AR050536A1 - Derivados de pirimidina, procesos de preparacion y composiciones farmaceuticas que los comprenden - Google Patents
Derivados de pirimidina, procesos de preparacion y composiciones farmaceuticas que los comprendenInfo
- Publication number
- AR050536A1 AR050536A1 ARP050103593A ARP050103593A AR050536A1 AR 050536 A1 AR050536 A1 AR 050536A1 AR P050103593 A ARP050103593 A AR P050103593A AR P050103593 A ARP050103593 A AR P050103593A AR 050536 A1 AR050536 A1 AR 050536A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- hydrogen
- alkoxy
- independently selected
- unsubstituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
La presente comprende procesos para su produccion, a su uso como productos farmacéuticos y a composiciones farmacéuticas que los comprenden. Reivindicacion 1: Un compuesto de formula (1), donde R0 es hidrogeno; R1 es un monocíclico de 6 miembros no susituido o sustituido o un heterociclo bicíclico de 10 miembros que comprende 1 o 2 heteroátomos seleccionados independientemente de N y O; R2 y R3 junto con el C y N a los cuales se encuentran unidos forman un heterociclo que comprende al menos 1 heteroátomo seleccionado independientemente de N que está no sustituido o sustituido una o más veces por un sustituyente seleccionado independientemente de alquilo inferior y oxo; R4 es hidrogeno; R5 es halogeno; R6 es hidrogeno; R7 es hidrogeno; R8 es hidrogeno; alcoxi C1-7; carbamoílo no sustituido o sustituido por alquilo C1-7; alcoxi C1-7-alcoxi C1-7; un heterociclo de 5 o 6 miembros que comprende 1, 2 heteroátomos seleccionados independientemente de N u O y está no sustituido o sustituido por un sustituyente seleccionado independientemente de hidroxi, alquilo C1-7, mono o di-alquilamino C1-7, un heterociclo de 6 miembros que comprende 1 o 2 átomos de N anulares no sustituido o sustituido por alquilo C1-7; heterociclil de 5 o 6 miembros-alcoxi C1-7 que comprende 1 átomo de n anular no sustituido o sustituido por alquilo C1-7; R9 es hidrogeno; R10 es hidrogeno, halogeno o alcoxi C1-7; o una sal del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0419160.7A GB0419160D0 (en) | 2004-08-27 | 2004-08-27 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR050536A1 true AR050536A1 (es) | 2006-11-01 |
Family
ID=33104745
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050103593A AR050536A1 (es) | 2004-08-27 | 2005-08-26 | Derivados de pirimidina, procesos de preparacion y composiciones farmaceuticas que los comprenden |
Country Status (24)
Country | Link |
---|---|
US (1) | US7910585B2 (es) |
EP (1) | EP1784399B1 (es) |
JP (1) | JP4674236B2 (es) |
KR (1) | KR100894349B1 (es) |
CN (1) | CN101006079A (es) |
AR (1) | AR050536A1 (es) |
AT (1) | ATE512960T1 (es) |
AU (1) | AU2005276585B2 (es) |
BR (1) | BRPI0514731A (es) |
CA (1) | CA2575720C (es) |
EC (1) | ECSP077259A (es) |
ES (1) | ES2366038T3 (es) |
GB (1) | GB0419160D0 (es) |
GT (1) | GT200500229A (es) |
IL (1) | IL181386A0 (es) |
MA (1) | MA28813B1 (es) |
NO (1) | NO20071504L (es) |
PE (1) | PE20060504A1 (es) |
PL (1) | PL1784399T3 (es) |
PT (1) | PT1784399E (es) |
RU (1) | RU2395507C2 (es) |
