MX2020008559A - Compuestos heterocíclicos como inhibidores de la quinasa. - Google Patents

Compuestos heterocíclicos como inhibidores de la quinasa.

Info

Publication number
MX2020008559A
MX2020008559A MX2020008559A MX2020008559A MX2020008559A MX 2020008559 A MX2020008559 A MX 2020008559A MX 2020008559 A MX2020008559 A MX 2020008559A MX 2020008559 A MX2020008559 A MX 2020008559A MX 2020008559 A MX2020008559 A MX 2020008559A
Authority
MX
Mexico
Prior art keywords
heterocyclic compounds
kinase inhibitors
compounds
find
cdk6
Prior art date
Application number
MX2020008559A
Other languages
English (en)
Inventor
Sarvajit Chakravarty
Son Minh Pham
Jiyun Chen
Anil Kumar Agarwal
Brahmam Pujala
Bhawana Bhatt
Jayakanth Kankanala
Amit Shete
Sanjeev Soni
Original Assignee
Nuvation Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nuvation Bio Inc filed Critical Nuvation Bio Inc
Publication of MX2020008559A publication Critical patent/MX2020008559A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Se proporcionan compuestos heterocíclicos como inhibidores de CDK4 o CDK6 u otros inhibidores de CDK; los compuestos pueden usarse como agentes terapéuticos para el tratamiento de enfermedades y pueden usarse particularmente en oncología.
MX2020008559A 2018-02-15 2019-02-15 Compuestos heterocíclicos como inhibidores de la quinasa. MX2020008559A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862631437P 2018-02-15 2018-02-15
PCT/US2019/018244 WO2019161224A1 (en) 2018-02-15 2019-02-15 Heterocyclic compounds as kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2020008559A true MX2020008559A (es) 2021-01-08

Family

ID=67542098

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020008559A MX2020008559A (es) 2018-02-15 2019-02-15 Compuestos heterocíclicos como inhibidores de la quinasa.

Country Status (13)

Country Link
US (2) US11174252B2 (es)
EP (1) EP3752491A4 (es)
JP (1) JP2021514359A (es)
KR (1) KR20200131246A (es)
CN (1) CN112334451A (es)
AU (1) AU2019220746A1 (es)
BR (1) BR112020015431A2 (es)
CA (1) CA3089592A1 (es)
IL (1) IL276509A (es)
MA (1) MA51846A (es)
MX (1) MX2020008559A (es)
SG (1) SG11202007754UA (es)
WO (1) WO2019161224A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018388404B2 (en) 2017-12-22 2023-11-02 HiberCell Inc. Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors
JP7301958B2 (ja) 2018-05-25 2023-07-03 オンコキューブ セラピューティクス エルエルシー 新規な抗がん薬候補としての非常に強力なｔａｃｃ３阻害剤
KR20220047329A (ko) * 2019-08-14 2022-04-15 누베이션 바이오 인크. 키나제 억제제로서의 헤테로시클릭 화합물
US20220281859A1 (en) * 2019-08-14 2022-09-08 Nuvation Bio Inc. Heterocyclic compounds as kinase inhibitors
CN113244386A (zh) * 2020-02-13 2021-08-13 上海君实生物医药科技股份有限公司 抗pd-1抗体在治疗肿瘤中的用途
CN116249701A (zh) * 2020-10-12 2023-06-09 上海海雁医药科技有限公司 取代的二（吡啶-2-基）胺衍生物、其组合物及医药上的用途
WO2022113003A1 (en) 2020-11-27 2022-06-02 Rhizen Pharmaceuticals Ag Cdk inhibitors
WO2022149057A1 (en) 2021-01-05 2022-07-14 Rhizen Pharmaceuticals Ag Cdk inhibitors
WO2022169897A1 (en) * 2021-02-03 2022-08-11 Nuvation Bio Inc. Crystalline forms of a cyclin-dependent kinase inhibitor
EP4323351A1 (en) * 2021-04-12 2024-02-21 A2A Pharmaceuticals, Inc. Compositions and methods for treating cancer
WO2022236255A2 (en) * 2021-05-03 2022-11-10 Nuvation Bio Inc. Heterocyclic compounds as kinase inhibitors
WO2022236253A1 (en) * 2021-05-03 2022-11-10 Nuvation Bio Inc. Heterocyclic compounds as kinase inhibitors
WO2022236257A1 (en) * 2021-05-03 2022-11-10 Nuvation Bio Inc. Heterocyclic compounds as kinase inhibitors
WO2022236256A1 (en) * 2021-05-03 2022-11-10 Nuvation Bio Inc. Heterocyclic compounds as kinase inhibitors
CN113264920B (zh) * 2021-05-10 2022-09-02 中国药科大学 一种嘧啶苯并六元环母核的cdk6抑制剂及其制备方法和应用
WO2022261643A1 (en) * 2021-06-09 2022-12-15 Nuvation Bio Inc. Treating cancers with a cyclin-dependent kinase inhibitor
WO2023205892A1 (en) * 2022-04-27 2023-11-02 Risen (Suzhou) Pharma Tech Co., Ltd. Cdk inhibitors and pharmaceutical uses thereof
WO2023208172A1 (en) * 2022-04-29 2023-11-02 Beigene , Ltd. Substituted 7- (pyrimidin-4-yl) quinolin-4 (1h) -one compounds as cyclin dependent kinase inhibitors
WO2024022487A1 (en) * 2022-07-29 2024-02-01 Allorion Therapeutics Inc Aminoheteroaryl kinase inhibitors
WO2024051702A1 (zh) * 2022-09-05 2024-03-14 浙江同源康医药股份有限公司 用作cdk4激酶抑制剂的化合物及其应用

