EA201690089A1 - ТИЕНО[2,3-b]ПИРИДИНЫ КАК МОДУЛЯТОРЫ СОСТОЯНИЯ МНОЖЕСТВЕННОЙ ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТИ - Google Patents

ТИЕНО[2,3-b]ПИРИДИНЫ КАК МОДУЛЯТОРЫ СОСТОЯНИЯ МНОЖЕСТВЕННОЙ ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТИ

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Publication number
EA201690089A1
EA201690089A1 EA201690089A EA201690089A EA201690089A1 EA 201690089 A1 EA201690089 A1 EA 201690089A1 EA 201690089 A EA201690089 A EA 201690089A EA 201690089 A EA201690089 A EA 201690089A EA 201690089 A1 EA201690089 A1 EA 201690089A1
Authority
EA
Eurasian Patent Office
Prior art keywords
ome
modulators
state
alkoxy
tieno
Prior art date
Application number
EA201690089A
Other languages
English (en)
Inventor
Ивар Калвиньш
Айварс Краузе
Сигне Гринберга
Лаура Краснова
Элина Ященко
Илона Домрачева
Илзе Адлере
Зигмарс Анджанс
Ирина Шестакова
Гунарс Дубурс
Original Assignee
Латвийский Институт Органического Синтеза
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Латвийский Институт Органического Синтеза filed Critical Латвийский Институт Органического Синтеза
Publication of EA201690089A1 publication Critical patent/EA201690089A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Тиено[2,3-b]пиридины с общей формулой (I), в которой R- это Me, CH, 3,4,5-(ОМе)СН, NH; R- это Н, CN, СОМе, СООСалкил, СООСНОМе, COOCHOPr (п); R- это CHR, 3,4-ОСНО-СН; 2-фуранил; R- это 4-Cl, 4-NO, 4-N(Cалкил) 2,3-(Cалкокси), 4-(Cалкокси), 3,4-(Cалкокси), 3,4,5-(Cалкокси); R- это NH, NHCOMe; R- это CN, СОМе, COCHR; СО-(2-нафтил); R- это Н, 4-F, 4-Cl, 3-ОМе, 4-ОМе, 2,4-(ОМе), 3,4,5-(ОМе), как модуляторы состояния множественной лекарственной устойчивости для повышения эффективности химиотерапии при лечении рака.
EA201690089A 2013-06-11 2013-06-11 ТИЕНО[2,3-b]ПИРИДИНЫ КАК МОДУЛЯТОРЫ СОСТОЯНИЯ МНОЖЕСТВЕННОЙ ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТИ EA201690089A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2013/054767 WO2014199195A1 (en) 2013-06-11 2013-06-11 THIENO[2,3-b]PYRIDINES AS MULTIDRUG RESISTANCE MODULATORS

Publications (1)

Publication Number Publication Date
EA201690089A1 true EA201690089A1 (ru) 2017-04-28

Family

ID=48986167

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201690089A EA201690089A1 (ru) 2013-06-11 2013-06-11 ТИЕНО[2,3-b]ПИРИДИНЫ КАК МОДУЛЯТОРЫ СОСТОЯНИЯ МНОЖЕСТВЕННОЙ ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТИ

Country Status (5)

Country Link
US (1) US9908893B2 (ru)
EP (1) EP3008073B1 (ru)
CA (1) CA2910514C (ru)
EA (1) EA201690089A1 (ru)
WO (1) WO2014199195A1 (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2812570C1 (ru) * 2023-07-19 2024-01-30 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Применение 3-амино-4-(5-метил-2-фурил)-5,6,7,8-тетрагидротиено[2,3-b]хинолин-2-ил](фенил)метанон в качестве противовоспалительного средства

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115043720B (zh) * 2022-07-04 2023-11-21 新疆医科大学 一种新型α-甲基查耳酮类化合物及其制备方法和应用

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NZ553329A (en) 2004-07-22 2010-09-30 Ptc Therapeutics Inc Thienopyridines for treating hepatitis C
GB0420719D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
ATE478876T1 (de) 2004-10-25 2010-09-15 Lilly Co Eli Thienopyridine als allosterische verstärker des m4-muscarinrezeptors
ATE476434T1 (de) 2004-12-09 2010-08-15 Xention Ltd Thienopyridinderivate als kaliumkanalinhibitoren
JP2008524134A (ja) 2004-12-17 2008-07-10 エフ．ホフマン−ラ ロシュ アーゲー Ｇａｂａ−ｂアロステリックエンハンサーとしてのチエノ−ピリジン誘導体
WO2006074919A2 (de) 2005-01-12 2006-07-20 Curacyte Discovery Gmbh 3 -AMINO- 6-ARYL (BZW.6-HETEROARYL) -THIENO [2 , 3-B] PYRIDIN-2-CARBONSÄUREAMIDE, DIESE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN UND IHRE VERWENDUNG ALS INHIBITOREN DER TNFα-FREISETZUNG
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GB0601962D0 (en) 2006-01-31 2006-03-15 Ucb Sa Therapeutic agents
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BRPI0819328A8 (pt) 2007-11-15 2016-02-10 Boehringer Ingelheim Int Compostos inibidores de replicação de vírus da imunodeficiência humana, composição farmacêutica e uso dos ditos compostos
EP2240494B1 (en) 2008-01-21 2016-03-30 UCB Biopharma SPRL Thieno-pyridine derivatives as mek inhibitors
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EP2308883A1 (en) * 2009-10-05 2011-04-13 Centre National De La Recherche Scientifique New derivatives of thieno[2,3-b]pyridine and 5,6,7,8 tetrahydrothieno[2,3 b]quinoline in particular useful in the treatment of malaria
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2812570C1 (ru) * 2023-07-19 2024-01-30 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Применение 3-амино-4-(5-метил-2-фурил)-5,6,7,8-тетрагидротиено[2,3-b]хинолин-2-ил](фенил)метанон в качестве противовоспалительного средства

Also Published As

Publication number Publication date
US20160137664A1 (en) 2016-05-19
EP3008073B1 (en) 2020-01-01
CA2910514A1 (en) 2014-12-18
WO2014199195A1 (en) 2014-12-18
US9908893B2 (en) 2018-03-06
EP3008073A1 (en) 2016-04-20
CA2910514C (en) 2018-05-15

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