ZA869400B - A process for the preparation of 7alpha-acetylthiosteroids - Google Patents
A process for the preparation of 7alpha-acetylthiosteroidsInfo
- Publication number
- ZA869400B ZA869400B ZA869400A ZA869400A ZA869400B ZA 869400 B ZA869400 B ZA 869400B ZA 869400 A ZA869400 A ZA 869400A ZA 869400 A ZA869400 A ZA 869400A ZA 869400 B ZA869400 B ZA 869400B
- Authority
- ZA
- South Africa
- Prior art keywords
- acetylthiosteroids
- 7alpha
- preparation
- alpha
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/008—3 membered carbocyclic rings in position 15/16
Abstract
A process for producing 7 alpha -acetylsteroids having the formula (I), in which R1, R2, R3 and R4 are hydrogen or (a) is the group (b) and (c) is the group (d). The process is characterized by the fact that a 3-oxo-17 alpha -pregna-4,6-dien-21,17-carbolacton having the formula (II), in which R3 and R4 have the meaning already described, is transformed with thioacetic acid in the presence of acids of Lewis.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19853544661 DE3544661A1 (en) | 1985-12-13 | 1985-12-13 | METHOD FOR PRODUCING 7 (ALPHA) -ACETYLTHIOSTEROIDES |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA869400B true ZA869400B (en) | 1987-08-26 |
Family
ID=6288679
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA869400A ZA869400B (en) | 1985-12-13 | 1986-12-12 | A process for the preparation of 7alpha-acetylthiosteroids |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0226101B1 (en) |
JP (1) | JPS63501949A (en) |
AT (1) | ATE49978T1 (en) |
AU (1) | AU6725187A (en) |
DE (2) | DE3544661A1 (en) |
HU (1) | HU196608B (en) |
WO (1) | WO1987003599A1 (en) |
ZA (1) | ZA869400B (en) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3013012A (en) * | 1960-12-22 | 1961-12-12 | Searle & Co | Alkanoylthio-17alpha-carboxyethyl-17beta-hydroxyandrosten-3-one lactones |
DE2652761C2 (en) * | 1976-11-16 | 1985-11-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | 15,16-methylene-spirolactones, processes for their preparation and pharmaceuticals containing them |
JPS53116361A (en) * | 1977-03-17 | 1978-10-11 | Mitsubishi Chem Ind Ltd | Preparation of 7 acylthioo44enee33oxosteroid |
DE3227598A1 (en) * | 1982-07-22 | 1984-01-26 | Schering AG, 1000 Berlin und 4709 Bergkamen | 7 (ALPHA) -ACYLTHIO-15.16-METHYLENE-3-OXO-17 (ALPHA) -PREGNA-1.4-DIEN-21,17-CARBOLACTONE, METHOD FOR THE PRODUCTION AND USE THEREOF AS A MEDICINAL PRODUCT |
-
1985
- 1985-12-13 DE DE19853544661 patent/DE3544661A1/en not_active Withdrawn
-
1986
- 1986-11-28 WO PCT/DE1986/000486 patent/WO1987003599A1/en unknown
- 1986-11-28 DE DE8686116565T patent/DE3668626D1/en not_active Expired - Lifetime
- 1986-11-28 JP JP62500020A patent/JPS63501949A/en active Pending
- 1986-11-28 AT AT86116565T patent/ATE49978T1/en not_active IP Right Cessation
- 1986-11-28 AU AU67251/87A patent/AU6725187A/en not_active Abandoned
- 1986-11-28 HU HU865586A patent/HU196608B/en not_active IP Right Cessation
- 1986-11-28 EP EP86116565A patent/EP0226101B1/en not_active Expired - Lifetime
- 1986-12-12 ZA ZA869400A patent/ZA869400B/en unknown
Also Published As
Publication number | Publication date |
---|---|
HU196608B (en) | 1988-12-28 |
WO1987003599A1 (en) | 1987-06-18 |
HUT44271A (en) | 1988-02-29 |
EP0226101B1 (en) | 1990-01-31 |
EP0226101A1 (en) | 1987-06-24 |
ATE49978T1 (en) | 1990-02-15 |
DE3668626D1 (en) | 1990-03-08 |
JPS63501949A (en) | 1988-08-04 |
DE3544661A1 (en) | 1987-06-19 |
AU6725187A (en) | 1987-06-30 |
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