ES2089256T3 - Antagonista de la endotelina. - Google Patents

Antagonista de la endotelina.

Info

Publication number
ES2089256T3
ES2089256T3 ES92102498T ES92102498T ES2089256T3 ES 2089256 T3 ES2089256 T3 ES 2089256T3 ES 92102498 T ES92102498 T ES 92102498T ES 92102498 T ES92102498 T ES 92102498T ES 2089256 T3 ES2089256 T3 ES 2089256T3
Authority
ES
Spain
Prior art keywords
salt
peptide
amino acid
carbon atoms
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92102498T
Other languages
English (en)
Inventor
Mitsuhiro Wakimasu
Takashi Kikuchi
Kazuki Kubo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ES2089256T3 publication Critical patent/ES2089256T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

SE EXPONE UN PEPTIDO REPRESENTADO POR LA FORMULA (I) O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO: DONDE M REPRESENTA UN GRUPO MERCAPTOACILO; P, Q, R, S, T, U, V, W, X, Y Y Z , CADA UNO REPRESENTA RESIDUOS AMINO ACIDOS, DONDE UNA CADENA LATERAL DEL AMINO ACIDO DE Y ES BIEN UN GRUPO HIDROCARBURO ALIFATICO SATURADO PROVISTO DE 1 A 15 ATOMOS DE CARBONO O UN GRUPO HIDROCARBURO ALIFATICO SATURADO NO SUSTITUIDO PROVISTO DE 4 A 15 ATOMOS DE CARBONO DISTINTOS DE (1S)-1-METILPROPIL; (2) UN METODO PARA PRODUCIR EL PEPTIDO ANTES MENCIONADO O LA SAL DEL MISMO, QUE COMPRENDE EL SOMETER AL PEPTIDO REPRESENTADO POR LA FORMULA (II) O UNA SAL DEL MISMO A UNA REACCION DE OXIDACION: DONDE M, P, Q, R, S, T, U, V, W, X, Y Y Z SON IGUALES A LOS ANTERIORMENTE DEFINIDOS; Y (3) UTILIZACION DEL PEPTIDO ANTES MENCIONADO O DE LA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO COMO AGENTE ANTI-ENDOTELIO.
ES92102498T 1991-02-15 1992-02-14 Antagonista de la endotelina. Expired - Lifetime ES2089256T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2222091 1991-02-15
JP33723591 1991-12-19

Publications (1)

Publication Number Publication Date
ES2089256T3 true ES2089256T3 (es) 1996-10-01

Family

ID=26359402

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92102498T Expired - Lifetime ES2089256T3 (es) 1991-02-15 1992-02-14 Antagonista de la endotelina.

Country Status (7)

