EA201690089A1 - ТИЕНО[2,3-b]ПИРИДИНЫ КАК МОДУЛЯТОРЫ СОСТОЯНИЯ МНОЖЕСТВЕННОЙ ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТИ - Google Patents

ТИЕНО[2,3-b]ПИРИДИНЫ КАК МОДУЛЯТОРЫ СОСТОЯНИЯ МНОЖЕСТВЕННОЙ ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТИ

Info

Publication number
EA201690089A1
EA201690089A1 EA201690089A EA201690089A EA201690089A1 EA 201690089 A1 EA201690089 A1 EA 201690089A1 EA 201690089 A EA201690089 A EA 201690089A EA 201690089 A EA201690089 A EA 201690089A EA 201690089 A1 EA201690089 A1 EA 201690089A1
Authority
EA
Eurasian Patent Office
Prior art keywords
ome
modulators
state
alkoxy
tieno
Prior art date
Application number
EA201690089A
Other languages
English (en)
Inventor
Ивар Калвиньш
Айварс Краузе
Сигне Гринберга
Лаура Краснова
Элина Ященко
Илона Домрачева
Илзе Адлере
Зигмарс Анджанс
Ирина Шестакова
Гунарс Дубурс
Original Assignee
Латвийский Институт Органического Синтеза
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Латвийский Институт Органического Синтеза filed Critical Латвийский Институт Органического Синтеза
Publication of EA201690089A1 publication Critical patent/EA201690089A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Тиено[2,3-b]пиридины с общей формулой (I), в которой R- это Me, CH, 3,4,5-(ОМе)СН, NH; R- это Н, CN, СОМе, СООСалкил, СООСНОМе, COOCHOPr (п); R- это CHR, 3,4-ОСНО-СН; 2-фуранил; R- это 4-Cl, 4-NO, 4-N(Cалкил) 2,3-(Cалкокси), 4-(Cалкокси), 3,4-(Cалкокси), 3,4,5-(Cалкокси); R- это NH, NHCOMe; R- это CN, СОМе, COCHR; СО-(2-нафтил); R- это Н, 4-F, 4-Cl, 3-ОМе, 4-ОМе, 2,4-(ОМе), 3,4,5-(ОМе), как модуляторы состояния множественной лекарственной устойчивости для повышения эффективности химиотерапии при лечении рака.
EA201690089A 2013-06-11 2013-06-11 ТИЕНО[2,3-b]ПИРИДИНЫ КАК МОДУЛЯТОРЫ СОСТОЯНИЯ МНОЖЕСТВЕННОЙ ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТИ EA201690089A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2013/054767 WO2014199195A1 (en) 2013-06-11 2013-06-11 THIENO[2,3-b]PYRIDINES AS MULTIDRUG RESISTANCE MODULATORS

Publications (1)

Publication Number Publication Date
EA201690089A1 true EA201690089A1 (ru) 2017-04-28

Family

ID=48986167

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201690089A EA201690089A1 (ru) 2013-06-11 2013-06-11 ТИЕНО[2,3-b]ПИРИДИНЫ КАК МОДУЛЯТОРЫ СОСТОЯНИЯ МНОЖЕСТВЕННОЙ ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТИ

Country Status (5)

Country Link
US (1) US9908893B2 (ru)
EP (1) EP3008073B1 (ru)
CA (1) CA2910514C (ru)
EA (1) EA201690089A1 (ru)
WO (1) WO2014199195A1 (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2812570C1 (ru) * 2023-07-19 2024-01-30 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Применение 3-амино-4-(5-метил-2-фурил)-5,6,7,8-тетрагидротиено[2,3-b]хинолин-2-ил](фенил)метанон в качестве противовоспалительного средства

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115043720B (zh) * 2022-07-04 2023-11-21 新疆医科大学 一种新型α-甲基查耳酮类化合物及其制备方法和应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0313766D0 (en) * 2003-06-13 2003-07-23 Xenova Ltd Pharmaceutical compounds
MXPA06011799A (es) 2004-04-12 2006-12-15 Sankyo Co Derivados de tienopiridina.
MX2007000762A (es) 2004-07-22 2007-04-02 Ptc Therapeutics Inc Tienopiridinas para tratamientode hepatitis c.
GB0420719D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
EP1807434B1 (en) 2004-10-25 2010-08-25 Eli Lilly And Company Thienopyridines as allosteric potentiators of the m4 muscarinic receptor
WO2006061642A1 (en) 2004-12-09 2006-06-15 Xention Discovery Limited Compounds
CA2591211A1 (en) 2004-12-17 2006-06-22 Parichehr Malherbe Thieno-pyridine derivatives as gaba-b allosteric enhancers
WO2006074919A2 (de) 2005-01-12 2006-07-20 Curacyte Discovery Gmbh 3 -AMINO- 6-ARYL (BZW.6-HETEROARYL) -THIENO [2 , 3-B] PYRIDIN-2-CARBONSÄUREAMIDE, DIESE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN UND IHRE VERWENDUNG ALS INHIBITOREN DER TNFα-FREISETZUNG
HUP0501170A2 (en) 2005-12-20 2007-09-28 Richter Gedeon Nyrt 2-heteroaryl-3-phenyl-thieno[2,3-b]pyridines, process for their preparation, their use and pharmaceutical compositions containing them
HUP0501168A3 (en) 2005-12-20 2007-10-29 Richter Gedeon Nyrt 2-(acyl, oxycarbonyl or aminocarbonyl)-3-phenyl-thieno[2,3-b]pyridines, process for their preparation, their use and pharmaceutical composition containing them
GB0601962D0 (en) 2006-01-31 2006-03-15 Ucb Sa Therapeutic agents
EP2029568A4 (en) * 2006-05-19 2010-10-13 Univ Hong Kong Polytechnic FLAVONOID DIMERS AND METHODS OF MAKING AND USING SAME
EP2029608A1 (en) 2006-06-06 2009-03-04 Boehringer Ingelheim International GmbH Substituted 3-amino-thieno[2,3-b] pyridine-2-carboxamide compounds, their preparation and use
GB0714384D0 (en) 2007-07-23 2007-09-05 Ucb Pharma Sa theraputic agents
EP2220095B1 (en) 2007-11-15 2013-01-02 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
WO2009093008A1 (en) 2008-01-21 2009-07-30 Ucb Pharma S.A. Thieno-pyridine derivatives as mek inhibitors
GB0811304D0 (en) 2008-06-19 2008-07-30 Ucb Pharma Sa Therapeutic agents
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
EP2308883A1 (en) * 2009-10-05 2011-04-13 Centre National De La Recherche Scientifique New derivatives of thieno[2,3-b]pyridine and 5,6,7,8 tetrahydrothieno[2,3 b]quinoline in particular useful in the treatment of malaria
EP2512242B8 (en) 2009-12-18 2015-12-09 GlaxoSmithKline Intellectual Property Limited Novel compounds
US8759371B2 (en) 2010-07-01 2014-06-24 Amgen Inc. Heterocyclic compounds and their uses

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2812570C1 (ru) * 2023-07-19 2024-01-30 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Применение 3-амино-4-(5-метил-2-фурил)-5,6,7,8-тетрагидротиено[2,3-b]хинолин-2-ил](фенил)метанон в качестве противовоспалительного средства

Also Published As

Publication number Publication date
US20160137664A1 (en) 2016-05-19
CA2910514C (en) 2018-05-15
CA2910514A1 (en) 2014-12-18
EP3008073A1 (en) 2016-04-20
WO2014199195A1 (en) 2014-12-18
US9908893B2 (en) 2018-03-06
EP3008073B1 (en) 2020-01-01

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