DE69224613D1 - Peptide, Herstellung und deren Verwendung - Google Patents
Peptide, Herstellung und deren VerwendungInfo
- Publication number
- DE69224613D1 DE69224613D1 DE69224613T DE69224613T DE69224613D1 DE 69224613 D1 DE69224613 D1 DE 69224613D1 DE 69224613 T DE69224613 T DE 69224613T DE 69224613 T DE69224613 T DE 69224613T DE 69224613 D1 DE69224613 D1 DE 69224613D1
- Authority
- DE
- Germany
- Prior art keywords
- group
- lower alkyl
- alkyl group
- integer
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 108050009340 Endothelin Proteins 0.000 abstract 1
- 102000002045 Endothelin Human genes 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP34665991 | 1991-12-27 | ||
| JP1201392 | 1992-01-27 | ||
| JP26993292 | 1992-10-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69224613D1 true DE69224613D1 (de) | 1998-04-09 |
| DE69224613T2 DE69224613T2 (de) | 1998-06-18 |
Family
ID=27279672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69224613T Expired - Fee Related DE69224613T2 (de) | 1991-12-27 | 1992-12-23 | Peptide, Herstellung und deren Verwendung |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5614497A (de) |
| EP (1) | EP0552489B1 (de) |
| AT (1) | ATE163649T1 (de) |
| CA (1) | CA2086079A1 (de) |
| DE (1) | DE69224613T2 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0626174A3 (de) * | 1993-04-21 | 1996-01-03 | Takeda Chemical Industries Ltd | Verfahren und Zusammensetzung für die Prophylaxe und/oder Behandlung von Organunterfunktion. |
| CA2229263A1 (en) * | 1995-09-26 | 1997-04-03 | Toshifumi Watanabe | Peptide derivatives, their production and use |
| EP2792747A1 (de) | 2000-06-23 | 2014-10-22 | Genentech, Inc. | Zusammensetzungen und Verfahren zur Diagnose und Behandlung von Erkrankungen in Verbindung mit Angiogenese |
| EP2075253A1 (de) | 2000-06-23 | 2009-07-01 | Genentech, Inc. | Methoden und Verbindungen zur Diagnose und Behandlung von Krankheiten, an denen Angiogenese beteiligt ist |
| CN100500691C (zh) * | 2005-10-20 | 2009-06-17 | 中国人民解放军军事医学科学院毒物药物研究所 | 2位含脯氨酸或环状氨基酸的肽类内皮素受体拮抗剂 |
| US20100022568A1 (en) * | 2006-04-13 | 2010-01-28 | Actelion Pharmaceeuticals Ltd. | Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis |
| JP5736533B2 (ja) * | 2007-07-19 | 2015-06-17 | 学校法人北里研究所 | 抗ストレス作用と嗜好性向上効果を備えたペプチド性ペットフード素材 |
| US8246298B2 (en) * | 2009-02-26 | 2012-08-21 | General Electric Company | Borescope boss and plug cooling |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8919726D0 (en) * | 1989-08-31 | 1989-10-11 | Fujisawa Pharmaceutical Co | Ws7338 substances and preparation thereof |
| EP0470256A1 (de) * | 1990-02-26 | 1992-02-12 | Takeda Chemical Industries, Ltd. | Peptidderivate und deren herstellung |
| US5430022A (en) * | 1990-05-14 | 1995-07-04 | Fujisawa Pharmaceutical Co., Ltd. | Peptide compound and its preparation |
| US5284828A (en) * | 1990-05-14 | 1994-02-08 | Fujisawa Pharmaceutical Co. Ltd. | Peptide compound and its preparation |
| US5496928A (en) * | 1990-06-07 | 1996-03-05 | Banyu Pharmaceutical Co., Ltd. | Endothelin antagonistic substance |
| CA2043741C (en) * | 1990-06-07 | 2003-04-01 | Kiyofumi Ishikawa | Endothelin antagonistic peptide derivatives |
| ES2089256T3 (es) * | 1991-02-15 | 1996-10-01 | Takeda Chemical Industries Ltd | Antagonista de la endotelina. |
| AU673731B2 (en) * | 1993-06-03 | 1996-11-21 | Banyu Pharmaceutical Co., Ltd. | Novel endothelin antagonistic peptide |
-
1992
- 1992-12-17 US US07/992,131 patent/US5614497A/en not_active Expired - Fee Related
- 1992-12-22 CA CA002086079A patent/CA2086079A1/en not_active Abandoned
- 1992-12-23 AT AT92121908T patent/ATE163649T1/de not_active IP Right Cessation
- 1992-12-23 DE DE69224613T patent/DE69224613T2/de not_active Expired - Fee Related
- 1992-12-23 EP EP92121908A patent/EP0552489B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE163649T1 (de) | 1998-03-15 |
| EP0552489B1 (de) | 1998-03-04 |
| EP0552489A2 (de) | 1993-07-28 |
| EP0552489A3 (de) | 1994-02-16 |
| US5614497A (en) | 1997-03-25 |
| CA2086079A1 (en) | 1993-06-28 |
| DE69224613T2 (de) | 1998-06-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |