ECSP088441A - Derivados de pirazolo [4,3-d]pirimidin-5-il usados como inhibidores de pde5 - Google Patents

Derivados de pirazolo [4,3-d]pirimidin-5-il usados como inhibidores de pde5

Info

Publication number
ECSP088441A
ECSP088441A EC2008008441A ECSP088441A ECSP088441A EC SP088441 A ECSP088441 A EC SP088441A EC 2008008441 A EC2008008441 A EC 2008008441A EC SP088441 A ECSP088441 A EC SP088441A EC SP088441 A ECSP088441 A EC SP088441A
Authority
EC
Ecuador
Prior art keywords
pirazolo
pirimidin
derivatives
pde5 inhibitors
pyrazolo
Prior art date
Application number
EC2008008441A
Other languages
English (en)
Inventor
Michael B Tollefson
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of ECSP088441A publication Critical patent/ECSP088441A/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

La presente invención comprende el ácido 1-(1-(2-etoxietil)-3-etil-7-4(4-metilpiridin-2-ilamino)-1H-pirazolo[4,3-d]pirimidin-5-il)piperidina-4-carboxilico y sus sales. La invención además comprende las composiciones farmacéuticas, los procedimientos de tratamiento, y los procedimientos de síntesis que se refieren al ácido 1-(1-(2-etoxietil)-3-etil-7-(4-metilpiridin-2-ilamino)-1H-pirazolo [4,3-d]pirimidin-5-il)piperidina-4-carboxilico y sus sales.
EC2008008441A 2005-11-10 2008-05-08 Derivados de pirazolo [4,3-d]pirimidin-5-il usados como inhibidores de pde5 ECSP088441A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73532005P 2005-11-10 2005-11-10

Publications (1)

Publication Number Publication Date
ECSP088441A true ECSP088441A (es) 2008-06-30

Family

ID=37685872

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008441A ECSP088441A (es) 2005-11-10 2008-05-08 Derivados de pirazolo [4,3-d]pirimidin-5-il usados como inhibidores de pde5

Country Status (29)

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US (2) US20090156618A1 (es)
EP (1) EP1948661B1 (es)
JP (1) JP4208959B1 (es)
KR (1) KR101012592B1 (es)
CN (1) CN101305007B (es)
AP (1) AP2008004437A0 (es)
AR (1) AR057885A1 (es)
AT (1) ATE435865T1 (es)
AU (1) AU2006313486B2 (es)
BR (1) BRPI0618284A2 (es)
CA (1) CA2629339C (es)
CR (1) CR9966A (es)
DE (1) DE602006007728D1 (es)
DK (1) DK1948661T3 (es)
DO (1) DOP2006000248A (es)
EA (1) EA200800920A1 (es)
EC (1) ECSP088441A (es)
ES (1) ES2326919T3 (es)
IL (1) IL190456A (es)
MA (1) MA29943B1 (es)
NL (1) NL2000291C2 (es)
NO (1) NO20082593L (es)
PE (1) PE20070764A1 (es)
RS (1) RS20080197A (es)
TN (1) TNSN08209A1 (es)
TW (1) TW200738723A (es)
UY (1) UY29909A1 (es)
WO (1) WO2007054778A1 (es)
ZA (1) ZA200803173B (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10653698B2 (en) 2014-08-12 2020-05-19 Mezzion Pharma Co., Ltd. Methods of improving myocardial performance in Fontan patients using udenafil compositions
US12576081B2 (en) 2019-09-24 2026-03-17 Mezzion Pharma Co., Ltd. Methods and compositions for improving exercise performance, single ventricular performance, cardiac output and myocardial performance index (MPI) in single ventricular heart disease, using udenafil compositions

