ATE435865T1 - Als pde5-inhibitoren verwendete pyrazoloä4,3- düpyrimidin-5-ylderivate - Google Patents
Als pde5-inhibitoren verwendete pyrazoloä4,3- düpyrimidin-5-ylderivateInfo
- Publication number
- ATE435865T1 ATE435865T1 AT06809195T AT06809195T ATE435865T1 AT E435865 T1 ATE435865 T1 AT E435865T1 AT 06809195 T AT06809195 T AT 06809195T AT 06809195 T AT06809195 T AT 06809195T AT E435865 T1 ATE435865 T1 AT E435865T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrazoloa4
- düpyrimidine
- derivatives used
- pde5 inhibitors
- pde5
- Prior art date
Links
- 229940123333 Phosphodiesterase 5 inhibitor Drugs 0.000 title 1
- 239000002590 phosphodiesterase V inhibitor Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Gynecology & Obstetrics (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Pregnancy & Childbirth (AREA)
- Child & Adolescent Psychology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73532005P | 2005-11-10 | 2005-11-10 | |
| PCT/IB2006/003132 WO2007054778A1 (en) | 2005-11-10 | 2006-10-31 | Pyrazolo[4,3-d]pyrimidin-5-yl)derivative used as pde5 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE435865T1 true ATE435865T1 (de) | 2009-07-15 |
Family
ID=37685872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06809195T ATE435865T1 (de) | 2005-11-10 | 2006-10-31 | Als pde5-inhibitoren verwendete pyrazoloä4,3- düpyrimidin-5-ylderivate |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US20090156618A1 (de) |
| EP (1) | EP1948661B1 (de) |
| JP (1) | JP4208959B1 (de) |
| KR (1) | KR101012592B1 (de) |
| CN (1) | CN101305007B (de) |
| AP (1) | AP2008004437A0 (de) |
| AR (1) | AR057885A1 (de) |
| AT (1) | ATE435865T1 (de) |
| AU (1) | AU2006313486B2 (de) |
| BR (1) | BRPI0618284A2 (de) |
| CA (1) | CA2629339C (de) |
| CR (1) | CR9966A (de) |
| DE (1) | DE602006007728D1 (de) |
| DK (1) | DK1948661T3 (de) |
| DO (1) | DOP2006000248A (de) |
| EA (1) | EA200800920A1 (de) |
| EC (1) | ECSP088441A (de) |
| ES (1) | ES2326919T3 (de) |
| IL (1) | IL190456A (de) |
| MA (1) | MA29943B1 (de) |
| NL (1) | NL2000291C2 (de) |
| NO (1) | NO20082593L (de) |
| PE (1) | PE20070764A1 (de) |
| RS (1) | RS20080197A (de) |
| TN (1) | TNSN08209A1 (de) |
| TW (1) | TW200738723A (de) |
| UY (1) | UY29909A1 (de) |
| WO (1) | WO2007054778A1 (de) |
| ZA (1) | ZA200803173B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2324020A2 (de) * | 2008-08-01 | 2011-05-25 | Biocryst Pharmaceuticals, Inc. | Piperidinderivate als jak3-inhibitoren |
| WO2010043633A1 (en) * | 2008-10-15 | 2010-04-22 | Palau Pharma, S. A. | 2h-pyrazolo [4,3-d]pyrimidin-5-amine derivatives as h4 histamine receptor antagonists for the treatment of allergic, immunological and inflammatory diseases |
| JP2013523809A (ja) * | 2010-04-05 | 2013-06-17 | エスケー ケミカルズ カンパニー リミテッド | Ｐｄｅ５抑制剤を含む皮膚しわ改善用組成物 |
| WO2012118042A1 (ja) * | 2011-02-28 | 2012-09-07 | 独立行政法人国立循環器病研究センター | 悪性腫瘍転移抑制用医薬 |
