à base de pirimidina úteis no tratamento de distúrbios envolvendo proliferação celular anormal, incluindo, mas não limitado a, tumores e cânceres.
BR112018077155-4A 2016-07-01 2017-06-29 processo para preparar um composto, e, composto BR112018077155A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662357797P 2016-07-01 2016-07-01
US62/357,797 2016-07-01
PCT/US2017/040102 WO2018005865A1 (en) 2016-07-01 2017-06-29 Synthesis of n-(heteroaryl)-pyrrolo[3,2-d]pyrimidin-2-amines

Publications (1)

Publication Number Publication Date
BR112018077155A2 true BR112018077155A2 (pt) 2019-04-02

Family

ID=60786476

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018077155-4A BR112018077155A2 (pt) 2016-07-01 2017-06-29 processo para preparar um composto, e, composto

Country Status (13)

Country Link
US (2) US10865210B2 (pt)
EP (1) EP3478295A4 (pt)
JP (1) JP7106462B2 (pt)
KR (1) KR102445288B1 (pt)
CN (1) CN109789142B (pt)
AU (2) AU2017290362B2 (pt)
BR (1) BR112018077155A2 (pt)
CA (1) CA3028752A1 (pt)
EA (1) EA201990189A1 (pt)
IL (1) IL263911B (pt)
MX (1) MX2019000199A (pt)
NZ (1) NZ749275A (pt)
WO (1) WO2018005865A1 (pt)

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JP2020527593A (ja) 2017-07-18 2020-09-10 ニューベイション・バイオ・インコーポレイテッドＮｕｖａｔｉｏｎ Ｂｉｏ Ｉｎｃ． １，８−ナフチリジノン化合物およびその使用
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WO2019161224A1 (en) 2018-02-15 2019-08-22 GiraFpharma LLC Heterocyclic compounds as kinase inhibitors
CN108299317A (zh) * 2018-03-20 2018-07-20 爱斯特（成都）生物制药股份有限公司 1,4-二氮杂螺[5,5]十一烷盐酸盐的合成方法
WO2019199883A1 (en) * 2018-04-09 2019-10-17 G1 Therapeutics, Inc. Treatment of cancers having driving oncogenic mutations
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SG11202101807SA (en) * 2018-08-24 2021-03-30 G1 Therapeutics Inc Improved synthesis of 1,4-diazaspiro[5.5]undecan-3-one
WO2020150674A1 (en) 2019-01-18 2020-07-23 Nuvation Bio Inc. Heterocyclic compounds as adenosine antagonists
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MX2022014573A (es) 2020-05-19 2022-12-15 G1 Therapeutics Inc Compuestos inhibidores de cinasa dependiente de ciclina para el tratamiento de trastornos medicos.
US10988479B1 (en) 2020-06-15 2021-04-27 G1 Therapeutics, Inc. Morphic forms of trilaciclib and methods of manufacture thereof
EP4164653A1 (en) * 2020-06-15 2023-04-19 G1 Therapeutics, Inc. Morphic forms of trilaciclib and methods of manufacture thereof
US20230374028A1 (en) 2020-10-08 2023-11-23 Teva Pharmaceuticals International Gmbh Solid state forms of trilaciclib and of trilaciclib salts
CN113788837B (zh) * 2021-08-02 2022-08-26 深圳湾实验室坪山生物医药研发转化中心 Trilaciclib的合成方法
CN113754600A (zh) * 2021-11-10 2021-12-07 天津敬康生物科技有限公司 1,4-二氮杂螺[5,5]十一烷-3-酮的制备方法
CN114014863B (zh) * 2021-12-21 2022-11-29 武汉九州钰民医药科技有限公司 骨髓保护剂曲拉西利的制备方法
CN114014864B (zh) * 2021-12-21 2022-11-25 武汉九州钰民医药科技有限公司 一种曲拉西利化合物的制备工艺
WO2023164255A1 (en) * 2022-02-28 2023-08-31 Teva Pharmaceuticals International Gmbh Crystalline forms of trilaciclib and trilaciclib salts
US11970403B2 (en) * 2022-06-27 2024-04-30 Saudi Arabian Oil Company Method of zeolite synthesis including pH-modified water-soluble oxidized disulfide oil composition
US11958751B2 (en) * 2022-06-27 2024-04-16 Saudi Arabian Oil Company Method of synthesizing materials integrating supernatant recycle
CN115477653B (zh) * 2022-10-11 2024-04-09 安徽省庆云医药股份有限公司 一种曲拉西利关键中间体及曲拉西利的制备方法

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Also Published As

Publication number Publication date
AU2017290362B2 (en) 2021-08-05
JP2019520380A (ja) 2019-07-18
RU2019102643A (ru) 2020-08-03
IL263911B (en) 2021-10-31
CA3028752A1 (en) 2018-01-04
CN109789142B (zh) 2022-08-23
EP3478295A4 (en) 2019-12-04
CN109789142A (zh) 2019-05-21
US20210122755A1 (en) 2021-04-29
KR20190025651A (ko) 2019-03-11
AU2021261879A1 (en) 2021-12-02
MX2019000199A (es) 2019-09-23
EP3478295A1 (en) 2019-05-08
AU2017290362A1 (en) 2019-01-17
IL263911A (en) 2019-01-31
AU2021261879B2 (en) 2024-01-04
NZ749275A (en) 2023-06-30
US11629150B2 (en) 2023-04-18
US20190135820A1 (en) 2019-05-09
KR102445288B1 (ko) 2022-09-19
US10865210B2 (en) 2020-12-15
RU2019102643A3 (pt) 2020-08-21
EA201990189A1 (ru) 2019-06-28
WO2018005865A1 (en) 2018-01-04
JP7106462B2 (ja) 2022-07-26

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Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI N? 10196/2001, QUE MODIFICOU A LEI N? 9279/96, A CONCESS?O DA PATENTE EST? CONDICIONADA ? ANU?NCIA PR?VIA DA ANVISA. CONSIDERANDO A APROVA??O DOS TERMOS DO PARECER N? 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL N? 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVID?NCIAS CAB?VEIS.

B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021

B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]