MA29943B1 - Derives de pyrazolo[4,3-d] pyrimidine-5-yle utilises comme inhibiteurs de pde5 - Google Patents
Derives de pyrazolo[4,3-d] pyrimidine-5-yle utilises comme inhibiteurs de pde5Info
- Publication number
- MA29943B1 MA29943B1 MA30918A MA30918A MA29943B1 MA 29943 B1 MA29943 B1 MA 29943B1 MA 30918 A MA30918 A MA 30918A MA 30918 A MA30918 A MA 30918A MA 29943 B1 MA29943 B1 MA 29943B1
- Authority
- MA
- Morocco
- Prior art keywords
- pyrazolo
- yle
- pyrimidine
- derivatives
- formula
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract
LA PRÉSENTE INVENTION CONCERNE UN ACIDE 1-(1-(2-ÉTHOXYÉTHYL-3-ÉTHYL-7-(4-MÉTHYLPYRIDIN-2- YLAMINO)-LH-PYRAZOLO[4,3-D]PYRIMIDIN-5-YL)PIPÉRIDINE 4-CARBOXYLIQUE REPRÉSENTÉ PAR LA FORMULE (I) ET SES SELS. L'INVENTION CONCERNE ÉGALEMENT DES COMPOSITIONS PHARMACEUTIQUES, DES MÉTHODES DE TRAITEMENT ET DES PROCÉDÉS DE SYNTHÈSE CONCERNANT LA FORMULE (I). L'ACIDE REPRÉSENTÉ PAR LA FORMULE (I) ET SES SELS S'UTILISENT POUR INHIBER L'ENZYME PDE5.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73532005P | 2005-11-10 | 2005-11-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA29943B1 true MA29943B1 (fr) | 2008-11-03 |
Family
ID=37685872
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA30918A MA29943B1 (fr) | 2005-11-10 | 2008-05-09 | Derives de pyrazolo[4,3-d] pyrimidine-5-yle utilises comme inhibiteurs de pde5 |
Country Status (30)
Country | Link |
---|---|
US (2) | US20090156618A1 (fr) |
EP (1) | EP1948661B1 (fr) |
JP (1) | JP4208959B1 (fr) |
KR (1) | KR101012592B1 (fr) |
CN (1) | CN101305007B (fr) |
AP (1) | AP2008004437A0 (fr) |
AR (1) | AR057885A1 (fr) |
AT (1) | ATE435865T1 (fr) |
AU (1) | AU2006313486B2 (fr) |
BR (1) | BRPI0618284A2 (fr) |
CA (1) | CA2629339C (fr) |
CR (1) | CR9966A (fr) |
DE (1) | DE602006007728D1 (fr) |
DK (1) | DK1948661T3 (fr) |
DO (1) | DOP2006000248A (fr) |
EA (1) | EA200800920A1 (fr) |
EC (1) | ECSP088441A (fr) |
ES (1) | ES2326919T3 (fr) |
HK (1) | HK1120803A1 (fr) |
IL (1) | IL190456A (fr) |
MA (1) | MA29943B1 (fr) |
NL (1) | NL2000291C2 (fr) |
NO (1) | NO20082593L (fr) |
PE (1) | PE20070764A1 (fr) |
RS (1) | RS20080197A (fr) |
TN (1) | TNSN08209A1 (fr) |
TW (1) | TW200738723A (fr) |
UY (1) | UY29909A1 (fr) |
WO (1) | WO2007054778A1 (fr) |
ZA (1) | ZA200803173B (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2732628A1 (fr) * | 2008-08-01 | 2010-02-04 | Biocryst Pharmaceuticals, Inc. | Agents therapeutiques |
WO2010043633A1 (fr) * | 2008-10-15 | 2010-04-22 | Palau Pharma, S. A. | Dérivés de 2h-pyrazolo[4,3-d]pyrimidin-5-amine utilisés comme antagonistes des récepteurs h4 de l'histamine pour le traitement de maladies allergiques, immunologiques et inflammatoires |
WO2011126250A2 (fr) * | 2010-04-05 | 2011-10-13 | 에스케이케미칼 주식회사 | Composition contenant un inhibiteur de pde5 pour l'atténuation des rides de la peau |
WO2012118042A1 (fr) * | 2011-02-28 | 2012-09-07 | 独立行政法人国立循環器病研究センター | Agent médicinal pour l'inhibition de la métastase d'une tumeur maline |
MX363696B (es) | 2011-04-21 | 2019-03-28 | Origenis Gmbh | Pirazolo[4,3-d]pirimidinas utiles como inhibidores de cinasas. |
WO2014060112A1 (fr) | 2012-10-19 | 2014-04-24 | Origenis Gmbh | Pyrazolo[4,3-d]pyrimidines utiles en tant qu'inhibiteurs de kinases |
CN104755086A (zh) * | 2012-10-23 | 2015-07-01 | 辉瑞公司 | 四取代的吡唑并[4,3-d]嘧啶化合物用于治疗糖尿病肾病的用途 |
KR20240122604A (ko) | 2014-08-12 | 2024-08-12 | 주식회사 메지온 | 유데나필 조성물을 이용하여 폰탄 환자에서 심근 성능을 개선시키는 방법 |
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JP2002514162A (ja) | 1996-07-08 | 2002-05-14 | デュポン ファーマシューティカルズ カンパニー | Xa因子阻害薬およびトロンビン阻害薬としてのアミジノインドール類、アミジノアゾール類、およびそれらの類似体 |
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GB9822238D0 (en) * | 1998-10-12 | 1998-12-09 | Pfizer Ltd | Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof |
CA2347950C (fr) | 1998-10-23 | 2005-05-03 | Pfizer Inc. | Inhibiteurs de cgmp pde5 de pyrazolopyrimidinone servant a traiter le dysfonctionnement sexuel |
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WO2002016348A1 (fr) | 2000-08-09 | 2002-02-28 | Astrazeneca Ab | Derives bicycliques antiangiogeniques |
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GEP20084329B (en) * | 2003-04-29 | 2008-03-25 | Pfizer Ltd | 5,7-diaminopyrazolo [4,3-d] pyrimidines useful in the treatment of hypertension |
RS52730B (sr) | 2003-05-22 | 2013-08-30 | Takeda Gmbh | Kompozicija koja sadrži pde4 inhibitor i pde5 inhibitor |
AU2004289303A1 (en) | 2003-11-10 | 2005-05-26 | Synta Pharmaceuticals, Corp. | Fused heterocyclic compounds |
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