PE20060504A1 - Derivados de pirimidina en el tratamiento de cancer - Google Patents
Derivados de pirimidina en el tratamiento de cancerInfo
- Publication number
- PE20060504A1 PE20060504A1 PE2005000980A PE2005000980A PE20060504A1 PE 20060504 A1 PE20060504 A1 PE 20060504A1 PE 2005000980 A PE2005000980 A PE 2005000980A PE 2005000980 A PE2005000980 A PE 2005000980A PE 20060504 A1 PE20060504 A1 PE 20060504A1
- Authority
- PE
- Peru
- Prior art keywords
- kinase
- methyl
- substituted
- cancer
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R0 ES H, R1 ES MONOCICLO SUSTITUIDO DE 6 ELEMENTOS O BICICLO-HETEROCICLO DE 10 ELEMENTOS CON 1-2 HETEROATOMOS DE N, O; R2 Y R3 JUNTO AL C Y N AL QUE ESTA UNIDO, FORMA UN HETEROCICLO QUE CONTIENE UN HETEROATOMO SELECCIONADO DE N, SUSTITUIDO O NO; R4 ES H; R5 ES HALOGENO; R6 Y R7 SON H; R8 ES H, ALCOXI C1-C7, CARBAMOILO SUSTITUIDO O NO POR ALQUILO C1-C7, ENTRE OTROS; R9 ES H; R10 ES H, HALOGENO, ALCOXI C1-C7. SON COMPUESTOS PREFERIDOS: 7-[5-CLORO-2-(2-METOXI-FENILAMINO)PIRIMIDI-4-NILAMINO]-2-METIL-4-PIPERAZI-1-NIL-2,3DIHIDRO-ISOINDO-1-LONA; 7-[5-CLORO-2-(2-METOXI-FENILAMINO)-PIRIMIDI-4-NILAMINO]-2-METIL-4-(4-METIL-PIPERAZI-1-NIL)-2,3-DIHIDRO-ISOINDO-1-LONA; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FERMACEUTICA Y A UN METODO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE CINASA NPM-ALK (ACTIVDAD TIROSIN-CINASA PROTEICA DEL LIGANDO INDEPENDIENTE DEL LINFOMA CINASA ANAPLASICA) UTILES EN EL TRATAMIENTO DE TUMOR DE PECHO, CANCER INTESTINAL, CANCER ESTOMACAL, MELANOMA, TUMOR DE VEJIGA, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0419160.7A GB0419160D0 (en) | 2004-08-27 | 2004-08-27 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060504A1 true PE20060504A1 (es) | 2006-07-18 |
Family
ID=33104745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005000980A PE20060504A1 (es) | 2004-08-27 | 2005-08-25 | Derivados de pirimidina en el tratamiento de cancer |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7910585B2 (es) |
| EP (1) | EP1784399B1 (es) |
| JP (1) | JP4674236B2 (es) |
| KR (1) | KR100894349B1 (es) |
| CN (1) | CN101006079A (es) |
| AR (1) | AR050536A1 (es) |
| AT (1) | ATE512960T1 (es) |
| AU (1) | AU2005276585B2 (es) |
| BR (1) | BRPI0514731A (es) |
| CA (1) | CA2575720C (es) |
| EC (1) | ECSP077259A (es) |
| ES (1) | ES2366038T3 (es) |
| GB (1) | GB0419160D0 (es) |
| GT (1) | GT200500229A (es) |
| IL (1) | IL181386A0 (es) |
| MA (1) | MA28813B1 (es) |
| NO (1) | NO20071504L (es) |
| PE (1) | PE20060504A1 (es) |
| PL (1) | PL1784399T3 (es) |
| PT (1) | PT1784399E (es) |
| RU (1) | RU2395507C2 (es) |
| TN (1) | TNSN07074A1 (es) |
| TW (1) | TW200621728A (es) |
| WO (1) | WO2006021457A2 (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0305929D0 (en) * | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
| GB0419161D0 (en) * | 2004-08-27 | 2004-09-29 | Novartis Ag | Organic compounds |
| US8168383B2 (en) | 2006-04-14 | 2012-05-01 | Cell Signaling Technology, Inc. | Gene defects and mutant ALK kinase in human solid tumors |
