IL116776A - Acylated bicyclic (di)azepine vasopressin and oxytocin antagonists and their preparation - Google Patents
Acylated bicyclic (di)azepine vasopressin and oxytocin antagonists and their preparationInfo
- Publication number
- IL116776A IL116776A IL11677696A IL11677696A IL116776A IL 116776 A IL116776 A IL 116776A IL 11677696 A IL11677696 A IL 11677696A IL 11677696 A IL11677696 A IL 11677696A IL 116776 A IL116776 A IL 116776A
- Authority
- IL
- Israel
- Prior art keywords
- vasopressin
- azepine
- preparation
- oxytocin antagonists
- acylated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/373,839 US5696112A (en) | 1995-01-17 | 1995-01-17 | Fused heterocyclic azepines as vasopressin antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
IL116776A0 IL116776A0 (en) | 1996-05-14 |
IL116776A true IL116776A (en) | 2000-10-31 |
Family
ID=23474102
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11677696A IL116776A (en) | 1995-01-17 | 1996-01-16 | Acylated bicyclic (di)azepine vasopressin and oxytocin antagonists and their preparation |
Country Status (23)
Country | Link |
---|---|
US (2) | US5696112A (de) |
EP (1) | EP0811008B1 (de) |
JP (1) | JPH10512572A (de) |
KR (1) | KR19980703098A (de) |
CN (1) | CN1177356A (de) |
AR (1) | AR010195A1 (de) |
AT (1) | ATE251166T1 (de) |
AU (1) | AU716008B2 (de) |
BR (1) | BR9607153A (de) |
CA (1) | CA2210571A1 (de) |
CZ (1) | CZ224697A3 (de) |
DE (1) | DE69630209T2 (de) |
DK (1) | DK0811008T3 (de) |
EA (1) | EA001427B1 (de) |
ES (1) | ES2207672T3 (de) |
HU (1) | HUP9800466A3 (de) |
IL (1) | IL116776A (de) |
MX (1) | MX9705312A (de) |
NZ (1) | NZ302119A (de) |
PT (1) | PT811008E (de) |
TW (1) | TW342385B (de) |
WO (1) | WO1996022294A1 (de) |
ZA (1) | ZA96298B (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997017349A1 (fr) * | 1995-11-09 | 1997-05-15 | Japan Tobacco Inc. | Derives heterocycliques fusionnes pentagonaux d'azepine et leur emploi pharmaceutique |
US6235900B1 (en) | 1999-02-04 | 2001-05-22 | American Home Products Corporation | Tricyclic pyridine N-oxides vasopressin agonists |
US6297234B1 (en) | 1999-02-04 | 2001-10-02 | American Home Products Corporation | Arylthiophene vasopressin agonists |
US6437006B1 (en) | 1999-09-27 | 2002-08-20 | American Cyanamid Company | Pharmaceutical carrier formulation |
DK1381370T3 (da) * | 2001-04-12 | 2007-05-21 | Wyeth Corp | N-Biphenylcarbonyl- og N-phenylpyridylcarbonyl-substituerede bi- og tricykliske azepiner og diazepiner som vasopressin-agonister |
US7064120B2 (en) * | 2001-04-12 | 2006-06-20 | Wyeth | Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists |
US7109193B2 (en) | 2001-04-12 | 2006-09-19 | Wyeth | Tricyclic diazepines tocolytic oxytocin receptor antagonists |
DE60222879T2 (de) * | 2001-04-12 | 2008-07-24 | Wyeth | Cyclohexylphenyl vasopressin agonisten |
US7022699B2 (en) | 2001-04-12 | 2006-04-04 | Wyeth | Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators |
US6977254B2 (en) * | 2001-04-12 | 2005-12-20 | Wyeth | Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists |
US6900200B2 (en) | 2001-04-12 | 2005-05-31 | Wyeth | Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists |
US7202239B2 (en) * | 2001-04-12 | 2007-04-10 | Wyeth | Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists |
US7326700B2 (en) * | 2001-04-12 | 2008-02-05 | Wyeth | Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists |
SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
EP1632494A1 (de) * | 2004-08-24 | 2006-03-08 | Ferring B.V. | Vasopressin v1a antagonisten |
KR101081293B1 (ko) * | 2006-01-18 | 2011-11-08 | 에프. 호프만-라 로슈 아게 | 11 베타-에이치에스디1 억제제로서 티아졸 |
