AR090566A1 - Proceso para la produccion de inhibidores de crr - Google Patents

Proceso para la produccion de inhibidores de crr

Info

Publication number
AR090566A1
AR090566A1 ARP130101059A ARP130101059A AR090566A1 AR 090566 A1 AR090566 A1 AR 090566A1 AR P130101059 A ARP130101059 A AR P130101059A AR P130101059 A ARP130101059 A AR P130101059A AR 090566 A1 AR090566 A1 AR 090566A1
Authority
AR
Argentina
Prior art keywords
formula
inhibitors
crr
production
alkyl
Prior art date
Application number
ARP130101059A
Other languages
English (en)
Inventor
Duran Adil
Schmid Rolf
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP12162852 priority Critical
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR090566A1 publication Critical patent/AR090566A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

Proceso para preparar inhibidores de CCR3. Reivindicación 1: Un proceso para preparar compuestos de la fórmula (1) caracterizado porque a) un compuesto de la fórmula (2) se hace reaccionar con NHR¹R² en un compuesto de la fórmula (3) y b) después de ello, se acopla con un compuesto de la fórmula (4), en donde para las fórmulas (1), (3) y NHR¹R², de modo dependiente entre sí R¹ es H, alquilo C₁₋₆, alquil C₀₋₄-cicloalquilo C₃₋₆, haloalquilo C₁₋₆; R² es H, alquilo C₁₋₆; X es un anión seleccionado del grupo que consiste en cloruro o ½ dibenzoiltartrato; j es 1 ó 2.
ARP130101059A 2012-04-02 2013-03-27 Proceso para la produccion de inhibidores de crr AR090566A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP12162852 2012-04-02

Publications (1)

Publication Number Publication Date
AR090566A1 true AR090566A1 (es) 2014-11-19

Family

ID=47998462

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP130101059A AR090566A1 (es) 2012-04-02 2013-03-27 Proceso para la produccion de inhibidores de crr

Country Status (9)

Country Link
US (1) US8680280B2 (es)
EP (1) EP2834229B1 (es)
JP (1) JP6255550B2 (es)
AR (1) AR090566A1 (es)
DK (1) DK2834229T3 (es)
ES (1) ES2641862T3 (es)
TW (1) TW201400474A (es)
UY (1) UY34719A (es)
WO (1) WO2013149926A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8278302B2 (en) 2009-04-08 2012-10-02 Boehringer Ingelheim International Gmbh Substituted piperidines as CCR3 antagonists
JP5794713B2 (ja) 2010-10-07 2015-10-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ccr3インヒビターの共結晶及び塩
US8680280B2 (en) 2012-04-02 2014-03-25 Boehringer Ingelheim International Gmbh Process for the manufacturing of CRR inhibitors
US10213421B2 (en) 2012-04-04 2019-02-26 Alkahest, Inc. Pharmaceutical formulations comprising CCR3 antagonists
CA3058654A1 (en) 2017-04-05 2018-10-11 Alkahest Inc. Methods and compositions for treating retina-associated disease using ccr3-inhibitors

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7907121L (sv) 1979-08-27 1981-02-28 Astra Laekemedel Ab Ftalimidinderivat
JP2807577B2 (ja) 1990-06-15 1998-10-08 エーザイ株式会社 環状アミド誘導体
JPH08134041A (ja) * 1994-11-10 1996-05-28 Fuji Photo Film Co Ltd ピラゾールアミド類の製造方法
AU2335699A (en) 1998-01-21 1999-08-09 Kyowa Hakko Kogyo Co. Ltd. Chemokine receptor antagonists and methods of use therefor
US6140349A (en) 1998-02-02 2000-10-31 Merck & Co., Inc. Cyclic amine modulators of chemokine receptor activity
AU2654399A (en) 1998-02-02 1999-08-16 Merck & Co., Inc. Cyclic amine modulators of chemokine receptor activity
CN1946402A (zh) 2004-02-05 2007-04-11 先灵公司 用作ccr3拮抗剂的哌啶衍生物
JP2006137718A (ja) 2004-11-12 2006-06-01 Astellas Pharma Inc インドール若しくはインダゾール誘導体
US8030003B2 (en) 2004-12-07 2011-10-04 Children's Hospital Medical Center Diagnosis of eosinophilic esophagitis based on presence of an elevated level of eotaxin-3
DOP2006000051A (es) 2005-02-24 2006-08-31 Lilly Co Eli Inhibidores de vegf-r2 y métodos
WO2007116313A2 (en) 2006-04-12 2007-10-18 Pfizer Limited Pyrrolidine derivatives as modulators of chemokine ccr5 receptors
GB0701992D0 (en) 2007-02-02 2007-03-14 7Tm Pharma As Grehlin Receptor Modulators
US8008092B2 (en) 2007-10-09 2011-08-30 University Of Kentucky Research Foundation CCR3 inhibition for ocular angiogenesis and macular degeneration
TW201000446A (en) 2008-05-30 2010-01-01 Astrazeneca Ab New compounds useful in pain therapy
US8278302B2 (en) 2009-04-08 2012-10-02 Boehringer Ingelheim International Gmbh Substituted piperidines as CCR3 antagonists
JP5794713B2 (ja) 2010-10-07 2015-10-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ccr3インヒビターの共結晶及び塩
US8680280B2 (en) 2012-04-02 2014-03-25 Boehringer Ingelheim International Gmbh Process for the manufacturing of CRR inhibitors
US20130261153A1 (en) 2012-04-03 2013-10-03 Boehringer Ingelheim International Gmbh Use of ccr3-inhibitors
US10213421B2 (en) 2012-04-04 2019-02-26 Alkahest, Inc. Pharmaceutical formulations comprising CCR3 antagonists

