MX2022014573A - Compuestos inhibidores de cinasa dependiente de ciclina para el tratamiento de trastornos medicos. - Google Patents
Compuestos inhibidores de cinasa dependiente de ciclina para el tratamiento de trastornos medicos.Info
- Publication number
- MX2022014573A MX2022014573A MX2022014573A MX2022014573A MX2022014573A MX 2022014573 A MX2022014573 A MX 2022014573A MX 2022014573 A MX2022014573 A MX 2022014573A MX 2022014573 A MX2022014573 A MX 2022014573A MX 2022014573 A MX2022014573 A MX 2022014573A
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- inhibiting compounds
- cyclin
- dependent kinase
- medical disorders
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 102000003903 Cyclin-dependent kinases Human genes 0.000 title 1
- 108090000266 Cyclin-dependent kinases Proteins 0.000 title 1
- 102000015792 Cyclin-Dependent Kinase 2 Human genes 0.000 abstract 1
- 108010024986 Cyclin-Dependent Kinase 2 Proteins 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 230000022131 cell cycle Effects 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000013160 medical therapy Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención se encuentra en el área de los compuestos inhibidores del ciclo celular para el tratamiento de trastornos que implican la proliferación celular anormal, e incluye inhibidores selectivos de CDK2 para la terapia médica y sus sales y composiciones farmacéuticamente aceptables.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063027113P | 2020-05-19 | 2020-05-19 | |
| US202063085672P | 2020-09-30 | 2020-09-30 | |
| PCT/US2021/032976 WO2021236650A1 (en) | 2020-05-19 | 2021-05-18 | Cyclin-dependent kinase inhibiting compounds for the treatment of medical disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022014573A true MX2022014573A (es) | 2022-12-15 |
Family
ID=78707529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022014573A MX2022014573A (es) | 2020-05-19 | 2021-05-18 | Compuestos inhibidores de cinasa dependiente de ciclina para el tratamiento de trastornos medicos. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11643416B2 (es) |
| EP (1) | EP4153597A4 (es) |
| JP (1) | JP2023528257A (es) |
| KR (1) | KR20230012547A (es) |
| CN (1) | CN115698014A (es) |
| AU (1) | AU2021273744A1 (es) |
| CA (1) | CA3173678A1 (es) |
| IL (1) | IL298294A (es) |
| MX (1) | MX2022014573A (es) |
| TW (1) | TW202208372A (es) |
| WO (1) | WO2021236650A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL298294A (en) * | 2020-05-19 | 2023-01-01 | G1 Therapeutics Inc | Cyclin-dependent kinase inhibitory compounds for the treatment of medical disorders |
| TW202341982A (zh) * | 2021-12-24 | 2023-11-01 | 大陸商上海齊魯銳格醫藥研發有限公司 | Ｃｄｋ２抑制劑及其用途 |
| WO2023249974A2 (en) * | 2022-06-20 | 2023-12-28 | Incyclix Bio, Inc. | Cyclin-dependent kinase 2 inhibitors for medical treatment |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5359073A (en) * | 1992-11-24 | 1994-10-25 | G. D. Searle & Co. | Substituted-phenyl (N,N'-cycloalkyl/alkyl carboxamide)-1H/3H-imidazo[4,5-b]pyridine compounds as PAF antagonists |
