WO2000046225A3 - Pyridobenzodiazepine and pyridobenzoxazepine carboxyamide vasopressin agonists - Google Patents

Pyridobenzodiazepine and pyridobenzoxazepine carboxyamide vasopressin agonists Download PDF

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Publication number
WO2000046225A3
WO2000046225A3 PCT/US2000/000886 US0000886W WO0046225A3 WO 2000046225 A3 WO2000046225 A3 WO 2000046225A3 US 0000886 W US0000886 W US 0000886W WO 0046225 A3 WO0046225 A3 WO 0046225A3
Authority
WO
WIPO (PCT)
Prior art keywords
pyridobenzoxazepine
pyridobenzodiazepine
carboxyamide
carboxyamides
vasopressin agonists
Prior art date
Application number
PCT/US2000/000886
Other languages
French (fr)
Other versions
WO2000046225A2 (en
Inventor
Robert John Steffan
Amedeo Arturo Failli
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Priority to CA002358895A priority Critical patent/CA2358895A1/en
Priority to AU28496/00A priority patent/AU2849600A/en
Priority to JP2000597295A priority patent/JP2002536375A/en
Priority to EP00906916A priority patent/EP1149097A2/en
Publication of WO2000046225A2 publication Critical patent/WO2000046225A2/en
Publication of WO2000046225A3 publication Critical patent/WO2000046225A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus

Abstract

The present invention provides benzoheterocyclic carboxyamides, particularly pyridobenzodiazepine and pyridobenzoxazepine carboxyamides, of general formula (I), wherein: W is O or NH, optionally substituted, as well as methods and pharmaceutical compositions utilizing these compounds for providing a temporary delay of urination or for the treatment of disorder which may be remedied or alleviated by vasopressin agonist activity, including diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, bleeding or coagulation disorders.
PCT/US2000/000886 1999-02-04 2000-01-13 Pyridobenzodiazepine and pyridobenzoxazepine carboxyamide vasopressin agonists WO2000046225A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002358895A CA2358895A1 (en) 1999-02-04 2000-01-13 Pyridobenzodiazepine and pyridobenzoxazepine carboxyamide vasopressin agonists
AU28496/00A AU2849600A (en) 1999-02-04 2000-01-13 Pyridobenzodiazepine and pyridobenzoxazepine carboxyamide vasopressin agonists
JP2000597295A JP2002536375A (en) 1999-02-04 2000-01-13 Pyridobenzodiazepine and pyridobenzoxazepine carboxamido vasopressin agonists
EP00906916A EP1149097A2 (en) 1999-02-04 2000-01-13 Pyridobenzodiazepine and pyridobenzoxazepine carboxyamide vasopressin agonists

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24468199A 1999-02-04 1999-02-04
US09/244,681 1999-02-04

Publications (2)

Publication Number Publication Date
WO2000046225A2 WO2000046225A2 (en) 2000-08-10
WO2000046225A3 true WO2000046225A3 (en) 2000-12-14

Family

ID=22923710

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/000886 WO2000046225A2 (en) 1999-02-04 2000-01-13 Pyridobenzodiazepine and pyridobenzoxazepine carboxyamide vasopressin agonists

Country Status (6)

Country Link
EP (1) EP1149097A2 (en)
JP (1) JP2002536375A (en)
CN (1) CN1339035A (en)
AU (1) AU2849600A (en)
CA (1) CA2358895A1 (en)
WO (1) WO2000046225A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201005623D0 (en) 2010-04-01 2010-05-19 Vantia Ltd New polymorph
WO2016089830A1 (en) * 2014-12-05 2016-06-09 Merck Sharp & Dohme Corp. Novel tricyclic compounds as inhibitors of mutant idh enzymes
EP3226690B1 (en) * 2014-12-05 2020-05-20 Merck Sharp & Dohme Corp. Novel tricyclic compounds as inhibitors of mutant idh enzymes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849735A (en) * 1995-01-17 1998-12-15 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
WO1999006403A1 (en) * 1997-07-30 1999-02-11 American Home Products Corporation Tricyclic vasopressin agonists

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849735A (en) * 1995-01-17 1998-12-15 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
WO1999006403A1 (en) * 1997-07-30 1999-02-11 American Home Products Corporation Tricyclic vasopressin agonists

Also Published As

Publication number Publication date
CA2358895A1 (en) 2000-08-10
AU2849600A (en) 2000-08-25
WO2000046225A2 (en) 2000-08-10
JP2002536375A (en) 2002-10-29
CN1339035A (en) 2002-03-06
EP1149097A2 (en) 2001-10-31

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