KR850008157A - 아미노산 및 이 에스테르의 n-아실유도체의 제조방법 - Google Patents

아미노산 및 이 에스테르의 n-아실유도체의 제조방법 Download PDF

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KR850008157A
KR850008157A KR1019850003642A KR850003642A KR850008157A KR 850008157 A KR850008157 A KR 850008157A KR 1019850003642 A KR1019850003642 A KR 1019850003642A KR 850003642 A KR850003642 A KR 850003642A KR 850008157 A KR850008157 A KR 850008157A
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derivative
group
dihydro
ethyl
carbonyl
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KR1019850003642A
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English (en)
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끌로드(외 2) 라루엘레
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원본미기재
빵메디까 소시에떼 아노님
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Publication of KR850008157A publication Critical patent/KR850008157A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

아미노산 및 이 에스테르의 N-아실유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (13)

  1. 다음 일반식(Ⅰ)에 해당하는 아미노산 및 이 에스테르의 1-에틸피리딘-4-온-3-카르복실 유도체.
  2. 제1항에 있어서, 제약학적으로 수용가능한 산 부가염.
  3. 제1항에 있어서, 제약학적으로 수용가능한 염기의 부가염.
  4. 제1항에서 3항 중 어느 하나에 있어서, Q와 피리돈이 함께 1-에틸-1,4-디히드로-6,7-메틸렌디옥시-4-옥소퀴놀린-3-일 유도체를 생성하는 유도체.
  5. 제1항에서 3항중 어느 하나에 있어서, Q와 피리돈이 함께 1-에틸-1,4-디히드로-7-메틸-4-옥소-1,8-나프티리딘-3-일 유도체를 생성하는 유도체.
  6. 제1항에 있어서, 4-N-(1-에틸-1,4-디히드로-6,7-메틸렌디옥시-4-옥소-퀴놀린-3-카르보닐)아미노낙산으로 된 유도체.
  7. 제1항에 있어서, 디에틸(L)-N-(1-에틸-1,4-디히드로-6,7-메틸렌디옥시-4-옥소퀴놀린-3-카르보닐)글루타메이트로된 유도체.
  8. 제1항에 있어서, 디에틸(L)-N-(1-에틸-1,4-디히드로-6,7-메틸렌디옥시-4-옥소퀴놀린-3-카르보닐)아스파르테이트로된 유도체.
  9. 제1항에 있어서, 디에틸(L)-N-(1-에틸-1,4-디히드로-7-메틸-4-옥소-1,8-나프티리딘-3--카르보닐)아스파르테이트로된 유도체.
  10. 제1항에 있어서, 디에틸(L)-N-(1-에틸-1,4-디히드로-7-메틸-4-옥소-1,8-나프티리딘-3-카르보닐)글루타메이트로 된 유도체.
  11. 제1항에서 10항중 어느 하나에 있어서, 치환된 1-에틸피리딘-4-온-3-카르복실산의 반응성 유도체를 적당한 용매에서 아미노산에스테르와 반응시켜, 이 결과의 에스테르를 비누화로 블록되지 않게 하고 반응은 N-아실화에 적당한 용매에서 이루어지는 것을 특징으로 하는 방법.
  12. 제11항에 있어서, 사용된 아미노산 에스테르의 -그룹을 제외한 반응성 그룹이 블록되는 것을 특징으로 하는 방법.
  13. 제1항에서 10항중 어느 한항에 있어서, 최소한 하나의 화합물을 그 자체로 또는 하나 또는 그 이상의 활성성분 및/또는 제약학적으로 가능한 보조제와 결합하여 이루어진 약.
    여기서, A는 1-6개의 탄소원자를 갖는 곧은 또는 가지달린 포화탄화수소 라디칼 또는 6개의 탄소원자를 갖는 포화고리를 나타내고, X는 -COOH라디칼, -COO알킬라디칼(탄소원자 1-4개의 알킬) 또는 Y가 -COOH 또는 -COO 알킬일 때 수소원자 또는 -CH3그룹을 나타내고, Y는 -COOH라디칼, -COO알킬라디칼(탄소원자 1-4개의 알킬), -NH2그룹, -SH그룹, -SCH2그룹, -NH-CH(=NH)-NH2그룹, 치환되거나 치환되지 않은 페닐그룹, 인들린-3-일그룹 또는 5-히드록시 인돌린-3-일 그룹을 나타내며, Q는 선택적으로 치환된 방향족 고리 또는 1또는 2개의 질소원자를 갖는 선택적으로 치환된 헤테로 고리를 나타낸다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850003642A 1984-05-23 1985-05-23 아미노산 및 이 에스테르의 n-아실유도체의 제조방법 KR850008157A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8408036 1984-05-23
FR8408036A FR2564832B1 (fr) 1984-05-23 1984-05-23 Nouveaux n-acyl derives d'amino-acides et leurs esters, leur procede de preparation et medicaments les contenant

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KR850008157A true KR850008157A (ko) 1985-12-13

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KR1019850003642A KR850008157A (ko) 1984-05-23 1985-05-23 아미노산 및 이 에스테르의 n-아실유도체의 제조방법

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Country Link
US (1) US4621088A (ko)
EP (1) EP0165155A1 (ko)
JP (1) JPS60260578A (ko)
KR (1) KR850008157A (ko)
FR (1) FR2564832B1 (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2583751B1 (fr) * 1985-06-20 1989-10-13 Panmedica Nouveaux antibacteriens contenant des derives des acides oxo-4-pyridine carboxyliques et leur procede de preparation
GB8727737D0 (en) * 1987-11-26 1987-12-31 Ici Plc Antitumour agents
US5057523A (en) * 1988-09-22 1991-10-15 Abbott Laboratories Dipeptide quinolone derivatives
US5057520A (en) * 1989-03-24 1991-10-15 Abbott Laboratories 7-(peptidylpyrolidinyl)naphthyridine antibacterial compounds
JP3215112B2 (ja) * 1992-03-13 2001-10-02 シーメンス アクチエンゲゼルシヤフト 二層型被覆管を有する原子炉燃料棒
US5681832A (en) * 1995-02-17 1997-10-28 The United States Of America As Represented By The Department Of Health And Human Services Aroylaniline compounds, pharmaceutical compositions, and methods of using same to inhibit viral activity
WO1997004779A1 (en) * 1995-08-02 1997-02-13 Chiroscience Limited Quinolones and their therapeutic use
DE69631423T2 (de) * 1995-08-02 2004-12-02 Darwin Discovery Ltd., Slough Chinolone und deren therapeutische verwendung
US6143760A (en) 1997-08-25 2000-11-07 Neurogen Corporation Substituted 4-oxo-napthyridine-3-carboxamides: GABA brain receptor ligands
GB201409044D0 (en) * 2014-05-21 2014-07-02 Ucl Business Plc New compounds

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3524858A (en) * 1967-05-18 1970-08-18 Warner Lambert Pharmaceutical 1,4 - dihydro-1-substituted alkyl-6,7-methylenedioxy - 4 - oxoquinoline-3-carboxylic acid
US3590036A (en) * 1968-11-18 1971-06-29 George Y Lesher Naphthyridine-3-carboxylic acids,their derivatives and preparation thereof
US4024255A (en) * 1973-04-05 1977-05-17 Allen & Hanburys Limited Tetrazole containing naphthyridine-3-carboxamides
FR2509728A1 (fr) * 1981-07-17 1983-01-21 Roussel Uclaf Nouveaux derives de la quinoleine, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant

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EP0165155A1 (fr) 1985-12-18
US4621088A (en) 1986-11-04
FR2564832A1 (fr) 1985-11-29
FR2564832B1 (fr) 1987-05-15
JPS60260578A (ja) 1985-12-23

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