MX2007004273A - Nuevas azaindol-tiazolinonas como agentes anti-cancerosos. - Google Patents

Nuevas azaindol-tiazolinonas como agentes anti-cancerosos.

Info

Publication number
MX2007004273A
MX2007004273A MX2007004273A MX2007004273A MX2007004273A MX 2007004273 A MX2007004273 A MX 2007004273A MX 2007004273 A MX2007004273 A MX 2007004273A MX 2007004273 A MX2007004273 A MX 2007004273A MX 2007004273 A MX2007004273 A MX 2007004273A
Authority
MX
Mexico
Prior art keywords
cancer agents
thiazolinones
azaindole
novel azaindole
novel
Prior art date
Application number
MX2007004273A
Other languages
English (en)
Inventor
Achyutharao Sidduri
Shaoqing Chen
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2007004273A publication Critical patent/MX2007004273A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invencion describe los derivados de azaindol-tiazolinona de la formula general (1) que demuestran actividad antiproliferativa de CDK1 y CDK2, y son Utiles como agentes anti-cancerosos; se describen tambien los procesos para la fabricacion de dichos compuestos asi como los medicamentos que los contienen.
MX2007004273A 2004-10-14 2005-10-05 Nuevas azaindol-tiazolinonas como agentes anti-cancerosos. MX2007004273A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61867204P 2004-10-14 2004-10-14
PCT/EP2005/010702 WO2006040049A1 (en) 2004-10-14 2005-10-05 Novel azaindole thiazolinones as anti-cancer agents

Publications (1)

Publication Number Publication Date
MX2007004273A true MX2007004273A (es) 2007-05-11

Family

ID=35423339

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007004273A MX2007004273A (es) 2004-10-14 2005-10-05 Nuevas azaindol-tiazolinonas como agentes anti-cancerosos.

Country Status (15)

Country Link
US (1) US7247727B2 (es)
EP (1) EP1805175B1 (es)
JP (1) JP2008516903A (es)
KR (1) KR100875870B1 (es)
CN (1) CN100569773C (es)
AT (1) ATE388149T1 (es)
AU (1) AU2005293831B2 (es)
BR (1) BRPI0518158A (es)
CA (1) CA2582986A1 (es)
DE (1) DE602005005211T2 (es)
ES (1) ES2301066T3 (es)
MX (1) MX2007004273A (es)
PL (1) PL1805175T3 (es)
RU (1) RU2391342C2 (es)
WO (1) WO2006040049A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7371862B2 (en) 2005-11-11 2008-05-13 Pfizer Italia S.R.L. Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
FR2907120B1 (fr) 2006-10-12 2013-01-11 Sanofi Aventis Nouveaux derives imidazolones,leur preparation a titre de medicaments,compositions pharmaceutiques,utilisation comme inhibiteurs de proteines kinases notamment cdc7
FR2926463B1 (fr) * 2008-01-22 2010-08-13 Centre Nat Rech Scient Utilisation d'inhibiteurs d'aminopeptidase ou de composes azaindole pour la prevention ou le traitement de metastases cancereuses d'origine epitheliale
WO2012002568A1 (en) * 2010-06-29 2012-01-05 Sbi Biotech Co., Ltd. Azaindole derivative
EP2692728B1 (en) * 2011-03-31 2018-07-04 Carna Biosciences Inc. Novel furanone derivative
KR101277161B1 (ko) 2011-07-08 2013-06-20 주식회사 엠엠테크 글라스 박형화 시스템
RU2521390C1 (ru) * 2013-03-14 2014-06-27 Общество с ограниченной ответственностью "Тиацен" Производное роданина и средство для профилактики опухолевых заболеваний
EP2974726A4 (en) 2013-03-14 2017-01-04 Tiacen Ltd Agent for the prophylaxis and/or treatment of neoplastic diseases
JP6569908B2 (ja) 2014-01-31 2019-09-04 カルナバイオサイエンス株式会社 抗がん剤組成物
KR102491260B1 (ko) * 2019-12-26 2023-01-27 연세대학교 산학협력단 피롤리딘 유도체 및 이를 포함하는 베타-아밀로이드 또는 타우 단백질 관련 질병의 예방 또는 치료용 약학 조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996014843A2 (en) 1994-11-10 1996-05-23 Cor Therapeutics, Inc. Pharmaceutical pyrazole compositions useful as inhibitors of protein kinases
WO1997034876A1 (en) 1996-03-15 1997-09-25 Zeneca Limited Cinnoline derivatives and use as medicine
KR20010082501A (ko) 1997-10-27 2001-08-30 개리 이. 프라이드만 4-아미노티아졸 유도체, 그 제조방법 및 싸이클린-의존성키나아제의 억제제로서의 이용방법
US6335342B1 (en) * 2000-06-19 2002-01-01 Pharmacia & Upjohn S.P.A. Azaindole derivatives, process for their preparation, and their use as antitumor agents
WO2003028724A1 (en) 2001-10-04 2003-04-10 Smithkline Beecham Corporation Chk1 kinase inhibitors
AU2003255528B2 (en) * 2002-07-10 2009-07-16 Merck Serono Sa Azolidinone-vinyl fused-benzene derivatives
WO2004028535A1 (en) * 2002-09-26 2004-04-08 Pintex Pharmaceuticals, Inc. Pin1-modulating compounds and methods of use thereof
EP1567112B1 (en) * 2002-11-22 2008-10-15 Smithkline Beecham Corporation THIAZOLIDIN-4-ONES FOR INHIBITING hYAK3 PROTEINS

Also Published As

Publication number Publication date
KR20070053342A (ko) 2007-05-23
KR100875870B1 (ko) 2008-12-26
RU2007117764A (ru) 2008-11-20
JP2008516903A (ja) 2008-05-22
CN101039943A (zh) 2007-09-19
EP1805175B1 (en) 2008-03-05
US20060084674A1 (en) 2006-04-20
CN100569773C (zh) 2009-12-16
DE602005005211T2 (de) 2009-03-19
RU2391342C2 (ru) 2010-06-10
AU2005293831A1 (en) 2006-04-20
WO2006040049A1 (en) 2006-04-20
DE602005005211D1 (de) 2008-04-17
BRPI0518158A (pt) 2008-11-04
CA2582986A1 (en) 2006-04-20
US7247727B2 (en) 2007-07-24
EP1805175A1 (en) 2007-07-11
AU2005293831B2 (en) 2011-01-06
ES2301066T3 (es) 2008-06-16
PL1805175T3 (pl) 2008-08-29
ATE388149T1 (de) 2008-03-15

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