MXPA05013349A - Derivados de 2-amino-pirimidina como inhibidores de quinasa raf. - Google Patents

Derivados de 2-amino-pirimidina como inhibidores de quinasa raf.

Info

Publication number
MXPA05013349A
MXPA05013349A MXPA05013349A MXPA05013349A MXPA05013349A MX PA05013349 A MXPA05013349 A MX PA05013349A MX PA05013349 A MXPA05013349 A MX PA05013349A MX PA05013349 A MXPA05013349 A MX PA05013349A MX PA05013349 A MXPA05013349 A MX PA05013349A
Authority
MX
Mexico
Prior art keywords
raf kinase
kinase inhibitors
aminopyrimidine derivatives
compounds
phenyl radical
Prior art date
Application number
MXPA05013349A
Other languages
English (en)
Inventor
Michael Lloyd Sabio
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MXPA05013349A publication Critical patent/MXPA05013349A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Esta solicitud da a conocer compuestos que inhiben la quinasa Raf, que tienen la formula (I) (ver formula (I)): en donde R1 es un radical de fenilo o un radical de heterorarilo; y R2 es un radical de fenilo; o un N-oxido o una sal farmaceuticamente aceptable de los mismos. Los compuestos son utiles para el tratamiento de enfermedades proliferativas, tales como cancer.
MXPA05013349A 2003-06-13 2004-06-11 Derivados de 2-amino-pirimidina como inhibidores de quinasa raf. MXPA05013349A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47870903P 2003-06-13 2003-06-13
PCT/EP2004/006317 WO2004110452A1 (en) 2003-06-13 2004-06-11 2-aminopyrimidine derivatives as raf kinase inhibitors

Publications (1)

Publication Number Publication Date
MXPA05013349A true MXPA05013349A (es) 2006-03-09

Family

ID=33551850

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05013349A MXPA05013349A (es) 2003-06-13 2004-06-11 Derivados de 2-amino-pirimidina como inhibidores de quinasa raf.

Country Status (14)

Country Link
US (1) US20060293340A1 (es)
EP (1) EP1635835B1 (es)
JP (1) JP2006527230A (es)
CN (1) CN1805748B (es)
AT (1) ATE454152T1 (es)
AU (1) AU2004246800B2 (es)
BR (1) BRPI0411365A (es)
CA (1) CA2529090A1 (es)
DE (1) DE602004024988D1 (es)
ES (1) ES2338557T3 (es)
MX (1) MXPA05013349A (es)
PL (1) PL1635835T3 (es)
PT (1) PT1635835E (es)
WO (1) WO2004110452A1 (es)

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US8735415B2 (en) 2004-09-09 2014-05-27 Natco Pharma Limited Acid addition salts of (3,5-Bis trifluoromethyl)-N-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide
EP1786799B1 (en) * 2004-09-09 2012-07-04 Natco Pharma Limited Novel phenylaminopyrimidine derivatives as inhibitors of bcr-abl kinase
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KR20070106036A (ko) * 2005-02-25 2007-10-31 노파르티스 아게 Ｂｃｒ-ａｂｌ 및 ｒａｆ 억제제의 제약 조합물
KR100674813B1 (ko) * 2005-08-05 2007-01-29 일양약품주식회사 Ｎ-페닐-2-피리미딘-아민 유도체 및 그의 제조방법
EA200870217A1 (ru) * 2006-01-30 2009-02-27 Экселиксис, Инк. 4-арил-2-аминопиримидины или 4-арил-2-аминоалкилпиримидины в качестве модуляторов jak-2 и содержащие их фармацевтические композиции
US20100216791A1 (en) * 2006-08-17 2010-08-26 Astrazeneca Pyridinylquinazolinamine derivatives and their use as b-raf inhibitors
KR101420892B1 (ko) 2006-11-16 2014-07-17 에프.아이.에스. 파브리카 이탈리아나 신테티치 에스.피.에이. 이마티닙 및 그들의 중간체 및 그 제조방법
EA019524B1 (ru) * 2007-05-04 2014-04-30 Айрм Ллк СОЕДИНЕНИЯ И КОМПОЗИЦИИ КАК ИНГИБИТОРЫ КИНАЗЫ с-kit И PDGFR
JP5710251B2 (ja) * 2007-06-07 2015-04-30 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 新規ヘテロ環化合物およびその使用
JP5559043B2 (ja) 2007-06-07 2014-07-23 イントラ−セルラー・セラピーズ・インコーポレイテッド 新規ヘテロ環化合物およびその使用
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CA2716949A1 (en) * 2008-02-29 2009-09-11 Array Biopharma Inc. N- (6-aminopyridin-3-yl) -3- (sulfonamido) benzamide derivatives as b-raf inhibitors for the treatment of cancer
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US8067422B2 (en) 2008-03-04 2011-11-29 Natco Pharma Limited Crystal form of phenylamino pyrimidine derivatives
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EA024729B1 (ru) * 2009-11-13 2016-10-31 Джиноско Киназные ингибиторы
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Also Published As

Publication number Publication date
BRPI0411365A (pt) 2006-07-25
CN1805748B (zh) 2010-05-26
EP1635835B1 (en) 2010-01-06
US20060293340A1 (en) 2006-12-28
CN1805748A (zh) 2006-07-19
ES2338557T3 (es) 2010-05-10
WO2004110452A1 (en) 2004-12-23
DE602004024988D1 (de) 2010-02-25
PT1635835E (pt) 2010-03-17
AU2004246800A1 (en) 2004-12-23
EP1635835A1 (en) 2006-03-22
CA2529090A1 (en) 2004-12-23
JP2006527230A (ja) 2006-11-30
AU2004246800B2 (en) 2008-12-04
PL1635835T3 (pl) 2010-06-30
ATE454152T1 (de) 2010-01-15

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