UA95223C2 - Производные пиридопиримидина, их получение, их применение в терапии - Google Patents

Производные пиридопиримидина, их получение, их применение в терапии

Info

Publication number
UA95223C2
UA95223C2 UAA200701578A UAA200701578A UA95223C2 UA 95223 C2 UA95223 C2 UA 95223C2 UA A200701578 A UAA200701578 A UA A200701578A UA A200701578 A UAA200701578 A UA A200701578A UA 95223 C2 UA95223 C2 UA 95223C2
Authority
UA
Ukraine
Prior art keywords
pyrido
preparation
therapeutic use
pyrimidine derivatives
general formula
Prior art date
Application number
UAA200701578A
Other languages
English (en)
Ukrainian (uk)
Inventor
Бернар Бурри
Пьер Казелла
Самир Жегам
Пьер Перро
Original Assignee
Санофи Авентис
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи Авентис filed Critical Санофи Авентис
Publication of UA95223C2 publication Critical patent/UA95223C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Объектом изобретения являются производные пиридо[2,3-d]пиримидина общей формулы (I) в форме основы или соли присоединения с фармацевтически приемлемой кислотой, в виде гидратов или сольватов, а также в форме энантиомеров, доастереоозомеров и их смесей, их получение и их применение в терапии.Объектом изобретения являются также способ получения, фармацевтические композиции, содержащие соединение общей формулы (I), и их применение в терапии.
UAA200701578A 2004-07-15 2005-07-13 Производные пиридопиримидина, их получение, их применение в терапии UA95223C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0407898A FR2873118B1 (fr) 2004-07-15 2004-07-15 Derives de pyrido-pyrimidine, leur application en therapeutique

Publications (1)

Publication Number Publication Date
UA95223C2 true UA95223C2 (ru) 2011-07-25

Family

ID=34947008

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200701578A UA95223C2 (ru) 2004-07-15 2005-07-13 Производные пиридопиримидина, их получение, их применение в терапии

Country Status (28)

Country Link
US (2) US7544682B2 (ru)
EP (1) EP1773835B1 (ru)
JP (1) JP5161568B2 (ru)
KR (1) KR101236676B1 (ru)
CN (1) CN101124223A (ru)
AR (1) AR049845A1 (ru)
AU (1) AU2005271071B2 (ru)
BR (1) BRPI0513287A (ru)
CA (1) CA2572614A1 (ru)
CR (1) CR8842A (ru)
EA (1) EA011406B1 (ru)
EC (1) ECSP067111A (ru)
FR (1) FR2873118B1 (ru)
GT (1) GT200500191A (ru)
HN (1) HN2005000370A (ru)
IL (1) IL180256A (ru)
MA (1) MA28742B1 (ru)
MX (1) MX2007000508A (ru)
NO (1) NO20070837L (ru)
PA (1) PA8639301A1 (ru)
PE (1) PE20060380A1 (ru)
SV (1) SV2006002170A (ru)
TN (1) TNSN06440A1 (ru)
TW (1) TWI391390B (ru)
UA (1) UA95223C2 (ru)
UY (1) UY29015A1 (ru)
WO (1) WO2006016067A2 (ru)
ZA (1) ZA200700992B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2873118B1 (fr) * 2004-07-15 2007-11-23 Sanofi Synthelabo Derives de pyrido-pyrimidine, leur application en therapeutique
US7750015B2 (en) * 2005-05-17 2010-07-06 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
US7737155B2 (en) * 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
CA2608405A1 (en) * 2005-05-17 2006-11-23 Schering Corporation Heterocycles as nicotinic acid receptor agonists for the treatment of dyslipidemia
FR2887882B1 (fr) 2005-07-01 2007-09-07 Sanofi Aventis Sa Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
FR2896246B1 (fr) 2006-01-13 2008-08-15 Sanofi Aventis Sa Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
JP2009525961A (ja) * 2006-01-20 2009-07-16 シェーリング コーポレイション 異常脂質血症の処置のためのニコチン酸受容体アゴニストとしての複素環
FR2910813B1 (fr) * 2006-12-28 2009-02-06 Sanofi Aventis Sa Nouvelle utilisation therapeutique pour le traitement des leucemies
SA08280783B1 (ar) * 2007-01-11 2011-04-24 استرازينيكا ايه بي مشتقات بيريدوبيريميدين كمثبطات pde4
TW200835497A (en) * 2007-01-11 2008-09-01 Astrazeneca Ab Chemical compounds 636
RU2010101052A (ru) * 2007-06-15 2011-07-20 Банью Фармасьютикал Ко., Лтд (Jp) Производные бициклоанилина
FR2933701A1 (fr) * 2008-07-08 2010-01-15 Sanofi Aventis Derives anticancereux, leur preparation et leur application en therapeutique
FR2955109B1 (fr) * 2010-01-08 2012-09-07 Sanofi Aventis Derives de 5-oxo-5,8-dihydro-pyrido[2, 3-d]pyrimidine, leur preparation et leur application en therapeutique