| DK2447359T3 (en) | 2006-04-14 | 2016-02-08 | Cell Signaling Technology Inc | Genetic defects and mutated ALK kinase in human solid tumors |
| WO2008051547A1 (en) | 2006-10-23 | 2008-05-02 | Cephalon, Inc. | Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and c-met inhibitors |
| CN101616895A (zh) | 2006-12-08 | 2009-12-30 | Irm责任有限公司 | 作为蛋白激酶抑制剂的化合物和组合物 |
| JP2010513272A (ja) * | 2006-12-14 | 2010-04-30 | メルク エンド カムパニー インコーポレーテッド | アシルビピペリジニル化合物、そのような化合物を含む組成物、及び治療方法 |
| TWI389893B (zh) | 2007-07-06 | 2013-03-21 | Astellas Pharma Inc | 二（芳胺基）芳基化合物 |
| EP2303861B1 (en) | 2008-06-17 | 2014-04-23 | AstraZeneca AB | Pyridine compounds |
| JO3067B1 (ar) * | 2008-10-27 | 2017-03-15 | Glaxosmithkline Llc | بيرميدينات بيرازولو امينو كمثبطات ل fak |
| AR074210A1 (es) | 2008-11-24 | 2010-12-29 | Boehringer Ingelheim Int | Derivados de pirimidina como inhibidores de ptk2-quinasa |
| TW201024281A (en) | 2008-11-24 | 2010-07-01 | Boehringer Ingelheim Int | New compounds |
| ES2659725T3 (es) * | 2009-05-05 | 2018-03-19 | Dana-Farber Cancer Institute, Inc. | Inhibidores de EGFR y procedimiento de tratamiento de trastornos |
| TW201100441A (en) | 2009-06-01 | 2011-01-01 | Osi Pharm Inc | Amino pyrimidine anticancer compounds |
| CN101935317B (zh) * | 2009-07-01 | 2013-08-28 | 上海药明康德新药开发有限公司 | 2-甲基-7-(取代嘧啶-4-氨基)-4-(取代哌啶-1-基)异吲哚啉-1-酮及中间体的合成方法 |
| TWI513694B (zh) * | 2010-05-11 | 2015-12-21 | Amgen Inc | 抑制間變性淋巴瘤激酶的嘧啶化合物 |
| US20120244141A1 (en) | 2010-09-28 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors |
| PT2646448T (pt) | 2010-11-29 | 2017-10-04 | Osi Pharmaceuticals Llc | Inibidores macrocíclicos de cinases |
| JP5937111B2 (ja) | 2011-02-17 | 2016-06-22 | カンサー・セラピューティクス・シーアールシー・プロプライエタリー・リミテッドＣａｎｃｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｃｒｃ Ｐｔｙ Ｌｉｍｉｔｅｄ | Ｆａｋ阻害剤 |
| US9174946B2 (en) | 2011-02-17 | 2015-11-03 | Cancer Therapeutics Crc Pty Ltd | Selective FAK inhibitors |
| JP6469567B2 (ja) | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Ｅｇｆｒ発動性がんの細胞増殖阻害用化合物 |
| JP6108570B2 (ja) * | 2013-02-13 | 2017-04-05 | 学校法人福岡大学 | 迅速アレルギー検査方法 |
| CN104803925B (zh) * | 2015-04-16 | 2018-01-12 | 温州医科大学 | 一类以fgfr为靶点的2，4，5‑三取代嘧啶类化合物及其制备方法和用途 |
| WO2018010142A1 (en) * | 2016-07-14 | 2018-01-18 | Shanghai Meton Pharmaceutical Co., Ltd | Iso-citrate dehydrogenase (idh) inhibitor |
| BR112022004451A2 (pt) * | 2019-09-13 | 2022-06-21 | Nimbus Saturn Inc | Antagonistas de hpk1 e usos dos mesmos |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
| US6776480B2 (en) | 2001-07-18 | 2004-08-17 | Sola International Holdings, Ltd. | Spectacle frames for shaped lenses defined by monoformal carrier surfaces |
| US6939874B2 (en) | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
| TWI329105B (en) * | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
| AU2003231231A1 (en) * | 2002-05-06 | 2003-11-11 | Bayer Pharmaceuticals Corporation | Pyridinyl amino pyrimidine derivatives useful for treating hyper-proliferative disorders |