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110165183A1 (en) * 2008-08-01 2011-07-07 Biocryst Pharmaceuticals, Inc. Piperidine derivatives as jak3 inhibitors
WO2010043633A1 (en) * 2008-10-15 2010-04-22 Palau Pharma, S. A. 2h-pyrazolo [4,3-d]pyrimidin-5-amine derivatives as h4 histamine receptor antagonists for the treatment of allergic, immunological and inflammatory diseases
CN102970965A (zh) * 2010-04-05 2013-03-13 Sk化学公司 含有pde5抑制剂的减少皮肤皱纹的合成物
EP3189835B1 (en) * 2011-02-28 2018-07-25 National Cerebral and Cardiovascular Center Medical agent for suppressing malignant tumor metastasis
MX363696B (es) 2011-04-21 2019-03-28 Origenis Gmbh Pirazolo[4,3-d]pirimidinas utiles como inhibidores de cinasas.
WO2014060112A1 (en) 2012-10-19 2014-04-24 Origenis Gmbh Pyrazolo[4,3-d]pyrimidines as kinase inhibitors
WO2014064566A1 (en) * 2012-10-23 2014-05-01 Pfizer Inc. Use of a tetrasubstituted pyrazolo[4,3-d]pyrimidine compound for treating diabetic nephropathy

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002514162A (ja) 1996-07-08 2002-05-14 デュポン ファーマシューティカルズ カンパニー Ｘａ因子阻害薬およびトロンビン阻害薬としてのアミジノインドール類、アミジノアゾール類、およびそれらの類似体
HRP20000712A2 (en) 1998-04-20 2001-06-30 Pfizer PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION
GB9822238D0 (en) * 1998-10-12 1998-12-09 Pfizer Ltd Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof
EP1123296B1 (en) 1998-10-23 2003-09-17 Pfizer Limited PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION
DE19942474A1 (de) 1999-09-06 2001-03-15 Merck Patent Gmbh Pyrazolo[4,3-d]pyrimidine
CN1249051C (zh) 2000-04-28 2006-04-05 阿卡蒂亚药品公司 毒蕈碱性激动剂
DE10031584A1 (de) 2000-06-29 2002-01-10 Merck Patent Gmbh 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine
WO2002016348A1 (en) 2000-08-09 2002-02-28 Astrazeneca Ab Antiangiogenic bicyclic derivatives
ATE478872T1 (de) 2002-03-28 2010-09-15 Ustav Ex Botan Av Cr V V I I O Pyrazoloä4,3-düpyrimidine, verfahren zu ihrer herstellung und therapeutische anwendung
EA008596B1 (ru) * 2003-04-29 2007-06-29 Пфайзер Инк. 5,7-ДИАМИНОПИРАЗОЛО[4,3-d]ПИРИМИДИНЫ, ПОЛЕЗНЫЕ ПРИ ЛЕЧЕНИИ ГИПЕРТЕНЗИИ
EA012279B1 (ru) 2003-05-22 2009-08-28 Никомед Гмбх Композиция, включающая ингибитор pde4 и ингибитор pde5
AU2004289303A1 (en) 2003-11-10 2005-05-26 Synta Pharmaceuticals, Corp. Fused heterocyclic compounds
GB0327319D0 (en) * 2003-11-24 2003-12-24 Pfizer Ltd Novel pharmaceuticals
GB0327323D0 (en) * 2003-11-24 2003-12-31 Pfizer Ltd Novel pharmaceuticals
DE602005011784D1 (de) * 2004-04-07 2009-01-29 Pfizer Pyrazoloä4,3-düpyrimidine
CA2572331A1 (en) 2004-07-02 2006-02-09 Exelixis, Inc. C-met modulators and method of use
JP2008517994A (ja) * 2004-10-28 2008-05-29 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 新規医薬品

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10653698B2 (en) 2014-08-12 2020-05-19 Mezzion Pharma Co., Ltd. Methods of improving myocardial performance in Fontan patients using udenafil compositions
US12048701B2 (en) 2014-08-12 2024-07-30 Mezzion Pharma Co., Ltd. Methods of improving myocardial performance in Fontan patients using udenafil compositions
US12576081B2 (en) 2019-09-24 2026-03-17 Mezzion Pharma Co., Ltd. Methods and compositions for improving exercise performance, single ventricular performance, cardiac output and myocardial performance index (MPI) in single ventricular heart disease, using udenafil compositions

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