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* Cited by examiner, † Cited by third party
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GB1171218A (en) * 1967-11-09 1969-11-19 Parke Davis & Co New Heterocyclic Amine Compounds and Methods for their Production
MD1861G2 (ru) 1994-11-14 2002-09-30 Уорнер-Ламберт Кампэни Производные 6-арилпиридо [2,3-d] пиримидинов и нафтиридинов, фармацевтические композиции на их основе, способы лечения и ингибирования пролиферации и миграции клеток рецепторов тирозин киназы
IL115256A0 (en) * 1994-11-14 1995-12-31 Warner Lambert Co 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
IL117923A (en) 1995-05-03 2000-06-01 Warner Lambert Co Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
US5620981A (en) 1995-05-03 1997-04-15 Warner-Lambert Company Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
EP1218336A2 (en) 1999-09-20 2002-07-03 Takeda Chemical Industries, Ltd. Melanin concentrating hormone antagonist
PE20011066A1 (es) 2000-01-25 2001-10-22 Warner Lambert Co PIRIDO [2,3-d] PIRIMIDIN-2,7-DIAMINAS INHIBIDORES DE CINASAS
US7053070B2 (en) * 2000-01-25 2006-05-30 Warner-Lambert Company Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors
AP2002002643A0 (en) 2000-03-06 2002-12-31 Warner Lambert Co 5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors
JP2004519422A (ja) 2000-08-04 2004-07-02 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー ２−（４−ピリジル）アミノ−６−ジアルコキシフェニルピリド〔２，３−ｄ〕ピリミジン−７−オン
US20030105115A1 (en) 2001-06-21 2003-06-05 Metcalf Chester A. Novel pyridopyrimidines and uses thereof
WO2003026665A1 (en) * 2001-09-26 2003-04-03 Bayer Pharmaceuticals Corporation 2-phenylamino-4-(5-pyrazolylamino)-pyrimidine derivatives as kinase inhibitors, in particular, src kinase inhibitors
AU2002361846A1 (en) * 2001-12-21 2003-07-15 Bayer Pharmaceuticals Corporation Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
RU2310657C2 (ru) * 2002-04-03 2007-11-20 Ф.Хоффманн-Ля Рош Аг Имидазоконденсированные соединения и фармацевтическая композиция, содержащая их
AU2002952453A0 (en) * 2002-11-01 2002-11-21 Novogen Research Pty Ltd Aminated isoflavonoid derivatives and uses thereof
TW200413381A (en) * 2002-11-04 2004-08-01 Hoffmann La Roche Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents
US20050009849A1 (en) 2003-01-03 2005-01-13 Veach Darren R. Pyridopyrimidine kinase inhibitors
TW200502236A (en) * 2003-03-28 2005-01-16 Hoffmann La Roche Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
JP4758349B2 (ja) * 2003-10-08 2011-08-24 アイアールエム・リミテッド・ライアビリティ・カンパニー タンパク質キナーゼ阻害剤としての化合物および組成物
WO2005105097A2 (en) 2004-04-28 2005-11-10 Gpc Biotech Ag Pyridopyrimidines for treating inflammatory and other diseases
FR2873118B1 (fr) * 2004-07-15 2007-11-23 Sanofi Synthelabo Derives de pyrido-pyrimidine, leur application en therapeutique
FR2887882B1 (fr) 2005-07-01 2007-09-07 Sanofi Aventis Sa Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
FR2896246B1 (fr) 2006-01-13 2008-08-15 Sanofi Aventis Sa Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.

Also Published As

Publication number Publication date
AU2005271071A1 (en) 2006-02-16
FR2873118A1 (fr) 2006-01-20
KR20070037489A (ko) 2007-04-04
EP1773835A2 (fr) 2007-04-18
UY29015A1 (es) 2006-02-24
EA200700144A1 (ru) 2007-08-31
ZA200700992B (en) 2008-05-28
JP5161568B2 (ja) 2013-03-13
IL180256A (en) 2014-04-30
EA011406B1 (ru) 2009-02-27
PE20060380A1 (es) 2006-06-06
IL180256A0 (en) 2007-07-04
WO2006016067A3 (fr) 2006-06-01
HN2005000370A (es) 2009-06-01
US7893259B2 (en) 2011-02-22
TW200607808A (en) 2006-03-01
KR101236676B1 (ko) 2013-02-22
PA8639301A1 (es) 2006-11-09
WO2006016067A2 (fr) 2006-02-16
MA28742B1 (fr) 2007-07-02
MX2007000508A (es) 2007-03-29
US20090233923A1 (en) 2009-09-17
BRPI0513287A (pt) 2008-05-06
CA2572614A1 (fr) 2006-02-16
JP2008506673A (ja) 2008-03-06
AU2005271071B2 (en) 2011-09-15
TNSN06440A1 (fr) 2008-02-22
US7544682B2 (en) 2009-06-09
ECSP067111A (es) 2007-01-26
FR2873118B1 (fr) 2007-11-23
SV2006002170A (es) 2006-01-13
CN101124223A (zh) 2008-02-13
EP1773835B1 (fr) 2014-09-24
GT200500191A (es) 2006-03-07
NO20070837L (no) 2007-04-16
AR049845A1 (es) 2006-09-06
US20070167469A1 (en) 2007-07-19
TWI391390B (zh) 2013-04-01
CR8842A (es) 2007-08-28

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