WO2006074919A3 - 3 -AMINO- 6-ARYL (BZW.6-HETEROARYL) -THIENO [2 , 3-B] PYRIDIN-2-CARBONSÄUREAMIDE, DIESE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN UND IHRE VERWENDUNG ALS INHIBITOREN DER TNFα-FREISETZUNG - Google Patents

3 -AMINO- 6-ARYL (BZW.6-HETEROARYL) -THIENO [2 , 3-B] PYRIDIN-2-CARBONSÄUREAMIDE, DIESE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN UND IHRE VERWENDUNG ALS INHIBITOREN DER TNFα-FREISETZUNG Download PDF

Info

Publication number
WO2006074919A3
WO2006074919A3 PCT/EP2006/000199 EP2006000199W WO2006074919A3 WO 2006074919 A3 WO2006074919 A3 WO 2006074919A3 EP 2006000199 W EP2006000199 W EP 2006000199W WO 2006074919 A3 WO2006074919 A3 WO 2006074919A3
Authority
WO
WIPO (PCT)
Prior art keywords
carboxamides
thieno
pyridin
aryl
amino
Prior art date
Application number
PCT/EP2006/000199
Other languages
English (en)
French (fr)
Other versions
WO2006074919A2 (de
Inventor
Claudia Reichelt
Alexander Ludwig
Alexander Schulze
Mohammed Daghish
Siegfried Leistner
Andreas Kroedel
Jochen Heinicke
Original Assignee
Curacyte Discovery Gmbh
Claudia Reichelt
Alexander Ludwig
Alexander Schulze
Mohammed Daghish
Siegfried Leistner
Andreas Kroedel
Jochen Heinicke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP05000522A external-priority patent/EP1683799A1/de
Priority claimed from EP05000521A external-priority patent/EP1681292A1/de
Application filed by Curacyte Discovery Gmbh, Claudia Reichelt, Alexander Ludwig, Alexander Schulze, Mohammed Daghish, Siegfried Leistner, Andreas Kroedel, Jochen Heinicke filed Critical Curacyte Discovery Gmbh
Publication of WO2006074919A2 publication Critical patent/WO2006074919A2/de
Publication of WO2006074919A3 publication Critical patent/WO2006074919A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Die Erfindung betrifft neue 3-Amino-6-aryl-thieno[2,3-b]pyridin-2-carbonsäureamide der allgemeinen Formel (1), Verfahren zu deren Herstellung, pharmazeutische Zubereitungen, die diese Verbindungen und/oder deren Tautomere und gegebenenfalls daraus herstellbare physiologisch verträgliche Salze und/oder deren Solvate enthalten, sowie die Verwendung dieser Verbindungen, deren Tautomere, Salze oder Solvate als Inhibitoren der TNFα-Freisetzung.
PCT/EP2006/000199 2005-01-12 2006-01-11 3 -AMINO- 6-ARYL (BZW.6-HETEROARYL) -THIENO [2 , 3-B] PYRIDIN-2-CARBONSÄUREAMIDE, DIESE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN UND IHRE VERWENDUNG ALS INHIBITOREN DER TNFα-FREISETZUNG WO2006074919A2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05000522A EP1683799A1 (de) 2005-01-12 2005-01-12 3-Amino-6aryl(bzw.6-heteroaryl)-4-R²-thieno[2,3-b]pyridin-2-carbonsäureamide, diese enthaltende pharmazeutische Zubereitungen und deren Verwendung als Inhibitoren der TNFalpha-Freisetzung
EP05000521A EP1681292A1 (de) 2005-01-12 2005-01-12 3-Amino-6-aryl(bzw.6-heteroaryl)-thieno¬2,3-b|pyridin-2-carbonsäureamide, diese enthaltende pharmazeutische Zubereitungen und ihre Verwendung als Inhibitoren der TNFalpha-Freisetzung
EP05000521.4 2005-01-12
EP05000522.2 2005-01-12

Publications (2)

Publication Number Publication Date
WO2006074919A2 WO2006074919A2 (de) 2006-07-20
WO2006074919A3 true WO2006074919A3 (de) 2007-02-01

Family

ID=36677984

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/000199 WO2006074919A2 (de) 2005-01-12 2006-01-11 3 -AMINO- 6-ARYL (BZW.6-HETEROARYL) -THIENO [2 , 3-B] PYRIDIN-2-CARBONSÄUREAMIDE, DIESE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN UND IHRE VERWENDUNG ALS INHIBITOREN DER TNFα-FREISETZUNG

Country Status (1)

Country Link
WO (1) WO2006074919A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2601856T3 (es) 2007-06-08 2017-02-16 Mannkind Corporation Inhibidores de la IRE-1A
US20110269790A1 (en) * 2009-01-05 2011-11-03 Shireesha Boyapati Novel thienopyridines as pharmacologically active agents
RU2475490C1 (ru) * 2011-08-17 2013-02-20 Федеральное государственное образовательное учреждение высшего профессионального образования "Кубанский государственный аграрный университет" N-АЦИЛИРОВАННЫЕ 3-АМИНО-4,6-ДИМЕТИЛТИЕНО[2,3-b]ПИРИДИН-2-КАРБОКСАМИДЫ В КАЧЕСТВЕ АНТИДОТОВ 2,4-Д НА ПОДСОЛНЕЧНИКЕ
EA201690089A1 (ru) 2013-06-11 2017-04-28 Латвийский Институт Органического Синтеза ТИЕНО[2,3-b]ПИРИДИНЫ КАК МОДУЛЯТОРЫ СОСТОЯНИЯ МНОЖЕСТВЕННОЙ ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТИ
EP4013408A1 (de) * 2019-08-12 2022-06-22 Hadasit Medical Research Services and Development Ltd. Verfahren und zusammensetzungen zur verhinderung von durch biologische zielgerichtete krebsarzneimittel verursachten hauttoxizitäten