Also Published As

Publication number Publication date
DK2834229T3 (da) 2017-11-20
US20130261307A1 (en) 2013-10-03
JP6255550B2 (ja) 2018-01-10
UY34719A (es) 2013-10-31
TW201400474A (zh) 2014-01-01
US8680280B2 (en) 2014-03-25
EP2834229A1 (en) 2015-02-11
EP2834229B1 (en) 2017-08-09
JP2015516959A (ja) 2015-06-18
WO2013149926A1 (en) 2013-10-10
ES2641862T3 (es) 2017-11-14

Similar Documents

Publication Publication Date Title
AR090566A1 (es) Proceso para la produccion de inhibidores de crr
BR112016018851A8 (pt) processo para fornecer um composto de fórmula (iv)
SA516370979B1 (ar) عملية لتحضير مركبات ألومينوكسان بواسطة تفاعل ألكيل ألومنيوم مع كحولات أليلية
MX2017012184A (es) Metodo para manufacturar compuesto novedoso que contiene nitrogeno o sal del mismo e intermediario de manufacturacion del compuesto novedoso que contiene nitrogeno o sal del mismo.
MX2016000390A (es) Proceso para fabricar haloacetamidas.
MX2014014138A (es) Procedimiento nuevo para la preparacion de acido 2-ciclopentil-6-metoxi-isonicotinico.
CR20160030A (es) Nuevos compuestos isoindolina o isoquinolina, un proceso para su preparación y composiciones farmacéuticas que los contienen
MX2016016917A (es) Agente fluoroalquilante.
AR092355A1 (es) Fluoruros de fluoropicolinoilo y procesos para su preparacion
TN2014000329A1 (en) Method for preparing compound by novel michael addition reaction using water or various acids as additive
MX2016005223A (es) Tinturas dispersas, su preparacion y su uso.
AR088358A1 (es) Proceso de obtencion de acidos isoxazolil-metoxi-nicotinicos
BR112015019305A2 (pt) processo para a produção de composto de piridazinona e seus intermediários de produção
GB2523674A (en) Compounds as inhibitor of DNA double-strand break repair, methods and applications thereof
AR107549A1 (es) Un proceso para preparar compuesto de pirrolo[3,2-d]pirimidina y su intermediario
MX2017004815A (es) Metodo para la polimeracion de acido (met)acrilico en solucion.
SG10201901578UA (en) Processes for the preparation of pyrimidinylcyclopentane compounds
BR112013024314A2 (pt) derivados quinolina como fungicidas
PH12015501840A1 (en) Production method of pyridazinone compounds
UY35503A (es) Titulo: procedimiento de síntesis de derivados de la 7,8-dimetoxi-1,3 -dihidro-2h-3- benzazepin -2- ona y aplicación a la síntesis de la ivabradina
MX2015015346A (es) Procedimiento para la preparacion de intermediarios de acido boronico.
MX2015017747A (es) Proceso para producir 2-fenil-1, 3-benzoxazoles.
IN2014DN10440A (es)
AR107109A1 (es) Proceso para elaborar crotonilaminopiridinas
PH12017502146A1 (en) Process for preparing carbazoles

Legal Events

Date Code Title Description
FB Suspension of granting procedure