PE20070139A1 - DERIVADOS DE PIRIDO[2,3-d]PIRIMIDINA Y SU PREPARACION - Google Patents

DERIVADOS DE PIRIDO[2,3-d]PIRIMIDINA Y SU PREPARACION

Info

Publication number
PE20070139A1
PE20070139A1 PE2006000754A PE2006000754A PE20070139A1 PE 20070139 A1 PE20070139 A1 PE 20070139A1 PE 2006000754 A PE2006000754 A PE 2006000754A PE 2006000754 A PE2006000754 A PE 2006000754A PE 20070139 A1 PE20070139 A1 PE 20070139A1
Authority
PE
Peru
Prior art keywords
dimethylethyl
pyrimidin
urea
alkyl
pyrimidine
Prior art date
Application number
PE2006000754A
Other languages
English (en)
Inventor
Bernard Bourrie
Pierre Casellas
Claude Muneaux
Pierre Perreaut
Samir Jegham
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PE20070139A1 publication Critical patent/PE20070139A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Abstract

SE REFIERE A UN COMPUESTO DERIVADO DE PIRIDO[2,3-d]PIRIMIDINA DE FORMULA (I) DONDE R1 ES ALQUILO (C1-C6), ALQUIL(C1-C6)-CICLOALQUILO(C3-C7), CH2COR3, FENILO, ENTRE OTROS, DONDE R3 ES OH, ALCOXI(C1-C4), NH, ALQUILAMINO(C1-C4), ENTRE OTROS; Ar1 ES UN RADICAL DE FORMULA (e), (f), ENTRE OTROS; Ar2 ES FENILO OPCIONALMENTE SUSTITUIDO CON HALOGENO, ALQUILO(C1-C4), TRIFLUOROMETILO O ALCOXI(C1-C4). SON COMPUESTOS PREFERIDOS: N-[2-(2,1,3-BENZOTIADIAZOL-4-ILAMINO)-6-(2,6-DICLOROFENIL)PIRIDO[2,3-d]PIRIMIDIN-7-IL]-N'-(1,1-DIMETILETIL)-UREA, N-[6-(2,6-DICLOROFENIL)-2-[(1,3-DIHIDRO-2,2-DIOXIDO-2,1-BENZISOTIAZOL-5-IL)AMINO]PIRIDO[2,3-d]PIRIMIDIN-7-IL]-N'-(1,1-DIMETILETIL)-UREA, N-[6-(2,6-DICLOROFENIL)-2-[(2-METIL-6-BENZOXAZOLIL)AMINO]PIRIDO[2,3-d]PIRIMIDIN-7-IL]-N'-(1,1-DIMETILETIL)-UREA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA PROLIFERACION DE CELULAS TUMORALES SIENDO UTILES EN EL TRATAMIENTO DE LEUCEMIAS, CANCER DE MAMA, CANCER DE PULMON, ARTERIOESCLEROSIS
PE2006000754A 2005-07-01 2006-06-28 DERIVADOS DE PIRIDO[2,3-d]PIRIMIDINA Y SU PREPARACION PE20070139A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0507032A FR2887882B1 (fr) 2005-07-01 2005-07-01 Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique

Publications (1)

Publication Number Publication Date
PE20070139A1 true PE20070139A1 (es) 2007-03-07

Family

ID=36096420

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000754A PE20070139A1 (es) 2005-07-01 2006-06-28 DERIVADOS DE PIRIDO[2,3-d]PIRIMIDINA Y SU PREPARACION

Country Status (41)

