WO2006074919A3 - 3 -AMINO- 6-ARYL (BZW.6-HETEROARYL) -THIENO [2 , 3-B] PYRIDIN-2-CARBONSÄUREAMIDE, DIESE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN UND IHRE VERWENDUNG ALS INHIBITOREN DER TNFα-FREISETZUNG - Google Patents
3 -AMINO- 6-ARYL (BZW.6-HETEROARYL) -THIENO [2 , 3-B] PYRIDIN-2-CARBONSÄUREAMIDE, DIESE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN UND IHRE VERWENDUNG ALS INHIBITOREN DER TNFα-FREISETZUNG Download PDFInfo
- Publication number
- WO2006074919A3 WO2006074919A3 PCT/EP2006/000199 EP2006000199W WO2006074919A3 WO 2006074919 A3 WO2006074919 A3 WO 2006074919A3 EP 2006000199 W EP2006000199 W EP 2006000199W WO 2006074919 A3 WO2006074919 A3 WO 2006074919A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- carboxamides
- thieno
- pyridin
- aryl
- amino
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Die Erfindung betrifft neue 3-Amino-6-aryl-thieno[2,3-b]pyridin-2-carbonsäureamide der allgemeinen Formel (1), Verfahren zu deren Herstellung, pharmazeutische Zubereitungen, die diese Verbindungen und/oder deren Tautomere und gegebenenfalls daraus herstellbare physiologisch verträgliche Salze und/oder deren Solvate enthalten, sowie die Verwendung dieser Verbindungen, deren Tautomere, Salze oder Solvate als Inhibitoren der TNFα-Freisetzung.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05000522A EP1683799A1 (de) | 2005-01-12 | 2005-01-12 | 3-Amino-6aryl(bzw.6-heteroaryl)-4-R²-thieno[2,3-b]pyridin-2-carbonsäureamide, diese enthaltende pharmazeutische Zubereitungen und deren Verwendung als Inhibitoren der TNFalpha-Freisetzung |
EP05000521A EP1681292A1 (de) | 2005-01-12 | 2005-01-12 | 3-Amino-6-aryl(bzw.6-heteroaryl)-thieno¬2,3-b|pyridin-2-carbonsäureamide, diese enthaltende pharmazeutische Zubereitungen und ihre Verwendung als Inhibitoren der TNFalpha-Freisetzung |
EP05000521.4 | 2005-01-12 | ||
EP05000522.2 | 2005-01-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006074919A2 WO2006074919A2 (de) | 2006-07-20 |
WO2006074919A3 true WO2006074919A3 (de) | 2007-02-01 |
Family
ID=36677984
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2006/000199 WO2006074919A2 (de) | 2005-01-12 | 2006-01-11 | 3 -AMINO- 6-ARYL (BZW.6-HETEROARYL) -THIENO [2 , 3-B] PYRIDIN-2-CARBONSÄUREAMIDE, DIESE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN UND IHRE VERWENDUNG ALS INHIBITOREN DER TNFα-FREISETZUNG |
Country Status (1)
Country | Link |
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WO (1) | WO2006074919A2 (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2601856T3 (es) | 2007-06-08 | 2017-02-16 | Mannkind Corporation | Inhibidores de la IRE-1A |
US20110269790A1 (en) * | 2009-01-05 | 2011-11-03 | Shireesha Boyapati | Novel thienopyridines as pharmacologically active agents |
RU2475490C1 (ru) * | 2011-08-17 | 2013-02-20 | Федеральное государственное образовательное учреждение высшего профессионального образования "Кубанский государственный аграрный университет" | N-АЦИЛИРОВАННЫЕ 3-АМИНО-4,6-ДИМЕТИЛТИЕНО[2,3-b]ПИРИДИН-2-КАРБОКСАМИДЫ В КАЧЕСТВЕ АНТИДОТОВ 2,4-Д НА ПОДСОЛНЕЧНИКЕ |
EA201690089A1 (ru) | 2013-06-11 | 2017-04-28 | Латвийский Институт Органического Синтеза | ТИЕНО[2,3-b]ПИРИДИНЫ КАК МОДУЛЯТОРЫ СОСТОЯНИЯ МНОЖЕСТВЕННОЙ ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТИ |
EP4013408A1 (de) * | 2019-08-12 | 2022-06-22 | Hadasit Medical Research Services and Development Ltd. | Verfahren und zusammensetzungen zur verhinderung von durch biologische zielgerichtete krebsarzneimittel verursachten hauttoxizitäten |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4239887A (en) * | 1979-10-31 | 1980-12-16 | Usv Pharmaceutical Corporation | Pyridothienotriazines |
WO2003103661A1 (en) * | 2002-06-06 | 2003-12-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | SUBSTITUTED 3-AMINO-THIENO[2,3-b]PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AND PROCESSES FOR PREPARING AND THEIR USES |
-
2006
- 2006-01-11 WO PCT/EP2006/000199 patent/WO2006074919A2/de not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4239887A (en) * | 1979-10-31 | 1980-12-16 | Usv Pharmaceutical Corporation | Pyridothienotriazines |
WO2003103661A1 (en) * | 2002-06-06 | 2003-12-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | SUBSTITUTED 3-AMINO-THIENO[2,3-b]PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AND PROCESSES FOR PREPARING AND THEIR USES |
Non-Patent Citations (9)
Title |
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DATABASE ZREGISTRY 10 December 2003 (2003-12-10), XP002338885, Database accession no. 625369-51-9 * |
DATABASE ZREGISTRY CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 10 December 2003 (2003-12-10), XP002338881, Database accession no. 625377-77-7 * |
DATABASE ZREGISTRY CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 10 December 2003 (2003-12-10), XP002338882, Database accession no. 625377-37-9 * |
DATABASE ZREGISTRY CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 10 December 2003 (2003-12-10), XP002338883, Database accession no. 625377-30-2 * |
DATABASE ZREGISTRY CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 10 December 2003 (2003-12-10), XP002338884, Database accession no. 625369-64-4 * |
DATABASE ZREGISTRY CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 11 February 2003 (2003-02-11), XP002338886, Database accession no. 488725-85-5 * |
DATABASE ZREGISTRY CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 15 March 2004 (2004-03-15), XP002338880, Database accession no. 663217-08-1 * |
DATABASE ZREGISTRY CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 24 May 2002 (2002-05-24), XP002338887, Database accession no. 421576-35-4 * |
WAGNER G ET AL: "Synthese von 3-alkyl-2-amno-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4 onen aus 3-Ethoxycarbonylamino-thieno[2,3-b]pyridin-2-carbonsäureeth ylestern und -2-carbonsäureamiden", PHARMAZIE, DIE, PHARMAZEUTISCHER VERL., ESCHBORN, DE, vol. 48, no. 2, 1993, pages 95 - 99, XP002310689, ISSN: 0031-7144 * |
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Publication number | Publication date |
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WO2006074919A2 (de) | 2006-07-20 |
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