JP5690286B2 (ja) * | 2009-03-04 | 2015-03-25 | イデニク プハルマセウティカルス,インコーポレイテッド | ホスホチオフェン及びホスホチアゾールhcvポリメラーゼ阻害剤 |
WO2010116176A1 (en) | 2009-04-09 | 2010-10-14 | Astrazeneca Ab | Pyrazolo [4, 5-e] pyrimidine derivative and its use to treat diabetes and obesity |
US10626126B2 (en) | 2016-04-08 | 2020-04-21 | Pulmocide Limited | Compounds |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA821020B (en) * | 1981-02-18 | 1983-10-26 | Thomae Gmbh Dr K | Azepine derivatives, process for their preparation and pharmaceutical compositions thereof |
US4766108A (en) * | 1986-12-04 | 1988-08-23 | Smith Kline Beckman Corporation | Tyr-Arg-vasopressin antagonists |
US5055448A (en) * | 1987-06-25 | 1991-10-08 | Medical College Of Ohio | Linear derivatives of arginine vasopressin antagonists |
ES2056259T3 (es) * | 1989-02-10 | 1994-10-01 | Otsuka Pharma Co Ltd | Derivados de carboestirilo. |
KR0167349B1 (ko) * | 1989-10-20 | 1999-02-18 | 오스카 아끼히꼬 | 벤조헤테로 고리 화합물 |
US5258510A (en) * | 1989-10-20 | 1993-11-02 | Otsuka Pharma Co Ltd | Benzoheterocyclic compounds |
US5070187A (en) * | 1989-11-03 | 1991-12-03 | Trustees Of Boston University | Pharmacologically effective antagonists of arginine-vasopressin |
TW199153B (de) * | 1990-08-07 | 1993-02-01 | Dtsuka Seiyaku Kk | |
TW198715B (de) * | 1991-04-19 | 1993-01-21 | Dtsuka Seiyaku Kk | |
EP0533243B1 (de) * | 1991-09-16 | 1997-12-17 | Merck & Co. Inc. | Hydantoin und Succinimid-substituierte Spiroindanylcamphorsulfonyl als Oxytocin-Antagonisten |
US5204349A (en) * | 1991-09-16 | 1993-04-20 | Merck & Co., Inc. | Amide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists |
EP0533242A3 (en) * | 1991-09-16 | 1993-09-15 | Merck & Co. Inc. | Substituted derivatives of piperazinylcamphorsulfonyl oxytocin antagonists |
EP0533240A3 (en) * | 1991-09-16 | 1993-09-29 | Merck & Co. Inc. | Substituted amine derivatives of piperazinylcamphorsulfonyl oxytocin antagonists |
AU657431B2 (en) * | 1992-08-20 | 1995-03-09 | Otsuka Pharmaceutical Co., Ltd. | Benzoheterocyclic compounds as oxytocin and vasopressin antagonists |
TW270927B (de) * | 1992-10-16 | 1996-02-21 | Otsuka Pharma Co Ltd | |
AU5533894A (en) * | 1992-11-25 | 1994-06-22 | Yamanouchi Pharmaceutical Co., Ltd. | Benzanilide derivative |
WO1994014796A1 (en) * | 1992-12-21 | 1994-07-07 | Yamanouchi Pharmaceutical Co., Ltd. | Novel n-(pyridylcarbonyl)benzazepine derivative and intermediate therefor |
AU6219994A (en) * | 1993-03-11 | 1994-09-26 | Yamanouchi Pharmaceutical Co., Ltd. | Compound with vasopressin antagonism |
GB9307527D0 (en) * | 1993-04-13 | 1993-06-02 | Fujisawa Pharmaceutical Co | New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
-
1995
- 1995-01-17 US US08/373,839 patent/US5696112A/en not_active Expired - Lifetime
- 1995-06-02 US US08/460,418 patent/US5654297A/en not_active Expired - Lifetime
-
1996
- 1996-01-15 ZA ZA96298A patent/ZA96298B/xx unknown
- 1996-01-15 AR ARP960101028A patent/AR010195A1/es not_active Application Discontinuation
- 1996-01-16 WO PCT/US1996/001096 patent/WO1996022294A1/en active IP Right Grant
- 1996-01-16 CA CA002210571A patent/CA2210571A1/en not_active Abandoned
- 1996-01-16 NZ NZ302119A patent/NZ302119A/en unknown
- 1996-01-16 CZ CZ972246A patent/CZ224697A3/cs unknown
- 1996-01-16 DE DE69630209T patent/DE69630209T2/de not_active Expired - Fee Related
- 1996-01-16 BR BR9607153A patent/BR9607153A/pt unknown
- 1996-01-16 ES ES96903711T patent/ES2207672T3/es not_active Expired - Lifetime
- 1996-01-16 TW TW085100460A patent/TW342385B/zh active
- 1996-01-16 IL IL11677696A patent/IL116776A/xx not_active IP Right Cessation
