BRPI0518158A - tiazolinonas de azaindol como agentes anti-cáncer - Google Patents
tiazolinonas de azaindol como agentes anti-cáncerInfo
- Publication number
- BRPI0518158A BRPI0518158A BRPI0518158-5A BRPI0518158A BRPI0518158A BR PI0518158 A BRPI0518158 A BR PI0518158A BR PI0518158 A BRPI0518158 A BR PI0518158A BR PI0518158 A BRPI0518158 A BR PI0518158A
- Authority
- BR
- Brazil
- Prior art keywords
- cancer agents
- thiazolinones
- azaindol
- cdk1
- azaindole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
TIAZOLINONAS DE AZAINDOL COMO AGENTES ANTI-CáNCER. A presente invenção descreve derivados de tíazolinona de azaindol da fórmula geral I que demonstram atividade antiproliferativa de CDKI e CDK2 e são úteis como agentes anti-câncer; processos para a fabricação dos referidos compostos, bem como medicamentos contendo-os.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61867204P | 2004-10-14 | 2004-10-14 | |
PCT/EP2005/010702 WO2006040049A1 (en) | 2004-10-14 | 2005-10-05 | Novel azaindole thiazolinones as anti-cancer agents |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0518158A true BRPI0518158A (pt) | 2008-11-04 |
Family
ID=35423339
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0518158-5A BRPI0518158A (pt) | 2004-10-14 | 2005-10-05 | tiazolinonas de azaindol como agentes anti-cáncer |
Country Status (15)
Country | Link |
---|---|
US (1) | US7247727B2 (pt) |
EP (1) | EP1805175B1 (pt) |
JP (1) | JP2008516903A (pt) |
KR (1) | KR100875870B1 (pt) |
CN (1) | CN100569773C (pt) |
AT (1) | ATE388149T1 (pt) |
AU (1) | AU2005293831B2 (pt) |
BR (1) | BRPI0518158A (pt) |
CA (1) | CA2582986A1 (pt) |
DE (1) | DE602005005211T2 (pt) |
ES (1) | ES2301066T3 (pt) |
MX (1) | MX2007004273A (pt) |
PL (1) | PL1805175T3 (pt) |
RU (1) | RU2391342C2 (pt) |
WO (1) | WO2006040049A1 (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7371862B2 (en) * | 2005-11-11 | 2008-05-13 | Pfizer Italia S.R.L. | Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
FR2907120B1 (fr) * | 2006-10-12 | 2013-01-11 | Sanofi Aventis | Nouveaux derives imidazolones,leur preparation a titre de medicaments,compositions pharmaceutiques,utilisation comme inhibiteurs de proteines kinases notamment cdc7 |
FR2926463B1 (fr) * | 2008-01-22 | 2010-08-13 | Centre Nat Rech Scient | Utilisation d'inhibiteurs d'aminopeptidase ou de composes azaindole pour la prevention ou le traitement de metastases cancereuses d'origine epitheliale |
JP2013533844A (ja) * | 2010-06-29 | 2013-08-29 | Sbiバイオテック株式会社 | アザインドール誘導体 |
USRE48140E1 (en) * | 2011-03-31 | 2020-08-04 | Carna Biosciences, Inc. | Furanone derivative |
KR101277161B1 (ko) | 2011-07-08 | 2013-06-20 | 주식회사 엠엠테크 | 글라스 박형화 시스템 |
EP2974726A4 (en) * | 2013-03-14 | 2017-01-04 | Tiacen Ltd | Agent for the prophylaxis and/or treatment of neoplastic diseases |
RU2521390C1 (ru) * | 2013-03-14 | 2014-06-27 | Общество с ограниченной ответственностью "Тиацен" | Производное роданина и средство для профилактики опухолевых заболеваний |
JP6569908B2 (ja) | 2014-01-31 | 2019-09-04 | カルナバイオサイエンス株式会社 | 抗がん剤組成物 |
CN114945569A (zh) * | 2019-12-26 | 2022-08-26 | 延世大学校产学协力团 | 吡咯烷衍生物,以及包含其的用于预防或治疗β-淀粉样蛋白或Tau蛋白相关疾病的药物组合物 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2203517A1 (en) | 1994-11-10 | 1996-05-23 | Alan M. Laibelman | Pharmaceutical pyrazole compositions useful as inhibitors of protein kinases |
WO1997034876A1 (en) | 1996-03-15 | 1997-09-25 | Zeneca Limited | Cinnoline derivatives and use as medicine |
YU22400A (sh) | 1997-10-27 | 2003-08-29 | Agouron Pharmaceuticals Inc. | Supstituisana 4-amino-tiazol-2-i jedinjenja kao cdks inhibitori |
US6335342B1 (en) * | 2000-06-19 | 2002-01-01 | Pharmacia & Upjohn S.P.A. | Azaindole derivatives, process for their preparation, and their use as antitumor agents |
WO2003028724A1 (en) * | 2001-10-04 | 2003-04-10 | Smithkline Beecham Corporation | Chk1 kinase inhibitors |
AU2003255528B2 (en) * | 2002-07-10 | 2009-07-16 | Merck Serono Sa | Azolidinone-vinyl fused-benzene derivatives |
EP1551396A1 (en) * | 2002-09-26 | 2005-07-13 | Pintex Pharmaceuticals, Inc. | Pin1-modulating compounds and methods of use thereof |
KR20050085115A (ko) * | 2002-11-22 | 2005-08-29 | 스미스클라인 비참 코포레이션 | 신규 화합물 |
-
2005
- 2005-10-05 ES ES05796364T patent/ES2301066T3/es active Active
- 2005-10-05 CN CNB2005800346494A patent/CN100569773C/zh not_active Expired - Fee Related
- 2005-10-05 BR BRPI0518158-5A patent/BRPI0518158A/pt not_active IP Right Cessation
- 2005-10-05 RU RU2007117764/04A patent/RU2391342C2/ru not_active IP Right Cessation
- 2005-10-05 CA CA002582986A patent/CA2582986A1/en not_active Abandoned
- 2005-10-05 AU AU2005293831A patent/AU2005293831B2/en not_active Expired - Fee Related
- 2005-10-05 PL PL05796364T patent/PL1805175T3/pl unknown
- 2005-10-05 US US11/243,855 patent/US7247727B2/en not_active Expired - Fee Related
- 2005-10-05 DE DE602005005211T patent/DE602005005211T2/de active Active
- 2005-10-05 KR KR1020077008500A patent/KR100875870B1/ko not_active IP Right Cessation
- 2005-10-05 EP EP05796364A patent/EP1805175B1/en not_active Not-in-force
- 2005-10-05 JP JP2007536044A patent/JP2008516903A/ja active Pending
- 2005-10-05 AT AT05796364T patent/ATE388149T1/de active
- 2005-10-05 WO PCT/EP2005/010702 patent/WO2006040049A1/en active IP Right Grant
- 2005-10-05 MX MX2007004273A patent/MX2007004273A/es active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
CA2582986A1 (en) | 2006-04-20 |
MX2007004273A (es) | 2007-05-11 |
RU2007117764A (ru) | 2008-11-20 |
AU2005293831B2 (en) | 2011-01-06 |
US7247727B2 (en) | 2007-07-24 |
RU2391342C2 (ru) | 2010-06-10 |
EP1805175B1 (en) | 2008-03-05 |
EP1805175A1 (en) | 2007-07-11 |
KR20070053342A (ko) | 2007-05-23 |
KR100875870B1 (ko) | 2008-12-26 |
DE602005005211D1 (de) | 2008-04-17 |
CN101039943A (zh) | 2007-09-19 |
ATE388149T1 (de) | 2008-03-15 |
AU2005293831A1 (en) | 2006-04-20 |
DE602005005211T2 (de) | 2009-03-19 |
ES2301066T3 (es) | 2008-06-16 |
PL1805175T3 (pl) | 2008-08-29 |
JP2008516903A (ja) | 2008-05-22 |
WO2006040049A1 (en) | 2006-04-20 |
US20060084674A1 (en) | 2006-04-20 |
CN100569773C (zh) | 2009-12-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AO NAO RECOLHIMENTO DA 7A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2208 DE 30/04/2013. |