Country Link
US (1) US5352659A (es)
EP (1) EP0499266B1 (es)
AT (1) ATE140236T1 (es)
CA (1) CA2061246A1 (es)
DE (1) DE69212011T2 (es)
ES (1) ES2089256T3 (es)
GR (1) GR3020961T3 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962490A (en) * 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
CA2043741C (en) * 1990-06-07 2003-04-01 Kiyofumi Ishikawa Endothelin antagonistic peptide derivatives
US5736509A (en) * 1990-12-14 1998-04-07 Texas Biotechnology Corporation Cyclic peptide surface feature mimics of endothelin
ES2089256T3 (es) * 1991-02-15 1996-10-01 Takeda Chemical Industries Ltd Antagonista de la endotelina.
EP0547317A1 (en) * 1991-12-19 1993-06-23 Takeda Chemical Industries, Ltd. Endothelin antagonists
US5614497A (en) * 1991-12-27 1997-03-25 Takeda Chemical Industries, Ltd. Peptide, production and use thereof
FR2687156B1 (fr) * 1992-02-12 1994-04-01 Roussel Uclaf Nouveaux derives peptidiques, procede de preparation et application a titre de medicaments de ces nouveaux derives.
EP0626174A3 (en) * 1993-04-21 1996-01-03 Takeda Chemical Industries Ltd Method and composition for the prophylaxis and / or treatment of underactive organs.
US6030991A (en) * 1993-05-20 2000-02-29 Texas Biotechnology Corp. Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6541498B2 (en) 1993-05-20 2003-04-01 Texas Biotechnology Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6613804B2 (en) 1993-05-20 2003-09-02 Encysive Pharmaceuticals, Inc. Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US6342610B2 (en) 1993-05-20 2002-01-29 Texas Biotechnology Corp. N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US6376523B1 (en) 1994-05-20 2002-04-23 Texas Biotechnology Corporation Benzenesulfonamides and the use thereof to modulate the activity of endothelin
CA2142985A1 (en) * 1993-06-25 1995-01-05 Kenji Shibata Endothelin-antagonizing peptide
US5977117A (en) 1996-01-05 1999-11-02 Texas Biotechnology Corporation Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
US5958905A (en) 1996-03-26 1999-09-28 Texas Biotechnology Corporation Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin
US5804585A (en) * 1996-04-15 1998-09-08 Texas Biotechnology Corporation Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
DE19652374A1 (de) * 1996-12-04 1998-06-10 Schering Ag Verwendung von Endothelin-Konjugaten in der Therapie, neue Endothelin-Konjugate, diese enthaltende Mittel, sowie Verfahren zu deren Herstellung
US5783705A (en) * 1997-04-28 1998-07-21 Texas Biotechnology Corporation Process of preparing alkali metal salys of hydrophobic sulfonamides
JP3455233B2 (ja) 1997-04-28 2003-10-14 テキサス・バイオテクノロジー・コーポレイシヨン エンドテリン介在障害治療用のスルホンアミド類
IL145406A0 (en) 1999-03-29 2002-06-30 Procter & Gamble Melanocortin receptor ligands
US7566452B1 (en) * 1999-05-04 2009-07-28 New York University Cancer treatment with endothelin receptor antagonists
DE60034605T2 (de) 1999-12-31 2007-09-06 Encysive Pharmaceuticals, Inc., Houston Sulfonamide und deren Derivate als Modulatoren der Endothelin-Aktivität
US20050175667A1 (en) * 2004-02-10 2005-08-11 Wenda Carlyle Use of endothelin antagonists to prevent restenosis
MX2008011844A (es) * 2006-03-13 2008-10-02 Encysive Pharmaceuticals Inc Formulaciones de sitaxsentano de sodio.
CN101404981A (zh) * 2006-03-13 2009-04-08 恩希赛弗制药公司 治疗舒张性心力衰竭的方法和组合物
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
EP2472258A3 (en) 2006-04-04 2012-11-28 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
US20080026061A1 (en) * 2006-06-22 2008-01-31 Reichwein John F Crystalline N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-methyl-4.5-(methylenedioxy)phenylacetyl]-thiophene-3-sulfonamide
WO2010144358A1 (en) 2009-06-08 2010-12-16 Singulex, Inc. Highly sensitive biomarker panels

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8919726D0 (en) * 1989-08-31 1989-10-11 Fujisawa Pharmaceutical Co Ws7338 substances and preparation thereof
CA2032559C (en) * 1989-12-28 2001-11-06 Kiyofumi Ishikawa Endothelin antagonistic cyclic pentapeptides
CA2053895A1 (en) * 1990-02-26 1991-08-27 Mitsuhiro Wakimasu Peptide derivatives and production thereof
ES2089256T3 (es) * 1991-02-15 1996-10-01 Takeda Chemical Industries Ltd Antagonista de la endotelina.

Also Published As

Publication number Publication date
DE69212011T2 (de) 1997-01-09
GR3020961T3 (en) 1996-12-31
US5352659A (en) 1994-10-04
EP0499266B1 (en) 1996-07-10
CA2061246A1 (en) 1992-08-16
DE69212011D1 (de) 1996-08-14
ATE140236T1 (de) 1996-07-15
EP0499266A1 (en) 1992-08-19

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