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4239887A (en) * 1979-10-31 1980-12-16 Usv Pharmaceutical Corporation Pyridothienotriazines
WO2003103661A1 (en) * 2002-06-06 2003-12-18 Boehringer Ingelheim Pharmaceuticals, Inc. SUBSTITUTED 3-AMINO-THIENO[2,3-b]PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AND PROCESSES FOR PREPARING AND THEIR USES

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4239887A (en) * 1979-10-31 1980-12-16 Usv Pharmaceutical Corporation Pyridothienotriazines
WO2003103661A1 (en) * 2002-06-06 2003-12-18 Boehringer Ingelheim Pharmaceuticals, Inc. SUBSTITUTED 3-AMINO-THIENO[2,3-b]PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AND PROCESSES FOR PREPARING AND THEIR USES

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DATABASE ZREGISTRY 10 December 2003 (2003-12-10), XP002338885, Database accession no. 625369-51-9 *
DATABASE ZREGISTRY CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 10 December 2003 (2003-12-10), XP002338881, Database accession no. 625377-77-7 *
DATABASE ZREGISTRY CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 10 December 2003 (2003-12-10), XP002338882, Database accession no. 625377-37-9 *
DATABASE ZREGISTRY CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 10 December 2003 (2003-12-10), XP002338883, Database accession no. 625377-30-2 *
DATABASE ZREGISTRY CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 10 December 2003 (2003-12-10), XP002338884, Database accession no. 625369-64-4 *
DATABASE ZREGISTRY CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 11 February 2003 (2003-02-11), XP002338886, Database accession no. 488725-85-5 *
DATABASE ZREGISTRY CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 15 March 2004 (2004-03-15), XP002338880, Database accession no. 663217-08-1 *
DATABASE ZREGISTRY CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 24 May 2002 (2002-05-24), XP002338887, Database accession no. 421576-35-4 *
WAGNER G ET AL: "Synthese von 3-alkyl-2-amno-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4 onen aus 3-Ethoxycarbonylamino-thieno[2,3-b]pyridin-2-carbonsäureeth ylestern und -2-carbonsäureamiden", PHARMAZIE, DIE, PHARMAZEUTISCHER VERL., ESCHBORN, DE, vol. 48, no. 2, 1993, pages 95 - 99, XP002310689, ISSN: 0031-7144 *

Also Published As

Publication number Publication date
WO2006074919A2 (de) 2006-07-20

Similar Documents

Publication Publication Date Title
IL185611A0 (en) Novel imidazo[1,5-a]pyridine derivatives, method for preparing same and pharmaceutical compositions containing same
WO2005037198A3 (en) Preparation of 1,7-disubstituted azabenzimidazoles as kinase inhibitors
WO2005108358A3 (en) Pyrrolidine derivatives useful as bace inhibitors
TW200640900A (en) 1-(2h)-isoquinolone derivative
WO2005105753A8 (en) Naphthalimide derivatives, methods for their production and pharmaceutical compositions therefrom
WO2007090141A3 (en) Pyrrolo [2, 3, b] pyridine derivatives useful as raf kinase inhibitors
ZA200409862B (en) Benzofused heteroaryl derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use
TW200626553A (en) Novel compounds
WO2008044243A3 (en) Novel process for the preparation of statins and their pharmaceutically acceptable salts thereof
WO2008120725A1 (ja) 新規ピロリノン誘導体およびそれを含有する医薬組成物
WO2006096444A3 (en) Chemical compounds
WO2002080846A3 (en) Epothilone derivatives and methods for making and using the same
GB0112348D0 (en) Compounds
UA95223C2 (ru) Производные пиридопиримидина, их получение, их применение в терапии
WO2004100865A3 (en) New benzimidazole derivatives
WO2004093800A3 (en) Thyronamine derivatives and analogs and methods of use thereof
PT1730144E (pt) Compostos de 1,4,8-triaza-espiro[4.5]decan-2-ona substituídos
MY186650A (en) Heteroaryl pyrrolidinyl and piperidinyl ketone derivatives
WO2007010356A3 (en) Process for the preparation of sulfonamide derivatives
WO2006074919A3 (de) 3 -AMINO- 6-ARYL (BZW.6-HETEROARYL) -THIENO [2 , 3-B] PYRIDIN-2-CARBONSÄUREAMIDE, DIESE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN UND IHRE VERWENDUNG ALS INHIBITOREN DER TNFα-FREISETZUNG
WO2006110173A3 (en) Novel compounds
WO2007080324A3 (fr) Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
WO2004111008A3 (en) Use of a compound of formula i for making a pharmaceutical composition
WO2005054172A3 (en) Jasmonate derivative compounds, pharmaceuticals compositions and methods of use thereof
ZA200900165B (en) 4-amino-3-arylamino-6-arylpyrazolo[3,4-D]pyrimidine derivatives, methods for their preparation and their use as antiviral agents

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06700842

Country of ref document: EP

Kind code of ref document: A2

WWW Wipo information: withdrawn in national office

Ref document number: 6700842

Country of ref document: EP