- 1996-01-16 CN CN96192356A patent/CN1177356A/zh active Pending
- 1996-01-16 DK DK96903711T patent/DK0811008T3/da active
- 1996-01-16 KR KR1019970704946A patent/KR19980703098A/ko not_active Application Discontinuation
- 1996-01-16 AT AT96903711T patent/ATE251166T1/de not_active IP Right Cessation
- 1996-01-16 HU HU9800466A patent/HUP9800466A3/hu unknown
- 1996-01-16 EA EA199700115A patent/EA001427B1/ru not_active IP Right Cessation
- 1996-01-16 PT PT96903711T patent/PT811008E/pt unknown
- 1996-01-16 MX MX9705312A patent/MX9705312A/es not_active IP Right Cessation
- 1996-01-16 JP JP8522453A patent/JPH10512572A/ja not_active Ceased
- 1996-01-16 AU AU47706/96A patent/AU716008B2/en not_active Ceased
- 1996-01-16 EP EP96903711A patent/EP0811008B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EA001427B1 (ru) | 2001-02-26 |
AR010195A1 (es) | 2000-06-07 |
CA2210571A1 (en) | 1996-07-25 |
AU716008B2 (en) | 2000-02-17 |
DE69630209D1 (de) | 2003-11-06 |
ATE251166T1 (de) | 2003-10-15 |
HUP9800466A3 (en) | 1998-12-28 |
EA199700115A1 (ru) | 1997-12-30 |
NZ302119A (en) | 2000-02-28 |
AU4770696A (en) | 1996-08-07 |
DK0811008T3 (da) | 2004-01-26 |
PT811008E (pt) | 2004-02-27 |
KR19980703098A (ko) | 1998-10-15 |
US5696112A (en) | 1997-12-09 |
WO1996022294A1 (en) | 1996-07-25 |
DE69630209T2 (de) | 2004-08-19 |
ES2207672T3 (es) | 2004-06-01 |
IL116776A0 (en) | 1996-05-14 |
EP0811008A1 (de) | 1997-12-10 |
BR9607153A (pt) | 1997-11-11 |
HUP9800466A2 (hu) | 1998-07-28 |
US5654297A (en) | 1997-08-05 |
CZ224697A3 (cs) | 1998-01-14 |
EP0811008B1 (de) | 2003-10-01 |
CN1177356A (zh) | 1998-03-25 |
TW342385B (en) | 1998-10-11 |
JPH10512572A (ja) | 1998-12-02 |
MX9705312A (es) | 1997-10-31 |
ZA96298B (en) | 1997-07-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL116776A (en) | Acylated bicyclic (di)azepine vasopressin and oxytocin antagonists and their preparation | |
IL116777A (en) | Tricyclic benzazepine vasopressin and oxytocin antagonists their preparation and pharmaceutical compositions containing them | |
HK1004132A1 (en) | Tricyclic benzazepine vasopressin antagonists | |
ZA96303B (en) | Tricyclic benzazepine vasopressin antagonists | |
ZA96300B (en) | Tricyclic benzazepine vasopressin antagonists | |
ZA96299B (en) | Tricyclic benzazepine vasopressin antagonists | |
IL112243A (en) | Benzazepine and benzodiazepine fribinogen antagonists a process for their preparation and pharmaceutical compositions containing them | |
HUT74808A (en) | Gnrh antagonists | |
HK1016973A1 (en) | Benzazepine derivatives with vasopressin agonistic activity | |
AU5593094A (en) | Bicyclic gnrh antagonists | |
IL107400A0 (en) | Bradykinin antagonists | |
AU3641497A (en) | Tricyclic benzazepine vasopressin antagonists | |
IL118299A0 (en) | Pharmacological use of AII-receptor antagonists | |
AU3296597A (en) | Tricyclic benzazepine vasopressin antagonists | |
IL108509A0 (en) | GnRH antagonist peptides | |
IL114046A0 (en) | New opioid peptide antagonists | |
SI0804438T1 (sl) | Triciklicni benzazepinski antagonisti vazopresina | |
GB9306489D0 (en) | Oxytocin antagonists | |
IL113441A0 (en) | Opioid peptide analoog | |
AU4974596A (en) | Betide-substituted gnrh antagonists | |
ZA88964B (en) | Oxytocin and vasopressin antagonists | |
IL119412A0 (en) | Gonadotropins and pharmaceutical compositions containing them | |
SI0873309T1 (en) | 3-spiro-indolin-2-one derivatives as vasopressin and/or oxytocin receptor ligands | |
IL118157A0 (en) | Compositions containing diacyl tartaric anhydrides and their preparation | |
KR100248605B1 (en) | Oxytocin antagonist |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |