ATE490254T1 - Imidazoä1,2-aüpyridin-verbindungen als vegf-r2- hemmer - Google Patents

Imidazoä1,2-aüpyridin-verbindungen als vegf-r2- hemmer

Info

Publication number
ATE490254T1
ATE490254T1 AT06735794T AT06735794T ATE490254T1 AT E490254 T1 ATE490254 T1 AT E490254T1 AT 06735794 T AT06735794 T AT 06735794T AT 06735794 T AT06735794 T AT 06735794T AT E490254 T1 ATE490254 T1 AT E490254T1
Authority
AT
Austria
Prior art keywords
imidazoä1
aüpyridine
vegf
inhibitors
compounds
Prior art date
Application number
AT06735794T
Other languages
English (en)
Inventor
David Barda
Timothy Burkholder
Joshua Clayton
Yan Hao
Perry Heath
James Henry
John Knobeloch
David Mendel
Johnathan Mclean
David Remick
Mark Rempala
Zhao-Qing Wang
Yvonne Yip
Boyu Zhong
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE490254T1 publication Critical patent/ATE490254T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT06735794T 2005-02-24 2006-02-23 Imidazoä1,2-aüpyridin-verbindungen als vegf-r2- hemmer ATE490254T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65598105P 2005-02-24 2005-02-24
PCT/US2006/006283 WO2006091671A1 (en) 2005-02-24 2006-02-23 Imidazo (1, 2-a) pyridine compounds as vegf-r2 inhibitors

Publications (1)

Publication Number Publication Date
ATE490254T1 true ATE490254T1 (de) 2010-12-15

Family

ID=36587138

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06735794T ATE490254T1 (de) 2005-02-24 2006-02-23 Imidazoä1,2-aüpyridin-verbindungen als vegf-r2- hemmer

Country Status (33)

Country Link
US (1) US7666879B2 (de)
EP (1) EP1904494B1 (de)
JP (1) JP5055136B2 (de)
KR (1) KR100904938B1 (de)
CN (1) CN101128461B (de)
AR (1) AR056186A1 (de)
AT (1) ATE490254T1 (de)
AU (1) AU2006216710B2 (de)
BR (1) BRPI0609047A2 (de)
CA (1) CA2599124C (de)
CR (1) CR9331A (de)
CY (1) CY1111154T1 (de)
DE (1) DE602006018615D1 (de)
DK (1) DK1904494T3 (de)
DO (1) DOP2006000051A (de)
EA (1) EA011691B1 (de)
ES (1) ES2354716T3 (de)
HR (1) HRP20100677T1 (de)
IL (1) IL184717A (de)
MA (1) MA29433B1 (de)
MX (1) MX2007010326A (de)
NO (1) NO20074666L (de)
NZ (2) NZ560402A (de)
PE (1) PE20061098A1 (de)
PL (1) PL1904494T3 (de)
PT (1) PT1904494E (de)
RS (1) RS51590B (de)
SI (1) SI1904494T1 (de)
TN (1) TNSN07323A1 (de)
TW (1) TW200640924A (de)
UA (1) UA91535C2 (de)
WO (1) WO2006091671A1 (de)
ZA (1) ZA200707136B (de)

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US8131527B1 (en) 2006-12-22 2012-03-06 Astex Therapeutics Ltd. FGFR pharmacophore compounds
EP2126574B1 (de) 2007-03-08 2015-12-23 The Board of Trustees of the Leland Stanford Junior University Mitochondriale aldehyd-dehydrogenase-2-modulatoren und verwendungsverfahren dafür
GB0720038D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New compounds
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GB0810902D0 (en) 2008-06-13 2008-07-23 Astex Therapeutics Ltd New compounds
WO2010028175A1 (en) 2008-09-08 2010-03-11 The Board Of Trustees Of The Leland Stanford Junior University Modulators of aldehyde dehydrogenase activity and methods of use thereof
EP2349279A4 (de) 2008-10-28 2013-12-25 Univ Leland Stanford Junior Aldehyddehydrogenase-modulatoren und anwendungsverfahren dafür
JO3265B1 (ar) 2008-12-09 2018-09-16 Novartis Ag مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض
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KR20150135332A (ko) 2013-03-14 2015-12-02 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 미토콘드리아 알데히드 탈수소효소-2 조절인자들 및 이들의 사용 방법
JP6616772B2 (ja) 2013-12-16 2019-12-04 アサナ・バイオサイエンシズ,リミテッド・ライアビリティ・カンパニー P2x3および/またはp2x2/3化合物ならびに方法
CN103772308B (zh) * 2013-12-31 2015-11-18 北京颖泰嘉和生物科技股份有限公司 5-氨基-3-(1-乙基-1-甲基丙基)异噁唑中间体的制备方法和异噁草胺的制备方法
CN107074778B (zh) * 2014-06-03 2019-12-13 代表亚利桑那大学的亚利桑那校董会 苯并咪唑类似物和相关方法
ES2747249T3 (es) 2014-07-17 2020-03-10 Sunshine Lake Pharma Co Ltd Derivados de 1-(5-(terc-butil)isoxazol-3-il)-3-(4-((fenil)etinil)fenil)urea y compuestos relacionados como inhibidores de FLT3 para el tratamiento de cáncer
CN104163790B (zh) * 2014-08-19 2016-02-10 贵州威顿晶磷电子材料股份有限公司 一种2-氨基-4-甲基-5溴吡啶的制备工艺
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AU2016315881B2 (en) 2015-09-03 2019-09-19 The Arizona Board Of Regents On Behalf Of The University Of Arizona Small molecule inhibitors of DYRK1A and uses thereof
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Also Published As

Publication number Publication date
MX2007010326A (es) 2007-10-16
PT1904494E (pt) 2010-12-23
DK1904494T3 (da) 2011-02-21
DE602006018615D1 (de) 2011-01-13
CR9331A (es) 2008-03-31
US7666879B2 (en) 2010-02-23
AU2006216710B2 (en) 2011-08-11
JP5055136B2 (ja) 2012-10-24
CN101128461A (zh) 2008-02-20
CA2599124C (en) 2013-08-06
EA011691B1 (ru) 2009-04-28
TW200640924A (en) 2006-12-01
SI1904494T1 (sl) 2011-02-28
NZ584753A (en) 2011-06-30
IL184717A0 (en) 2007-12-03
EP1904494B1 (de) 2010-12-01
UA91535C2 (en) 2010-08-10
US20090227622A1 (en) 2009-09-10
HRP20100677T1 (hr) 2011-01-31
AU2006216710A1 (en) 2006-08-31
IL184717A (en) 2011-11-30
BRPI0609047A2 (pt) 2010-11-16
EA200701802A1 (ru) 2008-02-28
NZ560402A (en) 2010-06-25
PL1904494T3 (pl) 2011-04-29
MA29433B1 (fr) 2008-05-02
ZA200707136B (en) 2008-11-26
WO2006091671A1 (en) 2006-08-31
NO20074666L (no) 2007-11-09
HK1118284A1 (en) 2009-02-06
KR20070099029A (ko) 2007-10-08
AR056186A1 (es) 2007-09-26
EP1904494A1 (de) 2008-04-02
DOP2006000051A (es) 2006-08-31
CN101128461B (zh) 2010-12-22
CY1111154T1 (el) 2015-06-11
RS51590B (sr) 2011-08-31
TNSN07323A1 (en) 2008-12-31
PE20061098A1 (es) 2006-10-20
ES2354716T3 (es) 2011-03-17
JP2008531574A (ja) 2008-08-14
CA2599124A1 (en) 2006-08-31
KR100904938B1 (ko) 2009-06-29

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