| WO2001068648A1 (en) | 2000-03-15 | 2001-09-20 | Aventis Pharma Deutschland Gmbh | Substituted beta-carbolines with ikb-kinase inhibiting activity |
| PL220952B1 (pl) | 2002-01-22 | 2016-01-29 | Warner Lambert Co | 2-(Pirydyn-2-yloamino)pirydo[2,3-d]pirymidyn-7-ony |
| EP1590341B1 (en) | 2003-01-17 | 2009-06-17 | Warner-Lambert Company LLC | 2-aminopyridine substituted heterocycles as inhibitors of cellular proliferation |
| US7946916B2 (en) | 2006-01-12 | 2011-05-24 | Waterleaf Ltd. | Variable payout wager games |
| BRPI0909957A2 (pt) | 2008-06-11 | 2016-04-19 | Genentech Inc | "composto, composição farmacêutica, método de inibir o crescimento anormal de células ou de tratar um distúrbio hiperproliferativo em um mamífero, método de tratamento do câncer em um mamífero" |
| US8685980B2 (en) | 2008-08-22 | 2014-04-01 | Novartis Ag | Pyrrolopyrimidine compounds and their uses |
| UY33227A (es) | 2010-02-19 | 2011-09-30 | Novartis Ag | Compuestos de pirrolopirimidina como inhibidores de la cdk4/6 |
| RU2621674C2 (ru) | 2010-10-25 | 2017-06-07 | Г1 Терапьютикс Инк., | Ингибиторы cdk |
| US8691830B2 (en) | 2010-10-25 | 2014-04-08 | G1 Therapeutics, Inc. | CDK inhibitors |
| US9840515B2 (en) | 2010-12-09 | 2017-12-12 | University of Pittsburgh—of the Commonwealth System of Higher Education | Protein kinase D inhibitors |
| EP2813506B1 (en) | 2010-12-16 | 2016-05-25 | F. Hoffmann-La Roche AG | Tricyclic PI3K inhibitor compounds and methods of use |
| EP3461825B1 (en) | 2011-09-30 | 2023-06-07 | C&C Research Laboratories | Novel heterocyclic derivatives and their uses |
| CA2868966C (en) | 2012-03-29 | 2021-01-26 | Francis Xavier Tavares | Lactam kinase inhibitors |
| US20140274896A1 (en) | 2013-03-15 | 2014-09-18 | G1 Therapeutics, Inc. | Transient Protection of Hematopoietic Stem and Progenitor Cells Against Ionizing Radiation |
| CN105407723A (zh) | 2013-03-15 | 2016-03-16 | G1治疗公司 | 高效的抗赘生剂和抗增生剂 |
| US9527857B2 (en) | 2013-03-15 | 2016-12-27 | GI Therapeutics, Inc. | HSPC-sparing treatments for RB-positive abnormal cellular proliferation |
| WO2015161287A1 (en) | 2014-04-17 | 2015-10-22 | G1 Therapeutics, Inc. | Tricyclic lactams for use in the protection of normal cells during chemotherapy |
| CA2950330C (en) | 2014-05-28 | 2019-04-30 | Shanghai Fochon Pharmaceutical Co Ltd | Certain protein kinase inhibitors |
| EP3191098A4 (en) | 2014-09-12 | 2018-04-25 | G1 Therapeutics, Inc. | Combinations and dosing regimes to treat rb-positive tumors |
| WO2016040848A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors |
| TW201803871A (zh) | 2016-06-24 | 2018-02-01 | 英塞特公司 | 作為ＰＩ３Ｋ-γ抑制劑之雜環化合物 |
| WO2018005863A1 (en) | 2016-07-01 | 2018-01-04 | G1 Therapeutics, Inc. | Pyrimidine-based compounds for the treatment of cancer |
| EA201990187A1 (ru) * | 2016-07-01 | 2019-07-31 | Г1 Терапьютикс, Инк. | Антипролиферационные средства на основе пиримидина |
| KR102445288B1 (ko) | 2016-07-01 | 2022-09-19 | 쥐원 쎄라퓨틱스, 인크. | N-(헤테로아릴)-피롤로[3,2-d]피리미딘-2-아민의 합성 |
| WO2018005533A1 (en) | 2016-07-01 | 2018-01-04 | G1 Therapeutics, Inc. | Antiproliferative pyrimidine-based compounds |
