DE602005005211D1 - Neue azaindol-thiazolinone als krebsmittel - Google Patents

Neue azaindol-thiazolinone als krebsmittel

Info

Publication number
DE602005005211D1
DE602005005211D1 DE602005005211T DE602005005211T DE602005005211D1 DE 602005005211 D1 DE602005005211 D1 DE 602005005211D1 DE 602005005211 T DE602005005211 T DE 602005005211T DE 602005005211 T DE602005005211 T DE 602005005211T DE 602005005211 D1 DE602005005211 D1 DE 602005005211D1
Authority
DE
Germany
Prior art keywords
thiazolinone
cancer
azaindol
new
cdk1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005005211T
Other languages
English (en)
Other versions
DE602005005211T2 (de
Inventor
Shaoqing Chen
Achyutharao Sidduri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE602005005211D1 publication Critical patent/DE602005005211D1/de
Application granted granted Critical
Publication of DE602005005211T2 publication Critical patent/DE602005005211T2/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE602005005211T 2004-10-14 2005-10-05 Neue azaindol-thiazolinone als krebsmittel Active DE602005005211T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61867204P 2004-10-14 2004-10-14
US618672P 2004-10-14
PCT/EP2005/010702 WO2006040049A1 (en) 2004-10-14 2005-10-05 Novel azaindole thiazolinones as anti-cancer agents

Publications (2)

Publication Number Publication Date
DE602005005211D1 true DE602005005211D1 (de) 2008-04-17
DE602005005211T2 DE602005005211T2 (de) 2009-03-19

Family

ID=35423339

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005005211T Active DE602005005211T2 (de) 2004-10-14 2005-10-05 Neue azaindol-thiazolinone als krebsmittel

Country Status (15)

Country Link
US (1) US7247727B2 (de)
EP (1) EP1805175B1 (de)
JP (1) JP2008516903A (de)
KR (1) KR100875870B1 (de)
CN (1) CN100569773C (de)
AT (1) ATE388149T1 (de)
AU (1) AU2005293831B2 (de)
BR (1) BRPI0518158A (de)
CA (1) CA2582986A1 (de)
DE (1) DE602005005211T2 (de)
ES (1) ES2301066T3 (de)
MX (1) MX2007004273A (de)
PL (1) PL1805175T3 (de)
RU (1) RU2391342C2 (de)
WO (1) WO2006040049A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7371862B2 (en) 2005-11-11 2008-05-13 Pfizer Italia S.R.L. Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
FR2907120B1 (fr) * 2006-10-12 2013-01-11 Sanofi Aventis Nouveaux derives imidazolones,leur preparation a titre de medicaments,compositions pharmaceutiques,utilisation comme inhibiteurs de proteines kinases notamment cdc7
FR2926463B1 (fr) * 2008-01-22 2010-08-13 Centre Nat Rech Scient Utilisation d'inhibiteurs d'aminopeptidase ou de composes azaindole pour la prevention ou le traitement de metastases cancereuses d'origine epitheliale
JP2013533844A (ja) * 2010-06-29 2013-08-29 Ｓｂｉバイオテック株式会社 アザインドール誘導体
USRE48140E1 (en) * 2011-03-31 2020-08-04 Carna Biosciences, Inc. Furanone derivative
KR101277161B1 (ko) 2011-07-08 2013-06-20 주식회사 엠엠테크 글라스 박형화 시스템
RU2521390C1 (ru) * 2013-03-14 2014-06-27 Общество с ограниченной ответственностью "Тиацен" Производное роданина и средство для профилактики опухолевых заболеваний
US9949961B2 (en) 2013-03-14 2018-04-24 Rahimdzhan Roziev Agent for the prophylaxis and/or treatment of neoplastic diseases
WO2015115355A1 (ja) 2014-01-31 2015-08-06 カルナバイオサイエンス株式会社 抗がん剤組成物
KR102491260B1 (ko) * 2019-12-26 2023-01-27 연세대학교 산학협력단 피롤리딘 유도체 및 이를 포함하는 베타-아밀로이드 또는 타우 단백질 관련 질병의 예방 또는 치료용 약학 조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996014843A2 (en) 1994-11-10 1996-05-23 Cor Therapeutics, Inc. Pharmaceutical pyrazole compositions useful as inhibitors of protein kinases
DE69734149T2 (de) 1996-03-15 2006-07-06 Astrazeneca Ab Cinoline derivate und verwendung als heilmittel
CA2306082A1 (en) 1997-10-27 1999-05-06 Agouron Pharmaceuticals, Inc. Substituted 4-amino-thiazol-2-y compounds as cdks inhibitors
US6335342B1 (en) * 2000-06-19 2002-01-01 Pharmacia & Upjohn S.P.A. Azaindole derivatives, process for their preparation, and their use as antitumor agents
WO2003028724A1 (en) * 2001-10-04 2003-04-10 Smithkline Beecham Corporation Chk1 kinase inhibitors
JP4782564B2 (ja) * 2002-07-10 2011-09-28 メルク セローノ ソシエテ アノニム アゾリジノン−ビニル縮合−ベンゼン誘導体
AU2003225669A1 (en) * 2002-09-26 2004-04-19 Pintex Pharmaceuticals, Inc. Pin1-modulating compounds and methods of use thereof
OA12963A (en) * 2002-11-22 2006-10-13 Smithkline Beecham Corp Novel chemical compounds.

Also Published As

Publication number Publication date
KR20070053342A (ko) 2007-05-23
CA2582986A1 (en) 2006-04-20
US7247727B2 (en) 2007-07-24
US20060084674A1 (en) 2006-04-20
AU2005293831B2 (en) 2011-01-06
PL1805175T3 (pl) 2008-08-29
RU2007117764A (ru) 2008-11-20
BRPI0518158A (pt) 2008-11-04
EP1805175A1 (de) 2007-07-11
JP2008516903A (ja) 2008-05-22
EP1805175B1 (de) 2008-03-05
KR100875870B1 (ko) 2008-12-26
ATE388149T1 (de) 2008-03-15
AU2005293831A1 (en) 2006-04-20
DE602005005211T2 (de) 2009-03-19
MX2007004273A (es) 2007-05-11
ES2301066T3 (es) 2008-06-16
WO2006040049A1 (en) 2006-04-20
CN101039943A (zh) 2007-09-19
CN100569773C (zh) 2009-12-16
RU2391342C2 (ru) 2010-06-10

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