DK0765314T3 - Benzoheterocykliske derivater, der kan anvendes som vasopressin- eller oxytocinmodulatorer - Google Patents

Benzoheterocykliske derivater, der kan anvendes som vasopressin- eller oxytocinmodulatorer

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Publication number
DK0765314T3
DK0765314T3 DK95921112T DK95921112T DK0765314T3 DK 0765314 T3 DK0765314 T3 DK 0765314T3 DK 95921112 T DK95921112 T DK 95921112T DK 95921112 T DK95921112 T DK 95921112T DK 0765314 T3 DK0765314 T3 DK 0765314T3
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DK
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Prior art keywords
vasopressin
oxytocin
activity
benzoheterocyclic derivatives
antagonist
Prior art date
Application number
DK95921112T
Other languages
English (en)
Inventor
Hidenori - Nakakirai-Aza Ogawa
Kazumi - Nakakirai-Aza-I Kondo
Keizo Kan
Takayuki Matsuzaki
Tomoichi Shinohara
Yoshihisa Tanada
Muneaki Naruto-Grand- Kurimura
Michiaki Tominaga
Yoichi Yabuuchi
Hiroshi Yamashita
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
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Publication of DK0765314T3 publication Critical patent/DK0765314T3/da

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    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
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    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
DK95921112T 1994-06-15 1995-06-07 Benzoheterocykliske derivater, der kan anvendes som vasopressin- eller oxytocinmodulatorer DK0765314T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP13235594 1994-06-15
JP7072795 1995-03-03
PCT/JP1995/001124 WO1995034540A1 (en) 1994-06-15 1995-06-07 Benzoheterocyclic derivatives useful as vasopressin or oxytocin modulators

Publications (1)

Publication Number Publication Date
DK0765314T3 true DK0765314T3 (da) 2003-08-25

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Family Applications (2)

Application Number Title Priority Date Filing Date
DK95921112T DK0765314T3 (da) 1994-06-15 1995-06-07 Benzoheterocykliske derivater, der kan anvendes som vasopressin- eller oxytocinmodulatorer
DK02007987T DK1221440T3 (da) 1994-06-15 1995-06-07 Benzoheterocykliske derivater der er nyttige som vasopressin- eller oxytocinmodulatorer

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DK02007987T DK1221440T3 (da) 1994-06-15 1995-06-07 Benzoheterocykliske derivater der er nyttige som vasopressin- eller oxytocinmodulatorer

Country Status (14)

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US (3) US6096735A (da)
EP (2) EP0765314B1 (da)
JP (1) JP2000351768A (da)
KR (1) KR100433375B1 (da)
CN (2) CN1104418C (da)
AT (2) ATE360617T1 (da)
CA (1) CA2192928C (da)
DE (2) DE69530690T2 (da)
DK (2) DK0765314T3 (da)
ES (2) ES2199251T3 (da)
MX (1) MX9606510A (da)
PT (2) PT1221440E (da)
TW (1) TW467899B (da)
WO (1) WO1995034540A1 (da)

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AR011913A1 (es) * 1997-03-06 2000-09-13 Yamano Masaki Derivados de 4,4-difluoro-2,3,4,5-tetrahidro-1h-1-benzoazepina y composiciones farmaceuticas de los mismos.
US6194407B1 (en) 1997-07-30 2001-02-27 American Home Products Corporation Tricyclic pyrido vasopressin agonists
US6511974B1 (en) 1997-07-30 2003-01-28 Wyeth Tricyclic vasopressin agonists
FR2781371B1 (fr) * 1998-07-21 2001-04-27 Oreal Composition cosmetique aqueuse transparente a une seule phase
US7138393B2 (en) 1998-07-24 2006-11-21 Wyeth Biologically active vasopressin agonist metabolites
US6090803A (en) * 1998-07-24 2000-07-18 American Home Products Corporation Tricyclic vasopressin agonists
US6344451B1 (en) 1999-02-04 2002-02-05 American Home Products Pyrrolobenzodiazepine carboxyamide vasopressin agonists
US6620807B1 (en) 1999-02-04 2003-09-16 Wyeth Pyridobenzodiazepine and pyridobenzoxazepine carboxyamide vasopressin agonists
US6235900B1 (en) 1999-02-04 2001-05-22 American Home Products Corporation Tricyclic pyridine N-oxides vasopressin agonists
DE19962923A1 (de) * 1999-12-24 2001-07-05 Bayer Ag Substituierte Benzoylcyclohexandione
GB0000079D0 (en) 2000-01-05 2000-02-23 Ferring Bv Novel antidiuretic agents
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CA2192928C (en) 2010-10-26
DE69530690D1 (de) 2003-06-12
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MX9606510A (es) 1997-03-29
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US6642223B2 (en) 2003-11-04
CN1150799A (zh) 1997-05-28
CN1313280A (zh) 2001-09-19
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US6096735A (en) 2000-08-01
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US6335327B1 (en) 2002-01-01
ATE360617T1 (de) 2007-05-15
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