| IL303038B1 (en) | 2016-12-05 | 2024-04-01 | G1 Therapeutics Inc | Preservation of immune response during chemotherapy regimens |
| AU2017370694A1 (en) | 2016-12-08 | 2019-07-25 | Icahn School Of Medicine At Mount Sinai | Compositions and methods for treating CDK4/6-mediated cancer |
| BR112019013814A2 (pt) | 2017-01-06 | 2020-01-21 | G1 Therapeutics Inc | método para tratamento de câncer ou de um tumor em um indivíduo, composição farmacêutica, combinação, e, kit. |
| US11395821B2 (en) | 2017-01-30 | 2022-07-26 | G1 Therapeutics, Inc. | Treatment of EGFR-driven cancer with fewer side effects |
| AU2018217809A1 (en) | 2017-02-10 | 2019-08-22 | G1 Therapeutics, Inc. | Benzothiophene estrogen receptor modulators |
| AU2018291026B2 (en) | 2017-06-29 | 2022-09-01 | G1 Therapeutics, Inc. | Morphic forms of GIT38 and methods of manufacture thereof |
| CN111867592A (zh) * | 2018-01-04 | 2020-10-30 | G1治疗公司 | 用于治疗异常细胞增殖的杂环化合物 |
| EP3738084A4 (en) | 2018-01-08 | 2021-11-17 | G1 Therapeutics, Inc. | G1T38 SUPERIOR DOSAGE RATES |
| CN112218634A (zh) | 2018-04-09 | 2021-01-12 | G1治疗公司 | 具有驱动致癌突变的癌症的治疗 |
| WO2019222521A1 (en) * | 2018-05-16 | 2019-11-21 | G1 Therapeutics, Inc. | Cdk inhibitors for the treatment of neoplastic disorders |
| AU2019321677A1 (en) | 2018-08-16 | 2021-03-11 | G1 Therapeutics, Inc. | Benzothiophene estrogen receptor modulators to treat medical disorders |
| KR20210049847A (ko) | 2018-08-24 | 2021-05-06 | 쥐원 쎄라퓨틱스, 인크. | 1,4-디아자스피로[5.5]운데칸-3-온의 개선된 합성 |
| EP3877422A4 (en) | 2018-11-09 | 2022-08-24 | G1 Therapeutics, Inc. | THERAPEUTIC DOSING SCHEDULES FOR THE TREATMENT OF CANCER WITH ERIBULIN AND SELECTIVE CDK4/6 INHIBITOR COMBINATIONS |
| CN111377924A (zh) | 2018-12-29 | 2020-07-07 | 武汉光谷通用名药物研究院有限公司 | 新型cdk4抑制剂及其用途 |
| CN111377935B (zh) | 2018-12-29 | 2021-06-29 | 武汉光谷通用名药物研究院有限公司 | 选择性cdk4/6抑制剂及其应用 |
| EP3986410A4 (en) | 2019-06-18 | 2023-06-28 | G1 Therapeutics, Inc. | Patient selection for enhancement of anti-tumor immunity in cancer patients |
| TW202128173A (zh) | 2019-10-09 | 2021-08-01 | 美商G1治療公司 | 失調之纖維母細胞生長因子受體訊息傳遞的癌症之標靶性治療 |
| IL298294A (en) * | 2020-05-19 | 2023-01-01 | G1 Therapeutics Inc | Cyclin-dependent kinase inhibitory compounds for the treatment of medical disorders |
| US10988479B1 (en) | 2020-06-15 | 2021-04-27 | G1 Therapeutics, Inc. | Morphic forms of trilaciclib and methods of manufacture thereof |
| EP4284371A1 (en) | 2021-01-29 | 2023-12-06 | Virokyne Therapeutics, Llc | Selective cyclin-dependent kinase inhibitors and methods of therapeutic use thereof |
-
2021
- 2021-05-18 IL IL298294A patent/IL298294A/en unknown
- 2021-05-18 CN CN202180036868.5A patent/CN115698014A/zh active Pending
- 2021-05-18 MX MX2022014573A patent/MX2022014573A/es unknown
- 2021-05-18 EP EP21807941.6A patent/EP4153597A4/en active Pending
- 2021-05-18 JP JP2022570281A patent/JP2023528257A/ja active Pending
- 2021-05-18 AU AU2021273744A patent/AU2021273744A1/en active Pending
- 2021-05-18 CA CA3173678A patent/CA3173678A1/en active Pending
- 2021-05-18 WO PCT/US2021/032976 patent/WO2021236650A1/en active Application Filing
- 2021-05-18 KR KR1020227043846A patent/KR20230012547A/ko active Search and Examination
- 2021-05-19 TW TW110118102A patent/TW202208372A/zh unknown
-
2022
- 2022-05-11 US US17/742,315 patent/US11643416B2/en active Active
-
2023
- 2023-04-20 US US18/137,286 patent/US20240150369A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20220306644A1 (en) | 2022-09-29 |
| TW202208372A (zh) | 2022-03-01 |
| AU2021273744A1 (en) | 2022-12-08 |
| US11643416B2 (en) | 2023-05-09 |
| JP2023528257A (ja) | 2023-07-04 |
| KR20230012547A (ko) | 2023-01-26 |
| CA3173678A1 (en) | 2021-11-25 |
| EP4153597A1 (en) | 2023-03-29 |
| CN115698014A (zh) | 2023-02-03 |
| US20240150369A1 (en) | 2024-05-09 |
| EP4153597A4 (en) | 2024-05-15 |
| IL298294A (en) | 2023-01-01 |
| WO2021236650A1 (en) | 2021-11-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2022014573A (es) | Compuestos inhibidores de cinasa dependiente de ciclina para el tratamiento de trastornos medicos. | |
| MX2020008559A (es) | Compuestos heterocíclicos como inhibidores de la quinasa. | |
| PH12020551717A1 (en) | Dual atm and dna-pk inhibitors for use in anti-tumor therapy | |
| CR20220584A (es) | Inhibidores de kras tricíclicos fusionados | |
| TN2019000110A1 (en) | Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors | |
| MX2021008342A (es) | Derivados de pirazol como inhibidores de calicreina plasmatica. | |
| MX2021004639A (es) | Combinaciones de inhibidores de desmetilasa-1 especifica de lisina (lsd1) para uso en el tratamiento de tumores solidos. | |
| EA201790122A1 (ru) | Производные 2-h-индазола в качестве ингибиторов циклинзависимых киназ (cdk) и их терапевтическое применение | |
| MX2023007192A (es) | Inhibidores de prmt5. | |
| MD20140086A2 (ro) | Derivaţi macrociclici pentru tratamentul bolilor proliferative | |
| EA202090052A1 (ru) | Содержащие имидазол ингибиторы alk2 киназы | |
| MX2021010321A (es) | Compuestos macrociclicos. | |
| MX2020010942A (es) | Inhibidores dobles de atm y adn-pk para uso en terapias antitumorales. | |
| MX2023009222A (es) | Inhibidores tricíclicos-amido-bicíclicos de prmt5. | |
| MX2023008968A (es) | Inhibidores de cdk2 y metodos de uso de los mismos. | |
| MX2024000357A (es) | Compuestos triciclicos como inhibidores de homologo de oncogen viral de sarcoma de rata kirsten (kras). | |
| MX2021012418A (es) | Compuestos heterociclicos y sus usos. | |
| MX2023009682A (es) | Inhibidores de tyk2 y sus usos. | |
| MX2021008667A (es) | Derivado de pirrolopirimidina y composición farmacéutica para prevenir o tratar enfermedades relacionadas con la proteína quinasa que comprende el mismo como principio activo. | |
| NZ772236A (en) | Pharmaceutical combination for use in age-related and/or degenerative diseases | |
| MX2018004868A (es) | Derivados de la pirrolidina. | |
| ZA202201499B (en) | Dual atm and dna-pk inhibitors for use in anti-tumor therapy | |
| MX2022006179A (es) | Derivados macrociclicos de indol como inhibidores de mcl-1. | |
| CR20210661A (es) | Inhibidores de jak cinasas basados en pirazolopirimidina sulfona y usos de los mismos | |
| MX2022010299A (es) | Derivados macrocíclicos de indol como inhibidores de mcl-1. |