| GB0305929D0 (en) | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
-
2004
- 2004-08-27 GB GBGB0419160.7A patent/GB0419160D0/en not_active Ceased
-
2005
- 2005-08-25 PE PE2005000980A patent/PE20060504A1/es not_active Application Discontinuation
- 2005-08-26 KR KR1020077004528A patent/KR100894349B1/ko not_active IP Right Cessation
- 2005-08-26 RU RU2007110946/04A patent/RU2395507C2/ru not_active IP Right Cessation
- 2005-08-26 BR BRPI0514731-0A patent/BRPI0514731A/pt not_active IP Right Cessation
- 2005-08-26 JP JP2007528756A patent/JP4674236B2/ja not_active Expired - Fee Related
- 2005-08-26 AT AT05782820T patent/ATE512960T1/de active
- 2005-08-26 GT GT200500229A patent/GT200500229A/es unknown
- 2005-08-26 US US11/660,714 patent/US7910585B2/en not_active Expired - Fee Related
- 2005-08-26 ES ES05782820T patent/ES2366038T3/es active Active
- 2005-08-26 EP EP05782820A patent/EP1784399B1/en active Active
- 2005-08-26 CA CA2575720A patent/CA2575720C/en not_active Expired - Fee Related
- 2005-08-26 PT PT05782820T patent/PT1784399E/pt unknown
- 2005-08-26 WO PCT/EP2005/009255 patent/WO2006021457A2/en active Application Filing
- 2005-08-26 PL PL05782820T patent/PL1784399T3/pl unknown
- 2005-08-26 CN CNA2005800280957A patent/CN101006079A/zh active Pending
- 2005-08-26 AU AU2005276585A patent/AU2005276585B2/en not_active Ceased
- 2005-08-26 TW TW094129174A patent/TW200621728A/zh unknown
- 2005-08-26 AR ARP050103593A patent/AR050536A1/es not_active Application Discontinuation
-
2007
- 2007-02-15 EC EC2007007259A patent/ECSP077259A/es unknown
- 2007-02-15 IL IL181386A patent/IL181386A0/en unknown
- 2007-02-21 MA MA29698A patent/MA28813B1/fr unknown
- 2007-02-26 TN TNP2007000074A patent/TNSN07074A1/en unknown
- 2007-03-22 NO NO20071504A patent/NO20071504L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GT200500229A (es) | 2006-03-29 |
| TW200621728A (en) | 2006-07-01 |
| CA2575720A1 (en) | 2006-03-02 |
| IL181386A0 (en) | 2007-07-04 |
| EP1784399A2 (en) | 2007-05-16 |
| AU2005276585B2 (en) | 2009-07-30 |
| KR20070038567A (ko) | 2007-04-10 |
| WO2006021457A2 (en) | 2006-03-02 |
| US20080293708A1 (en) | 2008-11-27 |
| JP2008510765A (ja) | 2008-04-10 |
| MA28813B1 (fr) | 2007-08-01 |
| BRPI0514731A (pt) | 2008-06-24 |
| US7910585B2 (en) | 2011-03-22 |
| JP4674236B2 (ja) | 2011-04-20 |
| CN101006079A (zh) | 2007-07-25 |
| PT1784399E (pt) | 2011-08-26 |
| CA2575720C (en) | 2012-10-02 |
| KR100894349B1 (ko) | 2009-04-22 |
| EP1784399B1 (en) | 2011-06-15 |
| ATE512960T1 (de) | 2011-07-15 |
| ES2366038T3 (es) | 2011-10-14 |
| TNSN07074A1 (en) | 2008-06-02 |
| RU2395507C2 (ru) | 2010-07-27 |
| NO20071504L (no) | 2007-05-25 |
| AU2005276585A1 (en) | 2006-03-02 |
| WO2006021457A3 (en) | 2006-07-13 |
| PL1784399T3 (pl) | 2011-11-30 |
| ECSP077259A (es) | 2007-03-29 |
| GB0419160D0 (en) | 2004-09-29 |
| AR050536A1 (es) | 2006-11-01 |
| RU2007110946A (ru) | 2008-10-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |