BR0208824A - Composto, métodos de tratamento de distúrbios que são remediados ou aliviados por atividade de agonista de vasopressina em um mamìfero, e de indução de retardamento temporário de urinação em um mamìfero, e, composição farmacêutica - Google Patents

Composto, métodos de tratamento de distúrbios que são remediados ou aliviados por atividade de agonista de vasopressina em um mamìfero, e de indução de retardamento temporário de urinação em um mamìfero, e, composição farmacêutica

Info

Publication number
BR0208824A
BR0208824A BR0208824-0A BR0208824A BR0208824A BR 0208824 A BR0208824 A BR 0208824A BR 0208824 A BR0208824 A BR 0208824A BR 0208824 A BR0208824 A BR 0208824A
Authority
BR
Brazil
Prior art keywords
mammal
remedied
methods
sub
agonist activity
Prior art date
Application number
BR0208824-0A
Other languages
English (en)
Inventor
Jay Scott Shumsky
John Paul Dusza
Thomas Joseph Caggiano
Kevin Anthony Memoli
Amadeo Arturo Failli
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BR0208824A publication Critical patent/BR0208824A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

"COMPOSTO, MéTODOS DE TRATAMENTO DE DISTúRBIOS QUE SãO REMEDIADOS OU ALIVIADOS POR ATIVIDADE DE AGONISTA DE VASOPRESSINA EM UM MAMìFERO, E DE INDUçãO DE RETARDAMENTO TEMPORáRIO DE URINAçãO EM UM MAMìFERO, E, COMPOSIçãO FARMACêUTICA". A presente invenção proporciona compostos de fórmulas gerais (I) e (II): nas quais Y é NR ou -(CH~ 2~)~ n~; R é H ou alquila; "Z" representa fenila opcionalmente substituída ou um anel aromático de 6 membros possuindo um átomo de nitrogênio; "W" representa uma fenila opcionalmente substituída ou um anel aromático de 5 membros possuindo um átomo de nitrogênio; "X" representa um anel aromático de 5 membros opcionalmente substituído possuindo um átomo de enxofre; bem como métodos e composições farmacêuticas utilizando estes compostos para a indução do retardamento temporário de urinação ou o tratamento de distúrbios remediados por atividade de agonista de vasopressina, incluindo diabetes insípido, enurese noturna, noctúria, incontinência urinária, ou distúrbios de coagulação e de sangramento.
BR0208824-0A 2001-04-12 2002-04-11 Composto, métodos de tratamento de distúrbios que são remediados ou aliviados por atividade de agonista de vasopressina em um mamìfero, e de indução de retardamento temporário de urinação em um mamìfero, e, composição farmacêutica BR0208824A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28338701P 2001-04-12 2001-04-12
PCT/US2002/011538 WO2002083685A1 (en) 2001-04-12 2002-04-11 Cyclohexylphenyl vasopressin agonists

Publications (1)

Publication Number Publication Date
BR0208824A true BR0208824A (pt) 2004-03-09

Family

ID=23085813

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0208824-0A BR0208824A (pt) 2001-04-12 2002-04-11 Composto, métodos de tratamento de distúrbios que são remediados ou aliviados por atividade de agonista de vasopressina em um mamìfero, e de indução de retardamento temporário de urinação em um mamìfero, e, composição farmacêutica

Country Status (12)

Country Link
US (2) US7053083B2 (pt)
EP (1) EP1381608B1 (pt)
JP (1) JP2004526771A (pt)
CN (1) CN1294134C (pt)
AT (1) ATE375346T1 (pt)
BR (1) BR0208824A (pt)
CA (1) CA2443870A1 (pt)
DE (1) DE60222879T2 (pt)
DK (1) DK1381608T3 (pt)
ES (1) ES2294130T3 (pt)
MX (1) MXPA03009159A (pt)
WO (1) WO2002083685A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0210397D0 (en) 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
CA2695634C (en) 2007-08-06 2018-01-23 Serenity Pharmaceuticals Corporation Methods and devices for desmopressin drug delivery
DK3225250T3 (da) 2008-05-21 2019-11-04 Ferring Bv Orodispersibel desmopressin til forlængelse af den indledende søvnperiode, som ikke forstyrres af nykturi
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
JP6557674B2 (ja) * 2014-03-12 2019-08-07 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク 新規クラスのミュー−オピオイド受容体アゴニスト
US10844027B2 (en) 2015-09-16 2020-11-24 The Trustees Of Columbia University In The City Of New York Carboxylic diarylthiazepineamines as mu-opioid receptor agonists
US10399972B2 (en) 2015-10-29 2019-09-03 Merck Sharp & Dohme Corp. Tricyclic compounds as inhibitors of mutant IDH enzymes

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686445A (en) 1993-07-29 1997-11-11 American Cyanamid Company Pyridobenzoxazepine and pyridobenzothiazepine vasopressin antagonists
US5516774A (en) * 1993-07-29 1996-05-14 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5736538A (en) * 1993-07-29 1998-04-07 American Cyanamid Company Tricyclic Benzazepine vasopressin antagonists
US5736540A (en) * 1993-07-29 1998-04-07 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5693635A (en) 1993-07-29 1997-12-02 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5760031A (en) 1993-07-29 1998-06-02 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5733905A (en) * 1993-07-29 1998-03-31 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5739128A (en) * 1993-07-29 1998-04-14 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5747487A (en) * 1993-07-29 1998-05-05 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
WO1995034540A1 (en) 1994-06-15 1995-12-21 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic derivatives useful as vasopressin or oxytocin modulators
US5849735A (en) * 1995-01-17 1998-12-15 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
AR002459A1 (es) 1995-01-17 1998-03-25 American Cyanamid Co Antagonistas de vasopresina de benzacepina triciclicos, una composicion farmaceutica que los contiene, un metodo para tratar enfermedades y unprocedimiento para su preparacion.
US5536718A (en) * 1995-01-17 1996-07-16 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5696112A (en) * 1995-01-17 1997-12-09 American Cyanamid Company Fused heterocyclic azepines as vasopressin antagonists
US5700796A (en) 1995-01-17 1997-12-23 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5753648A (en) 1995-01-17 1998-05-19 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5521173A (en) * 1995-01-17 1996-05-28 American Home Products Corporation Tricyclic benzazepine vasopressin antagonists
US5532235A (en) * 1995-01-17 1996-07-02 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
TW359669B (en) 1995-12-15 1999-06-01 Otsuka Pharma Co Ltd Benzazepine derivatives
AU4168999A (en) 1998-06-19 2000-01-05 Wakamoto Pharmaceutical Co., Ltd. Ocular tension lowering agents and phosphoric ester derivatives
TR200102069T2 (tr) 1999-01-19 2001-11-21 Ortho-Mcneil Pharmaceutical, Inc. Vasopresin reseptörü antagonistleri olarak trisiklik benzodiazepinler.

Also Published As

Publication number Publication date
US20020198191A1 (en) 2002-12-26
CA2443870A1 (en) 2002-10-24
JP2004526771A (ja) 2004-09-02
CN1294134C (zh) 2007-01-10
ATE375346T1 (de) 2007-10-15
WO2002083685A1 (en) 2002-10-24
US7329653B2 (en) 2008-02-12
US20060183734A1 (en) 2006-08-17
US7053083B2 (en) 2006-05-30
EP1381608A1 (en) 2004-01-21
CN1514834A (zh) 2004-07-21
EP1381608B1 (en) 2007-10-10
DE60222879D1 (de) 2007-11-22
ES2294130T3 (es) 2008-04-01
DK1381608T3 (da) 2008-02-04
MXPA03009159A (es) 2004-02-12
DE60222879T2 (de) 2008-07-24

Similar Documents

Publication Publication Date Title
DK1734041T3 (da) Inhibitorer for receptoren for ADP-blodplader
HK1068136A1 (en) Muscarinic antagonists
NO20000242D0 (no) Tricykliske vasopressin agonister
DE60114994D1 (de) Blutplättchen-adp-rezeptor-inhibitoren
ATE529107T1 (de) Ligustilid-derivate zur behandlung von entzündungserkrankungen
EA200400466A1 (ru) Производные пиперазина с антагонистической активностью к рецептору ccr1
CA2272291A1 (en) Crf antagonistic quino- and quinazolines
ATE444065T1 (de) 4(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidon-deriva e als pde-4-hemmer zur behandlung von neurologischen syndromen
EA200000614A1 (ru) 2,3-замещенные соединения индола в качестве ингибиторов сох-2
BR0208824A (pt) Composto, métodos de tratamento de distúrbios que são remediados ou aliviados por atividade de agonista de vasopressina em um mamìfero, e de indução de retardamento temporário de urinação em um mamìfero, e, composição farmacêutica
ES2176719T3 (es) Derivados de benzopirano que tienen una accion antagonista de leucotrienos.
EA200301203A1 (ru) Новые соединения и композиции как ингибиторы катепсина
DE69826677D1 (de) Trizyclische vasopressin agoniste
AR003416A1 (es) Nuevos derivados de acido hidroximico, procedimiento para preparar dichos derivados, compuestos intermediarios de aplicacion exclusiva en dichoprocedimiento, composiciones plaguicidas y procedimientos para el tratamiento de plantas con dichos derivados.
WO2000046224A3 (en) Tricyclic pyridine n-oxides vasopressin agonists
DK1337246T3 (da) Anvendelse af 6-dimethylaminomethyl-1-phenylcyclohexanforbindelser til behandling af urininkontinens
DK1353660T3 (da) Anvendelse af substituerede 6-dimethylaminomethyl-1-phenylcyclohexanforbindelser til behandling af urininkontinens
BR0113175A (pt) Derivados da quinolina como agentes antiinflamação
DE60000969D1 (de) Pyrrolobenzodiazepine carboxamide vasopressin agonisten
DE60117517D1 (de) Indolderivate als mcp-1 rezeptor antagonisten
WO2000046225A3 (en) Pyridobenzodiazepine and pyridobenzoxazepine carboxyamide vasopressin agonists
SE9902596D0 (sv) Pharmaceutically active compounds

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A(S) 9A ANUIDADE(S)

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2103 DE 26/04/2011.