Country Link
US (2) US7504406B2 (es)
EP (2) EP2020410B1 (es)
JP (1) JP4472009B2 (es)
KR (1) KR101298344B1 (es)
CN (2) CN101213196B (es)
AR (1) AR054812A1 (es)
AT (1) ATE423119T1 (es)
AU (1) AU2006264801B2 (es)
BR (1) BRPI0613020A2 (es)
CA (1) CA2610794C (es)
CR (1) CR9568A (es)
CY (2) CY1110457T1 (es)
DE (1) DE602006005246D1 (es)
DK (2) DK1902054T3 (es)
DO (1) DOP2006000145A (es)
EA (1) EA014312B1 (es)
EC (1) ECSP078011A (es)
ES (2) ES2322101T3 (es)
FR (1) FR2887882B1 (es)
HK (1) HK1122797A1 (es)
HR (2) HRP20090236T1 (es)
IL (1) IL187900A0 (es)
JO (1) JO2550B1 (es)
MA (1) MA29561B1 (es)
ME (1) ME01813B (es)
MX (1) MX2007016239A (es)
MY (1) MY143089A (es)
NO (1) NO20080418L (es)
NZ (1) NZ564072A (es)
PA (1) PA8684801A1 (es)
PE (1) PE20070139A1 (es)
PL (2) PL2020410T3 (es)
PT (2) PT1902054E (es)
RS (2) RS53211B (es)
SI (2) SI2020410T1 (es)
TN (1) TNSN07440A1 (es)
TW (1) TWI321566B (es)
UA (1) UA92021C2 (es)
UY (1) UY29645A1 (es)
WO (1) WO2007003765A1 (es)
ZA (1) ZA200711032B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2873118B1 (fr) 2004-07-15 2007-11-23 Sanofi Synthelabo Derives de pyrido-pyrimidine, leur application en therapeutique
FR2887882B1 (fr) * 2005-07-01 2007-09-07 Sanofi Aventis Sa Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
FR2896246B1 (fr) 2006-01-13 2008-08-15 Sanofi Aventis Sa Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
FR2910813B1 (fr) * 2006-12-28 2009-02-06 Sanofi Aventis Sa Nouvelle utilisation therapeutique pour le traitement des leucemies
WO2010042998A1 (en) 2008-10-17 2010-04-22 Akaal Pharma Pty Ltd S1p receptors modulators
CA2740484C (en) 2008-10-17 2021-09-21 Akaal Pharma Pty Ltd S1p receptors modulators and their use thereof
FR2948568B1 (fr) * 2009-07-30 2012-08-24 Sanofi Aventis Formulation pharmaceutique
CN103204822B (zh) * 2012-01-17 2014-12-03 上海科州药物研发有限公司 作为蛋白激酶抑制剂的苯并噁唑化合物及其制备方法和用途
EP2638911A1 (en) 2012-03-14 2013-09-18 Sanofi Novel combinations for treating acute myeloid leukaemia or chronic myeloid leukaemia
CN103833771A (zh) * 2012-11-22 2014-06-04 天津滨江药物研发有限公司 作为蛋白激酶Mek抑制剂的苯并五元杂环化合物及其制备方法和用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1171218A (en) 1967-11-09 1969-11-19 Parke Davis & Co New Heterocyclic Amine Compounds and Methods for their Production
JPH04128276A (ja) 1990-09-19 1992-04-28 Pfizer Pharmaceut Co Ltd アミノベンゾサルタム誘導体およびその用途
DE69515898T2 (de) * 1994-11-14 2000-08-17 Warner Lambert Co 6-ARYL-PYRIDO[2,3-d]PYRIMIDINE UND -NAPHTHYRIDINE ZUR HEMMUNG DER DURCH PROTEIN-TYROSIN-KINASE HERVORGERUFENEN ZELLVERMEHRUNG
IL115256A0 (en) 1994-11-14 1995-12-31 Warner Lambert Co 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
US5620981A (en) 1995-05-03 1997-04-15 Warner-Lambert Company Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
IL117923A (en) 1995-05-03 2000-06-01 Warner Lambert Co Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
AR030044A1 (es) * 2000-01-25 2003-08-13 Warner Lambert Co Pirido (2,3-d ) pirimidin-2,7-diaminas inhibidores de quinasas
EE200200506A (et) * 2000-03-06 2004-02-16 Warner-Lambert Company 5-alküülpürido[2,3-d]pürimidiinid kui türosiinkinaasi inhibiitorid
BR0112857A (pt) 2000-08-04 2005-02-09 Warner Lambert Co Compostos 2-(4-piridil)amino-6-dialcoxifenil-pirido-[2,3-d]pirimidin- 7-onas
AU2002324450A1 (en) * 2001-06-21 2003-01-08 Ariad Pharmaceuticals, Inc. Novel pyridopyrimidines and uses thereof
AU2002952453A0 (en) * 2002-11-01 2002-11-21 Novogen Research Pty Ltd Aminated isoflavonoid derivatives and uses thereof
WO2004063195A1 (en) 2003-01-03 2004-07-29 Sloan-Kettering Institute For Cancer Research Pyridopyrimidine kinase inhibitors
TW200502236A (en) * 2003-03-28 2005-01-16 Hoffmann La Roche Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
WO2005105097A2 (en) 2004-04-28 2005-11-10 Gpc Biotech Ag Pyridopyrimidines for treating inflammatory and other diseases
FR2873118B1 (fr) 2004-07-15 2007-11-23 Sanofi Synthelabo Derives de pyrido-pyrimidine, leur application en therapeutique
FR2887882B1 (fr) * 2005-07-01 2007-09-07 Sanofi Aventis Sa Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
FR2896246B1 (fr) 2006-01-13 2008-08-15 Sanofi Aventis Sa Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
US8338435B2 (en) * 2006-07-20 2012-12-25 Gilead Sciences, Inc. Substituted pyrido(3,2-D) pyrimidines and pharmaceutical compositions for treating viral infections

Also Published As

Publication number Publication date
DK2020410T3 (en) 2014-03-24
EP1902054B1 (fr) 2009-02-18
CN101213196B (zh) 2011-09-07
AR054812A1 (es) 2007-07-18
JP4472009B2 (ja) 2010-06-02
DE602006005246D1 (de) 2009-04-02
US20080176874A1 (en) 2008-07-24
EP2020410B1 (fr) 2013-12-18
CN102260258A (zh) 2011-11-30
TNSN07440A1 (en) 2009-03-17
TW200745102A (en) 2007-12-16
HRP20090236T1 (en) 2009-05-31
CY1110457T1 (el) 2015-04-29
FR2887882B1 (fr) 2007-09-07
EA200800223A1 (ru) 2008-06-30
CN101213196A (zh) 2008-07-02
FR2887882A1 (fr) 2007-01-05
EP1902054A1 (fr) 2008-03-26
EA014312B1 (ru) 2010-10-29
CA2610794A1 (fr) 2007-01-11
CA2610794C (fr) 2012-02-21
PA8684801A1 (es) 2007-01-17
ES2322101T3 (es) 2009-06-16
ZA200711032B (en) 2009-04-29
RS53211B (en) 2014-08-29
UA92021C2 (ru) 2010-09-27
DK1902054T3 (da) 2009-06-15
ME01813B (me) 2014-09-20
MA29561B1 (fr) 2008-06-02
CR9568A (es) 2008-02-20
ECSP078011A (es) 2008-01-23
NO20080418L (no) 2008-03-28
AU2006264801A1 (en) 2007-01-11
ES2450067T3 (es) 2014-03-21
TWI321566B (en) 2010-03-11
PT1902054E (pt) 2009-04-22
PT2020410E (pt) 2014-03-20
JP2008544975A (ja) 2008-12-11
ATE423119T1 (de) 2009-03-15
KR101298344B1 (ko) 2013-08-20
JO2550B1 (en) 2010-09-05
SI2020410T1 (sl) 2014-04-30
AU2006264801B2 (en) 2012-05-10
CN102260258B (zh) 2015-01-07
EP2020410A1 (fr) 2009-02-04
HK1122797A1 (en) 2009-05-29
UY29645A1 (es) 2007-01-31
US8008310B2 (en) 2011-08-30
HRP20140246T1 (hr) 2014-06-20
WO2007003765A1 (fr) 2007-01-11
IL187900A0 (en) 2008-03-20
SI1902054T1 (sl) 2009-06-30
US20090163522A1 (en) 2009-06-25
DOP2006000145A (es) 2008-01-31
US7504406B2 (en) 2009-03-17
KR20080021714A (ko) 2008-03-07
PL1902054T3 (pl) 2009-07-31
MY143089A (en) 2011-03-15
PL2020410T3 (pl) 2014-05-30
BRPI0613020A2 (pt) 2010-12-14
MX2007016239A (es) 2008-03-06
RS50781B (sr) 2010-08-31
NZ564072A (en) 2012-02-24
CY1114989T1 (el) 2016-12-14

Similar Documents

Publication Publication Date Title
PE20070139A1 (es) DERIVADOS DE PIRIDO[2,3-d]PIRIMIDINA Y SU PREPARACION
PE20060504A1 (es) Derivados de pirimidina en el tratamiento de cancer
EA200501866A1 (ru) Макроциклические производные хиназолина в качестве антипролиферативных средств
PE20061305A1 (es) Compuestos derivados de fenilacetamidas como inhibidores de proteincinasas
PE20141351A1 (es) Triazolopiridinas
BE2017C018I2 (es)
PE20130611A1 (es) Triazolopiridinas sustituidas
CY1118498T1 (el) Παραγωγα πυριδαζινονης
PE20061067A1 (es) Derivados de pirimidina
PE20110560A1 (es) NUEVOS DERIVADOS DE TRIAZOLO[4,3-a]PIRIDINA, SU PROCEDIMIENTO DE PREPARACION, SU APLICACION COMO MEDICAMENTOS, COMPOSICIONES FARMACEUTICAS Y NUEVA UTILIZACION PARTICULARMENTE COMO INHIBIDORES DE MET
GEP20084551B (en) 4-phenylamino-quinazolin-6-yl-amides
EA200701853A1 (ru) Производные циклопентапиридина и тетрагидрохинолина
IL191832A (en) Pyridiazinone compounds and their use in the preparation of drugs for the treatment of tumors
GEP20156282B (en) Compounds and compositions as protein kinase inhibitors
CY1112084T1 (el) Παραγωγα 5-φαινυλθειαζολης και χρηση ως αναστολεις της κινασης ρi3
EA201100971A1 (ru) Производные пиримидининдола для лечения злокачественного новообразования
MXPA05013349A (es) Derivados de 2-amino-pirimidina como inhibidores de quinasa raf.
MY148375A (en) Delta and epsilon crystal forms of imatinib mesylate
TW200614987A (en) Novel compounds
MY140235A (en) New benzimidazole derivatives
PE20091101A1 (es) AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO
PL376324A1 (en) Piperazinyl and diazapanyl benzamides and benzthioamides
CL2004001050A1 (es) Compuesto derivado de 3'-[4-oxo-3-{[(ciclopropil o 2,2,2-trifluoroetil)amino]carbonil}-1,8-naftiridin-1(4h)-il]-3-sustituido-1-1'-bifenil-4-il; composicion farmaceutica; y uso en el tratamiento o prevencion de asma, bronquitis cronica, enfermedad pul
WO2007125398A3 (en) : sulfonamide compounds as antagonists of the n-type calcium channel
GEP20074058B (en) 4-(7-halo-2-quino(xa) linyloxy-phenoxy-propionic acid derivatives as antineoplastic agents

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed