TW200745102A - Pyrido[2,3-d]pyrimidine derivatives, preparation thereof, therapeutic use thereof - Google Patents

Pyrido[2,3-d]pyrimidine derivatives, preparation thereof, therapeutic use thereof

Info

Publication number
TW200745102A
TW200745102A TW095123940A TW95123940A TW200745102A TW 200745102 A TW200745102 A TW 200745102A TW 095123940 A TW095123940 A TW 095123940A TW 95123940 A TW95123940 A TW 95123940A TW 200745102 A TW200745102 A TW 200745102A
Authority
TW
Taiwan
Prior art keywords
pyrido
preparation
pyrimidine derivatives
therapeutic use
potentially
Prior art date
Application number
TW095123940A
Other languages
Chinese (zh)
Other versions
TWI321566B (en
Inventor
Bernard Bourrie
Pierre Casellas
Samir Jegham
Claude Muneaux
Pierre Perreaut
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of TW200745102A publication Critical patent/TW200745102A/en
Application granted granted Critical
Publication of TWI321566B publication Critical patent/TWI321566B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Abstract

The present invention relates to pyrido[2,3-d]pyrimidine derivatives, to the preparation thereof and to the therapeutic use thereof. These compounds are potentially of use for treating cell proliferation conditions.
TW095123940A 2005-07-01 2006-06-30 Pyrido[2,3-d]pyrimidine derivatives, preparation thereof, therapeutic use thereof TWI321566B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0507032A FR2887882B1 (en) 2005-07-01 2005-07-01 PYRIDO [2,3-D] PYRIMIDINE DERIVATIVES, THEIR PREPARATION, THEIR THERAPEUTIC APPLICATION

Publications (2)

Publication Number Publication Date
TW200745102A true TW200745102A (en) 2007-12-16
TWI321566B TWI321566B (en) 2010-03-11

Family

ID=36096420

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095123940A TWI321566B (en) 2005-07-01 2006-06-30 Pyrido[2,3-d]pyrimidine derivatives, preparation thereof, therapeutic use thereof

Country Status (41)

Country Link
US (2) US7504406B2 (en)
EP (2) EP2020410B1 (en)
JP (1) JP4472009B2 (en)
KR (1) KR101298344B1 (en)
CN (2) CN101213196B (en)
AR (1) AR054812A1 (en)
AT (1) ATE423119T1 (en)
AU (1) AU2006264801B2 (en)
BR (1) BRPI0613020A2 (en)
CA (1) CA2610794C (en)
CR (1) CR9568A (en)
CY (2) CY1110457T1 (en)
DE (1) DE602006005246D1 (en)
DK (2) DK1902054T3 (en)
DO (1) DOP2006000145A (en)
EA (1) EA014312B1 (en)
EC (1) ECSP078011A (en)
ES (2) ES2322101T3 (en)
FR (1) FR2887882B1 (en)
HK (1) HK1122797A1 (en)
HR (2) HRP20090236T1 (en)
IL (1) IL187900A0 (en)
JO (1) JO2550B1 (en)
MA (1) MA29561B1 (en)
ME (1) ME01813B (en)
MX (1) MX2007016239A (en)
MY (1) MY143089A (en)
NO (1) NO20080418L (en)
NZ (1) NZ564072A (en)
PA (1) PA8684801A1 (en)
PE (1) PE20070139A1 (en)
PL (2) PL1902054T3 (en)
PT (2) PT1902054E (en)
RS (2) RS53211B (en)
SI (2) SI1902054T1 (en)
TN (1) TNSN07440A1 (en)
TW (1) TWI321566B (en)
UA (1) UA92021C2 (en)
UY (1) UY29645A1 (en)
WO (1) WO2007003765A1 (en)
ZA (1) ZA200711032B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2873118B1 (en) 2004-07-15 2007-11-23 Sanofi Synthelabo PYRIDO-PYRIMIDINE DERIVATIVES, THEIR APPLICATION IN THERAPEUTICS
FR2887882B1 (en) * 2005-07-01 2007-09-07 Sanofi Aventis Sa PYRIDO [2,3-D] PYRIMIDINE DERIVATIVES, THEIR PREPARATION, THEIR THERAPEUTIC APPLICATION
FR2896246B1 (en) 2006-01-13 2008-08-15 Sanofi Aventis Sa PYRIDO-PYRIMIDONE DERIVATIVES, THEIR PREPARATION, THEIR THERAPEUTIC APPLICATION
FR2910813B1 (en) * 2006-12-28 2009-02-06 Sanofi Aventis Sa NEW THERAPEUTIC USE FOR THE TREATMENT OF LEUKEMIA
CA2740484C (en) 2008-10-17 2021-09-21 Akaal Pharma Pty Ltd S1p receptors modulators and their use thereof
US9181182B2 (en) 2008-10-17 2015-11-10 Akaal Pharma Pty Ltd S1P receptors modulators
FR2948568B1 (en) * 2009-07-30 2012-08-24 Sanofi Aventis PHARMACEUTICAL FORMULATION
CN103204825B (en) * 2012-01-17 2015-03-04 上海科州药物研发有限公司 Benzothiazole compounds as protein kinase inhibitors, and preparation method and application thereof
EP2638911A1 (en) 2012-03-14 2013-09-18 Sanofi Novel combinations for treating acute myeloid leukaemia or chronic myeloid leukaemia
CN103833771A (en) * 2012-11-22 2014-06-04 天津滨江药物研发有限公司 Benzo five-membered heterocyclic compound serving as protein kinase Mek inhibitor, preparation method and application thereof

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
GB1171218A (en) 1967-11-09 1969-11-19 Parke Davis & Co New Heterocyclic Amine Compounds and Methods for their Production
JPH04128276A (en) 1990-09-19 1992-04-28 Pfizer Pharmaceut Co Ltd Aminobenzosultam derivative and its use
IL115256A0 (en) 1994-11-14 1995-12-31 Warner Lambert Co 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
WO1996015128A2 (en) * 1994-11-14 1996-05-23 Warner-Lambert Company 6-ARYL PYRIDO[2,3-d]PYRIMIDINES AND NAPHTHYRIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION
US5620981A (en) 1995-05-03 1997-04-15 Warner-Lambert Company Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
IL117923A (en) 1995-05-03 2000-06-01 Warner Lambert Co Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
EE200200405A (en) * 2000-01-25 2003-12-15 Warner-Lambert Company Pyrido [2,3-d] pyrimidine-2,7-diamines as kinase inhibitors
SK12472002A3 (en) * 2000-03-06 2003-04-01 Warner-Lambert Company 5-Alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors
ATE408613T1 (en) 2000-08-04 2008-10-15 Warner Lambert Co 2-(4-PYRIDYL)AMINO-6-DIALKOXYPHENYL-PYRIDO(2,3-D)PYRIMIDINE-7-ONE
US20030105115A1 (en) * 2001-06-21 2003-06-05 Metcalf Chester A. Novel pyridopyrimidines and uses thereof
AU2002952453A0 (en) * 2002-11-01 2002-11-21 Novogen Research Pty Ltd Aminated isoflavonoid derivatives and uses thereof
US20050009849A1 (en) 2003-01-03 2005-01-13 Veach Darren R. Pyridopyrimidine kinase inhibitors
TW200502236A (en) * 2003-03-28 2005-01-16 Hoffmann La Roche Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
WO2005105097A2 (en) 2004-04-28 2005-11-10 Gpc Biotech Ag Pyridopyrimidines for treating inflammatory and other diseases
FR2873118B1 (en) 2004-07-15 2007-11-23 Sanofi Synthelabo PYRIDO-PYRIMIDINE DERIVATIVES, THEIR APPLICATION IN THERAPEUTICS
FR2887882B1 (en) * 2005-07-01 2007-09-07 Sanofi Aventis Sa PYRIDO [2,3-D] PYRIMIDINE DERIVATIVES, THEIR PREPARATION, THEIR THERAPEUTIC APPLICATION
FR2896246B1 (en) 2006-01-13 2008-08-15 Sanofi Aventis Sa PYRIDO-PYRIMIDONE DERIVATIVES, THEIR PREPARATION, THEIR THERAPEUTIC APPLICATION
US8338435B2 (en) * 2006-07-20 2012-12-25 Gilead Sciences, Inc. Substituted pyrido(3,2-D) pyrimidines and pharmaceutical compositions for treating viral infections

Also Published As

Publication number Publication date
KR101298344B1 (en) 2013-08-20
NZ564072A (en) 2012-02-24
HRP20140246T1 (en) 2014-06-20
ATE423119T1 (en) 2009-03-15
WO2007003765A1 (en) 2007-01-11
PA8684801A1 (en) 2007-01-17
UY29645A1 (en) 2007-01-31
JP4472009B2 (en) 2010-06-02
ZA200711032B (en) 2009-04-29
CN102260258A (en) 2011-11-30
CY1114989T1 (en) 2016-12-14
EP1902054A1 (en) 2008-03-26
PT2020410E (en) 2014-03-20
FR2887882B1 (en) 2007-09-07
CR9568A (en) 2008-02-20
HRP20090236T1 (en) 2009-05-31
US20080176874A1 (en) 2008-07-24
AU2006264801A1 (en) 2007-01-11
RS53211B (en) 2014-08-29
JO2550B1 (en) 2010-09-05
JP2008544975A (en) 2008-12-11
EP2020410B1 (en) 2013-12-18
SI2020410T1 (en) 2014-04-30
ES2450067T3 (en) 2014-03-21
BRPI0613020A2 (en) 2010-12-14
CN101213196B (en) 2011-09-07
CN102260258B (en) 2015-01-07
PT1902054E (en) 2009-04-22
EA200800223A1 (en) 2008-06-30
CY1110457T1 (en) 2015-04-29
PL2020410T3 (en) 2014-05-30
MX2007016239A (en) 2008-03-06
CA2610794A1 (en) 2007-01-11
FR2887882A1 (en) 2007-01-05
ES2322101T3 (en) 2009-06-16
SI1902054T1 (en) 2009-06-30
ECSP078011A (en) 2008-01-23
CN101213196A (en) 2008-07-02
DE602006005246D1 (en) 2009-04-02
PE20070139A1 (en) 2007-03-07
TNSN07440A1 (en) 2009-03-17
RS50781B (en) 2010-08-31
MY143089A (en) 2011-03-15
CA2610794C (en) 2012-02-21
NO20080418L (en) 2008-03-28
DK2020410T3 (en) 2014-03-24
HK1122797A1 (en) 2009-05-29
MA29561B1 (en) 2008-06-02
DOP2006000145A (en) 2008-01-31
KR20080021714A (en) 2008-03-07
PL1902054T3 (en) 2009-07-31
EP1902054B1 (en) 2009-02-18
TWI321566B (en) 2010-03-11
IL187900A0 (en) 2008-03-20
AU2006264801B2 (en) 2012-05-10
AR054812A1 (en) 2007-07-18
EP2020410A1 (en) 2009-02-04
DK1902054T3 (en) 2009-06-15
US20090163522A1 (en) 2009-06-25
ME01813B (en) 2014-09-20
EA014312B1 (en) 2010-10-29
US7504406B2 (en) 2009-03-17
US8008310B2 (en) 2011-08-30
UA92021C2 (en) 2010-09-27

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MM4A Annulment or lapse of patent due to non-payment of fees