ATE388149T1 - Neue azaindol-thiazolinone als krebsmittel - Google Patents

Neue azaindol-thiazolinone als krebsmittel

Info

Publication number
ATE388149T1
ATE388149T1 AT05796364T AT05796364T ATE388149T1 AT E388149 T1 ATE388149 T1 AT E388149T1 AT 05796364 T AT05796364 T AT 05796364T AT 05796364 T AT05796364 T AT 05796364T AT E388149 T1 ATE388149 T1 AT E388149T1
Authority
AT
Austria
Prior art keywords
thiazolinones
azaindol
new
cancer medicine
cancer
Prior art date
Application number
AT05796364T
Other languages
English (en)
Inventor
Shaoqing Chen
Achyutharao Sidduri
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE388149T1 publication Critical patent/ATE388149T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT05796364T 2004-10-14 2005-10-05 Neue azaindol-thiazolinone als krebsmittel ATE388149T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61867204P 2004-10-14 2004-10-14

Publications (1)

Publication Number Publication Date
ATE388149T1 true ATE388149T1 (de) 2008-03-15

Family

ID=35423339

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05796364T ATE388149T1 (de) 2004-10-14 2005-10-05 Neue azaindol-thiazolinone als krebsmittel

Country Status (15)

Country Link
US (1) US7247727B2 (de)
EP (1) EP1805175B1 (de)
JP (1) JP2008516903A (de)
KR (1) KR100875870B1 (de)
CN (1) CN100569773C (de)
AT (1) ATE388149T1 (de)
AU (1) AU2005293831B2 (de)
BR (1) BRPI0518158A (de)
CA (1) CA2582986A1 (de)
DE (1) DE602005005211T2 (de)
ES (1) ES2301066T3 (de)
MX (1) MX2007004273A (de)
PL (1) PL1805175T3 (de)
RU (1) RU2391342C2 (de)
WO (1) WO2006040049A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7371862B2 (en) 2005-11-11 2008-05-13 Pfizer Italia S.R.L. Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
FR2907120B1 (fr) * 2006-10-12 2013-01-11 Sanofi Aventis Nouveaux derives imidazolones,leur preparation a titre de medicaments,compositions pharmaceutiques,utilisation comme inhibiteurs de proteines kinases notamment cdc7
FR2926463B1 (fr) * 2008-01-22 2010-08-13 Centre Nat Rech Scient Utilisation d'inhibiteurs d'aminopeptidase ou de composes azaindole pour la prevention ou le traitement de metastases cancereuses d'origine epitheliale
JP2013533844A (ja) * 2010-06-29 2013-08-29 Ｓｂｉバイオテック株式会社 アザインドール誘導体
CN103459388B (zh) * 2011-03-31 2015-11-25 卡尔那生物科学株式会社 新型呋喃酮衍生物
KR101277161B1 (ko) * 2011-07-08 2013-06-20 주식회사 엠엠테크 글라스 박형화 시스템
EP2974726A4 (de) * 2013-03-14 2017-01-04 Tiacen Ltd Mittel zur prophylaxe und/oder behandlung von neoplastischen krankheiten
RU2521390C1 (ru) * 2013-03-14 2014-06-27 Общество с ограниченной ответственностью "Тиацен" Производное роданина и средство для профилактики опухолевых заболеваний
JP6569908B2 (ja) 2014-01-31 2019-09-04 カルナバイオサイエンス株式会社 抗がん剤組成物
EP4083037A4 (de) * 2019-12-26 2024-01-24 Yonsei University, University-Industry Foundation(UIF). Pyrrolidinderivat und pharmazeutische zusammensetzung zur vorbeugung oder behandlung von beta-amyloid- oder tau-protein-assoziierten krankheiten, die diese enthalten
AU2022271290A1 (en) 2021-05-07 2023-11-23 Kymera Therapeutics, Inc. Cdk2 degraders and uses thereof
WO2026024674A1 (en) 2024-07-22 2026-01-29 Genesis Therapeutics, Inc. Methods of treating skp2-associated cancers

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2152385C1 (ru) * 1994-07-27 2000-07-10 Санкио Компани Лимитед Гетероциклические соединения, применимые в качестве аллостерических эффекторов при мускариновых рецепторах
DE69532817T2 (de) 1994-11-10 2005-01-13 Millenium Pharmaceuticals, Inc., Cambridge Verwendung von pyrazole verbindungen zur behandlung von glomerulonephritis, krebs, atherosklerose oder restenose
JP2000506880A (ja) 1996-03-15 2000-06-06 ゼネカ・リミテッド シンノリン誘導体及びその使用
UA66810C2 (uk) 1997-10-27 2004-06-15 Агорон Фармацевтикалз Інк. Похідні 4-амінотіазолу та композиції на їх основі як інгібітори циклінозалежних кіназ
US6335342B1 (en) * 2000-06-19 2002-01-01 Pharmacia & Upjohn S.P.A. Azaindole derivatives, process for their preparation, and their use as antitumor agents
WO2003028724A1 (en) * 2001-10-04 2003-04-10 Smithkline Beecham Corporation Chk1 kinase inhibitors
EA011807B1 (ru) * 2002-07-10 2009-06-30 Лаборатуар Сероно Са Азолидинонвинильные производные конденсированного бензола
JP2006500327A (ja) * 2002-07-10 2006-01-05 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 精子の運動性を増大させるための化合物の使用
WO2004028535A1 (en) * 2002-09-26 2004-04-08 Pintex Pharmaceuticals, Inc. Pin1-modulating compounds and methods of use thereof
JP2006509765A (ja) * 2002-11-22 2006-03-23 スミスクライン・ビーチャム・コーポレイション 新規化合物

Also Published As

Publication number Publication date
EP1805175B1 (de) 2008-03-05
MX2007004273A (es) 2007-05-11
ES2301066T3 (es) 2008-06-16
RU2007117764A (ru) 2008-11-20
US7247727B2 (en) 2007-07-24
BRPI0518158A (pt) 2008-11-04
WO2006040049A1 (en) 2006-04-20
DE602005005211T2 (de) 2009-03-19
PL1805175T3 (pl) 2008-08-29
KR20070053342A (ko) 2007-05-23
AU2005293831B2 (en) 2011-01-06
EP1805175A1 (de) 2007-07-11
RU2391342C2 (ru) 2010-06-10
CN101039943A (zh) 2007-09-19
DE602005005211D1 (de) 2008-04-17
AU2005293831A1 (en) 2006-04-20
CN100569773C (zh) 2009-12-16
KR100875870B1 (ko) 2008-12-26
CA2582986A1 (en) 2006-04-20
US20060084674A1 (en) 2006-04-20
JP2008516903A (ja) 2008-05-22

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