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK12472002A3 (sk) 2000-03-06 2003-04-01 Warner-Lambert Company 5-Alkylpyrido[2,3-d]pyrimidínové inhibítory tyrosínových kináz
EP1373257B9 (en) * 2001-03-29 2008-10-15 Vertex Pharmaceuticals Incorporated Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases
WO2004041814A1 (en) 2002-11-04 2004-05-21 Vertex Pharmaceuticals Incorporated Heteroaryl-pyramidine derivatives as jak inhibitors
MX2007001126A (es) 2004-07-27 2007-09-25 Sgx Pharmaceuticals Inc Moduladores de heterociclo cinasa de anillo fusionado.
US20060142312A1 (en) 2004-12-23 2006-06-29 Pfizer Inc C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones
DE602006016303D1 (de) 2005-08-25 2010-09-30 Pharmacopeia Llc 3,4-dihydro-2H-benzoÄ1,4Üoxazin- und 3,4-dihydro-2H-benzoÄ1,4Üthiazin-VERBINDUNGEN ALS ALPHA2C-ADRENOREZEPTOR-ANTAGONISTEN
CA2727174A1 (en) 2008-06-20 2010-01-21 Jiangao Song Aryl gpr119 agonists and uses thereof
DK2331547T3 (da) 2008-08-22 2014-11-03 Novartis Ag Pyrrolopyrimidinforbindelser som CDK-inhibitorer
US8674095B2 (en) 2008-12-19 2014-03-18 Afraxis Holdings, Inc. Compounds for treating neuropsychiatric conditions
JO2885B1 (en) 2008-12-22 2015-03-15 ايلي ليلي اند كومباني Protein kinase inhibitors
US9908884B2 (en) 2009-05-05 2018-03-06 Dana-Farber Cancer Institute, Inc. EGFR inhibitors and methods of treating disorders
UY33226A (es) 2010-02-19 2011-09-30 Novartis Ag Compuestos de pirrolopirimidina deuterada como inhibidores de la cdk4/6
UY33227A (es) * 2010-02-19 2011-09-30 Novartis Ag Compuestos de pirrolopirimidina como inhibidores de la cdk4/6
US20130231348A1 (en) 2010-06-09 2013-09-05 Afraxis, Inc. 8-(HETEROARYLMETHYL)PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS
WO2011156775A2 (en) 2010-06-10 2011-12-15 Afraxis, Inc. 8-(2'-heterocycyl)pyrido[2.3-d]pyrimidin-7(8h)-ones for the treatment of cns disorders
EP2580216A4 (en) 2010-06-10 2014-07-23 Afraxis Holdings Inc 8- (SULFONYLBENZYL) PYRIDO- [2,3-D-] PYRIMIDIN-7- (8H) -ONE FOR THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM
MY165584A (en) 2010-07-29 2018-04-05 Rigel Pharmaceuticals Inc Ampk-activating heterocyclic compounds and methods for using the same
ES2525866T3 (es) 2010-08-05 2014-12-30 Temple University - Of The Commonwealth System Of Higher Education 8-alquil-7-oxo-7,8-dihidropirido [2,3-d]pirimidina-6-carbonitrilos sustituidos en 2 y usos de los mismos
US8691830B2 (en) 2010-10-25 2014-04-08 G1 Therapeutics, Inc. CDK inhibitors
WO2013175415A1 (en) 2012-05-23 2013-11-28 Piramal Enterprises Limited Substituted pyrimidine compounds and uses thereof
AR091876A1 (es) 2012-07-26 2015-03-04 Novartis Ag Combinaciones farmaceuticas para el tratamiento de enfermedades proliferativas
RS59790B1 (sr) 2013-03-15 2020-02-28 G1 Therapeutics Inc Privremena zaštita normalnih ćelija tokom hemoterapije
US20140274896A1 (en) 2013-03-15 2014-09-18 G1 Therapeutics, Inc. Transient Protection of Hematopoietic Stem and Progenitor Cells Against Ionizing Radiation
US20150087673A1 (en) 2013-09-26 2015-03-26 Rigel Pharmaceuticals, Inc. Methods for using and biomarkers for ampk-activating compounds
US10016439B2 (en) 2014-01-31 2018-07-10 Ono Pharmaceutical Co., Ltd. Fused imidazole compounds
CA2950330C (en) 2014-05-28 2019-04-30 Shanghai Fochon Pharmaceutical Co Ltd Certain protein kinase inhibitors
WO2016015598A1 (en) 2014-07-26 2016-02-04 Sunshine Lake Pharma Co., Ltd. 2-amino-pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as cdk inhibitors and uses thereof
WO2016015605A1 (en) 2014-07-26 2016-02-04 Sunshine Lake Pharma Co., Ltd. Compounds as cdk small-molecule inhibitors and uses thereof
EP3191098A4 (en) * 2014-09-12 2018-04-25 G1 Therapeutics, Inc. Combinations and dosing regimes to treat rb-positive tumors
WO2016040848A1 (en) 2014-09-12 2016-03-17 G1 Therapeutics, Inc. Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors
JP6726677B2 (ja) 2015-03-11 2020-07-22 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッドChia Tai Tianqing Pharmaceutical Group Co., Ltd. 抗がん剤としての置換２−ｈ−ピラゾール誘導体
CN106608879A (zh) 2015-10-27 2017-05-03 甘李药业股份有限公司 一种蛋白激酶抑制剂及其制备方法和医药用途
CN106810536A (zh) 2015-11-30 2017-06-09 甘李药业股份有限公司 一种蛋白激酶抑制剂及其制备方法和医药用途
WO2017101763A1 (en) 2015-12-13 2017-06-22 Hangzhou Innogate Pharma Co., Ltd. Heterocycles useful as anti-cancer agents
WO2017114351A1 (en) 2015-12-27 2017-07-06 Chongqing Fochon Pharmaceutical Co., Ltd. Certain protein kinase inhibitors
TWI736578B (zh) 2016-02-06 2021-08-21 大陸商上海複尚慧創醫藥研究有限公司 6-5元稠合唑環衍生物及其藥物組合物，以及作為藥物的應用
CN107286180B (zh) 2016-04-11 2019-07-02 上海勋和医药科技有限公司 杂代吡啶并嘧啶酮衍生物作为cdk抑制剂及其应用
CN107286134B (zh) 2016-04-11 2019-04-12 上海勋和医药科技有限公司 2，4-二取代嘧啶衍生物作为cdk抑制剂及其应用
SI3442947T1 (sl) 2016-04-15 2023-10-30 Epizyme, Inc. Z aminom substituirane arilne ali heteroarilne spojine kot inhibitorji ehmt1 in ehmt2
CA3018434A1 (en) 2016-04-22 2017-10-26 Dana-Farber Cancer Institute, Inc. Degradation of cyclin-dependent kinase 4/6 (cdk4/6) by conjugation of cdk4/6 inhibitors with e3 ligase ligand and methods of use
US10835535B2 (en) 2016-05-07 2020-11-17 Shanghai Fochon Pharmaceutical Co., Ltd. Certain protein kinase inhibitors
WO2018005863A1 (en) 2016-07-01 2018-01-04 G1 Therapeutics, Inc. Pyrimidine-based compounds for the treatment of cancer
EP3478294A4 (en) 2016-07-01 2020-06-10 G1 Therapeutics, Inc. PYRIMIDINE-BASED ANTIPROLIFERATIVE ACTIVE SUBSTANCES
WO2018005533A1 (en) 2016-07-01 2018-01-04 G1 Therapeutics, Inc. Antiproliferative pyrimidine-based compounds
NZ749275A (en) 2016-07-01 2023-06-30 G1 Therapeutics Inc Synthesis of n-(heteroaryl)-pyrrolo[2,3-d]pyrimidin-2-amines
WO2018086591A1 (zh) 2016-11-11 2018-05-17 上海海雁医药科技有限公司 吡啶胺取代的杂三环化合物、其制法与医药上的用途
TWI732083B (zh) 2016-12-22 2021-07-01 大陸商貝達藥業股份有限公司 苯并咪唑衍生物、其藥物組合物及其應用
CN107382974B (zh) 2017-06-08 2020-06-05 扬州市三药制药有限公司 一种嘧啶胺类化合物作为周期蛋白依赖性激酶4/6抑制剂的应用
JP7337395B2 (ja) 2018-01-29 2023-09-04 ベータ ファーマ，インコーポレイテッド Ｃｄｋ４およびｃｄｋ６阻害剤としての２ｈ－インダゾール誘導体およびその治療上の使用
WO2019165204A1 (en) 2018-02-23 2019-08-29 Newave Pharmaceutical Inc. 1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidine-3-one compounds as inhibitors of wee-1 kinase
WO2020006210A1 (en) 2018-06-27 2020-01-02 Tufts Medical Center, Inc. Pyridopyrimidine compounds and methods of their use
WO2020023480A1 (en) 2018-07-23 2020-01-30 Dana-Farber Cancer Institute, Inc. Degradation of cyclin-dependent kinase 4/6 (cdk4/6) by conjugation of cdk4/6 inhibitors with e3 ligase ligand and methods of use
AU2019310595B2 (en) 2018-07-27 2022-11-24 1200 Pharma Llc CDK inhibitors and uses thereof
CN110835334B (zh) 2018-08-16 2022-10-18 中国药科大学 吲哚取代唑类化合物及其用途
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
US20220041577A1 (en) 2018-11-30 2022-02-10 Hangzhou Innogate Pharma Co., Ltd. Heterocyclic Compound as CDK-HDAC Double-Channel Inhibitor
CN113166110B (zh) 2018-12-12 2023-08-11 暨南大学 2-氨基嘧啶类化合物及其应用

Also Published As

Publication number Publication date
US11174252B2 (en) 2021-11-16
BR112020015431A2 (pt) 2020-12-08
US20230062022A1 (en) 2023-03-02
CA3089592A1 (en) 2019-08-22
CN112334451A (zh) 2021-02-05
EP3752491A4 (en) 2021-12-01
KR20200131246A (ko) 2020-11-23
IL276509A (en) 2020-09-30
MA51846A (fr) 2021-04-21
US20190248774A1 (en) 2019-08-15
AU2019220746A1 (en) 2020-08-27
WO2019161224A1 (en) 2019-08-22
EP3752491A1 (en) 2020-12-23
JP2021514359A (ja) 2021-06-10
SG11202007754UA (en) 2020-09-29

Similar Documents

Publication Publication Date Title
MX2020008559A (es) Compuestos heterocíclicos como inhibidores de la quinasa.
BR112022002532A2 (pt) Compostos heterocíclicos como inibidores de quinase
MX2020014245A (es) Inhibidores de quinasas dependientes de ciclinas.
PH12018500792A1 (en) Benzolactam compounds as protein kinase inhibitors
AU2018347307A1 (en) Heterocyclic compounds and uses thereof
CL2019000941A1 (es) Compuestos de pirazolo[1,5-a]piridina sustituidos como inhibidores de la quinasa ret.
IL275948A (en) History of H2-indazole as CDK4 and CDK6 inhibitors and their medical uses
EA201890001A1 (ru) Замещенные гетероциклические производные как ингибиторы циклинзависимой киназы (cdk)
MX2017009571A (es) Inhibidores heterociclicos de itk para el tratamiento de la inflamacion y cancer.
JOP20200209A1 (ar) مثبطات cd73
EP4010080C0 (en) HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER
MX2022004390A (es) Aminas biciclicas como inhibidores de la cinasa dependiente de ciclina 2 (cdk2).
CR20220066A (es) Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2
EP2576549A4 (en) Bicyclic Heteroarylkinase Inhibitors and Methods of Use
EA201790122A1 (ru) Производные 2-h-индазола в качестве ингибиторов циклинзависимых киназ (cdk) и их терапевтическое применение
PH12020552214A1 (en) Ectonucleotidase inhibitors and methods of use thereof
EA200970738A1 (ru) Ингибиторы активности akt
EA201790995A1 (ru) ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ И ИХ ПРИМЕНЕНИЕ ПРИ ЛЕЧЕНИИ ЗАБОЛЕВАНИЙ
MX2017004128A (es) Derivados de diarilurea como inhibidores de quinasa p38.
MX2017015574A (es) Inhibidores de tirosina quinasa de bruton.
TW201613919A (en) Inhibitors of Bruton's tyrosine kinase
MX2021015826A (es) Metodos para tratar cancer usando compuestos de pirimidina y piridina con actividad inhibidora de tirosina cinasa de bruton.
MX2021012418A (es) Compuestos heterociclicos y sus usos.
MX2017013875A (es) Ciertos inhibidores de la proteína quinasa.
EP3877422A4 (en) THERAPEUTIC DOSING SCHEDULES FOR THE TREATMENT OF CANCER WITH ERIBULIN AND SELECTIVE CDK4/6 INHIBITOR COMBINATIONS