| AU2012244550C1 (en) | 2011-04-21 | 2017-06-22 | Origenis Gmbh | Pyrazolo [4, 3-d] pyrimidines useful as kinase inhibitors |
| US9637491B2 (en) | 2012-10-19 | 2017-05-02 | Origenis Gmbh | Pyrazolo[4,3-D]pyrimidines as kinase inhibitors |
| CN104755086A (zh) * | 2012-10-23 | 2015-07-01 | 辉瑞公司 | 四取代的吡唑并[4,3-d]嘧啶化合物用于治疗糖尿病肾病的用途 |
| AU2015302271B2 (en) | 2014-08-12 | 2019-02-28 | Children’s Hospital of Philadelphia | Methods of improving myocardial performance in fontan patients using udenafil compositions |
| AU2020356193A1 (en) | 2019-09-24 | 2022-05-19 | Children's Hospital Of Philadelphia | Methods of improving exercise performance, single ventricular performance, and myocardial performance index (MPI) in single ventricle heart disease, using udenafil compositions |
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| JP2002514162A (ja) | 1996-07-08 | 2002-05-14 | デュポン ファーマシューティカルズ カンパニー | Ｘａ因子阻害薬およびトロンビン阻害薬としてのアミジノインドール類、アミジノアゾール類、およびそれらの類似体 |
| EP1371647B1 (de) | 1998-04-20 | 2005-07-13 | Pfizer Inc. | Pyridin-3-carbonsäurederivate und ihre Verwendung als Zwischenprodukte |
| GB9822238D0 (en) * | 1998-10-12 | 1998-12-09 | Pfizer Ltd | Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof |
| DE69911448T2 (de) | 1998-10-23 | 2004-04-08 | Pfizer Inc. | Pyrazolopyrimidinone, cgmp pde5 inhibitoren, zur behandlung von sexuellen funktionsstörungen |
| DE19942474A1 (de) | 1999-09-06 | 2001-03-15 | Merck Patent Gmbh | Pyrazolo[4,3-d]pyrimidine |
| RU2269523C2 (ru) | 2000-04-28 | 2006-02-10 | Акадиа Фармасьютикалз, Инк. | Мускариновые агонисты |
| DE10031584A1 (de) | 2000-06-29 | 2002-01-10 | Merck Patent Gmbh | 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine |
| WO2002016348A1 (en) | 2000-08-09 | 2002-02-28 | Astrazeneca Ab | Antiangiogenic bicyclic derivatives |
| ATE478872T1 (de) | 2002-03-28 | 2010-09-15 | Ustav Ex Botan Av Cr V V I I O | Pyrazoloä4,3-düpyrimidine, verfahren zu ihrer herstellung und therapeutische anwendung |
| EA008596B1 (ru) * | 2003-04-29 | 2007-06-29 | Пфайзер Инк. | 5,7-ДИАМИНОПИРАЗОЛО[4,3-d]ПИРИМИДИНЫ, ПОЛЕЗНЫЕ ПРИ ЛЕЧЕНИИ ГИПЕРТЕНЗИИ |
| WO2004103407A2 (en) | 2003-05-22 | 2004-12-02 | Altana Pharma Ag | Composition comprising a pde4 inhibitor and a pde5 inhibitor |
| EP1687002A4 (de) | 2003-11-10 | 2008-07-23 | Synta Pharmaceuticals Corp | Kondensierte heterozyklische verbindungen |
| GB0327319D0 (en) * | 2003-11-24 | 2003-12-24 | Pfizer Ltd | Novel pharmaceuticals |
| GB0327323D0 (en) * | 2003-11-24 | 2003-12-31 | Pfizer Ltd | Novel pharmaceuticals |
| DK1742950T3 (da) * | 2004-04-07 | 2009-03-16 | Pfizer Ltd | Pyrazolo-[4,3-D]-pyrimidiner |
| WO2006014325A2 (en) | 2004-07-02 | 2006-02-09 | Exelixis, Inc. | C-met modulators and method of use |
| JP2008517994A (ja) * | 2004-10-28 | 2008-05-29 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 新規医薬品 |
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