KR840000530A - 신규 벤조트리아졸의 제조방법 - Google Patents
신규 벤조트리아졸의 제조방법 Download PDFInfo
- Publication number
- KR840000530A KR840000530A KR1019820003302A KR820003302A KR840000530A KR 840000530 A KR840000530 A KR 840000530A KR 1019820003302 A KR1019820003302 A KR 1019820003302A KR 820003302 A KR820003302 A KR 820003302A KR 840000530 A KR840000530 A KR 840000530A
- Authority
- KR
- South Korea
- Prior art keywords
- carbon atoms
- groups
- group
- formula
- compound
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 4
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 title claims 2
- 239000012964 benzotriazole Substances 0.000 title claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 150000007522 mineralic acids Chemical class 0.000 claims 2
- 150000007524 organic acids Chemical class 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 238000009835 boiling Methods 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 150000004820 halides Chemical class 0.000 claims 1
- 150000007928 imidazolide derivatives Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- -1 methoxyphenyl Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000006384 methylpyridyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 150000007970 thio esters Chemical class 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (11)
- (a) 일반식 (Ⅱ)의 화합물을 무기 또는 유기 나이트-라이트와 반응시키거나,
- (b) 일반식 (Ⅲ)의 카복실산 또는 그의 무수물, 에스테르, 티오에스테르, 아미드, 이미다졸리드 또는 할라이드를 하이드라진과 반응시켜 일반식 (Ⅰ) 화합물을 생성하고, 필요하면 R2가 수소원자를 나타내지 않는 일반식 (Ⅰ) 화합물을 라세미체 분할법에 의해 그의 광학적 활성 에난티오머로 분활하고, 및/또는 수득한 일반식 (Ⅰ) 화합물을 무기 또는 유기산에 의해 그의 산부가염, 특히 생리학적으로 허용되는 산부가염으로 전환시키는 것을 특징으로 하여, 일반식 (Ⅰ)의 벤조트리아졸 및 그의 산부가염, 특히 생리학적으로 허용되는 무기 또는 유기산과의 산부가염을 제조하는 방법.
-
-
- 상기 일반식에서
- R1은 수소원자 ; 탄소수 1 내지 7의 알킬그룹 ; 탄소수 3 내지 7의 사이클로알킬그룹 ; 탄소수 1 내지 3의 알킬그룹 〔이는 페닐(이는 아미노 그룹, 디메틸아미노 그룹, 하나 또는 두 개의 하이드록시그룹, 하나 내지 세 개의 메톡시 그룹 및/또는 하나 내지 세 개의 할로겐 원자로 단일-, 이- 또는 삼- 치환될 수 있으며, 치환기는 같거나 다르다), 피리딜 또는 메틸피리딜 그룹으로 치환됨〕; 탄소수 2 내지 4의 알킬 그룹(말단 위치가 하이드록시 그룹 또는 탄소수 1 내지 3의 디알킬아미노 그룹으로 치환됨) ; 할로겐 원자로 임의 치환됨 페닐 그룹 ; 탄소수 1 내지 6의 직쇄 또는 측쇄 알카노일 그룹(이는 페닐, 메톡시페닐 또는 탄소수 3 내지 7의 사이클로 알킬그룹으로 치환될 수 있다) ; 또는 메틸 또는 메톡시 그룹으로 임의 치환된 페닐셜포닐 그룹을 나타내며.
- R2는 수소원자 또는 탄소수 1 내지 3의 알킬그룹을 나타낸다.
- 제 1 항에 있어서, 반응을 용매 중에서 수행하는 것을 특징으로 하는 방법.
- 제 1 항 (a) 및 2항에 있어서, 반응을 -10 내지 40℃에서, 바람직하게는 0내지 25℃에서 수행하는 것을 특징으로 하는 방법.
- 제 1 항 (b) 및 2항에 있어서, 반응을 0 내지 200℃에서, 바람직하게는 반응 혼합물의 비점에서 수행하는 것을 특징으로 하는 방법.
- ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3129447 | 1981-07-25 | ||
DEP3129447.2 | 1981-07-25 | ||
DE19813129447 DE3129447A1 (de) | 1981-07-25 | 1981-07-25 | "neue benztriazole, ihre herstellung und ihre verwendung als arzneimittel" |
Publications (2)
Publication Number | Publication Date |
---|---|
KR840000530A true KR840000530A (ko) | 1984-02-25 |
KR880001476B1 KR880001476B1 (ko) | 1988-08-13 |
Family
ID=6137768
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR8203302A KR880001476B1 (ko) | 1981-07-25 | 1982-07-23 | 벤조트리아졸의 제조방법 |
Country Status (27)
Country | Link |
---|---|
US (1) | US4616018A (ko) |
EP (1) | EP0071102B1 (ko) |
JP (1) | JPS5824582A (ko) |
KR (1) | KR880001476B1 (ko) |
AR (1) | AR230631A1 (ko) |
AT (1) | ATE16184T1 (ko) |
AU (1) | AU554184B2 (ko) |
CA (1) | CA1189076A (ko) |
CS (1) | CS226747B2 (ko) |
DD (1) | DD202564A5 (ko) |
DE (2) | DE3129447A1 (ko) |
DK (1) | DK331282A (ko) |
ES (2) | ES8308325A1 (ko) |
FI (1) | FI73994C (ko) |
GB (1) | GB2107703B (ko) |
GR (1) | GR76230B (ko) |
HU (1) | HU188585B (ko) |
IE (1) | IE53664B1 (ko) |
IL (1) | IL66385A (ko) |
NO (1) | NO159273C (ko) |
NZ (1) | NZ201364A (ko) |
PH (1) | PH19512A (ko) |
PL (1) | PL130643B1 (ko) |
PT (1) | PT75313B (ko) |
SU (1) | SU1179927A3 (ko) |
YU (1) | YU42783B (ko) |
ZA (1) | ZA825275B (ko) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8320005D0 (en) * | 1983-07-25 | 1983-08-24 | Fujisawa Pharmaceutical Co | Benzothiazoline derivatives |
DE3511110A1 (de) * | 1985-03-27 | 1986-10-02 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue pyridazinone, ihre herstellung und diese verbindungen enthaltende arzneimittel |
DE3734083A1 (de) * | 1987-10-08 | 1989-04-20 | Heumann Pharma Gmbh & Co | Benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
ES2080064T3 (es) * | 1988-07-11 | 1996-02-01 | Akzo Nobel Nv | Derivados de piridazinona. |
DE3934436A1 (de) * | 1989-06-01 | 1991-04-18 | Thomae Gmbh Dr K | 2-hydroxy-n-propylamine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
WO2003001968A2 (en) * | 2001-06-26 | 2003-01-09 | Beth Israel Deaconess Medical Center | Compositions and methods for inhibiting platelet activation and thrombosis |
GB201321740D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2516040C2 (de) * | 1974-06-10 | 1984-12-20 | Dr. Karl Thomae Gmbh, 7950 Biberach | Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
ES8101067A1 (es) * | 1978-08-25 | 1980-12-01 | Thomae Gmbh Dr K | Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona |
US4258185A (en) * | 1978-10-17 | 1981-03-24 | Yoshitomi Pharmaceutical Industries, Ltd. | Pyridazinone compounds |
DE2845220A1 (de) * | 1978-10-17 | 1980-04-30 | Yoshitomi Pharmaceutical | Pyridazinon-derivate, ihre salze mit saeuren, verfahren zu ihrer herstellung und ihre verwendung bei der behandlung von thrombosen und hypertonie |
-
1981
- 1981-07-25 DE DE19813129447 patent/DE3129447A1/de not_active Withdrawn
-
1982
- 1982-06-24 NO NO822119A patent/NO159273C/no unknown
- 1982-07-14 SU SU823463049A patent/SU1179927A3/ru active
- 1982-07-15 EP EP82106354A patent/EP0071102B1/de not_active Expired
- 1982-07-15 AT AT82106354T patent/ATE16184T1/de active
- 1982-07-15 DE DE8282106354T patent/DE3267020D1/de not_active Expired
- 1982-07-20 FI FI822549A patent/FI73994C/fi not_active IP Right Cessation
- 1982-07-20 PH PH27594A patent/PH19512A/en unknown
- 1982-07-21 AR AR290036A patent/AR230631A1/es active
- 1982-07-21 PL PL1982237601A patent/PL130643B1/pl unknown
- 1982-07-21 YU YU1597/82A patent/YU42783B/xx unknown
- 1982-07-22 CS CS825592A patent/CS226747B2/cs unknown
- 1982-07-22 HU HU822374A patent/HU188585B/hu unknown
- 1982-07-23 ZA ZA825275A patent/ZA825275B/xx unknown
- 1982-07-23 GR GR68843A patent/GR76230B/el unknown
- 1982-07-23 AU AU86377/82A patent/AU554184B2/en not_active Ceased
- 1982-07-23 DK DK331282A patent/DK331282A/da not_active Application Discontinuation
- 1982-07-23 DD DD82241897A patent/DD202564A5/de unknown
- 1982-07-23 KR KR8203302A patent/KR880001476B1/ko active
- 1982-07-23 JP JP57128813A patent/JPS5824582A/ja active Pending
- 1982-07-23 IE IE1781/82A patent/IE53664B1/en unknown
- 1982-07-23 IL IL66385A patent/IL66385A/xx unknown
- 1982-07-23 GB GB08221293A patent/GB2107703B/en not_active Expired
- 1982-07-23 ES ES514274A patent/ES8308325A1/es not_active Expired
- 1982-07-23 CA CA000407929A patent/CA1189076A/en not_active Expired
- 1982-07-23 PT PT75313A patent/PT75313B/pt unknown
- 1982-07-23 NZ NZ201364A patent/NZ201364A/en unknown
-
1983
- 1983-01-28 ES ES519351A patent/ES8400744A1/es not_active Expired
-
1985
- 1985-06-27 US US06/749,580 patent/US4616018A/en not_active Expired - Fee Related
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