TN (1) | TNSN07074A1 (es) |
TW (1) | TW200621728A (es) |
WO (1) | WO2006021457A2 (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0305929D0 (en) * | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
GB0419161D0 (en) * | 2004-08-27 | 2004-09-29 | Novartis Ag | Organic compounds |
EP2447360A1 (en) | 2006-04-14 | 2012-05-02 | Cell Signaling Technology, Inc. | Gene defects and mutant ALK kinase in human solid tumors |
US8168383B2 (en) | 2006-04-14 | 2012-05-01 | Cell Signaling Technology, Inc. | Gene defects and mutant ALK kinase in human solid tumors |
TWI432427B (zh) | 2006-10-23 | 2014-04-01 | Cephalon Inc | 作為ALK及c-MET抑制劑之2,4-二胺基嘧啶之融合雙環衍生物 |
US8039479B2 (en) | 2006-12-08 | 2011-10-18 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
JP2010513272A (ja) * | 2006-12-14 | 2010-04-30 | メルク エンド カムパニー インコーポレーテッド | アシルビピペリジニル化合物、そのような化合物を含む組成物、及び治療方法 |
TWI389893B (zh) * | 2007-07-06 | 2013-03-21 | Astellas Pharma Inc | 二(芳胺基)芳基化合物 |
EP2303861B1 (en) | 2008-06-17 | 2014-04-23 | AstraZeneca AB | Pyridine compounds |
JO3067B1 (ar) * | 2008-10-27 | 2017-03-15 | Glaxosmithkline Llc | بيرميدينات بيرازولو امينو كمثبطات ل fak |
AR074209A1 (es) | 2008-11-24 | 2010-12-29 | Boehringer Ingelheim Int | Derivados de pirimidina utiles para el tratamiento del cancer |
TWI491605B (zh) * | 2008-11-24 | 2015-07-11 | Boehringer Ingelheim Int | 新穎化合物 |
KR101705158B1 (ko) * | 2009-05-05 | 2017-02-09 | 다나-파버 캔서 인스티튜트 인크. | Egfr 억제제 및 질환 치료방법 |
TW201100441A (en) | 2009-06-01 | 2011-01-01 | Osi Pharm Inc | Amino pyrimidine anticancer compounds |
CN101935317B (zh) * | 2009-07-01 | 2013-08-28 | 上海药明康德新药开发有限公司 | 2-甲基-7-(取代嘧啶-4-氨基)-4-(取代哌啶-1-基)异吲哚啉-1-酮及中间体的合成方法 |
TWI513694B (zh) * | 2010-05-11 | 2015-12-21 | Amgen Inc | 抑制間變性淋巴瘤激酶的嘧啶化合物 |
US20120244141A1 (en) | 2010-09-28 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors |
JP6000273B2 (ja) * | 2010-11-29 | 2016-09-28 | オーエスアイ・ファーマシューティカルズ,エルエルシー | 大環状キナーゼ阻害剤 |
WO2012110773A1 (en) | 2011-02-17 | 2012-08-23 | Cancer Therapeutics Crc Pty Limited | Fak inhibitors |
CA2827172C (en) | 2011-02-17 | 2019-02-26 | Cancer Therapeutics Crc Pty Limited | Selective fak inhibitors |
JP6469567B2 (ja) | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Egfr発動性がんの細胞増殖阻害用化合物 |
WO2014126125A1 (ja) | 2013-02-13 | 2014-08-21 | 学校法人福岡大学 | 迅速アレルギー検査方法 |
CN104803925B (zh) * | 2015-04-16 | 2018-01-12 | 温州医科大学 | 一类以fgfr为靶点的2,4,5‑三取代嘧啶类化合物及其制备方法和用途 |
WO2018010142A1 (en) * | 2016-07-14 | 2018-01-18 | Shanghai Meton Pharmaceutical Co., Ltd | Iso-citrate dehydrogenase (idh) inhibitor |
KR20220105631A (ko) * | 2019-09-13 | 2022-07-27 | 님버스 새턴 인코포레이티드 | Hpk1 길항제 및 이의 용도 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9828511D0 (en) * | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
US6776480B2 (en) | 2001-07-18 | 2004-08-17 | Sola International Holdings, Ltd. | Spectacle frames for shaped lenses defined by monoformal carrier surfaces |
US6939874B2 (en) | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
TWI329105B (en) * | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
AU2003231231A1 (en) * | 2002-05-06 | 2003-11-11 | Bayer Pharmaceuticals Corporation | Pyridinyl amino pyrimidine derivatives useful for treating hyper-proliferative disorders |
GB0305929D0 (en) * | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
-
2004
- 2004-08-27 GB GBGB0419160.7A patent/GB0419160D0/en not_active Ceased
-
2005
- 2005-08-25 PE PE2005000980A patent/PE20060504A1/es not_active Application Discontinuation
- 2005-08-26 BR BRPI0514731-0A patent/BRPI0514731A/pt not_active IP Right Cessation
- 2005-08-26 EP EP05782820A patent/EP1784399B1/en active Active
- 2005-08-26 CA CA2575720A patent/CA2575720C/en not_active Expired - Fee Related
- 2005-08-26 WO PCT/EP2005/009255 patent/WO2006021457A2/en active Application Filing
- 2005-08-26 GT GT200500229A patent/GT200500229A/es unknown
- 2005-08-26 RU RU2007110946/04A patent/RU2395507C2/ru not_active IP Right Cessation
- 2005-08-26 AT AT05782820T patent/ATE512960T1/de active
- 2005-08-26 PL PL05782820T patent/PL1784399T3/pl unknown
- 2005-08-26 CN CNA2005800280957A patent/CN101006079A/zh active Pending
- 2005-08-26 JP JP2007528756A patent/JP4674236B2/ja not_active Expired - Fee Related
- 2005-08-26 KR KR1020077004528A patent/KR100894349B1/ko not_active IP Right Cessation
- 2005-08-26 AU AU2005276585A patent/AU2005276585B2/en not_active Ceased
- 2005-08-26 AR ARP050103593A patent/AR050536A1/es not_active Application Discontinuation
- 2005-08-26 PT PT05782820T patent/PT1784399E/pt unknown
- 2005-08-26 ES ES05782820T patent/ES2366038T3/es active Active
- 2005-08-26 US US11/660,714 patent/US7910585B2/en not_active Expired - Fee Related
- 2005-08-26 TW TW094129174A patent/TW200621728A/zh unknown
-
2007
- 2007-02-15 IL IL181386A patent/IL181386A0/en unknown
- 2007-02-15 EC EC2007007259A patent/ECSP077259A/es unknown
- 2007-02-21 MA MA29698A patent/MA28813B1/fr unknown
- 2007-02-26 TN TNP2007000074A patent/TNSN07074A1/en unknown
- 2007-03-22 NO NO20071504A patent/NO20071504L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PT1784399E (pt) | 2011-08-26 |
GB0419160D0 (en) | 2004-09-29 |
ECSP077259A (es) | 2007-03-29 |
CA2575720C (en) | 2012-10-02 |
ATE512960T1 (de) | 2011-07-15 |
RU2395507C2 (ru) | 2010-07-27 |
WO2006021457A2 (en) | 2006-03-02 |
JP2008510765A (ja) | 2008-04-10 |
AU2005276585A1 (en) | 2006-03-02 |
PL1784399T3 (pl) | 2011-11-30 |
GT200500229A (es) | 2006-03-29 |
KR20070038567A (ko) | 2007-04-10 |
US7910585B2 (en) | 2011-03-22 |
US20080293708A1 (en) | 2008-11-27 |
EP1784399B1 (en) | 2011-06-15 |
AU2005276585B2 (en) | 2009-07-30 |
ES2366038T3 (es) | 2011-10-14 |
IL181386A0 (en) | 2007-07-04 |
JP4674236B2 (ja) | 2011-04-20 |
WO2006021457A3 (en) | 2006-07-13 |
EP1784399A2 (en) | 2007-05-16 |
CA2575720A1 (en) | 2006-03-02 |
BRPI0514731A (pt) | 2008-06-24 |
CN101006079A (zh) | 2007-07-25 |
TNSN07074A1 (en) | 2008-06-02 |
TW200621728A (en) | 2006-07-01 |
NO20071504L (no) | 2007-05-25 |
RU2007110946A (ru) | 2008-10-10 |
PE20060504A1 (es) | 2006-07-18 |
MA28813B1 (fr) | 2007-08-01 |
KR100894349B1 (ko) | 2009-04-22 |
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Legal Events
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FA | Abandonment or withdrawal |